Cardiac fibroblasts: At the heart of myocardial remodeling

Pharmacology & Therapeutics - Tập 123 Số 2 - Trang 255-278 - 2009
Karen E. Porter1,2, Neil A. Turner1,2
1Division of Cardiovascular and Neuronal Remodelling, Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds LS2 9JT, UK
2Multidisciplinary Cardiovascular Research Centre (MCRC)

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Abdelrahman, 2005, Beneficial effects of PPAR-γ ligands in ischemia–reperfusion injury, inflammation and shock, Cardiovasc Res, 65, 772, 10.1016/j.cardiores.2004.12.008

Agocha, 1997, Hypoxia regulates basal and induced DNA synthesis and collagen type I production in human cardiac fibroblasts: effects of transforming growth factor-β1, thyroid hormone, angiotensin II and basic fibroblast growth factor, J Mol Cell Cardiol, 29, 2233, 10.1006/jmcc.1997.0462

Agocha, 1997, Characterization of adult human heart fibroblasts in culture: a comparative study of growth, proliferation and collagen production in human and rabbit cardiac fibroblasts and their response to transforming growth factor-beta1, Cell Tissue Res, 288, 87, 10.1007/s004410050795

Ainscough, 2009, Angiotensin II type-1 receptor activation in the adult heart causes blood pressure-independent hypertrophy and cardiac dysfunction, Cardiovasc Res, 81, 592, 10.1093/cvr/cvn230

Akiyama-Uchida, 2002, Norepinephrine enhances fibrosis mediated by TGF-β in cardiac fibroblasts, Hypertension, 40, 148, 10.1161/01.HYP.0000025443.61926.12

Anavekar, 2005, Angiotensin II receptor blockade and ventricular remodelling, J Renin Angiotensin Aldosterone Syst, 6, 43, 10.3317/jraas.2005.006

Ancey, 2002, Secretion of IL-6, IL-11 and LIF by human cardiomyocytes in primary culture, Cytokine, 18, 199, 10.1006/cyto.2002.1033

Angst, 1997, Dissociated spatial patterning of gap junctions and cell adhesion junctions during postnatal differentiation of ventricular myocardium, Circ Res, 80, 88, 10.1161/01.RES.80.1.88

Asai, 1999, β-adrenergic receptor blockade arrests myocyte damage and preserves cardiac function in the transgenic Gsα mouse, J Clin Invest, 104, 551, 10.1172/JCI7418

Asakawa, 2002, Peroxisome proliferator-activated receptor γ plays a critical role in inhibition of cardiac hypertrophy in vitro and in vivo, Circulation, 105, 1240, 10.1161/hc1002.105225

Asano, 2002, Altered expression of endothelin receptors in failing human left ventricles, J Mol Cell Cardiol, 34, 833, 10.1006/jmcc.2002.2022

Atance, 2004, Influence of the extracellular matrix on the regulation of cardiac fibroblast behavior by mechanical stretch, J Cell Physiol, 200, 377, 10.1002/jcp.20034

Banerjee, 2006, Dynamic interactions between myocytes, fibroblasts, and extracellular matrix, Ann N Y Acad Sci, 1080, 76, 10.1196/annals.1380.007

Baudino, 2006, Cardiac fibroblasts: friend or foe?, Am J Physiol Heart Circ Physiol, 291, H1015, 10.1152/ajpheart.00023.2006

Benjamin, 1989, Isoproterenol-induced myocardial fibrosis in relation to myocyte necrosis, Circ Res, 65, 657, 10.1161/01.RES.65.3.657

Benson, 2008, Inhibition of cardiovascular cell proliferation by angiotensin receptor blockers: are all molecules the same?, J Hypertens, 26, 973, 10.1097/HJH.0b013e3282f56ba5

Bergman, 2003, A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers, Biochem J, 369, 485, 10.1042/bj20020707

Bhambi, 1991, Effect of norepinephrine on myocardial collagen gene expression and response of cardiac fibroblasts after norepinephrine treatment, Am J Pathol, 139, 1131

Bing, 1997, Localization of alpha1(I) collagen mRNA in myocardium from the spontaneously hypertensive rat during the transition from compensated hypertrophy to failure, J Mol Cell Cardiol, 29, 2335, 10.1006/jmcc.1997.0465

Bishop, 1995, Collagen turnover and its regulation in the normal and hypertrophying heart, Eur Heart J, 16, 38, 10.1093/eurheartj/16.suppl_C.38

Borg, 1984, Recognition of extracellular matrix components by neonatal and adult cardiac myocytes, Dev Biol, 104, 86, 10.1016/0012-1606(84)90038-1

Bosman, 2003, Functional structure and composition of the extracellular matrix, J Pathol, 200, 423, 10.1002/path.1437

Bouzegrhane, 2002, Is angiotensin II a proliferative factor of cardiac fibroblasts?, Cardiovasc Res, 53, 304, 10.1016/S0008-6363(01)00448-5

Briest, 2003, Norepinephrine-induced interleukin-6 increase in rat hearts: differential signal transduction in myocytes and non-myocytes, Pflugers Arch, 446, 437, 10.1007/s00424-003-1043-x

Brilla, 1995, The renin–angiotensin–aldosterone system and myocardial collagen matrix remodelling in congestive heart failure, Eur Heart J, 16, 107, 10.1093/eurheartj/16.suppl_O.107

Brilla, 1994, Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosterone, J Mol Cell Cardiol, 26, 809, 10.1006/jmcc.1994.1098

Bristow, 2000, β-adrenergic receptor blockade in chronic heart failure, Circulation, 101, 558, 10.1161/01.CIR.101.5.558

Brodde, 1999, Adrenergic and muscarinic receptors in the human heart, Pharmacol Rev, 51, 651

Brown, 2005, The cardiac fibroblast: therapeutic target in myocardial remodeling and failure, Annu Rev Pharmacol Toxicol, 45, 657, 10.1146/annurev.pharmtox.45.120403.095802

Brown, 2007, Cytokines regulate matrix metalloproteinases and migration in cardiac fibroblasts, Biochem Biophys Res Commun, 362, 200, 10.1016/j.bbrc.2007.08.003

Bujak, 2007, The role of TGF-beta signaling in myocardial infarction and cardiac remodeling, Cardiovasc Res, 74, 184, 10.1016/j.cardiores.2006.10.002

Bürger, 2001, Catecholamines stimulate interleukin-6 synthesis in rat cardiac fibroblasts, Am J Physiol Heart Circ Physiol, 281, H14, 10.1152/ajpheart.2001.281.1.H14

Burgess, 2005, PPARγ agonists inhibit TGF-β induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis, Am J Physiol Lung Cell Mol Physiol, 288, L1146, 10.1152/ajplung.00383.2004

Butt, 1997, Mechanical load enhances the stimulatory effect of serum growth factors on cardiac fibroblast procollagen synthesis, J Mol Cell Cardiol, 29, 1141, 10.1006/jmcc.1996.0347

Calderone, 2006, Scar myofibroblasts of the infarcted rat heart express natriuretic peptides, J Cell Physiol, 207, 165, 10.1002/jcp.20548

Calderone, 1998, Nitric oxide, atrial natriuretic peptide, and cyclic GMP inhibit the growth-promoting effects of norepinephrine in cardiac myocytes and fibroblasts, J Clin Invest, 101, 812, 10.1172/JCI119883

Camelliti, 2005, Structural and functional characterisation of cardiac fibroblasts, Cardiovasc Res, 65, 40, 10.1016/j.cardiores.2004.08.020

Camelliti, 2004, Spatially and temporally distinct expression of fibroblast connexins after sheep ventricular infarction, Cardiovasc Res, 62, 415, 10.1016/j.cardiores.2004.01.027

Camelliti, 2006, Structural and functional coupling of cardiac myocytes and fibroblasts, Adv Cardiol, 42, 132, 10.1159/000092566

