Cardiomyopathy in cirrhosis: From pathophysiology to clinical care

JHEP Reports - Tập 6 - Trang 100911 - 2024
Hongqun Liu1, Jwan A. Naser2, Grace Lin2, Samuel S. Lee1
1Liver Unit, University of Calgary Cumming School of Medicine, Calgary, AB, Canada
2Division of Cardiology, Mayo Clinic, Rochester, MN, USA

Tài liệu tham khảo

Izzy, 2020, Redefining cirrhotic cardiomyopathy for the modern era, Hepatology, 71, 334, 10.1002/hep.30875 Yoon, 2020, Cirrhotic cardiomyopathy, Curr Gastroenterol Rep, 22, 45, 10.1007/s11894-020-00783-1 Liu, 2022, Pathogenic mechanisms underlying cirrhotic cardiomyopathy, Front Netw Physiol, 2, 849253, 10.3389/fnetp.2022.849253 Liu, 2021, Innate Immune Cells in Pressure Overload-Induced Cardiac Hypertrophy and Remodeling, Front Cell Dev Biol, 23 Gaskari, 2015, Blunted cardiac response to hemorrhage in cirrhotic rats is mediated by local macrophage-released endocannabinoids, J Hepatol, 62, 1272, 10.1016/j.jhep.2015.01.021 Zuo, 2018, Acute administration of tumour necrosis factor-alpha induces spontaneous calcium release via the reactive oxygen species pathway in atrial myocytes, Europace, 20, 1367, 10.1093/europace/eux271 Kao, 2010, Tumor necrosis factor-alpha decreases sarcoplasmic reticulum Ca2+-ATPase expressions via the promoter methylation in cardiomyocytes, Crit Care Med, 38, 217, 10.1097/CCM.0b013e3181b4a854 Rao, 2016, Role of tumour necrosis factor-a in the regulation of T-type calcium channel current in HL-1 cells, Clin Exp Pharmacol Physiol, 43, 706, 10.1111/1440-1681.12585 Gregolin, 2021, Myocardial dysfunction in cirrhotic cardiomyopathy is associated with alterations of phospholamban phosphorylation and IL-6 levels, Arch Med Res, 52, 284, 10.1016/j.arcmed.2020.11.004 Lee, 1990, Desensitization of myocardial beta-adrenergic receptors in cirrhotic rats, Hepatology, 12, 481, 10.1002/hep.1840120306 Ma, 2022, Role of anti-beta-1-adrenergic receptor antibodies in cardiac dysfunction in patients with cirrhotic cardiomyopathy, J Cardiovasc Transl Res, 15, 381, 10.1007/s12265-021-10161-5 Moller, 2018, Cirrhotic cardiomyopathy, J Hepatol, 69, 958, 10.1016/j.jhep.2018.01.006 Mashford, 1962, Studies of the cardiovascular system in the hypotension of liver failure, N Engl J Med, 267, 1071, 10.1056/NEJM196211222672105 Kellermayer, 2019, Titin mutations and muscle disease, Pflugers Arch, 471, 673, 10.1007/s00424-019-02272-5 Tharp, 2019, The giant protein titin’s role in cardiomyopathy: genetic, transcriptional, and post-translational modifications of TTN and their contribution to cardiac disease, Front Physiol, 10, 1436, 10.3389/fphys.2019.01436 Nagueh, 2004, Altered titin expression, myocardial stiffness, and left ventricular function in patients with dilated cardiomyopathy, Circulation, 110, 155, 10.1161/01.CIR.0000135591.37759.AF Glenn, 2011, Role of cardiac myofilament proteins titin and collagen in the pathogenesis of diastolic dysfunction in cirrhotic rats, J Hepatol, 55, 1249, 10.1016/j.jhep.2011.02.030 Honar, 2020, Impaired myosin isoform shift and calcium transients contribute to cellular pathogenesis of rat cirrhotic cardiomyopathy, Liver Int, 40, 2808, 10.1111/liv.14599 Liu, 2021, Advances in cirrhotic cardiomyopathy, Curr Opin Gastroenterol, 37, 187, 10.1097/MOG.0000000000000733 Ma, 1994, Membrane physical properties determine cardiac beta-adrenergic