Carnosic acid (CA) attenuates collagen-induced arthritis in db/db mice via inflammation suppression by regulating ROS-dependent p38 pathway

Free Radical Biology and Medicine - Tập 108 - Trang 418-432 - 2017
Guangtao Xia1, Xia Wang1, Hongsheng Sun1, Yuhong Qin2, Min Fu1
1Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong 250021, PR China
2School of Life Sciences, Tsinghua University, Beijing 100000, PR China

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Firestein, 2003, Evolving concepts of rheumatoid arthritis, Nature, 423, 356, 10.1038/nature01661

Walsh, 2005, Rheumatic diseases: the effects of inflammation on bone, Immunol. Rev., 208, 228, 10.1111/j.0105-2896.2005.00338.x

Solomon, 2010, Explaining the cardiovascular risk associated with rheumatoid arthritis: traditional risk factors versus markers of rheumatoid arthritis severity, Ann. Rheum. Dis., 69, 1920, 10.1136/ard.2009.122226

Maradit-Kremers, 2005, Cardiovascular death in rheumatoid arthritis: a population-based study, Arthritis Rheum., 52, 722, 10.1002/art.20878

Han, 2006, Cardiovascular disease and risk factors in patients with rheumatoid arthritis, psoriatic arthritis, and ankylosing spondylitis, J. Rheumatol., 33, 2167

Niu, 2015, The crosstalk of pathways involved in immune response maybe the shared molecular basis of rheumatoid arthritis and type 2 diabetes, PLoS One, 10, e0134990, 10.1371/journal.pone.0134990

Gabriel, 2008, Cardiovascular morbidity and mortality in rheumatoid arthritis, Am. J. Med., 121, S9, 10.1016/j.amjmed.2008.06.011

Gelfand, 2006, Risk of myocardial infarction in patients with psoriasis, Jama, 296, 1735, 10.1001/jama.296.14.1735

Gonzalez-Gay, 2006, Anti-tumor necrosis factor-alpha blockade improves insulin resistance in patients with rheumatoid arthritis, Clin. Exp. Rheumatol., 24, 83

Tam, 2007, Impact of TNF inhibition on insulin resistance and lipids levels in patients with rheumatoid arthritis, Clin. Rheumatol., 26, 1495, 10.1007/s10067-007-0539-8

de Oliveira, 2015, The dietary components carnosic acid and carnosol as neuroprotective agents: a mechanistic view, Mol. Neurobiol., 1

Petiwala, 2016, Carnosic acid promotes degradation of the androgen receptor and is regulated by the unfolded protein response pathway in vitro and in vivo, Carcinogenesis, 10.1093/carcin/bgw052

de Oliveira, 2015, Role for the PI3K/Akt/Nrf2 signaling pathway in the protective effects of carnosic acid against methylglyoxal-induced neurotoxicity in SH-SY5Y neuroblastoma cells, Chem.-Biol. Interact., 242, 396, 10.1016/j.cbi.2015.11.003

Nishimoto, 2016, Nrf2 activation ameliorates cytotoxic effects of arsenic trioxide in acute promyelocytic leukemia cells through increased glutathione levels and arsenic efflux from cells, Toxicol. Appl. Pharmacol., 305, 161, 10.1016/j.taap.2016.06.017

Quinonez-Flores, 2016, Oxidative stress relevance in the pathogenesis of the Rheumatoid Arthritis: a systematic review, BioMed. Res. Int., 2016, 6097417, 10.1155/2016/6097417

Kundu, 2012, Oxidative stress as a potential biomarker for determining disease activity in patients with Rheumatoid Arthritis, Free Radic. Res., 46, 1482, 10.3109/10715762.2012.727991

Navarro-Compan, 2013, Interaction between oxidative stress and smoking is associated with an increased risk of rheumatoid arthritis: a case-control study, Rheumatology, 52, 487, 10.1093/rheumatology/kes286

Lean, 2003, A crucial role for thiol antioxidants in estrogen-deficiency bone loss, J. Clin. Investig., 112, 915, 10.1172/JCI200318859

Manolagas, 2010, From estrogen-centric to aging and oxidative stress: a revised perspective of the pathogenesis of osteoporosis, Endocr. Rev., 31, 266, 10.1210/er.2009-0024

