Caution on the use of saliva measurements to monitor absorption of progesterone from transdermal creams in postmenopausal women

Cooper, 1998, Systemic absorption of progesterone from Progest cream in postmenopausal women, Lancet, 351, 1255, 10.1016/S0140-6736(05)79323-5 Lee, 1998, Use of Pro-gest cream in postmenopausal women, Lancet, 352, 905, 10.1016/S0140-6736(05)60044-X Elder, 1997, Generation of monoclonal progesterone antibodies by electrofusion techniques, Bioelectrochem. Bioenerg., 43, 35, 10.1016/S0302-4598(97)00012-3 Lewis, 1994, Re-examining steroid hormone metabolites as ovulation markers using monoclonal antibodies, Steroids, 59, 288, 10.1016/0039-128X(94)90115-5 Wren, 1999, Micronised transdermal progesterone and endometrial response, Lancet, 354, 1447, 10.1016/S0140-6736(99)03430-3 Leonetti, 1999, Transdermal progesterone cream for vasomotor symptoms and postmenopausal bone loss, Obstet. Gynecol., 94, 225, 10.1016/S0029-7844(99)00266-5 Burry, 1999, Percutaneous absorption of progesterone in postmenopausal women treated with transdermal estrogen, Am. J. Obstet. Gynecol., 180, 1504, 10.1016/S0002-9378(99)70046-3 Carey, 2000, A study to evaluate serum and urinary hormone levels following short and long term administration of two regimens of progesterone cream in postmenopausal women, Br. J. Obstet. Gynaecol., 107, 722, 10.1111/j.1471-0528.2000.tb13331.x Wang, 1985, Salivary progesterone: Relation to total and non-protein-bound blood levels, J. Steroid Biochem., 23, 975, 10.1016/0022-4731(85)90055-X Koefoed, 1994, The permeability of the human red cell membrane to steroid hormones, Biochim. Biophys. Acta, 1195, 55, 10.1016/0005-2736(94)90009-4 O'Leary, 2000, Salivary, but not serum or urinary levels of progesterone are elevated after topical application of progesterone cream to pre- and postmenopausal women, Clin. Endocrinol., 53, 615, 10.1046/j.1365-2265.2000.01130.x Laine, 1999, Progesterone metabolism in human saliva in vitro, J. Steroid Biochem. Mol. Biol., 70, 109, 10.1016/S0960-0760(99)00087-4 Li, 1995, The enzyme and inhibitors of 4-ene-3-oxosteroid 5α-oxidoreductase, Steroids, 60, 430, 10.1016/0039-128X(95)00021-H