receptor function in cirrhotic rats, Am J Physiol, 267, G87 Ma, 1997, Effects of altered cardiac membrane fluidity on beta-adrenergic receptor signalling in rats with cirrhotic cardiomyopathy, J Hepatol, 26, 904, 10.1016/S0168-8278(97)80259-0 Yoon, 2022, Galectin-3 inhibits cardiac contractility via a tumor necrosis factor alpha-dependent mechanism in cirrhotic rats, Clin Mol Hepatol, 28, 232, 10.3350/cmh.2021.0141 Izzy, 2021, Cirrhotic cardiomyopathy predicts posttransplant cardiovascular disease: revelations of the new diagnostic criteria, Liver Transpl, 27, 876, 10.1002/lt.26000 Cesari, 2021, Prevalence and prognostic value of cirrhotic cardiomyopathy as defined according to the proposed new classification, Clin Exp Hepatol, 7, 270, 10.5114/ceh.2021.108708 Singh, 2022, Impact of cirrhotic cardiomyopathy diagnosed according to different criteria on patients with cirrhosis awaiting liver transplantation: a retrospective cohort study, Dig Dis Sci, 67, 5315, 10.1007/s10620-022-07412-z Rimbas, 2020, Cirrhotic cardiomyopathy in the era of liver transplantation: time for precise stepwise evaluation, J Gastrointestin Liver Dis, 29, 665, 10.15403/jgld-3137 Kwon, 2020, Appraisal of cardiac ejection fraction with liver disease severity: implication in post-liver transplantation mortality, Hepatology, 71, 1364, 10.1002/hep.30913 Smiseth, 2016, Myocardial strain imaging: how useful is it in clinical decision making?, Eur Heart J, 37, 1196, 10.1093/eurheartj/ehv529 Sengupta, 2013, Early impairment of left ventricular function in patients with systemic hypertension: new insights with 2-dimensional speckle tracking echocardiography, Indian Heart J, 65, 48, 10.1016/j.ihj.2012.12.009 Yancy, 2013, 2013 ACCF/AHA guideline for the management of heart failure: a report of the American college of cardiology foundation/American heart association task force on practice guidelines, J Am Coll Cardiol, 62, e147, 10.1016/j.jacc.2013.05.019 Hammami, 2017, Cirrhotic cardiomyopathy: is there any correlation between the stage of cardiac impairment and the severity of liver disease?, Libyan J Med, 12, 10.1080/19932820.2017.1283162 Novo, 2018, Subclinical cardiovascular damage in patients with HCV cirrhosis before and after treatment with direct antiviral agents: a prospective study, Aliment Pharmacol Ther, 48, 740, 10.1111/apt.14934 Sampaio, 2013, Systolic and diastolic dysfunction in cirrhosis: a tissue-Doppler and speckle tracking echocardiography study, Liver Int, 33, 1158, 10.1111/liv.12187 Rimbas, 2018, New definition criteria of myocardial dysfunction in patients with liver cirrhosis: a speckle tracking and tissue Doppler imaging study, Ultrasound Med Biol, 44, 562, 10.1016/j.ultrasmedbio.2017.11.013 Zamirian, 2019, Reduced myocardial reserve in cirrhotic patients: an evaluation by dobutamine stress speckle tracking and tissue Doppler imaging (TDI) echocardiography, J Cardiovasc Thorac Res, 11, 127, 10.15171/jcvtr.2019.22 Nafati, 2018, Use of speckle-tracking strain in preload-dependent patients, need for cautious interpretation, Ann Intensive Care, 8, 29, 10.1186/s13613-018-0376-8 Mechelinck, 2020, Global longitudinal strain at rest as an independent predictor of mortality in liver transplant candidates: a retrospective clinical study, J Clin Med, 9, 10.3390/jcm9082616 Kim, 2020, Myocardial structural