Caspase-8 inhibition improves the outcome of bacterial infections in mice by promoting neutrophil activation

Van Opdenbosch, 2019, Caspases in cell death, inflammation, and disease, Immunity, 50, 1352, 10.1016/j.immuni.2019.05.020 Julien, 2017, Caspases and their substrates, Cell Death Differ., 24, 1380, 10.1038/cdd.2017.44 Orning, 2021, Multiple roles of caspase-8 in cell death, inflammation, and innate immunity, J. Leukoc. Biol., 109, 121, 10.1002/JLB.3MR0420-305R Tummers, 2017, Caspase-8: regulating life and death, Immunol. Rev., 277, 76, 10.1111/imr.12541 Newton, 2021, Dying cells fan the flames of inflammation, Science, 374, 1076, 10.1126/science.abi5934 Orning, 2018, Pathogen blockade of TAK1 triggers caspase-8-dependent cleavage of gasdermin D and cell death, Science, 362, 1064, 10.1126/science.aau2818 Shi, 2017, Pyroptosis: gasdermin-mediated programmed necrotic cell death, Trends Biochem. Sci., 42, 245, 10.1016/j.tibs.2016.10.004 Newton, 2019, Cleavage of RIPK1 by caspase-8 is crucial for limiting apoptosis and necroptosis, Nature, 574, 428, 10.1038/s41586-019-1548-x Oberst, 2011, Catalytic activity of the caspase-8-FLIP(L) complex inhibits RIPK3-dependent necrosis, Nature, 471, 363, 10.1038/nature09852 Chun, 2002, Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency, Nature, 419, 395, 10.1038/nature01063 Lehle, 2019, Intestinal inflammation and dysregulated immunity in patients with inherited caspase-8 deficiency, Gastroenterology, 156, 275, 10.1053/j.gastro.2018.09.041 Allam, 2014, Mitochondrial apoptosis is dispensable for NLRP3 inflammasome activation but non-apoptotic caspase-8 is required for inflammasome priming, EMBO Rep., 15, 982, 10.15252/embr.201438463 DeLaney, 2019, Caspase-8 promotes c-Rel-dependent inflammatory cytokine expression and resistance against Toxoplasma gondii, Proc. Natl. Acad. Sci. USA, 116, 11926, 10.1073/pnas.1820529116 Ganesan, 2014, Caspase-8 modulates dectin-1 and complement receptor 3-driven IL-1beta production in response to beta-glucans and the fungal pathogen, Candida albicans, J. Immunol., 193, 2519, 10.4049/jimmunol.1400276 Gurung, 2014, FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes, J. Immunol., 192, 1835, 10.4049/jimmunol.1302839 Man, 2013, Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1beta production, J. Immunol., 191, 5239, 10.4049/jimmunol.1301581 Philip, 2016, Activity of uncleaved caspase-8 controls anti-bacterial immune defense and TLR-induced cytokine production independent of cell death, PLoS Pathog., 12, 10.1371/journal.ppat.1005910 Weng, 2014, Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death, Proc. Natl. Acad. Sci. USA, 111, 7391, 10.1073/pnas.1403477111 Fritsch, 2019, Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis, Nature, 575, 683, 10.1038/s41586-019-1770-6 Holmes, 2016, Understanding the mechanisms and drivers of antimicrobial resistance, Lancet, 387, 176, 10.1016/S0140-6736(15)00473-0 Lentini, 2022, Neutrophils discriminate live from dead bacteria by integrating signals initiated by Fprs and TLRs, EMBO J., 41, 10.15252/embj.2021109386 Ley, 2018, Neutrophils: new insights and open questions, Sci. Immunol., 3, 10.1126/sciimmunol.aat4579 Theilgaard-Mönch, 2005, The transcriptional program of terminal granulocytic differentiation, Blood, 105, 1785, 10.1182/blood-2004-08-3346 Grieshaber-Bouyer, 2021, The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments, Nat. Commun., 12, 2856, 10.1038/s41467-021-22973-9 Landwehr-Kenzel, 2014, Interaction of Streptococcus agalactiae