Camelliti, 2004, Fibroblast network in rabbit sinoatrial node: structural and functional identification of homogeneous and heterogeneous cell coupling, Circ Res, 94, 828, 10.1161/01.RES.0000122382.19400.14

Cameron, 2000, Atrial (ANP) and brain natriuretic peptide (BNP) expression after myocardial infarction in sheep: ANP is synthesized by fibroblasts infiltrating the infarct, Endocrinology, 141, 4690, 10.1210/endo.141.12.7847

Campbell, 1997, Angiotensin II stimulated expression of transforming growth factor-β1 in cardiac fibroblasts and myofibroblasts, J Mol Cell Cardiol, 29, 1947, 10.1006/jmcc.1997.0435

Cao, 1995, Natriuretic peptides inhibit DNA synthesis in cardiac fibroblasts, Hypertension, 25, 227, 10.1161/01.HYP.25.2.227

Carver, 1991, Collagen expression in mechanically stimulated cardiac fibroblasts, Circ Res, 69, 116, 10.1161/01.RES.69.1.116

Chao, 2005, Inhibition of angiotensin II induced endothelin-1 gene expression by 17-β-oestradiol in rat cardiac fibroblasts, Heart, 91, 664, 10.1136/hrt.2003.031898

Chen, 2004, Angiotensin II regulation of collagen type I expression in cardiac fibroblasts: modulation by PPAR-γ ligand pioglitazone, Hypertension, 44, 655, 10.1161/01.HYP.0000144400.49062.6b

Chen, 2004, Functional effects of enhancing or silencing adenosine A2b receptors in cardiac fibroblasts, Am J Physiol Heart Circ Physiol, 287, H2478, 10.1152/ajpheart.00217.2004

Chen, 2004, Anoxia–reoxygenation stimulates collagen type-I and MMP-1 expression in cardiac fibroblasts: modulation by the PPAR-γ ligand pioglitazone, J Cardiovasc Pharmacol, 44, 682, 10.1097/00005344-200412000-00010

Chen, 2006, Angiotensin II-mediated oxidative stress and procollagen-1 expression in cardiac fibroblasts: blockade by pravastatin and pioglitazone, Am J Physiol Heart Circ Physiol, 291, H1738, 10.1152/ajpheart.00341.2006

Chen, 2004, Transforming growth factor β receptor endoglin is expressed in cardiac fibroblasts and modulates profibrogenic actions of angiotensin II, Circ Res, 95, 1167, 10.1161/01.RES.0000150369.68826.2f

Cheng, 2003, Involvement of reactive oxygen species in angiotensin II-induced endothelin-1 gene expression in rat cardiac fibroblasts, J Am Coll Cardiol, 42, 1845, 10.1016/j.jacc.2003.06.010

Cheng, 2003, Crucial role of extracellular signal-regulated kinase pathway in reactive oxygen species-mediated endothelin-1 gene expression induced by endothelin-1 in rat cardiac fibroblasts, Mol Pharmacol, 63, 1002, 10.1124/mol.63.5.1002

Chilton, 2005, K+ currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts, Am J Physiol Heart Circ Physiol, 288, H2931, 10.1152/ajpheart.01220.2004

Chinetti-Gbaguidi, 2005, Pleiotropic effects of fibrates, Curr Atheroscler Rep, 7, 396, 10.1007/s11883-005-0053-x

Chintalgattu, 2007, PPAR-γ agonists induce the expression of VEGF and its receptors in cultured cardiac myofibroblasts, Cardiovasc Res, 74, 140, 10.1016/j.cardiores.2007.01.010

Chintalgattu, 2004, Role of protein kinase Cδ in endothelin-induced type I collagen expression in cardiac myofibroblasts isolated from the site of myocardial infarction, J Pharmacol Exp Ther, 311, 691, 10.1124/jpet.104.070151

Chintalgattu, 2003, Cardiac myofibroblasts: a novel source of vascular endothelial growth factor (VEGF) and its receptors Flt-1 and KDR, J Mol Cell Cardiol, 35, 277, 10.1016/S0022-2828(03)00006-3

Chua, 1991, Effect of growth factors on collagen metabolism in cultured human heart fibroblasts, Connect Tissue Res, 26, 271, 10.3109/03008209109152444

Clancy, 2007, Role of hypoxia and cAMP in the transdifferentiation of human fetal cardiac fibroblasts: implications for progression to scarring in autoimmune-associated congenital heart block, Arthritis Rheum, 56, 4120, 10.1002/art.23061

Cohn, 2000, Cardiac remodeling — concepts and clinical implications: a consensus paper from an international forum on cardiac remodeling, J Am Coll Cardiol, 35, 569, 10.1016/S0735-1097(99)00630-0

Colombo, 2003, β-adrenergic receptor-mediated DNA synthesis in neonatal rat cardiac fibroblasts proceeds via a phosphatidylinositol 3-kinase dependent pathway refractory to the antiproliferative action of cyclic AMP, J Cell Physiol, 195, 322, 10.1002/jcp.10251

Colombo, 2001, β-Adrenergic stimulation of rat cardiac fibroblasts promotes protein synthesis via the activation of phosphatidylinositol 3-kinase, J Mol Cell Cardiol, 33, 1091, 10.1006/jmcc.2001.1381

Corda, 2000, Extracellular matrix and growth factors during heart growth, Heart Fail Rev, 5, 119, 10.1023/A:1009806403194

Cowling, 2002, Transcription factor NF-κB is necessary for up-regulation of type 1 angiotensin II receptor mRNA in rat cardiac fibroblasts treated with tumor necrosis factor-α or interleukin-1β, J Biol Chem, 277, 5719, 10.1074/jbc.M107515200

Cowling, 2005, Effects of cytokine treatment on angiotensin II type 1A receptor transcription and splicing in rat cardiac fibroblasts, Am J Physiol Heart Circ Physiol, 289, H1176, 10.1152/ajpheart.00088.2005

Crabos, 1994, Characterization of angiotensin II receptors in cultured adult rat cardiac fibroblasts. Coupling to signaling systems and gene expression, J Clin Invest, 93, 2372, 10.1172/JCI117243

D'Souza, 2004, Autocrine and paracrine actions of natriuretic peptides in the heart, Pharmacol Ther, 101, 113, 10.1016/j.pharmthera.2003.11.001

Dechend, 2001, Modulating angiotensin II-induced inflammation by HMG Co-A reductase inhibition, Am J Hypertens, 14, 55S, 10.1016/S0895-7061(01)02070-2

Deschamps, 2006, Pathways of matrix metalloproteinase induction in heart failure: bioactive molecules and transcriptional regulation, Cardiovasc Res, 69, 666, 10.1016/j.cardiores.2005.10.004

Desmouliere, 1995, Apoptosis mediates the decrease in cellularity during the transition between granulation tissue and scar, Am J Pathol, 146, 56

Dostal, 2001, Regulation of cardiac collagen: angiotensin and cross-talk with local growth factors, Hypertension, 37, 841, 10.1161/01.HYP.37.3.841

Dostal, 1999, The cardiac renin-angiotensin system: conceptual, or a regulator of cardiac function?, Circ Res, 85, 643, 10.1161/01.RES.85.7.643

Dostal, 2000, Regulation of angiotensinogen gene expression and protein in neonatal rat cardiac fibroblasts by glucocorticoid and β-adrenergic stimulation, Basic Res Cardiol, 95, 485, 10.1007/s003950070025

Drobic, 2007, Differential and combined effects of cardiotrophin-1 and TGF-β1 on cardiac myofibroblast proliferation and contraction, Am J Physiol Heart Circ Physiol, 293, H1053, 10.1152/ajpheart.00935.2006

