Cardiovascular parameters in anaesthetized guinea pigs: A safety pharmacology screening model

Bond, 1992, The effect of calcium channel modulators on blood pressure and pressure responses to noradrenaline in the guinea pig, European Journal of Pharmacology, 218, 179, 10.1016/0014-2999(92)90163-X Busch, 1994, The novel class III antiarrhythmics NE-10064 and NE10133 inhibit IsK channels expressed in Xenopus oocytes and IKs in guinea pig cardiac myocytes, Biochemical and Biophysical Research Communications, 202, 265, 10.1006/bbrc.1994.1922 Cavero, 2000, Drugs that prolong QT interval as an unwanted effect: Assessing their likelihood of inducing hazardous cardiac dysrrhythmias, Expert Opinion on Pharmacotherapy, 1, 947, 10.1517/14656566.1.5.947 Chiang, 2002, Effects of sildenafil on cardiac repolarization, Cardiovascular Research, 55, 290, 10.1016/S0008-6363(02)00438-8 Cieslar, 1986, Normal electrocardiogram in guinea pig, Acta Physiologica Polonica, 37, 139 CPMP (Committee for Proprietary Medicinal Products), 1997 De Clerck, 2002, In vivo measurement of QT prolongation, dispersion and arrhythmogenesis: Application to the preclinical cardiovascular safety pharmacology of a new chemical entity, Fundamental & Clinical Pharmacology, 16, 125, 10.1046/j.1472-8206.2002.00081.x DePasquale, 1994, Chronic monitoring of cardiovascular function in the conscious guinea pig using radio-telemetry, Clinical and Experimental Hypertension, 16, 245, 10.3109/10641969409067952 Drouin, 2004, Anesthetized guinea-pig model reliably assess HERG-blocking drugs, vol. 49, 222 Felzen, 1989, Inter-species variations in myocardial responsiveness to cardiac glycosides: Possible relations to the thyroid status, Journal of Molecular and Cellular Cardiology, 21, 165, 10.1016/0022-2828(89)90859-6 Fossa, 2004, Differential effect of HERG blocking agents on cardiac electrical alternans in the guinea pig, European Journal of Pharmacology, 486, 209, 10.1016/j.ejphar.2003.12.028 Gras, 1999, Effects of H1 antihistamines on animal models of QTc prolongation, Drug Safety, 21, 39, 10.2165/00002018-199921001-00006 Guidance for industry. (2001, July). ICH S7A safety pharmacology studies for human pharmaceuticals. U.S. Department of Health and Human Services, Food and Drug Administration (www.fda.gov/cber/guidelines.htm) ICH. Guidance for industry. (2004, June). ICH S7B Step 2 Revision. The nonclinical evaluation of the potential for delayed ventricular repolarization (QT interval prolongation) by human pharmaceuticals. U.S. Department of Health and Human Services, Food and Drug Administration (www.fda.gov/cber/guidelines.htm) ICH. Guth, 2004, Developing a strategy for the nonclinical assessment of proarrythmic risk of pharmaceuticals due to prolonged ventricular repolarization, Journal of Pharmacological and Toxicological Methods, 49, 159, 10.1016/j.vascn.2004.02.006 Hagerty, 1996, The in-vivo cardiovascular effects of a putative class III antiarrhythmic drug, AM 92016, Journal of Pharmacy and Pharmacology, 48, 417, 10.1111/j.2042-7158.1996.tb05944.x Hamlin, 2003, QT and RR intervals in conscious and anaesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles, Toxicological Sciences, 76, 437, 10.1093/toxsci/kfg254 Hammond, 2001, Methods of collecting and evaluating non-clinical cardiac electrophysiology data in the pharmaceutical industry: Results of an international survey, Cardiovascular Research, 49, 741, 10.1016/S0008-6363(00)00310-2 Hayes, 1994, Relationship between QaT and RR intervals in rats, guinea pigs, rabbits, and primates, Journal of Pharmacological and Toxicological Methods, 32, 201, 10.1016/1056-8719(94)90088-4 Howell, 1995, Hypotensive effect of an M2-selective muscarinic antagonist in anaesthetized guinea-pigs, Journal of Autonomic Pharmacology, 15, 19, 10.1111/j.1474-8673.1995.tb00344.x Japanese guidelines for nonclinical studies of drugs manual (1995). Editorial Supervision by Pharmaceutical and Cosmetics Division; Pharmaceutical Affairs Bureau, Japanese Ministry of Health and Welfare. Yakuji Nippo, Ltd. Kii, 2001, Effects of 5-HT(4) receptor agonists, cisapride and mosapride citrate on electrocardiogram in anaesthetized rats and guinea-pigs and conscious cats, Pharmacology and Toxicology, 89, 96, 10.1034/j.1600-0773.2001.d01-142.x