Cargo transport properties are enhanced by cylindrical microtubule geometry and elliptical contact zone on cargo surface

Akhmanova, 2015, Control of microtubule organization and dynamics: Two ends in the limelight, Nature Rev. Mol. Cell Biol., 16, 711, 10.1038/nrm4084 Araujo, 2020, Lysosomal size matters, Traffic, 21, 60, 10.1111/tra.12714 Bálint, 2013, Correlative live-cell and superresolution microscopy reveals cargo transport dynamics at microtubule intersections, Proc. Natl. Acad. Sci., 110, 3375, 10.1073/pnas.1219206110 Bandyopadhyay, 2014, Lysosome transport as a function of lysosome diameter, PLoS ONE, 9, 10.1371/journal.pone.0086847 Bergman, 2018, Cargo navigation across 3D microtubule intersections, Proc. Natl. Acad. Sci., 115, 537, 10.1073/pnas.1707936115 Bovyn, 2021, Diffusion of kinesin motors on cargo can enhance binding and run lengths during intracellular transport, Mol. Biol. Cell, 32, 984, 10.1091/mbc.E20-10-0658 Burute, 2019, Cellular logistics: Unraveling the interplay between microtubule organization and intracellular transport, Annu. Rev. Cell Dev. Biol., 35, 29, 10.1146/annurev-cellbio-100818-125149 Campàs, 2008, Coordination of Kinesin motors pulling on fluid membranes, Biophys. J., 94, 5009, 10.1529/biophysj.107.118554 Chaaban, 2017, A microtubule bestiary: structural diversity in tubulin polymers, Mol. Biol. Cell, 28, 2924, 10.1091/mbc.e16-05-0271 Erickson, 2011, How molecular motors are arranged on a cargo is important for vesicular transport, PLoS Comput. Biol., 7, 10.1371/journal.pcbi.1002032 Graham, 1972, An efficient algorith for determining the convex hull of a finite planar set, Inform. Process. Lett., 1, 132, 10.1016/0020-0190(72)90045-2 Groebner, 2019, Alcohol-induced microtubule acetylation leads to the accumulation of large, immobile lipid droplets, Am. J. Physiol Gastrointest. Liver Physiol., 317, G373, 10.1152/ajpgi.00026.2019 Jarvis, 1973, On the identification of the convex hull of a finite set of points in the plane, Inform. Process. Lett., 2, 18, 10.1016/0020-0190(73)90020-3 Jiang, 2019, Microtubule binding kinetics of membrane-bound Kinesin-1 predicts high motor copy numbers on intracellular cargo, Proc. Natl. Acad. Sci., 116, 26564, 10.1073/pnas.1916204116 Kamimura, 1992, Tubulin protofilaments and kinesin-dependent motility, J. Cell Biol., 118, 865, 10.1083/jcb.118.4.865 Khataee, 2019, Force generated by two Kinesin motors depends on the load direction and intermolecular coupling, Phys. Rev. Lett., 122, 10.1103/PhysRevLett.122.188101 Klumpp, 2005, Cooperative cargo transport by several molecular motors, Proc. Natl. Acad. Sci., 102, 17284, 10.1073/pnas.0507363102 Korn, 2009, Stochastic simulations of cargo transport by processive molecular motors, J. Chem. Phys., 131, 10.1063/1.3279305 Kunwar, 2010, Robust transport by multiple motors with nonlinear force–velocity relations and stochastic load sharing, Phys. Biol., 7, 10.1088/1478-3975/7/1/016012 Kunwar, 2011, Mechanical stochastic tug-of-war models cannot explain bidirectional lipid-droplet transport, Proc. Natl. Acad. Sci., 108, 18960, 10.1073/pnas.1107841108 Kunwar, 2008, Stepping, strain gating, and an unexpected force-velocity curve for multiple-motor-based transport, Curr. Biol., 18, 1173, 10.1016/j.cub.2008.07.027 Lee, 2017, Shoelace formula: Connecting the area of a polygon and the vector cross product, Math. Teach., 110, 631, 10.5951/mathteacher.110.8.0631 Li, 2018, A fluid membrane enhances the velocity of cargo transport by small teams of kinesin-1, J. Chem. Phys., 148, 10.1063/1.5006806 Nelson, 2014, Motor coupling through lipid membranes enhances transport velocities for ensembles of myosin Va, Proc. Natl. Acad. Sci., 111, E3986, 10.1073/pnas.1406535111 Pyrpassopoulos, 2020, Modulation of Kinesin’s load-bearing capacity by force geometry and the microtubule track, Biophys. J., 118, 243, 10.1016/j.bpj.2019.10.045 Rai, 2016, Dynein clusters into lipid microdomains on phagosomes to drive rapid transport toward lysosomes, Cell, 164, 722, 10.1016/j.cell.2015.12.054 Sabharwal, 2019, Crowd control: Effects of physical crowding on cargo movement in healthy and diseased neurons, Front. Cell. Neurosci., 13, 1, 10.3389/fncel.2019.00470 Sarpangala, 2022, Cargo surface fluidity can reduce inter-motor mechanical interference, promote load-sharing and enhance processivity in teams of molecular motors, PLoS Comput. Biol., 18, 10.1371/journal.pcbi.1010217 Verdeny-Vilanova, 2017, 3D motion of vesicles along microtubules helps them to circumvent obstacles in cells, J. Cell Sci., 130, 1904 Weisstein, 2002 Yadav, 2023, Sliding of motor tails on cargo surface due to drift and diffusion affects their team arrangement and collective transport, Phys. Biol., 20, 10.1088/1478-3975/ac99b2