Thannickal, 2000, Reactive oxygen species in cell signaling, Am. J. Physiol. Lung Cell. Mol. Physiol., 279, L1005, 10.1152/ajplung.2000.279.6.L1005

Wang, 2016, Erianin induces G2/M-phase arrest, apoptosis, and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells in vitro and in vivo, Cell Death Dis., 7, e2247, 10.1038/cddis.2016.138

Wang, 2016, Costunolide induces lung adenocarcinoma cell line A549 cells apoptosis through ROS (reactive oxygen species)-mediated endoplasmic reticulum stress, Cell Biol. Int., 40, 289, 10.1002/cbin.10564

Mantel, 2012, Mouse hematopoietic cell-targeted STAT3 deletion: stem/progenitor cell defects, mitochondrial dysfunction, ROS overproduction, and a rapid aging-like phenotype, Blood, 120, 2589, 10.1182/blood-2012-01-404004

Lee, 2005, A crucial role for reactive oxygen species in RANKL-induced osteoclast differentiation, Blood, 106, 852, 10.1182/blood-2004-09-3662

Armstrong, 2002, A RANK/TRAF6-dependent signal transduction pathway is essential for osteoclast cytoskeletal organization and resorptive function, J. Biol. Chem., 277, 44347, 10.1074/jbc.M202009200

Faccio, 2003, High dose M-CSF partially rescues the Dap12-/- osteoclast phenotype, J. Cell. Biochem., 90, 871, 10.1002/jcb.10694

Yip, 2005, Thapsigargin modulates osteoclastogenesis through the regulation of RANKL-induced signaling pathways and reactive oxygen species production, J. Bone Miner. Res.: Off. J. Am. Soc. Bone Miner. Res., 20, 1462, 10.1359/JBMR.050324

Matsumoto, 2016, Soluble Siglec-9 suppresses arthritis in a collagen-induced arthritis mouse model and inhibits M1 activation of RAW264.7 macrophages, Arthritis Res. Ther., 18, 133, 10.1186/s13075-016-1035-9

Costa-Rodrigues, 2010, Characterisation of the osteoclastogenic potential of human osteoblastic and fibroblastic conditioned media, J. Cell. Biochem., 109, 205, 10.1002/jcb.22398

Lu, 2014, Mibefradil reduces blood glucose concentration in db/db mice, Clinics, 69, 61, 10.6061/clinics/2014(01)09

Ediz, 2011, Relationship between anti-CCP antibodies and oxidant and anti-oxidant activity in patients with rheumatoid arthritis, Int. J. Med. Sci., 8, 139, 10.7150/ijms.8.139

Kim, 2015, Cudrania tricuspidata water extract improved obesity-induced hepatic insulin resistance in db/db mice by suppressing ER stress and inflammation, Food Nutr. Res., 59, 29165, 10.3402/fnr.v59.29165

Liu, 2016, Whole body vibration improves insulin resistance in db/db mice: amelioration of lipid accumulation and oxidative stress, Appl. Biochem. Biotechnol., 1

Wang, 2013, Latanoprost effectively ameliorates glucose and lipid disorders in db/db and ob/ob mice, Diabetologia, 56, 2702, 10.1007/s00125-013-3032-8

Park, 2009, Vascular endothelial growth factor inhibition by dRK6 causes endothelial apoptosis, fibrosis, and inflammation in the heart via the Akt/eNOS axis in db/db mice, Diabetes, 58, 2666, 10.2337/db09-0136

Tamura, 2013, Enzamin ameliorates adipose tissue inflammation with impaired adipocytokine expression and insulin resistance in db/db mice, J. Nutr. Sci., 2, e37, 10.1017/jns.2013.34

Solini, 2016, Saxagliptin prevents vascular remodeling and oxidative stress in db/db mice. Role of endothelial nitric oxide synthase uncoupling and cyclooxygenase, Vasc. Pharmacol., 76, 62, 10.1016/j.vph.2015.10.002

Li, 2010, Inhibition of reactive oxygen species by Lovastatin downregulates vascular endothelial growth factor expression and ameliorates blood-retinal barrier breakdown in db/db mice: role of NADPH oxidase 4, Diabetes, 59, 1528, 10.2337/db09-1057

Karagulle, 2016, Effect of spa therapy with saline balneotherapy on oxidant/antioxidant status in patients with rheumatoid arthritis: a single-blind randomized controlled trial, Int. J. Biometeorol., 1