Du, 2007, Phenylarsine oxide inhibited β-adrenergic receptor-mediated IL-6 secretion: inhibition of cAMP accumulation and CREB activation in cardiac fibroblasts, Biochem Biophys Res Commun, 352, 744, 10.1016/j.bbrc.2006.11.082

Du, 2005, AICAR stimulates IL-6 production via p38 MAPK in cardiac fibroblasts in adult mice: a possible role for AMPK, Biochem Biophys Res Commun, 337, 1139, 10.1016/j.bbrc.2005.09.174

Duan, 2005, Cardiomyocyte-specific knockout and agonist of peroxisome proliferator-activated receptor-γ both induce cardiac hypertrophy in mice, Circ Res, 97, 372, 10.1161/01.RES.0000179226.34112.6d

Dubey, 1997, Exogenous and endogenous adenosine inhibits fetal calf serum-induced growth of rat cardiac fibroblasts: role of A2B receptors, Circulation, 96, 2656, 10.1161/01.CIR.96.8.2656

Dubey, 1998, Adenosine inhibits collagen and protein synthesis in cardiac fibroblasts: role of A2B receptors, Hypertension, 31, 943, 10.1161/01.HYP.31.4.943

Dubey, 2000, Cardiac fibroblasts express the cAMP-adenosine pathway, Hypertension, 36, 337, 10.1161/01.HYP.36.3.337

Dubey, 2001, Endogenous cyclic AMP-adenosine pathway regulates cardiac fibroblast growth, Hypertension, 37, 1095, 10.1161/01.HYP.37.4.1095

Dubey, 2001, A2b receptors mediate the antimitogenic effects of adenosine in cardiac fibroblasts, Hypertension, 37, 716, 10.1161/01.HYP.37.2.716

Dumasia, 2005, Role of PPAR-γ agonist thiazolidinediones in treatment of pre-diabetic and diabetic individuals: a cardiovascular perspective, Curr Drug Targets Cardiovasc Haematol Disord, 5, 377, 10.2174/156800605774370362

Eghbali, 1989, Localization of types I, III and IV collagen mRNAs in rat heart cells by in situ hybridization, J Mol Cell Cardiol, 21, 103, 10.1016/0022-2828(89)91498-3

Eghbali, 1990, Collagen and the myocardium: fibrillar structure, biosynthesis and degradation in relation to hypertrophy and its regression, Mol Cell Biochem, 96, 1, 10.1007/BF00228448

Eghbali, 1991, Differential effects of transforming growth factor-beta 1 and phorbol myristate acetate on cardiac fibroblasts. Regulation of fibrillar collagen mRNAs and expression of early transcription factors, Circ Res, 69, 483, 10.1161/01.RES.69.2.483

Eghbali, 1991, Cardiac fibroblasts are predisposed to convert into myocyte phenotype: specific effect of transforming growth factor β, Proc Natl Acad Sci U S A, 88, 795, 10.1073/pnas.88.3.795

Endo, 2007, Bone marrow derived cells are involved in the pathogenesis of cardiac hypertrophy in response to pressure overload, Circulation, 116, 1176, 10.1161/CIRCULATIONAHA.106.650903

Epperson, 2009, Adenosine receptors and second messenger signaling pathways in rat cardiac fibroblasts, Am J Physiol Cell Physiol, 296, C1171, 10.1152/ajpcell.00290.2008

Erdmann, 2007, The effect of pioglitazone on recurrent myocardial infarction in 2,445 patients with type 2 diabetes and previous myocardial infarction: results from the PROactive (PROactive 05) Study, J Am Coll Cardiol, 49, 1772, 10.1016/j.jacc.2006.12.048

Fareh, 1996, Endothelin-1 and angiotensin II receptors in cells from rat hypertrophied heart. Receptor regulation and intracellular Ca2+ modulation, Circ Res, 78, 302, 10.1161/01.RES.78.2.302

Feld, 2002, Electrophysiological modulation of cardiomyocytic tissue by transfected fibroblasts expressing potassium channels: a novel strategy to manipulate excitability, Circulation, 105, 522, 10.1161/hc0402.102661

Fisher, 1995, Norepinephrine and ANG II stimulate secretion of TGF-β by neonatal rat cardiac fibroblasts in vitro, Am J Physiol, 268, C910, 10.1152/ajpcell.1995.268.4.C910

Fliegner, 2008, Up-regulation of PPARγ in myocardial infarction, Eur J Heart Fail, 10, 30, 10.1016/j.ejheart.2007.11.005

Frangogiannis, 2006, Targeting the inflammatory response in healing myocardial infarcts, Curr Med Chem, 13, 1877, 10.2174/092986706777585086

Fredj, 2005, Role of interleukin-6 in cardiomyocyte/cardiac fibroblast interactions during myocyte hypertrophy and fibroblast proliferation, J Cell Physiol, 204, 428, 10.1002/jcp.20307

Fujisaki, 1995, Natriuretic peptides inhibit angiotensin II-induced proliferation of rat cardiac fibroblasts by blocking endothelin-1 gene expression, J Clin Invest, 96, 1059, 10.1172/JCI118092

Fujita, 2008, Adiponectin protects against angiotensin II-induced cardiac fibrosis through activation of PPAR-α, Arterioscler Thromb Vasc Biol, 28, 863, 10.1161/ATVBAHA.107.156687

Fujita, 2007, Administration of granulocyte colony-stimulating factor after myocardial infarction enhances the recruitment of hematopoietic stem cell-derived myofibroblasts and contributes to cardiac repair, Stem Cells, 25, 2750, 10.1634/stemcells.2007-0275

Gabbiani, 1998, Evolution and clinical implications of the myofibroblast concept, Cardiovasc Res, 38, 545, 10.1016/S0008-6363(98)00065-0

Gabbiani, 2003, The myofibroblast in wound healing and fibrocontractive diseases, J Pathol, 200, 500, 10.1002/path.1427

Gallagher, 1998, Species variability in angiotensin receptor expression by cultured cardiac fibroblasts and the infarcted heart, Am J Physiol, 274, H801

Gallagher, 2008, Regulation of ACE2 in cardiac myocytes and fibroblasts, Am J Physiol Heart Circ Physiol, 295, H2373, 10.1152/ajpheart.00426.2008

Gardner, 2005, Peroxisome proliferator-activated receptor γ-independent activation of p38 MAPK by thiazolidinediones involves calcium/calmodulin-dependent protein kinase II and protein kinase R: correlation with endoplasmic reticulum stress, J Biol Chem, 280, 10109, 10.1074/jbc.M410445200

Gaudesius, 2003, Coupling of cardiac electrical activity over extended distances by fibroblasts of cardiac origin, Circ Res, 93, 421, 10.1161/01.RES.0000089258.40661.0C

Goldenberg, 2008, Update on the use of fibrates: focus on bezafibrate, Vasc Health Risk Manag, 4, 131, 10.2147/vhrm.2008.04.01.131

Goldsmith, 2004, Organization of fibroblasts in the heart, Dev Dyn, 230, 787, 10.1002/dvdy.20095

Goshima, 1969, Synchronized beating of embryonic mouse myocardial cells mediated by FL cells in monolayer culture, Exp Cell Res, 56, 387, 10.1016/0014-4827(69)90029-9

Gray, 1998, Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-β1 and endothelin-1 from fibroblasts, Cardiovasc Res, 40, 352, 10.1016/S0008-6363(98)00121-7

Grden, 2006, Expression of adenosine receptors in cardiac fibroblasts as a function of insulin and glucose level, Arch Biochem Biophys, 455, 10, 10.1016/j.abb.2006.08.022

Griffin, 2000, Gender-related differences in proliferative response of cardiac fibroblasts to hypoxia: effects of estrogen, Mol Cell Biochem, 215, 21, 10.1023/A:1026585420021

Grimm, 2001, Extracellular matrix proteins in cardiac fibroblasts derived from rat hearts with chronic pressure overload: effects of beta-receptor blockade, J Mol Cell Cardiol, 33, 487, 10.1006/jmcc.2000.1321