and functional changes in patients with liver cirrhosis awaiting liver transplantation: a comprehensive cardiovascular magnetic resonance and echocardiographic study, J Cardiovasc Magn Reson, 22, 25, 10.1186/s12968-020-00622-2 Chen, 2016, A detailed evaluation of cardiac function in cirrhotic patients and its alteration with or without liver transplantation, J Cardiol, 67, 140, 10.1016/j.jjcc.2015.08.001 Nagueh, 2016, Recommendations for the evaluation of left ventricular diastolic function by echocardiography: an update from the American society of echocardiography and the European association of cardiovascular imaging, J Am Soc Echocardiogr, 29, 277, 10.1016/j.echo.2016.01.011 Spann, 2022, Cirrhotic cardiomyopathy: appraisal of the original and revised criteria in predicting posttransplant cardiac outcomes, Liver Transpl, 28, 1321, 10.1002/lt.26460 Santos, 2015, E/e’ Ratio in Patients With Unexplained Dyspnea: lack of Accuracy in Estimating Left Ventricular Filling Pressure, Circ Heart Fail, 8, 749, 10.1161/CIRCHEARTFAILURE.115.002161 Pieske, 2019, How to diagnose heart failure with preserved ejection fraction: the HFA-PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC), Eur Heart J, 40, 3297, 10.1093/eurheartj/ehz641 Dowsley, 2012, Diastolic dysfunction in patients with end-stage liver disease is associated with development of heart failure early after liver transplantation, Transplantation, 94, 646, 10.1097/TP.0b013e31825f0f97 Wong, 2001, The cardiac response to exercise in cirrhosis, Gut, 49, 268, 10.1136/gut.49.2.268 Chayanupatkul, 2014, Cirrhotic cardiomyopathy: review of pathophysiology and treatment, Hepatol Int, 8, 308, 10.1007/s12072-014-9531-y Dimitroglou, 2019, Cardiac imaging in liver transplantation candidates: current knowledge and future perspectives, J Clin Med, 8, 10.3390/jcm8122132 Chamsi-Pasha, 2020, CMR in the evaluation of diastolic dysfunction and phenotyping of HFpEF: current role and future perspectives, JACC Cardiovasc Imaging, 13, 283, 10.1016/j.jcmg.2019.02.031 Charoenpanichkit, 2010, The 20 year evolution of dobutamine stress cardiovascular magnetic resonance, J Cardiovasc Magn Reson, 12, 59, 10.1186/1532-429X-12-59 Satoh, 2014, Distribution of late gadolinium enhancement in various types of cardiomyopathies: significance in differential diagnosis, clinical features and prognosis, World J Cardiol, 6, 585, 10.4330/wjc.v6.i7.585 American College of Cardiology Foundation Task Force on Expert Consensus, 2010, ACCF/ACR/AHA/NASCI/SCMR 2010 expert consensus document on cardiovascular magnetic resonance: a report of the American college of Cardiology foundation task force on expert consensus documents, J Am Coll Cardiol, 55, 2614, 10.1016/j.jacc.2009.11.011 Flett, 2010, Equilibrium contrast cardiovascular magnetic resonance for the measurement of diffuse myocardial fibrosis: preliminary validation in humans, Circulation, 122, 138, 10.1161/CIRCULATIONAHA.109.930636 Yang, 2019, Myocardial extracellular volume fraction adds prognostic information beyond myocardial replacement fibrosis, Circ Cardiovasc Imaging, 12, 10.1161/CIRCIMAGING.119.009535 Wiese, 2018, Myocardial extracellular volume quantified by magnetic resonance is increased in cirrhosis and related to poor outcome, Liver Int, 38, 1614, 10.1111/liv.13870 Carpenter, 2011, On T2∗ magnetic