Kharkwal, 2012, Ormeloxifene inhibits osteoclast differentiation in parallel to downregulating RANKL-induced ROS generation and suppressing the activation of ERK and JNK in murine RAW264.7 cells, J. Mol. Endocrinol., 48, 261, 10.1530/JME-11-0061

Lee, 2013, Acteoside suppresses RANKL-mediated osteoclastogenesis by inhibiting c-Fos induction and NF-kappaB pathway and attenuating ROS production, PLoS One, 8, e80873, 10.1371/journal.pone.0080873

Hsu, 2013, Yuwen02f1 suppresses LPS-induced endotoxemia and adjuvant-induced arthritis primarily through blockade of ROS formation, NFkB and MAPK activation, Biochem. Pharmacol., 85, 385, 10.1016/j.bcp.2012.11.002

Park, 2014, STA-21, a promising STAT-3 inhibitor that reciprocally regulates Th17 and Treg cells, inhibits osteoclastogenesis in mice and humans and alleviates autoimmune inflammation in an experimental model of rheumatoid arthritis, Arthritis Rheumatol., 66, 918, 10.1002/art.38305

Thummuri, 2015, Thymoquinone prevents RANKL-induced osteoclastogenesis activation and osteolysis in an in vivo model of inflammation by suppressing NF-KB and MAPK Signalling, Pharmacol. Res., 99, 63, 10.1016/j.phrs.2015.05.006

Qin, 2015, Natural Germacrane Sesquiterpenes inhibit osteoclast formation, bone resorption, RANKL-induced NF-kappaB activation, and IkappaBalpha degradation, Int. J. Mol. Sci., 16, 26599, 10.3390/ijms161125972

Tikellis, 2014, Dicarbonyl stress in the absence of hyperglycemia increases endothelial inflammation and atherogenesis similar to that observed in diabetes, Diabetes, 63, 3915, 10.2337/db13-0932

Barouch, 2003, Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice, Circulation, 108, 754, 10.1161/01.CIR.0000083716.82622.FD

Wold, 2004, Streptozotocin directly impairs cardiac contractile function in isolated ventricular myocytes via a p38 map kinase-dependent oxidative stress mechanism, Biochem. Biophys. Res. Commun., 318, 1066, 10.1016/j.bbrc.2004.04.138

Chen, 2015, Upconversion nanoprobes for efficiently in vitro imaging reactive oxygen species and in vivo diagnosing rheumatoid arthritis, Biomaterials, 39, 15, 10.1016/j.biomaterials.2014.10.066

Girardelli, 2013, A comparative analysis of serologic parameters and oxidative stress in osteoarthritis and rheumatoid arthritis: reply to Mishra and colleagues, Rheumatol. Int., 33, 2445, 10.1007/s00296-012-2436-y

Ambrozova, 2011, The effect of lipid peroxidation products on reactive oxygen species formation and nitric oxide production in lipopolysaccharide-stimulated RAW 264.7 macrophages, Toxicol. Vitr., 25, 145, 10.1016/j.tiv.2010.10.006

Miller, 2013, Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo, Free Radic. Biol. Med., 57, 1, 10.1016/j.freeradbiomed.2012.12.011

Miller, 2013, Administration of the Nrf2-ARE activators sulforaphane and carnosic acid attenuates 4-hydroxy-2-nonenal-induced mitochondrial dysfunction ex vivo, Free Radic. Biol. Med., 57, 1, 10.1016/j.freeradbiomed.2012.12.011

Wang, 2011, Carnosic acid prevents obesity and hepatic steatosis in ob/ob mice, Hepatol. Res.: Off. J. Jpn. Soc. Hepatol., 41, 87, 10.1111/j.1872-034X.2010.00747.x

Levine, 2014, Neurostimulation of the cholinergic anti-inflammatory pathway ameliorates disease in rat collagen-induced arthritis, PLoS One, 9, e104530, 10.1371/journal.pone.0104530

Costantino, 2013, Screening for latent tuberculosis infection in patients with chronic inflammatory arthritis: discrepancies between tuberculin skin test and interferon-gamma release assay results, J. Rheumatol., 40, 1986, 10.3899/jrheum.130303