Grobe, 2007, ACE2 overexpression inhibits hypoxia-induced collagen production by cardiac fibroblasts, Clin Sci (Lond), 113, 357, 10.1042/CS20070160

Guarda, 1993, Effects of endothelins on collagen turnover in cardiac fibroblasts, Cardiovasc Res, 27, 2130, 10.1093/cvr/27.12.2130

Guo, 2003, Type I collagen-induced MMP-2 activation coincides with up-regulation of membrane type 1-matrix metalloproteinase and TIMP-2 in cardiac fibroblasts, J Biol Chem, 278, 46699, 10.1074/jbc.M307238200

Guo, 2008, Imidaprilat inhibits matrix metalloproteinase-2 activity in human cardiac fibroblasts induced by interleukin-1β via NO-dependent pathway, Int J Cardiol, 126, 414, 10.1016/j.ijcard.2007.08.134

Gupta, 2006, Effects of static and cyclic loading in regulating extracellular matrix synthesis by cardiovascular cells, Cardiovasc Res, 72, 375, 10.1016/j.cardiores.2006.08.017

Gurantz, 2005, IL-1β and TNF-α upregulate angiotensin II type 1 (AT1) receptors on cardiac fibroblasts and are associated with increased AT1 density in the post-MI heart, J Mol Cell Cardiol, 38, 505, 10.1016/j.yjmcc.2004.12.015

Gurantz, 1999, Tumor necrosis factor-α upregulates angiotensin II type 1 receptors on cardiac fibroblasts, Circ Res, 85, 272, 10.1161/01.RES.85.3.272

Gurtner, 2008, Wound repair and regeneration, Nature, 453, 314, 10.1038/nature07039

Gustafsson, 2000, β-adrenergic stimulation of rat cardiac fibroblasts enhances induction of nitric-oxide synthase by interleukin-1β via message stabilization, Mol Pharmacol, 58, 1470, 10.1124/mol.58.6.1470

Guy, 2008, Functional angiotensin-converting enzyme 2 is expressed in human cardiac myofibroblasts, Exp Physiol, 93, 579, 10.1113/expphysiol.2007.040139

Hafizi, 1998, Expression of functional angiotensin-converting enzyme and AT1 receptors in cultured human cardiac fibroblasts, Circulation, 98, 2553, 10.1161/01.CIR.98.23.2553

Hafizi, 2004, Differential response of human cardiac fibroblasts to angiotensin I and angiotensin II, Peptides, 25, 1031, 10.1016/j.peptides.2004.03.011

Hafizi, 2004, Profibrotic effects of endothelin-1 via the ETA receptor in cultured human cardiac fibroblasts, Cell Physiol Biochem, 14, 285, 10.1159/000080338

Hagege, 2006, Skeletal myoblast transplantation in ischemic heart failure: long-term follow-up of the first phase I cohort of patients, Circulation, 114, I108, 10.1161/CIRCULATIONAHA.105.000521

Hao, 2008, Agonists at PPAR-γ suppress angiotensin II-induced production of plasminogen activator inhibitor-1 and extracellular matrix in rat cardiac fibroblasts, Br J Pharmacol, 153, 1409, 10.1038/bjp.2008.21

Hao, 2000, Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro, Am J Physiol Heart Circ Physiol, 279, H3020, 10.1152/ajpheart.2000.279.6.H3020

Harada, 1999, Effect of interleukin-1β on cardiac hypertrophy and production of natriuretic peptides in rat cardiocyte culture, J Mol Cell Cardiol, 31, 1997, 10.1006/jmcc.1999.1030

Haudek, 2008, Fc receptor engagement mediates differentiation of cardiac fibroblast precursor cells, Proc Natl Acad Sci U S A, 105, 10179, 10.1073/pnas.0804910105

Haudek, 2006, Bone marrow-derived fibroblast precursors mediate ischemic cardiomyopathy in mice, Proc Natl Acad Sci U S A, 103, 18284, 10.1073/pnas.0608799103

He, 2008, Involvement of ERK and AKT signaling in the growth effect of arginine vasopressin on adult rat cardiac fibroblast and the modulation by simvastatin, Mol Cell Biochem, 317, 33, 10.1007/s11010-008-9802-9

Heart Protection Study Collaborative Group, 2002, MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20,536 high-risk individuals: a randomised placebo-controlled trial, Lancet, 360, 7, 10.1016/S0140-6736(02)09327-3

Heimer, 1995, TGF-beta modulates the synthesis of proteoglycans by myocardial fibroblasts in culture, J Mol Cell Cardiol, 27, 2191, 10.1016/S0022-2828(95)91479-X

Heine, 2005, Strategies of conditional gene expression in myocardium: an overview, Methods Mol Med, 112, 109, 10.1007/978-1-59259-879-3_8

Hellkvist, 2002, Characterization of fibroblasts from rejecting tissue: the hyaluronan production is increased, Transplantation, 74, 1672, 10.1097/00007890-200212270-00004

Holmes, 2005, Structure and mechanics of healing myocardial infarcts, Annu Rev Biomed Eng, 7, 223, 10.1146/annurev.bioeng.7.060804.100453

Horio, 2003, Gene expression, secretion, and autocrine action of C-type natriuretic peptide in cultured adult rat cardiac fibroblasts, Endocrinology, 144, 2279, 10.1210/en.2003-0128

Huang, 2005, Peroxisome proliferator-activated receptor γ-independent ablation of cyclin D1 by thiazolidinediones and their derivatives in breast cancer cells, Mol Pharmacol, 67, 1342, 10.1124/mol.104.007732

Hunt, 2005, Circulation, 112, e154, 10.1161/CIRCULATIONAHA.105.167586

Huntley, 2006, BNP-induced activation of cGMP in human cardiac fibroblasts: interactions with fibronectin and natriuretic peptide receptors, J Cell Physiol, 209, 943, 10.1002/jcp.20793

Husse, 2007, Cyclical mechanical stretch modulates expression of collagen I and collagen III by PKC and tyrosine kinase in cardiac fibroblasts, Am J Physiol Regul Integr Comp Physiol, 293, R1898, 10.1152/ajpregu.00804.2006

Irons, 2006, Implications of rosiglitazone and pioglitazone on cardiovascular risk in patients with type 2 diabetes mellitus, Pharmacotherapy, 26, 168, 10.1592/phco.26.2.168

Iwami, 1996, Comparison of ANG II with other growth factors on Egr-1 and matrix gene expression in cardiac fibroblasts, Am J Physiol, 270, H2100

Iwata, 2005, Angiotensin-(1–7) binds to specific receptors on cardiac fibroblasts to initiate antifibrotic and antitrophic effects, Am J Physiol Heart Circ Physiol, 289, H2356, 10.1152/ajpheart.00317.2005

Jacobs, 1999, Tumor necrosis factor-α at acute myocardial infarction in rats and effects on cardiac fibroblasts, J Mol Cell Cardiol, 31, 1949, 10.1006/jmcc.1999.1007

Jaffre, 2004, Involvement of the serotonin 5-HT2B receptor in cardiac hypertrophy linked to sympathetic stimulation: control of interleukin-6, interleukin-1β, and tumor necrosis factor-α cytokine production by ventricular fibroblasts, Circulation, 110, 969, 10.1161/01.CIR.0000139856.20505.57

Jarvis, 2006, Comparison of infarct-derived and control ovine cardiac myofibroblasts in culture: response to cytokines and natriuretic peptide receptor expression profiles, Am J Physiol Heart Circ Physiol, 291, H1952, 10.1152/ajpheart.00764.2005

Jiang, 2007, The signalling of AT2 and the influence on the collagen metabolism of AT2 receptor in adult rat cardiac fibroblasts, Acta Cardiol, 62, 429, 10.2143/AC.62.5.2023404