resonance and cardiac iron, Circulation, 123, 1519, 10.1161/CIRCULATIONAHA.110.007641 O’Glasser, 2010, Hepatic and cardiac iron overload among patients with end-stage liver disease referred for liver transplantation, Clin Transpl, 24, 643, 10.1111/j.1399-0012.2009.01136.x Papadodima, 2019, Cardiac iron overload following liver transplantation in patients without hereditary hemochromatosis or severe hepatic iron deposition, Cardiovasc Pathol, 40, 7, 10.1016/j.carpath.2018.12.008 Abu Rajab, 2014, Iron overload secondary to cirrhosis: a mimic of hereditary haemochromatosis?, Histopathology, 65, 561, 10.1111/his.12417 Lewin, 2018, Cardiac MRI T2∗ in liver transplant candidates: application and performance of a novel imaging technique to identify patients at risk for poor posttransplant cardiac outcomes, Transpl Direct, 4, e363, 10.1097/TXD.0000000000000803 Liu, 2017, Cirrhotic cardiomyopathy: implications for liver transplantation, Liver Transpl, 23, 826, 10.1002/lt.24768 Razpotnik, 2021, The prevalence of cirrhotic cardiomyopathy according to different diagnostic criteria, Liver Int, 41, 1058, 10.1111/liv.14769 Arman, 2022, Cirrhotic cardiomyopathy per 2005 criteria is more common and less reversible than cirrhotic cardiomyopathy per 2019 criteria, Hepatoloty, 76, s514 2020, Correction, Hepatology, 72, 1161, 10.1002/hep.31463 Liu, 2021, Diagnostic criteria of cirrhotic cardiomyopathy: out with the old, in with the new?, Hepatology, 74, 3523, 10.1002/hep.32021 Glowczynska, 2022, Chronotropic incompetence in end-stage liver disease, PLoS One, 17, 10.1371/journal.pone.0270784 Zambruni, 2007, QT interval correction in patients with cirrhosis, J Cardiovasc Electrophysiol, 18, 77, 10.1111/j.1540-8167.2006.00622.x Bernardi, 1998, Q-T interval prolongation in cirrhosis: prevalence, relationship with severity, and etiology of the disease and possible pathogenetic factors, Hepatology, 27, 28, 10.1002/hep.510270106 Henriksen, 2007, Q-T interval (QT(C)) in patients with cirrhosis: relation to vasoactive peptides and heart rate, Scand J Clin Lab Invest, 67, 643, 10.1080/00365510601182634 Tsiompanidis, 2018, Liver cirrhosis-effect on QT interval and cardiac autonomic nervous system activity, World J Gastrointest Pathophysiol, 9, 28, 10.4291/wjgp.v9.i1.28 Ward, 1997, Potassium currents in atrial and ventricular myocytes from a rat model of cirrhosis, Am J Physiol, 273, G537 Kim, 2017, QT prolongation is associated with increased mortality in end stage liver disease, World J Cardiol, 9, 347, 10.4330/wjc.v9.i4.347 Li, 2021, Prolonged QTc interval predicts long-term mortality in cirrhosis: a propensity score matching analysis, Scand J Gastroenterol, 56, 570, 10.1080/00365521.2021.1901307 Ruiz-del-Arbol, 2013, Diastolic dysfunction is a predictor of poor outcomes in patients with cirrhosis, portal hypertension, and a normal creatinine, Hepatology, 58, 1732, 10.1002/hep.26509 Ruiz-del-Arbol, 2005, Circulatory function and hepatorenal syndrome in cirrhosis, Hepatology, 42, 439, 10.1002/hep.20766 Krag, 2010, Low cardiac output predicts development of hepatorenal syndrome and survival in patients with cirrhosis and ascites, Gut, 59, 105, 10.1136/gut.2009.180570 Rabie, 2009, The use of E/A ratio as a predictor of outcome in cirrhotic patients treated with transjugular intrahepatic portosystemic shunt, Am J