Hall, 1995, The role of reactive oxygen intermediates in osteoclastic bone resorption, Biochem. Biophys. Res. Commun., 207, 280, 10.1006/bbrc.1995.1184

Lee, 2015, Scoparone attenuates RANKL-induced osteoclastic differentiation through controlling reactive oxygen species production and scavenging, Exp. Cell Res., 331, 267, 10.1016/j.yexcr.2014.12.018

Chen, 2014, Estrogen inhibits RANKL-induced osteoclastic differentiation by increasing the expression of TRPV5 channel, J. Cell. Biochem., 115, 651, 10.1002/jcb.24700

Samanna, 2007, Actin polymerization modulates CD44 surface expression, MMP-9 activation, and osteoclast function, J. Cell. Physiol., 213, 710, 10.1002/jcp.21137

Xiao, 2016, Piperlongumine suppresses dendritic cell maturation by reducing production of reactive oxygen species and has therapeutic potential for Rheumatoid Arthritis, J. Immunol., 196, 4925, 10.4049/jimmunol.1501281

Cheng, 2016, A herbal formula comprising Rosae Multiflorae Fructus and Lonicerae Japonicae Flos, attenuates collagen-induced arthritis and inhibits TLR4 signalling in rats, Sci. Rep., 6, 20042, 10.1038/srep20042

Maines, 1986, Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible, J. Biol. Chem., 261, 411, 10.1016/S0021-9258(17)42488-4

Scapagnini, 2011, Modulation of Nrf2/ARE pathway by food polyphenols: a nutritional neuroprotective strategy for cognitive and neurodegenerative disorders, Mol. Neurobiol., 44, 192, 10.1007/s12035-011-8181-5

Topo, 2010, Thyroid hormones and D-aspartic acid, D-aspartate oxidase, D-aspartate racemase, H2O2, and ROS in rats and mice, Chem. Biodivers., 7, 1467, 10.1002/cbdv.200900360

Ahn, 2008, Simvastatin, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor, suppresses osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand through modulation of NF-kappaB pathway, Int. J. Cancer, 123, 1733, 10.1002/ijc.23745

Moon, 2011, Simvastatin inhibits osteoclast differentiation by scavenging reactive oxygen species, Exp. Mol. Med., 43, 605, 10.3858/emm.2011.43.11.067

von Metzler, 2009, Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated I kappaB kinase, J. Cancer Res. Clin. Oncol., 135, 173, 10.1007/s00432-008-0461-8

Md Zulfiker, 2016, Aqueous and ethanol extracts of Australian Cane toad skins suppress pro-inflammatory cytokine secretion in U937 cells via NF-kappaB signalling pathway, J. Cell. Biochem.

Bhattacharya, 2015, Dual role of GM-CSF as a pro-inflammatory and a regulatory cytokine: implications for immune therapy, J. Interferon Cytokine Res., 35, 585, 10.1089/jir.2014.0149

Gathungu, 2013, Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease, Inflamm. Bowel Dis., 19, 1671, 10.1097/MIB.0b013e318281f506

Rowin, 2012, Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: effects on regulatory T cells, Muscle Nerve, 46, 449, 10.1002/mus.23488

McDaniel, 2016, Emerging roles for noncanonical NF-κB signaling in the modulation of inflammatory bowel disease pathobiology, Inflamm. bowel Dis., 22, 2265, 10.1097/MIB.0000000000000858

Zhang, 2016, Methane limit LPS-induced NF-κB/MAPKs signal in macrophages and suppress immune response in mice by enhancing PI3K/AKT/GSK-3β-mediated IL-10 expression, Sci. Rep., 6, 29359, 10.1038/srep29359

S.M. Farooq, A. Kumar, H.M. Ashour Eye-mediated immune tolerance to type II collagen in arthritis-prone strains of mice, J. Cell. Mol. Med., 18, 2512–2518.

Farooq, 2012, Type II collagen induces peripheral tolerance in BALB/c mice via the generation of CD8+ T regulatory cells, PLoS One, 7, e48635, 10.1371/journal.pone.0048635

Han, 2007, Inhibition of osteoclast differentiation and bone resorption by sauchinone, Biochem. Pharmacol., 74, 911, 10.1016/j.bcp.2007.06.044

Lee, 2009, Inhibitory effect of luteolin on osteoclast differentiation and function, Cytotechnology, 61, 125, 10.1007/s10616-010-9253-5