Jugdutt, 2003, Remodeling of the myocardium and potential targets in the collagen degradation and synthesis pathways, Curr Drug Targets Cardiovasc Haematol Disord, 3, 1, 10.2174/1568006033337276

Jugdutt, 2003, Ventricular remodeling after infarction and the extracellular collagen matrix: when is enough enough?, Circulation, 108, 1395, 10.1161/01.CIR.0000085658.98621.49

Jugdutt, 1986, Healing after myocardial infarction in the dog: changes in infarct hydroxyproline and topography, J Am Coll Cardiol, 7, 91, 10.1016/S0735-1097(86)80265-0

Jugdutt, 1992, Effect of long-term captopril therapy on left ventricular remodeling and function during healing of canine myocardial infarction, J Am Coll Cardiol, 19, 713, 10.1016/S0735-1097(10)80298-0

Kalluri, 2003, Epithelial–mesenchymal transition and its implications for fibrosis, J Clin Invest, 112, 1776, 10.1172/JCI200320530

Kamkin, 2003, Cardiac fibroblasts and the mechano–electric feedback mechanism in healthy and diseased hearts, Prog Biophys Mol Biol, 82, 111, 10.1016/S0079-6107(03)00009-9

Kapoun, 2004, B-type natriuretic peptide exerts broad functional opposition to transforming growth factor-β in primary human cardiac fibroblasts: fibrosis, myofibroblast conversion, proliferation, and inflammation, Circ Res, 94, 453, 10.1161/01.RES.0000117070.86556.9F

Katwa, 2003, Cardiac myofibroblasts isolated from the site of myocardial infarction express endothelin de novo, Am J Physiol Heart Circ Physiol, 285, H1132, 10.1152/ajpheart.01141.2002

Katwa, 1993, Endothelin receptors in cultured adult rat cardiac fibroblasts, Cardiovasc Res, 27, 2125, 10.1093/cvr/27.12.2125

Katwa, 1997, Cultured myofibroblasts generate angiotensin peptides de novo, J Mol Cell Cardiol, 29, 1375, 10.1006/jmcc.1997.0376

Kelly, 2003, Cell type-specific regulation of angiogenic growth factor gene expression and induction of angiogenesis in nonischemic tissue by a constitutively active form of hypoxia-inducible factor 1, Circ Res, 93, 1074, 10.1161/01.RES.0000102937.50486.1B

Khan, 2006, Fibrosis in heart disease: understanding the role of transforming growth factor-beta in cardiomyopathy, valvular disease and arrhythmia, Immunology, 118, 10, 10.1111/j.1365-2567.2006.02336.x

Kim, 2002, β-adrenergic receptor-mediated DNA synthesis in cardiac fibroblasts is dependent on transactivation of the epidermal growth factor receptor and subsequent activation of extracellular signal-regulated kinases, J Biol Chem, 277, 32116, 10.1074/jbc.M204895200

Kizana, 2007, Gene transfer of connexin43 mutants attenuates coupling in cardiomyocytes: novel basis for modulation of cardiac conduction by gene therapy, Circ Res, 100, 1597, 10.1161/CIRCRESAHA.106.144956

Kizana, 2005, Fibroblasts can be genetically modified to produce excitable cells capable of electrical coupling, Circulation, 111, 394, 10.1161/01.CIR.0000153812.64956.EF

Klett, 1995, Evidence for differences in cultured left ventricular fibroblast populations isolated from spontaneously hypertensive and Wistar-Kyoto rats, J Hypertens, 13, 1421, 10.1097/00004872-199512000-00008

Kobayashi, 2004, β-blocker improves survival, left ventricular function, and myocardial remodeling in hypertensive rats with diastolic heart failure, Am J Hypertens, 17, 1112, 10.1016/j.amjhyper.2004.07.007

Kobayashi, 2008, Fibroblast sheets co-cultured with endothelial progenitor cells improve cardiac function of infarcted hearts, J Artif Organs, 11, 141, 10.1007/s10047-008-0421-8

Kohl, 2004, Cardiac cellular heterogeneity and remodelling, Cardiovasc Res, 64, 195, 10.1016/j.cardiores.2004.08.011

Kohl, 2005, Electrical coupling of fibroblasts and myocytes: relevance for cardiac propagation, J Electrocardiol, 38, 45, 10.1016/j.jelectrocard.2005.06.096

Koudssi, 1998, Cardiac fibroblasts arrest at the G1/S restriction point in response to interleukin (IL)-1β. Evidence for IL-1β-induced hypophosphorylation of the retinoblastoma protein, J Biol Chem, 273, 25796, 10.1074/jbc.273.40.25796

Kuruvilla, 2007, Endocardial endothelial cells stimulate proliferation and collagen synthesis of cardiac fibroblasts, Cell Biochem Biophys, 47, 65, 10.1385/CBB:47:1:65

Kuwahara, 2002, Transforming growth factor-beta function blocking prevents myocardial fibrosis and diastolic dysfunction in pressure-overloaded rats, Circulation, 106, 130, 10.1161/01.CIR.0000020689.12472.E0

Kveiborg, 2007, Carvedilol in the treatment of chronic heart failure: lessons from the Carvedilol Or Metoprolol European Trial, Vasc Health Risk Manag, 3, 31

Ladoux, 1993, Hypoxia is a strong inducer of vascular endothelial growth factor mRNA expression in the heart, Biochem Biophys Res Commun, 195, 1005, 10.1006/bbrc.1993.2144

LaFramboise, 2007, Cardiac fibroblasts influence cardiomyocyte phenotype in vitro, Am J Physiol Cell Physiol, 292, C1799, 10.1152/ajpcell.00166.2006

Lal, 2008, Stretch-induced regulation of angiotensinogen gene expression in cardiac myocytes and fibroblasts: Opposing roles of JNK1/2 and p38α MAP kinases, J Mol Cell Cardiol, 45, 770, 10.1016/j.yjmcc.2008.09.121

Leask, 2007, TGFβ, cardiac fibroblasts, and the fibrotic response, Cardiovasc Res, 74, 207, 10.1016/j.cardiores.2006.07.012

Lechat, 1998, Clinical effects of β-adrenergic blockade in chronic heart failure: a meta-analysis of double-blind, placebo-controlled, randomized trials, Circulation, 98, 1184, 10.1161/01.CIR.98.12.1184

Lee, 1995, Angiotensin II stimulates the autocrine production of transforming growth factor-β1 in adult rat cardiac fibroblasts, J Mol Cell Cardiol, 27, 2347, 10.1016/S0022-2828(95)91983-X

Leicht, 2003, Regulation of norepinephrine-induced proliferation in cardiac fibroblasts by interleukin-6 and p42/p44 mitogen activated protein kinase, Mol Cell Biochem, 243, 65, 10.1023/A:1021655023870

Leicht, 2000, Comitogenic effect of catecholamines on rat cardiac fibroblasts in culture, Cardiovasc Res, 48, 274, 10.1016/S0008-6363(00)00170-X

Lenga, 2008, Osteopontin expression is required for myofibroblast differentiation, Circ Res, 102, 319, 10.1161/CIRCRESAHA.107.160408

Li, 1999, Superoxide induces apoptosis in cardiomyocytes, but proliferation and expression of transforming growth factor-β1 in cardiac fibroblasts, FEBS Lett, 448, 206, 10.1016/S0014-5793(99)00370-1

Li, 1998, Differential expression of tissue inhibitors of metalloproteinases in the failing human heart, Circulation, 98, 1728, 10.1161/01.CIR.98.17.1728

Li, 2008, Effect of rosiglitazone on cardiac fibroblast proliferation, nitric oxide production and connective tissue growth factor expression induced by advanced glycation end-products, J Int Med Res, 36, 329, 10.1177/147323000803600216

