Cardiac troponin I is elevated in dogs and cats with azotaemia renal failure and in dogs with non‐cardiac systemic disease

Australian Veterinary Journal - Tập 86 Số 10 - Trang 390-394 - 2008
Francesco Porciello1, Mark Rishniw2, WE Herndon3, Francesco Birettoni1, Maria Teresa Antognoni1, Kenneth W. Simpson4
1Department of Clinical Sciences, University of Perugia, Umbria, Italy
2Department of Biomedical Sciences, Box 11, Veterinary Research Tower, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853, USA
3Southpaws Veterinary Referral Center, VA, USA
4Department of Clinical Sciences, Cornell University, NY, USA

Tóm tắt

Objective To determine if dogs and cats with renal failure, or other severe non‐cardiac disease, and no antemortem evidence of cardiac disease on basic clinical evaluation, have elevated levels of cardiac troponin I (cTnI).

Design Cross‐sectional study using 56 dogs and 14 cats with primary non‐cardiac disease (39 dogs with azotaemic renal failure, 14 cats with azotaemic renal failure, 17 dogs with non‐cardiac systemic disease); 7/25 dogs and 6/14 cats had murmurs detected on physical examination. Serum or heparinised plasma was collected and analysed for cTnI.

Results Cardiac troponin I concentrations were elevated above reference intervals in 70% of dogs and 70% of cats with azotaemic renal failure and in 70% of dogs with a variety of systemic non‐cardiac diseases. Cardiac troponin I concentrations did not correlate with the degree of azotaemia, presence of murmurs, hypertension or type of non‐cardiac illness.

Conclusions Cardiac troponin I concentration is often elevated in dogs and cats with azotaemic renal failure and in dogs with other systemic non‐cardiac illness, suggesting that these conditions often result in clinically inapparent myocardial injury or possibly altered elimination of cTnI.

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Australian Veterinary Journal

Tập 86 Số 10

390-394

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