Giảm nguy cơ tim mạch với semaglutide dùng một lần mỗi tuần ở những đối tượng mắc bệnh tiểu đường loại 2: phân tích hậu nghiệm về giới tính, tuổi tác và hồ sơ nguy cơ tim mạch ban đầu trong nghiên cứu SUSTAIN 6
Tóm tắt
Nghiên cứu SUSTAIN 6 đã chứng minh rằng semaglutide dùng một lần mỗi tuần (0.5 và 1.0 mg) đã giảm đáng kể các sự kiện tim mạch bất lợi lớn (MACE) so với giả dược ở những người mắc bệnh tiểu đường loại 2 (T2D) và có nguy cơ tim mạch cao. Các tác động của giới tính, độ tuổi và nguy cơ tim mạch ban đầu lên kết quả là những yếu tố quan trọng cần xem xét cho các nghiên cứu tiếp theo.
Các chủ thể được phân nhóm theo giới tính, độ tuổi (50–65 tuổi và > 65 tuổi), và hồ sơ nguy cơ tim mạch ban đầu (có tiền sử nhồi máu cơ tim [MI] hoặc đột quỵ so với không có tiền sử MI hoặc đột quỵ, và bệnh tim mạch đã được xác định [CVD] so với chỉ có các yếu tố nguy cơ tim mạch, bao gồm các đối tượng có bệnh thận mãn tính). Thời gian đến MACE và các thành phần riêng lẻ của nó (tử vong do tim mạch, nhồi máu cơ tim không tử vong, đột quỵ không tử vong), nhập viện do đau thắt ngực không ổn định hoặc suy tim, và tái vascular hóa (mạch vành và ngoại biên) đã được phân tích cho tất cả các nhóm con. Các phân tích bổ sung đã được thực hiện cho giới và độ tuổi để điều tra sự thay đổi từ ban đầu ở HbA1c và trọng lượng cơ thể, cũng như độ dung nạp của thuốc.
Từ khóa
#semaglutide #bệnh tiểu đường loại 2 #nguy cơ tim mạch #MACE #giới tính #tuổi tác #nghiên cứu SUSTAIN 6Tài liệu tham khảo
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