Gastroenterol, 104, 2458, 10.1038/ajg.2009.321 Cazzaniga, 2007, Diastolic dysfunction is associated with poor survival in patients with cirrhosis with transjugular intrahepatic portosystemic shunt, Gut, 56, 869, 10.1136/gut.2006.102467 Giannelli, 2020, Impact of cardiac function, refractory ascites and beta blockers on the outcome of patients with cirrhosis listed for liver transplantation, J Hepatol, 72, 463, 10.1016/j.jhep.2019.10.002 Altieri, 2022, Cardiovascular events after liver transplantation: MACE hurts, Rev Cardiovasc Med, 23, 91, 10.31083/j.rcm2303091 Gurram, 2022, Predicting cardiovascular complications after liver transplantation, 327 Sheibani, 2020, Protective effects of spermidine against cirrhotic cardiomyopathy in bile duct-ligated rats, J Cardiovasc Pharmacol, 76, 286, 10.1097/FJC.0000000000000872 Niaz, 2022, Evaluation of statins as a new therapy to alleviate chronotropic dysfunction in cirrhotic rats, Life Sci, 308, 120966, 10.1016/j.lfs.2022.120966 Bortoluzzi, 2013, Positive cardiac inotropic effect of albumin infusion in rodents with cirrhosis and ascites: molecular mechanisms, Hepatology, 57, 266, 10.1002/hep.26021 Mousavi, 2020, Taurine mitigates cirrhosis-associated heart injury through mitochondrial-dependent and antioxidative mechanisms, Clin Exp Hepatol, 6, 207, 10.5114/ceh.2020.99513 de Souza, 2021, Exercise training attenuates cirrhotic cardiomyopathy, J Cardiovasc Transl Res, 14, 674, 10.1007/s12265-020-09997-0 La Mura, 2013, Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction, Hepatology, 57, 1172, 10.1002/hep.26127 Marrone, 2015, KLF2 exerts antifibrotic and vasoprotective effects in cirrhotic rat livers: behind the molecular mechanisms of statins, Gut, 64, 1434, 10.1136/gutjnl-2014-308338 Pose, 2019, Statins: old drugs as new therapy for liver diseases?, J Hepatol, 70, 194, 10.1016/j.jhep.2018.07.019 Hothersall, 2006, Potential therapeutic role for statins in respiratory disease, Thorax, 61, 729, 10.1136/thx.2005.057976 Yang, 2010, Mechanisms of TNFalpha-induced cardiac dysfunction in cholestatic bile duct-ligated mice: interaction between TNFalpha and endocannabinoids, J Hepatol, 53, 298, 10.1016/j.jhep.2010.03.011 Wong, 2022, Albumin therapy for hepatic encephalopathy: current evidence and controversies, Metab Brain Dis Desai, 2017, Bile acid excess induces cardiomyopathy and metabolic dysfunctions in the heart, Hepatology, 65, 189, 10.1002/hep.28890 Liu, 2020, Taurine protects against cardiac dysfunction induced by pressure overload through SIRT1-p53 activation, Chem Biol Interact, 317, 10.1016/j.cbi.2020.108972 Nam, 2014, Cardiomyocyte apoptosis contributes to pathogenesis of cirrhotic cardiomyopathy in bile duct-ligated mice, Clin Sci (Lond), 127, 519, 10.1042/CS20130642 Inserte, 2003, Left ventricular hypertrophy in rats with biliary cirrhosis, Hepatology, 38, 589, 10.1053/jhep.2003.50369 Bayat, 2022, Silymarin administration attenuates cirrhotic-induced cardiac abnormality in the rats: a possible role of beta1-adrenergic receptors and L-type voltage-dependent calcium channels, Iran J Med Sci, 47, 367 Wanninger, 2011, Systemic and hepatic vein galectin-3 are increased in patients with alcoholic liver cirrhosis and negatively correlate with liver function, Cytokine, 55, 435, 10.1016/j.cyto.2011.06.001 Shah, 2010, Galectin-3, cardiac