Li, 2008, Atrial natriuretic peptide inhibits transforming growth factor β-induced Smad signaling and myofibroblast transformation in mouse cardiac fibroblasts, Circ Res, 102, 185, 10.1161/CIRCRESAHA.107.157677

Liao, 2004, Mechanical stretch induces mitochondria-dependent apoptosis in neonatal rat cardiomyocytes and G2/M accumulation in cardiac fibroblasts, Cell Res, 14, 16, 10.1038/sj.cr.7290198

Liao, 2008, Adiponectin induces interleukin-6 production and activates STAT3 in adult mouse cardiac fibroblasts, Biol Cell, 101, 263, 10.1042/BC20080117

Lijnen, 2000, Induction of cardiac fibrosis by transforming growth factor-β1, Mol Genet Metab, 71, 418, 10.1006/mgme.2000.3032

Lijnen, 2001, Angiotensin II-induced stimulation of collagen secretion and production in cardiac fibroblasts is mediated via angiotensin II subtype 1 receptors, J Renin Angiotensin Aldosterone Syst, 2, 117, 10.3317/jraas.2001.012

Lijnen, 2004, Collagen production in cardiac fibroblasts during inhibition of angiotensin-converting enzyme and aminopeptidases, J Hypertens, 22, 209, 10.1097/00004872-200401000-00031

Lijnen, 2008, Inhibition of superoxide dismutase induces collagen production in cardiac fibroblasts, Am J Hypertens, 21, 1129, 10.1038/ajh.2008.242

Lin, 1995, Gene expression of natriuretic peptide receptors in myocardial cells, Circ Res, 77, 750, 10.1161/01.RES.77.4.750

Lindahl, 2002, Activation of fibroblast procollagen α1(I) transcription by mechanical strain is transforming growth factor-β-dependent and involves increased binding of CCAAT-binding factor (CBF/NF-Y) at the proximal promoter, J Biol Chem, 277, 6153, 10.1074/jbc.M108966200

Liu, 2006, cAMP inhibits transforming growth factor-β-stimulated collagen synthesis via inhibition of extracellular signal-regulated kinase 1/2 and Smad signaling in cardiac fibroblasts, Mol Pharmacol, 70, 1992, 10.1124/mol.106.028951

Liu, 2008, Adenylyl cyclase type 6 overexpression selectively enhances β-adrenergic and prostacyclin receptor-mediated inhibition of cardiac fibroblast function because of colocalization in lipid rafts, Naunyn Schmiedebergs Arch Pharmacol, 377, 359, 10.1007/s00210-007-0196-0

Long, 2001, The role of interleukin-1 in the failing heart, Heart Fail Rev, 6, 81, 10.1023/A:1011428824771

Lotze, 2002, Carvedilol inhibits platelet-derived growth factor-induced signal transduction in human cardiac fibroblasts, J Cardiovasc Pharmacol, 39, 576, 10.1097/00005344-200204000-00014

MacKenna, 2000, Role of mechanical factors in modulating cardiac fibroblast function and extracellular matrix synthesis, Cardiovasc Res, 46, 257, 10.1016/S0008-6363(00)00030-4

Maki, 2000, Effect of neutral endopeptidase inhibitor on endogenous atrial natriuretic peptide as a paracrine factor in cultured cardiac fibroblasts, Br J Pharmacol, 131, 1204, 10.1038/sj.bjp.0703679

Makino, 2006, Peroxisome proliferator-activated receptor-γ ligands attenuate brain natriuretic peptide production and affect remodeling in cardiac fibroblasts in reoxygenation after hypoxia, Cell Biochem Biophys, 44, 65, 10.1385/CBB:44:1:065

Mann, 1998, Activation of matrix metalloproteinases in the failing human heart: breaking the tie that binds, Circulation, 98, 1699, 10.1161/01.CIR.98.17.1699

Manner, 2001, The origin, formation and developmental significance of the epicardium: a review, Cells Tissues Organs, 169, 89, 10.1159/000047867

Martin, 2005, In vitro inhibitory effects of atorvastatin on cardiac fibroblasts: implications for ventricular remodelling, Clin Exp Pharmacol Physiol, 32, 697, 10.1111/j.1440-1681.2005.04256.x

Maruyama, 1999, Interleukin-1β upregulates cardiac expression of vascular endothelial growth factor and its receptor KDR/flk-1 via activation of protein tyrosine kinases, J Mol Cell Cardiol, 31, 607, 10.1006/jmcc.1998.0895

Marx, 2004, Peroxisome proliferator-activated receptors and atherogenesis: regulators of gene expression in vascular cells, Circ Res, 94, 1168, 10.1161/01.RES.0000127122.22685.0A

Marx, 2005, Pioglitazone reduces neointima volume after coronary stent implantation: a randomized, placebo-controlled, double-blind trial in nondiabetic patients, Circulation, 112, 2792, 10.1161/CIRCULATIONAHA.105.535484

Mendez, 2003, PPARγ inhibition of cyclooxygenase-2, PGE2 synthase, and inducible nitric oxide synthase in cardiac myocytes, Hypertension, 42, 844, 10.1161/01.HYP.0000085332.69777.D1

Meszaros, 2000, Identification of G protein-coupled signaling pathways in cardiac fibroblasts: cross talk between Gq and Gs, Am J Physiol Cell Physiol, 278, C154, 10.1152/ajpcell.2000.278.1.C154

Meyer, 2006, Intracoronary bone marrow cell transfer after myocardial infarction: eighteen months' follow-up data from the randomized, controlled BOOST (BOne marrOw transfer to enhance ST-elevation infarct regeneration) trial, Circulation, 113, 1287, 10.1161/CIRCULATIONAHA.105.575118

Mitchell, 2007, IL-1β stimulates rat cardiac fibroblast migration via MAP kinase pathways, Am J Physiol Heart Circ Physiol, 292, H1139, 10.1152/ajpheart.00881.2005

Modesti, 1999, Characterization of endothelin-1 receptor subtypes in isolated human cardiomyocytes, J Cardiovasc Pharmacol, 34, 333, 10.1097/00005344-199909000-00003

Moiseeva, 2007, Effect of pravastatin on phenotypical transformation of fibroblasts and hypertrophy of cardiomyocytes in culture, Bull Exp Biol Med, 143, 54, 10.1007/s10517-007-0015-0

Möllmann, 2006, Bone marrow -derived cells contribute to infarct remodelling, Cardiovasc Res, 71, 661, 10.1016/j.cardiores.2006.06.013

Mookerjee, 2005, Relaxin modulates fibroblast function, collagen production, and matrix metalloproteinase-2 expression by cardiac fibroblasts, Ann N Y Acad Sci, 1041, 190, 10.1196/annals.1282.028

Moorman, 2003, Cardiac chamber formation: development, genes, and evolution, Physiol Rev, 83, 1223, 10.1152/physrev.00006.2003

Morales, 2005, Expression of Discoidin Domain Receptor 2 (DDR2) in the developing heart, Microsc Microanal, 11, 260, 10.1017/S1431927605050518

Morley, 2007, Hypoxic inhibition of human cardiac fibroblast invasion and MMP-2 activation may impair adaptive myocardial remodelling, Biochem Soc Trans, 35, 905, 10.1042/BST0350905

Motte, 2006, Endothelin receptor antagonists, Pharmacol Ther, 110, 386, 10.1016/j.pharmthera.2005.08.012

Moustakas, 2001, Smad regulation in TGF-beta signal transduction, J Cell Sci, 114, 4359, 10.1242/jcs.114.24.4359

Mughal, 2009, Peroxisome proliferator-activated receptor γ-independent effects of thiazolidinediones on human cardiac myofibroblast function, Clin Exp Pharmacol Physiol, 36, 478, 10.1111/j.1440-1681.2008.05088.x

