Chuyển giao oligonucleotit đối kháng c-abl và bcr đến các tế bào myeloid chưa trưởng thành bình thường do lipit mang điện tích dương: Nghiên cứu sự hấp thu, hiệu ứng sinh học và điều chỉnh biểu hiện gen

Ben-Neriah Y, Daley GQ, Mes-Masson AM, Witte ON, Baltimore D (1986) The chronic myelogenous leukemia specific p210 protein is the product of the bcr-abl hybrid gene. Science 233:212–215 Benett CF, Chiang MY, Chan H, Shoemaker JEE, Mirabelli CK (1992) Cationic lipids enhance cellular uptake and activity of phosphorothioate antisense oligonucleotides. Mol Pharmacol 41:1023–1033 Bergan R, Connell Y, Fahmy B, Kyle E, Neckers L (1994) Aptameric inhibition of p210bcr-abl tyrosine kinase autophosphorylation by oligodeoxynucleotides of defined sequence and backbone structure. Nucleic Acids Res 22:2150–2154 Capaccioli S, Di Pasquale G, Mini E, Mazzei T, Quattrone A (1993) Cationic lipids improve antisense oligonucleotide uptake and prevent degradation in cultured cells and in human serum. Biochem Biophys Res Commun 197:818–825 Caracciolo D, Valtieri M, Venturelli D, Peschle C, Gewirtz AM, Calabretta B (1989) Lineage-specific requirement of cabl function in normal hematopoiesis. Science 245:1107–1110 Chin DJ, Green GA, Zon G, Skoza JR, Staubinger RM (1990) Rapid nuclear accumulation of injected oligonucleotides. New Biologist 2:1091–100 Chromczynski P, Sacci N (1987) Single step method of RNA isolation by acid-guanidinium-thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156–164 Geselowitz DA, Neckers LM (1992) Analysis of oligonucleotide binding, internalization, and intracellular trafficking utilizing a novel radiolabeled cross-linker. Antisense Res Dev 2:17–25 Giles RV, Tidd DM (1992) Increased specificity for antisense oligodeoxynucleotide targeting of RNA-cleavage by RNAse H using chimeric methypphosphonate/phosphodiester structures. Nucleic Acids Res 20:763–770 Helene C, Toulme JJ (1990) Specific regulation of gene expression by antisense, sense and antigene nucleic acids. Biochim Biophys Acta 1049:99–125 Keller G, Kennedy M, Papayannopoulou T, Wiles MV (1993) Hematopoietic commitment during embryonic stem cell differentiation in culture. Mol Cell Biol 13:473–86 Leonetti JP, Mechti N, Degols G, Gagnor C, Lebleu B (1991) Intracellular distribution of microinjected oligonucleotides. Proc Natl Acad Sci USA 88:2702–2706 Liberati AM, Donti E, Rosso C, Lo Coco F, Dore F, Pardini S, Cocco S, Addis M, Saglio G (1994) Repeated PCR in CML during IFN-alpha therapy. Eur J Haematol 52:152–155 Mc Laughlin LW, Piel N 1984) Oligonucleotide synthesis. A practical approach. In: Gait MJ (ed) Chromatographic purification of synthetic oligonucleotides. IRL Press, Oxford, pp 117–133 Nowell PC, Hungerford DA (1960) A minute chromosome in human granulocytic leukemia. Science 132:1497–1500 Saiki RK, Gelfand DH, Stoffel S, Scharf SJ, Higuchi R, Horn GT, Mullis KB, Erlich HA (1988) Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase. Science 239:487–490 Spiller DG, Tidd DM (1992) The uptake of chimeric oligonucleotide analogues in human leukemia MOLT-4 cells. Anticancer Drug Des 7:115–119 Thierry AR, Dritschilo A (1992) Intracellular availability of unmodified, phosphorothioated and liposomally encapsulated oligodeoxynucleotides for antisense activity. Nucleic Acids Res 20:5691–5698 Woolf TM, Jennings CG, Rebagliati M, Melton DA (1990) The stability and toxicity and effectiveness of unmodified and phosphorothioate antisense oligodeoxynucleotides inXenopus oocytes and embryos. Nucleic Acids Res 18:1763–9 Zhao Q, Matson S, Herrera CJ, Fisher E, Yu H, Krieg AM (1993) Comparison of cellular binding and uptake of antisense phosphodiester, phosphorothioate, and mixed phosphorothioate and methyphosphonate oligonucleotides. Antisense Res Dev 3:53–66