and cellular innate immunity in colonization and disease, Front. Immunol., 5, 519, 10.3389/fimmu.2014.00519 Mancuso, 2009, Bacterial recognition by TLR7 in the lysosomes of conventional dendritic cells, Nat. Immunol., 10, 587, 10.1038/ni.1733 Mancuso, 2004, Dual role of TLR2 and myeloid differentiation factor 88 in a mouse model of invasive group B streptococcal disease, J. Immunol., 172, 6324, 10.4049/jimmunol.172.10.6324 Teti, 1993, Cytokine appearance and effects of anti-tumor necrosis factor alpha antibodies in a neonatal rat model of group B streptococcal infection, Infect. Immun., 61, 227, 10.1128/iai.61.1.227-235.1993 Poreba, 2013, Caspase substrates and inhibitors, Cold Spring Harb. Perspect. Biol., 5, 10.1101/cshperspect.a008680 Newton, 2020, Multitasking kinase RIPK1 regulates cell death and inflammation, Cold Spring Harb. Perspect. Biol., 12, 10.1101/cshperspect.a036368 Pham, 2008, Neutrophil serine proteases fine-tune the inflammatory response, Int. J. Biochem. Cell Biol., 40, 1317, 10.1016/j.biocel.2007.11.008 Biondo, 2019, The dual role of innate immunity during influenza, Biomed. J., 42, 8, 10.1016/j.bj.2018.12.009 Patel, 2020, RIP1 inhibition blocks inflammatory diseases but not tumor growth or metastases, Cell Death Differ., 27, 161, 10.1038/s41418-019-0347-0 Signorino, 2014, Role of Toll-like receptor 13 in innate immune recognition of group B streptococci, Infect. Immun., 82, 5013, 10.1128/IAI.02282-14 Teti, 1997, Age-related sensitivity of neonatal mice to toxicity induced by heat-killed group B streptococci, Adv. Exp. Med. Biol., 418, 945, 10.1007/978-1-4899-1825-3_222 Mancuso, 2007, Type I IFN signaling is crucial for host resistance against different species of pathogenic bacteria, J. Immunol., 178, 3126, 10.4049/jimmunol.178.5.3126 Watson, 1993, A brief history of the pneumococcus in biomedical research: a panoply of scientific discovery, Clin. Infect. Dis., 17, 913, 10.1093/clinids/17.5.913 Famà, 2020, Nucleic acid-sensing toll-like receptors play a dominant role in innate immune recognition of pneumococci, mBio, 11, 10.1128/mBio.00415-20 Kovalenko, 2009, Caspase-8 deficiency in epidermal keratinocytes triggers an inflammatory skin disease, J. Exp. Med., 206, 2161, 10.1084/jem.20090616 Yuan, 2016, Roles of caspases in necrotic cell death, Cell, 167, 1693, 10.1016/j.cell.2016.11.047 Tecchio, 2014, Neutrophil-derived cytokines: facts beyond expression, Front. Immunol., 5, 508, 10.3389/fimmu.2014.00508 Thornberry, 1997, A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis, J. Biol. Chem., 272, 17907, 10.1074/jbc.272.29.17907 Pereira, 2008, Some commonly used caspase substrates and inhibitors lack the specificity required to monitor individual caspase activity, Biochem. Biophys. Res. Commun., 377, 873, 10.1016/j.bbrc.2008.10.101 Poreba, 2019, Caspase selective reagents for diagnosing apoptotic mechanisms, Cell Death Differ., 26, 229, 10.1038/s41418-018-0110-y Feng, 2007, Cleavage of RIP3 inactivates its caspase-independent apoptosis pathway by removal of kinase domain, Cell. Signal., 19, 2056, 10.1016/j.cellsig.2007.05.016 Lin, 1999, Cleavage of the death domain kinase RIP by caspase-8 prompts TNF-induced apoptosis, Genes Dev., 13, 2514, 10.1101/gad.13.19.2514 Pasparakis, 2015, Necroptosis and its role in inflammation, Nature, 517, 311, 10.1038/nature14191 Daniels, 2019, The nucleotide sensor ZBP1 and kinase RIPK3 induce the enzyme IRG1 to promote an antiviral metabolic state in neurons, Immunity, 50, 64, 10.1016/j.immuni.2018.11.017 Daniels, 