Cardioprotective Abilities of White Wine

Annals of the New York Academy of Sciences - Tập 957 Số 1 - Trang 308-316 - 2002
Jianhua Cui1, Árpád Tósaki1, Gerald A. Cordis1, A Bertelli2, A Bertelli3, Nilanjana Maulik1, Dipak K. Das1
1Cardiovascular Research Center, University of Connecticut School of Medicine, Farmington, Connecticut 06030-1110, USA
2Institute of Anatomy, University of Milan, Milan, Italy
3Department of Pharmacology, University of Milan, Milan, Italy

Tóm tắt

Abstract: To study if white wines, like red wine, can also protect the heart from ischemia reperfusion injury, ethanol‐free extracts of three different white wines (WW1, WW2 and WW3) (100 mg/100 g body weight) were given orally to Sprague Dawley rats (200 g body weight) for three weeks. Control rats were given water only for the same period of time. After three weeks, rats were anesthetized and sacrificed, and the hearts excised for the preparation of isolated working rat heart. All hearts were subjected to 30 min global ischemia followed by two hours of reperfusion. The results demonstrated that among the three different white wines, only WW2 showed cardioprotection as evidenced by improved post‐ischemic ventricular recovery compared to control. The amount of malonaldehyde production in white wine‐fed rat hearts were lower compared to that found in control hearts indicating reduced formation of the reactive oxygen species. In vitro studies using chemiluminescence technique revealed that these white wines scavenged both superoxide anions and hydroxyl radicals. The results of our study demonstrated that only WW2 white wine provided cardioprotection as evidenced by the improved the post‐ischemic contractile recovery and reduced myocardial infarct size. The cardioprotective effect of this white wine may be attributed, at least in part, from its ability to function as an in vivo antioxidant.

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Tài liệu tham khảo

10.1093/ajcn/61.3.549

10.1016/0140-6736(92)91277-F

10.1097/00005344-200002000-00013

Bertelli A.A.E., 1995, Antiplatelet activity of synthetic and natural resveratrol in red wine, Int. J. Tissue Reac., 17, 1

10.1016/S0891-5849(99)00063-5

10.1006/jmcc.1999.0961

Pataki T. I. Bak P. Kovacs et al.2002. Grape seed proanthocyanidins reduced ischemia/reperfusion‐induced injury in isolated rat hearts. Am. J. Clin. Nutrition.75:.

10.1016/S0891-5849(01)00626-8

Engelman D., 1995, Hypoxic preconditioning preserves antioxidant reserve in the working rat heart, Cardiovasc. Res., 29, 133

Yoshida T., 1997, Glutathione peroxidase knockout mice are susceptible to myocardial ischemia reperfusion injury, Circulation, 96, 216

10.1021/jf000010j

10.3109/10715769709097854

10.1002/(SICI)1098-2825(1997)11:5<287::AID-JCLA6>3.0.CO;2-4

10.3109/10715769509145649

10.1016/S0076-6879(94)33063-8

Tosaki A., 1993, Comparisons of ESR and HPLC methods for the detection of hydroxyl radicals in ischemic/reperfused hearts, A relationship between the genesis of oxygen-free radicals and reperfusion-induced arrhythmias. Biochem. Pharmacol., 45, 961

10.1016/0140-6736(93)92876-U

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Annals of the New York Academy of Sciences

Tập 957 Số 1

308-316

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