Nagamatsu, 2006, Heterotrimeric G protein Gα13-induced induction of cytokine mRNAs through two distinct pathways in cardiac fibroblasts, J Pharmacol Sci, 101, 144, 10.1254/jphs.FP0051036

Nagase, 1999, Matrix metalloproteinases, J Biol Chem, 274, 21491, 10.1074/jbc.274.31.21491

Nakajima, 2000, Atrial but not ventricular fibrosis in mice expressing a mutant transforming growth factor-beta(1) transgene in the heart, Circ Res, 86, 571, 10.1161/01.RES.86.5.571

Nakatsuji, 1997, In vivo responses of macrophages and myofibroblasts in the healing following isoproterenol-induced myocardial injury in rats, Virchows Arch, 430, 63, 10.1007/BF01008018

Nian, 2004, Inflammatory cytokines and postmyocardial infarction remodeling, Circ Res, 94, 1543, 10.1161/01.RES.0000130526.20854.fa

Nishida, 2007, Gα12/13-mediated up-regulation of TRPC6 negatively regulates endothelin-1-induced cardiac myofibroblast formation and collagen synthesis through nuclear factor of activated T cells activation, J Biol Chem, 282, 23117, 10.1074/jbc.M611780200

Nissen, 2007, Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes, N Engl J Med, 356, 2457, 10.1056/NEJMoa072761

Norris, 2008, Neonatal and adult cardiovascular pathophysiological remodeling and repair: developmental role of periostin, Ann N Y Acad Sci, 1123, 30, 10.1196/annals.1420.005

Ogata, 2004, The peroxisome proliferator-activated receptor α activator fenofibrate inhibits endothelin-1-induced cardiac fibroblast proliferation, J Cardiovasc Pharmacol 44 Suppl, 1, S279, 10.1097/01.fjc.0000166274.24797.0e

Ohkubo, 1997, Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolism, Circulation, 96, 3954, 10.1161/01.CIR.96.11.3954

Olson, 2005, Inhibition of cardiac fibroblast proliferation and myofibroblast differentiation by resveratrol, Am J Physiol Heart Circ Physiol, 288, H1131, 10.1152/ajpheart.00763.2004

Ostrom, 2003, Angiotensin II enhances adenylyl cyclase signaling via Ca2+/calmodulin. Gq-Gs cross-talk regulates collagen production in cardiac fibroblasts, J Biol Chem, 278, 24461, 10.1074/jbc.M212659200

Palmer, 1995, Interleukin-1β induces cardiac myocyte growth but inhibits cardiac fibroblast proliferation in culture, J Clin Invest, 95, 2555, 10.1172/JCI117956

Pan, 2008, Interplay of angiotensin II and angiotensin(1–7) in the regulation of matrix metalloproteinases of human cardiocytes, Exp Physiol, 93, 599, 10.1113/expphysiol.2007.041830

Panunti, 2006, Effects of PPAR gamma agonists on cardiovascular function in obese, non-diabetic patients, Vascul Pharmacol, 45, 29, 10.1016/j.vph.2005.11.013

Papakrivopoulou, 2004, Differential roles of extracellular signal-regulated kinase 1/2 and p38MAPK in mechanical load-induced procollagen α1(I) gene expression in cardiac fibroblasts, Cardiovasc Res, 61, 736, 10.1016/j.cardiores.2003.12.018

Patel, 2001, Simvastatin induces regression of cardiac hypertrophy and fibrosis and improves cardiac function in a transgenic rabbit model of human hypertrophic cardiomyopathy, Circulation, 104, 317, 10.1161/hc2801.094031

Paumelle, 2008, Cross-talk between statins and PPARα in cardiovascular diseases: clinical evidence and basic mechanisms, Trends Cardiovasc Med, 18, 73, 10.1016/j.tcm.2008.01.001

Peng, 2002, Tumor necrosis factor-α-induced AT1 receptor upregulation enhances angiotensin II-mediated cardiac fibroblast responses that favor fibrosis, Circ Res, 91, 1119, 10.1161/01.RES.0000047090.08299.D5

Perrone, 2005, Synthesis and biological evaluation of new clofibrate analogues as potential PPARα agonists, Eur J Med Chem, 40, 143, 10.1016/j.ejmech.2004.09.018

Petrov, 2002, Stimulation of collagen production by transforming growth factor-β1 during differentiation of cardiac fibroblasts to myofibroblasts, Hypertension, 39, 258, 10.1161/hy0202.103268

Piacentini, 2000, Endothelin-1 stimulates cardiac fibroblast proliferation through activation of protein kinase C, J Mol Cell Cardiol, 32, 565, 10.1006/jmcc.2000.1109

Pikkarainen, 2006, Inverse regulation of preproendothelin-1 and endothelin-converting enzyme-1β genes in cardiac cells by mechanical load, Am J Physiol Regul Integr Comp Physiol, 290, R1639, 10.1152/ajpregu.00559.2005

Porter, 2004, Tumor necrosis factor α induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin, Cardiovasc Res, 64, 507, 10.1016/j.cardiores.2004.07.020

Porter, 2004, Simvastatin reduces human atrial myofibroblast proliferation independently of cholesterol lowering via inhibition of RhoA, Cardiovasc Res, 61, 745, 10.1016/j.cardiores.2003.11.032

Raffetto, 2008, Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease, Biochem Pharmacol, 75, 346, 10.1016/j.bcp.2007.07.004

Ramos, 2007, Cardiac cell-based therapy: cell types and mechanisms of actions, Cell Transplant, 16, 951, 10.3727/096368907783338208

Redondo, 1998, Effect of atrial natriuretic peptide and cyclic GMP phosphodiesterase inhibition on collagen synthesis by adult cardiac fibroblasts, Br J Pharmacol, 124, 1455, 10.1038/sj.bjp.0701994

Regitz-Zagrosek, 1998, Myocardial angiotensin receptors in human hearts, Basic Res Cardiol, 93, 37, 10.1007/s003950050207

Ricote, 1998, Expression of the peroxisome proliferator-activated receptor γ (PPARγ) in human atherosclerosis and regulation in macrophages by colony stimulating factors and oxidized low density lipoprotein, Proc Natl Acad Sci U S A, 95, 7614, 10.1073/pnas.95.13.7614

Rook, 1992, Differences in gap junction channels between cardiac myocytes, fibroblasts, and heterologous pairs, Am J Physiol, 263, C959, 10.1152/ajpcell.1992.263.5.C959

Rosenkranz, 2004, TGF-β1 and angiotensin networking in cardiac remodeling, Cardiovasc Res, 63, 423, 10.1016/j.cardiores.2004.04.030

Rosenkranz, 2002, Alterations of beta-adrenergic signaling and cardiac hypertrophy in transgenic mice overexpressing TGF-beta(1), Am J Physiol Heart Circ Physiol, 283, H1253, 10.1152/ajpheart.00578.2001

Rossini, 2008, HMGB1-stimulated human primary cardiac fibroblasts exert a paracrine action on human and murine cardiac stem cells, J Mol Cell Cardiol, 44, 683, 10.1016/j.yjmcc.2008.01.009

Roy, 2003, Oxygen sensing by primary cardiac fibroblasts: a key role of p21(Waf1/Cip1/Sdi1), Circ Res, 92, 264, 10.1161/01.RES.0000056770.30922.E6

Roy, 2009, MicroRNA expression in response to murine myocardial infarction: miR-21 regulates fibroblast metalloprotease-2 via phosphatase and tensin homologue, Cardiovasc Res, 82, 21, 10.1093/cvr/cvp015

Roy, 2007, P21waf1/cip1/sdi1 as a central regulator of inducible smooth muscle actin expression and differentiation of cardiac fibroblasts to myofibroblasts, Mol Biol Cell, 18, 4837, 10.1091/mbc.E07-03-0270

Roy, 2003, Characterization of perceived hyperoxia in isolated primary cardiac fibroblasts and in the reoxygenated heart, J Biol Chem, 278, 47129, 10.1074/jbc.M308703200

