Cardiac-specific research platforms engender novel insights into mitochondrial dynamism

Current Opinion in Physiology - Tập 3 - Trang 110-115 - 2018
Gerald W Dorn1
1Department of Internal Medicine, Washington University School of Medicine, Campus Box 8220, 660 S. Euclid Ave., St. Louis, MO 63110, USA

Tài liệu tham khảo

Detmer, 2007, Functions and dysfunctions of mitochondrial dynamics, Nat Rev Mol Cell Biol, 8, 870, 10.1038/nrm2275 Chen, 2010, Dual autonomous mitochondrial cell death pathways are activated by Nix/BNip3L and induce cardiomyopathy, Proc Natl Acad Sci U S A, 107, 9035, 10.1073/pnas.0914013107 Gong, 2015, Parkin-mediated mitophagy directs perinatal cardiac metabolic maturation in mice, Science, 350, aad2459, 10.1126/science.aad2459 Huang, 2013, Conversion from CUL4-based COP1-SPA E3 apparatus to UVR8-COP1-SPA complexes underlies a distinct biochemical function of COP1 under UV-B, Proc Natl Acad Sci U S A, 110, 16669, 10.1073/pnas.1316622110 Dorn, 2013, Mitochondrial dynamics in heart disease, Biochim Biophys Acta, 1833, 233, 10.1016/j.bbamcr.2012.03.008 Song, 2015, Mitoconfusion: noncanonical functioning of dynamism factors in static mitochondria of the heart, Cell Metab, 21, 195, 10.1016/j.cmet.2014.12.019 Glancy, 2017, Power grid protection of the muscle mitochondrial reticulum, Cell Rep, 19, 487, 10.1016/j.celrep.2017.03.063 Pallanck, 2013, Mitophagy: mitufusin recruits a mitochondrial killer, Curr Biol, 23, R570, 10.1016/j.cub.2013.05.032 Chen, 2013, PINK1-phosphorylated mitofusin 2 is a Parkin receptor for culling damaged mitochondria, Science, 340, 471, 10.1126/science.1231031 Lee, 2012, Mitofusin 2 is necessary for striatal axonal projections of midbrain dopamine neurons, Hum Mol Genet, 21, 4827, 10.1093/hmg/dds352 Matsumine, 1997, Localization of a gene for an autosomal recessive form of juvenile Parkinsonism to chromosome 6q25.2-27, Am J Hum Genet, 60, 588 Kitada, 1998, Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism, Nature, 392, 605, 10.1038/33416 Valente, 2004, Hereditary early-onset Parkinson's disease caused by mutations in PINK1, Science, 304, 1158, 10.1126/science.1096284 Hatano, 2004, Novel PINK1 mutations in early-onset parkinsonism, Ann Neurol, 56, 424, 10.1002/ana.20251 Zuchner, 2004, Mutations in the mitochondrial GTPase mitofusin 2 cause Charcot-Marie-Tooth neuropathy type 2A, Nat Genet, 36, 449, 10.1038/ng1341 Zhu, 2005, Charcot-Marie-Tooth with pyramidal signs is genetically heterogeneous: families with and without MFN2 mutations, Neurology, 65, 496, 10.1212/01.wnl.0000171345.62270.29 Delettre, 2000, Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophy, Nat Genet, 26, 207, 10.1038/79936 Waterham, 2007, A lethal defect of mitochondrial and peroxisomal fission, N Engl J Med, 356, 1736, 10.1056/NEJMoa064436 Yoon, 2016, Lethal disorder of mitochondrial fission caused by mutations in DNM1L, J Pediatr, 171, 10.1016/j.jpeds.2015.12.060 Vanstone, 2016, DNM1L-related mitochondrial fission defect presenting as refractory epilepsy, Eur J Hum Genet, 24, 1084, 10.1038/ejhg.2015.243 Sheffer, 2016, Postnatal microcephaly and pain insensitivity due to a de novo heterozygous DNM1L mutation causing impaired mitochondrial fission and function, Am J Med Genet A, 170, 1603, 10.1002/ajmg.a.37624 Chao, 2016, Missense variants in the middle domain of DNM1L in cases of infantile encephalopathy alter peroxisomes and mitochondria when assayed in Drosophila, Hum Mol Genet, 25, 1846, 10.1093/hmg/ddw059 Cogliati, 2013, Mitochondrial cristae shape determines respiratory chain supercomplexes assembly and respiratory efficiency, Cell, 155, 160, 10.1016/j.cell.2013.08.032 Kasahara, 2013, Mitochondrial fusion directs cardiac myocyte differentiation via calcineurin and Notch signaling, Science, 342, 734, 10.1126/science.1241359 Song, 2014, Super-suppression of mitochondrial reactive oxygen species signaling impairs compensatory autophagy in primary mitophagic cardiomyopathy, Circ Res, 115, 348, 10.1161/CIRCRESAHA.115.304384 Song, 2015, Mitochondrial fission and fusion factors reciprocally orchestrate mitophagic culling in mouse hearts and cultured fibroblasts, Cell Metab, 21, 273, 10.1016/j.cmet.2014.12.011 Ishihara, 2015, Dynamics of mitochondrial DNA nucleoids regulated by mitochondrial fission is essential for maintenance of homogeneously active mitochondria during neonatal heart development, Mol Cell Biol, 35, 211, 10.1128/MCB.01054-14 Wai, 2015, Imbalanced OPA1 processing and mitochondrial fragmentation cause heart failure in mice, Science, 350, 10.1126/science.aad0116 Song, 2017, Abrogating mitochondrial dynamics in mouse hearts accelerates mitochondrial senescence, Cell Metab, 26, 10.1016/j.cmet.2017.09.023 Franco, 2016, Correcting mitochondrial fusion by manipulating mitofusin conformations, Nature, 540, 74, 10.1038/nature20156 Rocha, 2018, Mfn2 agonists reverse mitochondrial defects in preclinical models of Charcot Marie Tooth disease type 2A, Science, 360, 336, 10.1126/science.aao1785 Twig, 2008, Fission and selective fusion govern mitochondrial segregation and elimination by autophagy, EMBO J, 27, 433, 10.1038/sj.emboj.7601963 Shirihai, 2015, How mitochondrial dynamism orchestrates mitophagy, Circ Res, 116, 1835, 10.1161/CIRCRESAHA.116.306374 Dorn, 2015, Mitochondrial biogenesis and dynamics in the developing and diseased heart, Genes Dev, 29, 1981, 10.1101/gad.269894.115 Youle, 2011, Mechanisms of mitophagy, Nat Rev Mol Cell Biol, 12, 9, 10.1038/nrm3028 Chen, 2007, Mitochondrial fusion protects against neurodegeneration in the cerebellum, Cell, 130, 548, 10.1016/j.cell.2007.06.026 Ishihara, 2009, Mitochondrial fission factor Drp1 is essential for embryonic development and synapse formation in mice, Nat Cell Biol, 11, 958, 10.1038/ncb1907 Sohal, 2001, Temporally regulated and tissue-specific gene manipulations in the adult and embryonic heart using a tamoxifen-inducible Cre protein, Circ Res, 89, 20, 10.1161/hh1301.092687