Koga, 1989, Comparative effects of ouabain on isolated papillary muscle from tree shrews, guinea-pigs and rats, Journal of Pharmacy and Pharmacology, 41, 212, 10.1111/j.2042-7158.1989.tb06435.x Komeno, 2003, Electrophysiological characterization of 22 drugs in isolated guinea pig papillary muscles (JPMA QT PRODACT) Koomen, 1984, Biphasic positive inotropic actions of ouabain on rat, guinea-pig and cat heart: A mathematical description, Basic Research in Cardiology. Supplement, 79, 102 Landsdell, 2003, In vitro and in vivo studies to examine the potential for compounds to prolong QT interval—quintiles experience Lu, 1993, Inhibition of Na+/Ca2+ overload with R56865 protects against cardiac arrhythmias elicited by ouabain in vivo in guinea-pigs, European Journal of Pharmacology, 235, 89, 10.1016/0014-2999(93)90824-2 Lu, 1995, Antifibrillary action of class I–IV antiarrhythmic agents in the model of ventricular fibrillation threshold of anesthetized guinea pigs, Journal of Cardiovascular Pharmacology, 26, 132, 10.1097/00005344-199507000-00021 Minematsu, 1999, Pharmacokinetic/pharmacodynamic analysis of tacrolimus induced QT prolongation in guinea pigs, Biological & Pharmaceutical Bulletin, 22, 1341, 10.1248/bpb.22.1341 Minematsu, 1999, Sustained QT prolongation induced by tacrolimus in guinea pigs, Life Sciences, 65, PL197, 10.1016/S0024-3205(99)00396-3 Miyazaki, 2004, Comparison of the sensitivity between canine telemetry assay and isoflurane-anesthetized model (JPMA QT Product), vol. 49, 224 Monahan, 1990, Torsades des pointes occurring in association with terfenadine use, JAMA, 264, 2788, 10.1001/jama.1990.03450210088038 Pinney, 1995, Terfenadine increases the QT interval in isolated guinea pigs heart, Journal of Cardiovascular Pharmacology, 25, 30, 10.1097/00005344-199501000-00006 Roccon, 1996, Study of SR 142801, a new potent non-peptide NK3 receptor antagonist on cardiovascular responses in conscious guinea-pig, British Journal of Pharmacology, 118, 1095, 10.1111/j.1476-5381.1996.tb15511.x Salinas, 1991, Protective effects of dazmegrel on the PAF potential of ouabain-induced cardiac arrhythmias, European Journal of Pharmacology, 209, 105, 10.1016/0014-2999(91)90018-L Schierock, 2000, Continuous assessment of multiple vital physiological functions in conscious freely moving rats using telemetry and a plethysmography system, Journal of Pharmacological and Toxicological Methods, 43, 211, 10.1016/S1056-8719(00)00101-5 Soma, 1983, Anesthetic and analgesic considerations in the experimental animal, Annals of the New York Academy of Sciences, 406, 32, 10.1111/j.1749-6632.1983.tb53483.x Sosunov, 1996, Chronic in vivo and in vitro effects of amiodarone on guinea pig hearts, Journal of Pharmacology and Experimental Therapeutics, 278, 906 Szilagyi, 2004, The effects of levosimendan and OR-1896 on isolated hearts, myocyte-sized preparations and phosphodiesterase enzymes of the guinea pig, European Journal of Pharmacology, 486, 67, 10.1016/j.ejphar.2003.12.005 Testai, 2004, QT prolongation in anaesthetized guinea-pigs: An experimental approach for preliminary screening of torsadogenicity of drugs and drug candidates, Journal of Applied Toxicology, 24, 217, 10.1002/jat.975 Thomas, 1991, Effect of B-HT 920 on cardiotoxic effects of ouabain in guinea pigs, Indian Journal of Experimental Biology, 29, 1084 Thomas, 1986, Effects of α-adrenoceptor agonists and antagonists on ouabain-induced arrhythmias and cardiac arrest in guinea-pig, British Journal of Pharmacology, 89, 385, 10.1111/j.1476-5381.1986.tb10271.x Tonini, 1999, Review article: Cardiac adverse effects of gastrointestinal prokinetics, Alimentary Pharmacology & Therapeutics, 13, 1585, 10.1046/j.1365-2036.1999.00655.x Tripathi, 1988, Effect of some non-steriodal anti-inflammatory drugs on ouabain induced arrhythmias in guinea pigs, British Journal of Pharmacology, 93, 747, 10.1111/j.1476-5381.1988.tb11458.x Weinhouse, 1989, Cardiac glycoside toxicity in small laboratory animals, Life Sciences, 44, 441, 10.1016/0024-3205(89)90459-1 Wolfensohn, 1998 Wu, 2004, Antiarrhythmic effects of randolazine in a guinea pig in vitro model of long-QT syndrome, Journal of Pharmacology and Experimental Therapeutics, 310, 599, 10.1124/jpet.104.066100