structure and function, and long-term mortality in patients with acutely decompensated heart failure, Eur J Heart Fail, 12, 826, 10.1093/eurjhf/hfq091 Weir, 2013, Galectin-3 and cardiac function in survivors of acute myocardial infarction, Circ Heart Fail, 6, 492, 10.1161/CIRCHEARTFAILURE.112.000146 van Kimmenade, 2006, Utility of amino-terminal pro-brain natriuretic peptide, galectin-3, and apelin for the evaluation of patients with acute heart failure, J Am Coll Cardiol, 48, 1217, 10.1016/j.jacc.2006.03.061 Sharma, 2004, Galectin-3 marks activated macrophages in failure-prone hypertrophied hearts and contributes to cardiac dysfunction, Circulation, 110, 3121, 10.1161/01.CIR.0000147181.65298.4D Souza, 2017, Association of cardiac galectin-3 expression, myocarditis, and fibrosis in chronic chagas disease cardiomyopathy, Am J Pathol, 187, 1134, 10.1016/j.ajpath.2017.01.016 Yu, 2013, Genetic and pharmacological inhibition of galectin-3 prevents cardiac remodeling by interfering with myocardial fibrogenesis, Circ Heart Fail, 6, 107, 10.1161/CIRCHEARTFAILURE.112.971168 Zheng, 2022, Effects of high-intensity and moderate-intensity exercise training on cardiopulmonary function in patients with coronary artery disease: a meta-analysis, Front Cardiovasc Med, 9, 10.3389/fcvm.2022.961414 Chahal, 2021, Review article: comprehensive analysis of cirrhotic cardiomyopathy, Aliment Pharmacol Ther, 53, 985, 10.1111/apt.16305 Bodys-Pelka, 2021, What’s new in cirrhotic cardiomyopathy?-review article, J Pers Med, 11 Yoon, 2021, beta-blockers in advanced cirrhosis: more friend than enemy, Clin Mol Hepatol, 27, 425, 10.3350/cmh.2020.0234 Silvestre, 2018, beta-Blocker therapy for cirrhotic cardiomyopathy: a randomized-controlled trial, Eur J Gastroenterol Hepatol, 30, 930, 10.1097/MEG.0000000000001128 Alvarado-Tapias, 2020, Short-term hemodynamic effects of beta-blockers influence survival of patients with decompensated cirrhosis, J Hepatol, 73, 829, 10.1016/j.jhep.2020.03.048 Krag, 2012, The window hypothesis: haemodynamic and non-haemodynamic effects of beta-blockers improve survival of patients with cirrhosis during a window in the disease, Gut, 61, 967, 10.1136/gutjnl-2011-301348 Fukuta, 2019, Effects of exercise training on cardiac function, exercise capacity, and quality of life in heart failure with preserved ejection fraction: a meta-analysis of randomized controlled trials, Heart Fail Rev, 24, 535, 10.1007/s10741-019-09774-5 Blumenthal, 2012, Effects of exercise training on depressive symptoms in patients with chronic heart failure: the HF-ACTION randomized trial, JAMA, 308, 465, 10.1001/jama.2012.8720 Yuan, 2019, Cardiac health in patients with hepatitis B virus-related cirrhosis, Medicine (Baltimore), 98 Mookerjee, 2016, Treatment with non-selective beta blockers is associated with reduced severity of systemic inflammation and improved survival of patients with acute-on-chronic liver failure, J Hepatol, 64, 574, 10.1016/j.jhep.2015.10.018 Lee, 2022, Prolonged QT interval in cirrhosis: twisting time?, Gut Liver, 16, 849, 10.5009/gnl210537 Vink, 2018, Determination and interpretation of the QT interval, Circulation, 138, 2345, 10.1161/CIRCULATIONAHA.118.033943 Albillos, 2023, Beta-blockers in the era of precision medicine in patients with cirrhosis, J Hepatol, 78, 866, 10.1016/j.jhep.2022.12.005