Cardioprotection by Thymosin Beta 4

Vitamins and Hormones - Tập 102 - Trang 209-226 - 2016
G.T. Pipes1, J. Yang1
1Cardiovascular Drug Discovery, Discovery Biology Research & Development, Bristol-Myers Squibb, Pennington, NJ, United States

Tài liệu tham khảo

Badamchian, 2003, Thymosin beta(4) reduces lethality and down-regulates inflammatory mediators in endotoxin-induced septic shock, International Immunopharmacology, 3, 1225, 10.1016/S1567-5769(03)00024-9 Bao, 2013, Cardioprotection by systemic dosing of thymosin beta four following ischemic myocardial injury, Frontiers in Pharmacology, 4, 149, 10.3389/fphar.2013.00149 Bednarek, 2008, Ku80 as a novel receptor for thymosin beta4 that mediates its intracellular activity different from G-actin sequestering, The Journal of Biological Chemistry, 283, 1534, 10.1074/jbc.M707539200 Bicer, 2011, Thymosin beta 4 is associated with collateral development in coronary artery disease, Scandinavian Journal of Clinical and Laboratory Investigation, 71, 625, 10.3109/00365513.2011.599417 Bock-Marquette, 2004, Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair, Nature, 432, 466, 10.1038/nature03000 Bock-Marquette, 2009, Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo, Journal of Molecular and Cellular Cardiology, 46, 728, 10.1016/j.yjmcc.2009.01.017 Brieger, 2007, Thymosin beta 4 expression and nuclear transport are regulated by hMLH1, Biochemical and Biophysical Research Communications, 364, 731, 10.1016/j.bbrc.2007.10.010 Castoldi, 2010, Prevention of myocardial fibrosis by N-acetyl-seryl-aspartyl-lysyl-proline in diabetic rats, Clinical Science (London, England), 118, 211, 10.1042/CS20090234 Cheng, 2008, Advances of AKT pathway in human oncogenesis and as a target for anti-cancer drug discovery, Current Cancer Drug Targets, 8, 2, 10.2174/156800908783497159 Choudry, 2015, Increases in plasma Tbeta4 after intracardiac cell therapy in chronic ischemic heart failure is associated with symptomatic improvement, Regenerative Medicine, 10, 403, 10.2217/rme.15.9 Cierniewski, 2012, Thymosin beta4 is rapidly internalized by cells and does not induce intracellular Ca2+ elevation, Annals of the New York Academy of Sciences, 1269, 44, 10.1111/j.1749-6632.2012.06685.x Clauss, 1991, Human thymosin-beta 4/6-26 gene is part of a multigene family composed of seven members located on seven different chromosomes, Genomics, 9, 174, 10.1016/0888-7543(91)90236-8 Conte, 2012, Protective effects of thymosin beta4 in a mouse model of lung fibrosis, Annals of the New York Academy of Sciences, 1269, 69, 10.1111/j.1749-6632.2012.06694.x Estrella, 2014, Transcriptional networks regulating the costamere, sarcomere, and other cytoskeletal structures in striated muscle, Cellular and Molecular Life Sciences, 71, 1641, 10.1007/s00018-013-1512-0 Evans, 2013, Thymosin beta4-sulfoxide attenuates inflammatory cell infiltration and promotes cardiac wound healing, Nature Communications, 4, 2081, 10.1038/ncomms3081 Fan, 2009, Spatial coordination of actin polymerization and ILK-Akt2 activity during endothelial cell migration, Developmental Cell, 16, 661, 10.1016/j.devcel.2009.03.009 Franco, 2009, SRF in angiogenesis: Branching the vascular system, Cell Adhesion & Migration, 3, 264, 10.4161/cam.3.3.8291 Freeman, 2011, Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling, The FASEB Journal, 25, 907, 10.1096/fj.10-169417 Gardner, 2009, Cardiac magnetic resonance versus transthoracic echocardiography for the assessment of cardiac volumes and regional function after myocardial infarction: An intrasubject comparison using simultaneous intrasubject recordings, Cardiovascular Ultrasound, 7, 38, 10.1186/1476-7120-7-38 Goldstein, 1966, Preparation, assay, and partial purification of a thymic lymphocytopoietic factor (thymosin), Proceedings of the National Academy of Sciences of the United States of America, 56, 1010, 10.1073/pnas.56.3.1010 Grant, 1999, Thymosin beta4 enhances endothelial cell differentiation and angiogenesis, Angiogenesis, 3, 125, 10.1023/A:1009041911493 