2017, RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation, Cell, 169, 301, 10.1016/j.cell.2017.03.011 Najjar, 2016, RIPK1 and RIPK3 kinases promote cell-death-independent inflammation by toll-like receptor 4, Immunity, 45, 46, 10.1016/j.immuni.2016.06.007 Saleh, 2017, Kinase activities of RIPK1 and RIPK3 can direct IFN-beta synthesis induced by lipopolysaccharide, J. Immunol., 198, 4435, 10.4049/jimmunol.1601717 Moriwaki, 2014, The necroptosis adaptor RIPK3 promotes injury-induced cytokine expression and tissue repair, Immunity, 41, 567, 10.1016/j.immuni.2014.09.016 Kang, 2013, Caspase-8 blocks kinase RIPK3-mediated activation of the NLRP3 inflammasome, Immunity, 38, 27, 10.1016/j.immuni.2012.09.015 Moriwaki, 2016, Necroptosis-independent signaling by the RIP kinases in inflammation, Cell. Mol. Life Sci., 73, 2325, 10.1007/s00018-016-2203-4 Newton, 2019, Activity of caspase-8 determines plasticity between cell death pathways, Nature, 575, 679, 10.1038/s41586-019-1752-8 Günther, 2015, Caspase-8 controls the gut response to microbial challenges by Tnf-alpha-dependent and independent pathways, Gut, 64, 601, 10.1136/gutjnl-2014-307226 Biondo, 2014, The interleukin-1beta/CXCL1/2/neutrophil axis mediates host protection against group B streptococcal infection, Infect. Immun., 82, 4508, 10.1128/IAI.02104-14 Lentini, 2020, Neutrophils enhance their own influx to sites of bacterial infection via endosomal TLR-dependent Cxcl2 production, J. Immunol., 204, 660, 10.4049/jimmunol.1901039 Mohammadi, 2016, Neutrophils directly recognize group B streptococci and contribute to interleukin-1beta production during infection, PLoS One, 11, 10.1371/journal.pone.0160249 Mandal, 2018, Caspase-8 collaborates with caspase-11 to drive tissue damage and execution of endotoxic shock, Immunity, 49, 42, 10.1016/j.immuni.2018.06.011 Wallis, 2022, Host-directed immunotherapy of viral and bacterial infections: past, present and future, Nat. Rev. Immunol., 23, 121, 10.1038/s41577-022-00734-z Alphonse, 2021, Pan-caspase inhibition as a potential host-directed immunotherapy against MRSA and other bacterial skin infections, Sci. Transl. Med., 13, 10.1126/scitranslmed.abe9887 Man, 2017, Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases, Immunol. Rev., 277, 61, 10.1111/imr.12534 Li, 1995, Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock, Cell, 80, 401, 10.1016/0092-8674(95)90490-5 Newton, 2004, Kinase RIP3 is dispensable for normal NF-kappa Bs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4, Mol. Cell Biol., 24, 1464, 10.1128/MCB.24.4.1464-1469.2004 Murphy, 2013, The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism, Immunity, 39, 443, 10.1016/j.immuni.2013.06.018 Erlandsson, 1998, Interferon-beta is required for interferon-alpha production in mouse fibroblasts, Curr. Biol., 8, 223, 10.1016/S0960-9822(98)70086-7 Salmena, 2003, Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity, Genes Dev., 17, 883, 10.1101/gad.1063703 Costa, 2012, Activation of the NLRP3 inflammasome by group B streptococci, J. Immunol., 188, 1953, 10.4049/jimmunol.1102543 Huet, 2013, Ensuring animal welfare while meeting scientific aims using a murine pneumonia model of septic shock, Shock, 39, 488, 10.1097/SHK.0b013e3182939831 Lentini, 2021, Role of endosomal TLRs in Staphylococcus aureus infection, J. Immunol., 207, 1448, 10.4049/jimmunol.2100389 Biondo, 2005, MyD88 and TLR2, but not TLR4, are required for host defense against Cryptococcus neoformans, Eur. J. Immunol., 35, 870, 10.1002/eji.200425799