Cardiac glycosides from Cascabela thevetioides by HPLC-MS analysis
Tóm tắt
The present work investigates the chemical composition of seeds of Cascabela thevetioides (Kunth) Lip-pold, an ornamental shrub of México. Six thevetia cardiac glycosides or thevetosides (thevetin A, B, and C, acetylthevetin A, B and C) were identified from the methanol extract of seeds of C. thevetioides by High-Performance Liquid Chromatography-Mass Spectrometry and by comparison of mass spectral fragmentation patterns. Enzymatic hydrolysis of a sample of thevetosides from methanol extract of seeds and subsequent High-Performance Liquid Chromatography-Mass Spectrometry analysis yielded the monoglycosides neriifolin, acetylneriifolin and acetylperuvoside, previously reported for this plant. For the fisrt time thevetin A, B and C, and acetylthevetin A, B and C are reported as components of seeds of C. thevetioides.
Tài liệu tham khảo
Abe, F., Chen, R.F., Yamauchi, T., 1996. Dinormonoterpenoids and their apiosylglu-cosides from Thevetia peruviana. Phytochemistry 43, 161–163.
Amaringo, F., 2011. Thevetin B: glicósido cardiotónico predominante en Thevetia peruviana. Sci. Tech XVI (298), 303.
Argueta, A., Cano, L., Rodarte, M., Gallardo, M., 1994. Atlas de las plantas de la medicina tradicional mexicana. Instituto Nacional Indigenista, México, D.F., México.
Bandara, V., Weinstein, S.A., White, J., Eddleston, M., 2010. A review of the natural history, toxinology, diagnosis and clinical management of Nerium oleander (common oleander) and Thevetia peruviana (yellow oleander) poisoning. Toxicon 56, 273–281.
Cruz, A., Guzman, A., Iriarte, J., Medina, R., Muchowski, J.M., Maddox, M.L., 1979. 18, 20-Oxido-20, 22-dihydroneriifolin, an unusual oxygenated cardanolide. J. Org. Chem. 44, 3511–3515.
DagerAlbalawi, M.A., 2016. Chemistry, spectroscopic characteristics and biological activity of natural occurring cardiac glycosides. IOSRJ. Biotechnol. Biochem. 2, 20–35.
Essiett, U., Udolfa, I., 2014. Chemical profiles of leaf, stem and flower of Thevetia peruviana (Pers.) K. Scum. Eur. J. Biomed. Pharm. Sci. 1, 35–44.
Galsky, A.G., Wilsey, J.P., Powell, R.G., 1980. Crown gall tumor disc bioassay. Plant Physiol. 65, 184–185.
Kohls, S., Scholz-Böttcher, B.M., Teske, J., Rullkötter, J., 2015. Isolation and quantification of six cardiac glycosides from the seeds of Thevetia peruviana provide a basis for toxological survey. Indian J. Chem. — Sect. B Org. Med. Chem 54B, 1502–1510.
Kohls, S., Scholz-Böttcher, B.M., Teske, J., Zark, P., Rullkötter, J., 2012. Cardiac glycosides from yellow oleander (Thevetia peruviana) seeds. Phytochemistry 75, 114–127.
Liu, Q., Tang, J.S., Hu, M.J., Liu, J., Chen, H.F., Gao, H., Wang, G.H., Li, S.L., Hao, X.J., Zhang, X.K., Yao, X.S., 2013. Antiproliferative cardiac glycosides from the latex of Antiaris toxicaria. J. Nat. Prod. 76, 1771–1780.
McLaughlin, J.L., Freedman, B., Powell, R.G., Smith, CR., 1980. Neriifolin and 2′- Acetylneriifolin: insecticidal and cytotoxic agents of Thevetia thevetioides seeds. J. Econ. Entomol. 73, 398–402.
Rojas, A.M., 2009. Tratado de medicina tradicional mexicana. In: Bases históricas, teoría y práctica clínico-terapéutica, 3rd ed. Tlahui, Cuernavaca, Morelos, México.
Voigtländer, H.W., Balsam, G., Herbst, G., 1968. Über acetyl-cardenolide aus Thevetia peruviana. Arch. Pharm. 10, 538–544.