Grillon, 1990, Involvement of thymosin beta 4 and endoproteinase Asp-N in the biosynthesis of the tetrapeptide AcSerAspLysPro a regulator of the hematopoietic system, FEBS Letters, 274, 30 Hannappel, 2007, beta-Thymosins, Annals of the New York Academy of Sciences, 1112, 21, 10.1196/annals.1415.018 Hannappel, 2010, Thymosin beta4 and its posttranslational modifications, Annals of the New York Academy of Sciences, 1194, 27, 10.1111/j.1749-6632.2010.05485.x Herrmann, 2005, Thypedin, the multi copy precursor for the hydra peptide pedin, is a beta-thymosin repeat-like domain containing protein, Mechanisms of Development, 122, 1183, 10.1016/j.mod.2005.07.003 Hinkel, 2015, C-terminal variable AGES domain of Thymosin beta4: The molecule's primary contribution in support of post-ischemic cardiac function and repair, Journal of Molecular and Cellular Cardiology, 87, 113, 10.1016/j.yjmcc.2015.07.004 Hinkel, 2010, Thymosin beta4: A key factor for protective effects of eEPCs in acute and chronic ischemia, Annals of the New York Academy of Sciences, 1194, 105, 10.1111/j.1749-6632.2010.05489.x Hinkel, 2008, Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection, Circulation, 117, 2232, 10.1161/CIRCULATIONAHA.107.758904 Hinkel, 2014, MRTF-A controls vessel growth and maturation by increasing the expression of CCN1 and CCN2, Nature Communications, 5, 3970, 10.1038/ncomms4970 Ho, 2007, Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells, Investigative Ophthalmology & Visual Science, 48, 27, 10.1167/iovs.06-0826 Husson, 2010, Multifunctionality of the beta-thymosin/WH2 module: G-actin sequestration, actin filament growth, nucleation, and severing, Annals of the New York Academy of Sciences, 1194, 44, 10.1111/j.1749-6632.2010.05473.x Icardo, 2001, Origin and course of the coronary arteries in normal mice and in iv/iv mice, Journal of Anatomy, 199, 473, 10.1046/j.1469-7580.2001.19940473.x Koutrafouri, 2001, Effect of thymosin peptides on the chick chorioallantoic membrane angiogenesis model, Biochimica et Biophysica Acta, 1568, 60, 10.1016/S0304-4165(01)00200-8 Kumar, 2011, Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts, PLoS One, 6, e26912, 10.1371/journal.pone.0026912 Lee, 2008, Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment, FEBS Letters, 582, 2161, 10.1016/j.febslet.2008.03.058 Legate, 2006, ILK, PINCH and parvin: The tIPP of integrin signalling, Nature Reviews. Molecular Cell Biology, 7, 20, 10.1038/nrm1789 Liu, 2009, N-acetyl-seryl-aspartyl-lysyl-proline prevents cardiac remodeling and dysfunction induced by galectin-3, a mammalian adhesion/growth-regulatory lectin, American Journal of Physiology. Heart and Circulatory Physiology, 296, H404, 10.1152/ajpheart.00747.2008 Lv, 2011, Relationship between serum thymosin beta4 levels and coronary collateral development, Coronary Artery Disease, 22, 401, 10.1097/MCA.0b013e3283487d68 Maiese, 2009, The “O” class: Crafting clinical care with FoxO transcription factors, Advances in Experimental Medicine and Biology, 665, 242, 10.1007/978-1-4419-1599-3_18 Mikhailov, 2012, In search of novel targets for heart disease: Myocardin and myocardin-related transcriptional cofactors, Biochemistry Research International, 2012, 973723, 10.1155/2012/973723 Morita, 2013, G-actin sequestering protein thymosin-β4 regulates the activity of myocardin-related transcription factor, Biochemical & Biophysical Research Communications, 437, 331, 10.1016/j.bbrc.2013.06.069 Peng, 2010, Ac-SDKP inhibits transforming growth factor-beta1-induced differentiation of human cardiac fibroblasts into myofibroblasts, American Journal of Physiology. Heart and Circulatory Physiology, 298, H1357, 10.1152/ajpheart.00464.2009 Peng, 2014, Thymosin-beta4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction, American Journal of Physiology. Heart and Circulatory Physiology, 307, H741, 10.1152/ajpheart.00129.2014 Posern, 2004, Mutant actins that stabilise F-actin use distinct mechanisms to activate the SRF coactivator MAL, The EMBO Journal, 23, 3973, 