Carotid intima media thickness, brachial flow mediated dilation and previous history of gestational diabetes mellitus

Journal of Obstetrics and Gynaecology Research - Tập 38 Số 8 - Trang 1057-1063 - 2012
Hossein Fakhrzadeh1, Sudabeh Alatab1, Farshad Sharifi1, Mojde Mirarefein1, Zohreh Badamchizadeh1, Maryam Ghaderpanahi1, Amir Pejman Hashemi Taheri2, Bagher Larijani1
1Endocrinology and Metabolism Research Center,
2Radiology Department, Tehran University of Medical Sciences, Tehran, Iran

Tóm tắt

Abstract

Aim:  Gestational diabetes mellitus (GDM) is a common pregnancy condition with long‐term complications. We examined the association between inflammatory mediators and early atherosclerosis process by measuring the flow mediated dilatation (FMD) of brachial artery and carotid intima media thickness (CIMT) in women with previous GDM (pGDM).

Material and Methods:  Women with and without pGDM with an average of 4 years following the indexed pregnancy, participated in this study. Serum levels of IL‐6, hs‐CRP, adiponectin, homocystein and other biomedical parameters were measured. The existence of early atherogenesis process was evaluated by measuring CIMT and FMD.

Results:  HOMA‐IR and insulin were significantly higher in women with pGDM. Women with pGDM had slightly higher CIMT and significantly lower percent of brachial FMD. FMD and CIMT, adjusted for age and blood pressure, showed the same pattern. FMD showed no correlation with biochemical or inflammatory markers.

Conclusion:  Follow‐up of this group of women, who are at increased risk of cardiovascular disease, with FMD should be considered.

Từ khóa


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Thông tin xuất bản

Journal of Obstetrics and Gynaecology Research

Tập 38 Số 8

1057-1063

Thông tin tác giả