Cardiometabolic effects of ZingiberOfficinale Roscoe extracts in Type 2 diabetic Cameroonians patients after six weeks of add-on Therapy : A single clinical-arm trial

Kengne, 2005, Cardiovascular Complications of Diabetes Mellitus in Sub-Saharan Africa, Circulation, 112, 3592, 10.1161/CIRCULATIONAHA.105.544312 IDF diabetes atlas - 2015 Atlas [Internet]. [cited 2017 Nov 7]. Available from: http://www.diabetesatlas.org/resources/2015-atlas.html Trang, 2017, Treating Disease Mechanisms in Patients With Heart Failure and Diabetes Mellitus, Curr Heart Fail Rep, 14, 445, 10.1007/s11897-017-0371-7 Tankeu, 2016, Oscillating blood pressure therapeutic target in type 2 diabetes patients with hypertension, Ann Transl Med, 4, 10.21037/atm.2016.11.16 Boudina, 2010, Diabetic cardiomyopathy, causes and effects, Rev EndocrMetabDisord, 11, 31 Martín-Timón, 2014, Type 2 diabetes and cardiovascular disease: Have all risk factors the same strength?, World J Diabetes, 5, 444, 10.4239/wjd.v5.i4.444 Zinman, 2015, Empagliflozin, Cardiovascular Outcomes, and Mortality in Type 2 Diabetes, N Engl J Med, 373, 2117, 10.1056/NEJMoa1504720 King, 1999, The UK Prospective Diabetes Study (UKPDS): clinical and therapeutic implications for type 2 diabetes, Br J ClinPharmacol, 48, 643 Tankeu, 2017, Spécificités de la prise en charge de l'hypertensionartérielle chez le patient diabétique sub-saharien, Médecine Mal Métaboliques, 11, 148, 10.1016/S1957-2557(17)30035-4 Stuart, 2005 Ventola, 2010, Current Issues Regarding Complementary and Alternative Medicine (CAM) in the United States, Pharm Ther, 35, 461 Bode, 2011, The Amazing and Mighty Ginger Anh, 2020, Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials, Nutrients, 12, 10.3390/nu12010157 Liu, 2015, Identification and characterization of [6]-shogaol from ginger as inhibitor of vascular smooth muscle cell proliferation, MolNutr Food Res, 59, 843 Tabassum, 2011, Role of natural herbs in the treatment of hypertension, Pharmacogn Rev, 5, 30, 10.4103/0973-7847.79097 Whitley, 2002, Statistics review 4: Sample size calculations, Crit Care, 6, 335, 10.1186/cc1521 Verma, 2016, Effect of Empagliflozin on Left Ventricular Mass and Diastolic Function in Individuals With Diabetes: An Important Clue to the EMPA-REG OUTCOME Trial?, Diabetes Care, 39, e212, 10.2337/dc16-1312 Evangelista, 2008, European Association of Echocardiography recommendations for standardization of performance, digital storage and reporting of echocardiographic studies, Eur J Echocardiogr, 9, 438, 10.1093/ejechocard/jen174 MoriskyDE, GreenLW, LevineDM. Concurrent and Predictive Validity of a Self-reported Measure of Medication Adherence: Med Care. 1986 Jan;24(1):67–74. 2013, World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects, JAMA, 310, 2191, 10.1001/jama.2013.281053 Kass, 1993, Diastolic compliance of hypertrophied ventricle is not acutely altered by pharmacologic agents influencing active processes, Ann Intern Med, 119, 466, 10.7326/0003-4819-119-6-199309150-00004 Nishimura, 1993, Failure of calcium channel blockers to improve ventricular relaxation in humans, J Am CollCardiol, 21, 182, 10.1016/0735-1097(93)90735-J Kobayashi, 1987, Gingerol, a novel cardiotonic agent, activates the Ca2+-pumping ATPase in skeletal and cardiac sarcoplasmic reticulum, BiochimBiophysActa BBA - Biomembr, 903, 96, 10.1016/0005-2736(87)90159-3 Ali, 2008, Some phytochemical, pharmacological and toxicological properties of ginger (Zingiberofficinale Roscoe): a review of recent research, Food ChemToxicolInt J Publ Br IndBiol Res Assoc, 46, 409, 10.1016/j.fct.2007.09.085 Ghayur, 2005, Cardiovascular effects of ginger aqueous extract and its phenolic constituents are mediated through multiple pathways, VasculPharmacol, 43, 234 Ojulari, 2014, The Effect of ZingiberOfficinale (Ginger) Extract on Blood Pressure and Heart Rate in Healthy Humans, IOSR J Dent Med Sci, 13, 76, 10.9790/0853-131037678 ElRokh, 2010, Antihypercholesterolaemic effect of ginger rhizome (Zingiberofficinale) in rats, Inflammopharmacology, 18, 309, 10.1007/s10787-010-0053-5 Tabibi, 2016, Effects of Ginger on Serum Lipids and Lipoproteins in Peritoneal Dialysis Patients: A Randomized Controlled Trial, Perit Dial Int J IntSocPerit Dial, 36, 140, 10.3747/pdi.2015.00006 Heimes, 2009, Impact of the 5-HT3 receptor channel system for insulin secretion and interaction of ginger extracts, Eur J Pharmacol, 624, 58, 10.1016/j.ejphar.2009.09.049