10.1038/sj.emboj.7600404 Postrach, 2014, Adeno-associated viral vector 2.9 thymosin ss4 application attenuates rejection after heart transplantation: Results of a preclinical study in the pig, Transplantation, 98, 835, 10.1097/TP.0000000000000327 Rasoul, 2004, Antifibrotic effect of Ac-SDKP and angiotensin-converting enzyme inhibition in hypertension, Journal of Hypertension, 22, 593, 10.1097/00004872-200403000-00023 Ruff, 2010, A randomized, placebo-controlled, single and multiple dose study of intravenous thymosin beta4 in healthy volunteers, Annals of the New York Academy of Sciences, 1194, 223, 10.1111/j.1749-6632.2010.05474.x Safer, 1991, Thymosin beta 4 and Fx, an actin-sequestering peptide, are indistinguishable, The Journal of Biological Chemistry, 266, 4029, 10.1016/S0021-9258(20)64278-8 Salto-Tellez, 2004, Myocardial infarction in the C57BL/6J mouse: A quantifiable and highly reproducible experimental model, Cardiovascular Pathology, 13, 91, 10.1016/S1054-8807(03)00129-7 Sanders, 1992, Thymosin beta 4 (Fx peptide) is a potent regulator of actin polymerization in living cells, Proceedings of the National Academy of Sciences of the United States of America, 89, 4678, 10.1073/pnas.89.10.4678 Sluijter, 2014, Novel therapeutic strategies for cardioprotection, Pharmacology & Therapeutics, 144, 60, 10.1016/j.pharmthera.2014.05.005 Smart, 2011, De novo cardiomyocytes from within the activated adult heart after injury, Nature, 474, 640, 10.1038/nature10188 Smart, 2010, Thymosin beta4 facilitates epicardial neovascularization of the injured adult heart, Annals of the New York Academy of Sciences, 1194, 97, 10.1111/j.1749-6632.2010.05478.x Smart, 2007, Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization, Nature, 445, 177, 10.1038/nature05383 Smart, 2007, Thymosin beta-4 is essential for coronary vessel development and promotes neovascularization via adult epicardium, Annals of the New York Academy of Sciences, 1112, 171, 10.1196/annals.1415.000 Sopko, 2011, Significance of thymosin beta4 and implication of PINCH-1-ILK-alpha-parvin (PIP) complex in human dilated cardiomyopathy, PloS One, 6, e20184, 10.1371/journal.pone.0020184 Trembley, 2015, Myocardin-related transcription factors control the motility of epicardium-derived cells and the maturation of coronary vessels, Development, 142, 21, 10.1242/dev.116418 van Berlo, 2014, c-kit+cells minimally contribute cardiomyocytes to the heart, Nature, 509, 337, 10.1038/nature13309 Vartiainen, 2007, Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL, Science, 316, 1749, 10.1126/science.1141084 Xin, 2006, A threshold of GATA4 and GATA6 expression is required for cardiovascular development, Proceedings of the National Academy of Sciences of the United States of America, 103, 11189, 10.1073/pnas.0604604103 Xue, 2014, Structural basis of thymosin-beta4/profilin exchange leading to actin filament polymerization, Proceedings of the National Academy of Sciences of the United States of America, 111, E4596, 10.1073/pnas.1412271111 Yang, 2004, A beneficial role of cardiac P2X4 receptors in heart failure: Rescue of the calsequestrin overexpression model of cardiomyopathy, American Journal of Physiology. Heart and Circulatory Physiology, 287, H1096, 10.1152/ajpheart.00079.2004 Young, 1999, Thymosin beta 4 sulfoxide is an anti-inflammatory agent generated by monocytes in the presence of glucocorticoids, Nature Medicine, 5, 1424, 10.1038/71002 Zarbock, 1990, Solution conformation of thymosin beta 4: A nuclear magnetic resonance and simulated annealing study, Biochemistry, 29, 7814, 10.1021/bi00486a006 Zhang, 2014, Endothelial progenitor cells and vascular repair, Current Opinion in Hematology, 21, 224, 10.1097/MOH.0000000000000041 Zhou, 2012, Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes, Journal of Molecular and Cellular Cardiology, 52, 43, 10.1016/j.yjmcc.2011.08.020 Zuo, 2013, Thymosin beta4 and its degradation product, Ac-SDKP, are novel reparative factors in renal fibrosis, Kidney International, 84, 1166, 10.1038/ki.2013.209