Ruvinov, 2008, Transplantation of genetically engineered cardiac fibroblasts producing recombinant human erythropoietin to repair the infarcted myocardium, Fibrogenesis Tissue Repair, 1, 7, 10.1186/1755-1536-1-7

Ruwhof, 2000, Cyclic stretch induces the release of growth promoting factors from cultured neonatal cardiomyocytes and cardiac fibroblasts, Mol Cell Biochem, 208, 89, 10.1023/A:1007046105745

Ryden, 2007, Adjudication of serious heart failure in patients from PROactive, Lancet, 369, 189, 10.1016/S0140-6736(07)60106-8

Sacks, 1996, The effect of pravastatin on coronary events after myocardial infarction in patients with average cholesterol levels. Cholesterol and Recurrent Events Trial investigators, N Engl J Med, 335, 1001, 10.1056/NEJM199610033351401

Sakai, 2002, Peroxisome proliferator-activated receptor-γ activators inhibit endothelin-1-related cardiac hypertrophy in rats, Clin Sci (Lond), 103, 16S, 10.1042/CS103S016S

Samuel, 2004, Relaxin modulates cardiac fibroblast proliferation, differentiation, and collagen production and reverses cardiac fibrosis in vivo, Endocrinology, 145, 4125, 10.1210/en.2004-0209

Sanghi, 2005, Activation of protein kinase A by atrial natriuretic peptide in neonatal rat cardiac fibroblasts: role in regulation of the local renin-angiotensin system, Regul Pept, 132, 1, 10.1016/j.regpep.2005.06.007

Sano, 2001, ERK and p38 MAPK, but not NF-κB, are critically involved in reactive oxygen species-mediated induction of IL-6 by angiotensin II in cardiac fibroblasts, Circ Res, 89, 661, 10.1161/hh2001.098873

Sano, 1998, Increased mRNA expression of cardiac renin–angiotensin system and collagen synthesis in spontaneously hypertensive rats, Mol Cell Biochem, 178, 51, 10.1023/A:1006830401072

Sato, 2003, Regulation of the human tumor necrosis factor-α promoter by angiotensin II and lipopolysaccharide in cardiac fibroblasts: different cis-acting promoter sequences and transcriptional factors, J Mol Cell Cardiol, 35, 1197, 10.1016/S0022-2828(03)00210-4

Sayed, 2007, MicroRNAs play an essential role in the development of cardiac hypertrophy, Circ Res, 100, 416, 10.1161/01.RES.0000257913.42552.23

Scandinavian Simvastatin Survival Study Group, 1994, Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S), Lancet, 344, 1383

Schultz, 2002, TGF-beta1 mediates the hypertrophic cardiomyocyte growth induced by angiotensin II, J Clin Invest, 109, 787, 10.1172/JCI0214190

Senthil, 2005, Prevention of cardiac hypertrophy by atorvastatin in a transgenic rabbit model of human hypertrophic cardiomyopathy, Circ Res, 97, 285, 10.1161/01.RES.0000177090.07296.ac

Shames, 2002, Ischemia alone is sufficient to induce TNF-α mRNA and peptide in the myocardium, Shock, 17, 114, 10.1097/00024382-200202000-00006

Shinzato, 2007, Beneficial effects of pioglitazone on left ventricular hypertrophy in genetically hypertensive rats, Hypertens Res, 30, 863, 10.1291/hypres.30.863

Shiojima, 1999, Embryonic smooth muscle myosin heavy chain SMemb is expressed in pressure-overloaded cardiac fibroblasts, Jpn Heart J, 40, 803, 10.1536/jhj.40.803

Shiroshita-Takeshita, 2007, Effects of simvastatin on the development of the atrial fibrillation substrate in dogs with congestive heart failure, Cardiovasc Res, 74, 75, 10.1016/j.cardiores.2007.01.002

Shivakumar, 2008, Paracrine effects of hypoxic fibroblast-derived factors on the MPT-ROS threshold and viability of adult rat cardiac myocytes, Am J Physiol Heart Circ Physiol, 294, H2653, 10.1152/ajpheart.91443.2007

Sigel, 1996, Regulation of proliferative response of cardiac fibroblasts by transforming growth factor-β1, J Mol Cell Cardiol, 28, 1921, 10.1006/jmcc.1996.0185

Singh, 2008, Activation of the intracellular renin–angiotensin system in cardiac fibroblasts by high glucose: role in extracellular matrix production, Am J Physiol Heart Circ Physiol, 294, H1675, 10.1152/ajpheart.91493.2007

Sivakumar, 2008, Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy, Mol Cell Biochem, 307, 159, 10.1007/s11010-007-9595-2

Siwik, 2000, Interleukin-1β and tumor necrosis factor-α decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro, Circ Res, 86, 1259, 10.1161/01.RES.86.12.1259

Siwik, 2001, Oxidative stress regulates collagen synthesis and matrix metalloproteinase activity in cardiac fibroblasts, Am J Physiol Cell Physiol, 280, C53, 10.1152/ajpcell.2001.280.1.C53

Sola, 2006, Atorvastatin improves left ventricular systolic function and serum markers of inflammation in nonischemic heart failure, J Am Coll Cardiol, 47, 332, 10.1016/j.jacc.2005.06.088

Spinale, 2002, Matrix metalloproteinases: regulation and dysregulation in the failing heart, Circ Res, 90, 520, 10.1161/01.RES.0000013290.12884.A3

Spinale, 2000, A matrix metalloproteinase induction/activation system exists in the human left ventricular myocardium and is upregulated in heart failure, Circulation, 102, 1944, 10.1161/01.CIR.102.16.1944

Squires, 2005, Altered fibroblast function following myocardial infarction, J Mol Cell Cardiol, 39, 699, 10.1016/j.yjmcc.2005.07.008

Stacy, 2007, Effect of angiotensin II on primary cardiac fibroblast matrix metalloproteinase activities, Perfusion, 22, 51, 10.1177/0267659106074793

Staels, 2005, Therapeutic roles of peroxisome proliferator-activated receptor agonists, Diabetes, 54, 2460, 10.2337/diabetes.54.8.2460

Staufenberger, 2001, Angiotensin II type 1 receptor regulation and differential trophic effects on rat cardiac myofibroblasts after acute myocardial infarction, J Cell Physiol, 187, 326, 10.1002/jcp.1079

Stawowy, 2004, Regulation of matrix metalloproteinase MT1-MMP/MMP-2 in cardiac fibroblasts by TGF-β1 involves furin-convertase, Cardiovasc Res, 63, 87, 10.1016/j.cardiores.2004.03.010

Stewart, 2006, 17beta-estradiol modulation of angiotensin II-stimulated response in cardiac fibroblasts, J Mol Cell Cardiol, 41, 97, 10.1016/j.yjmcc.2006.04.019

Sun, 1996, Angiotensin converting enzyme and myofibroblasts during tissue repair in the rat heart, J Mol Cell Cardiol, 28, 851, 10.1006/jmcc.1996.0080

Sun, 2000, Infarct scar: a dynamic tissue, Cardiovasc Res, 46, 250, 10.1016/S0008-6363(00)00032-8

Sun, 2003, RAS and connective tissue in the heart, Int J Biochem Cell Biol, 35, 919, 10.1016/S1357-2725(02)00276-5

Sun, 1998, Angiotensin II, transforming growth factor-beta1 and repair in the infarcted heart, J Mol Cell Cardiol, 30, 1559, 10.1006/jmcc.1998.0721

Suzuki, 1997, Purification of endothelin from a conditioned medium of cardiac fibroblastic cells using beating rate assay of myocytes cultured in a serum-free medium, J Mol Cell Cardiol, 29, 2087, 10.1006/jmcc.1997.0443

Suzuki, 2004, Dynamics and mediators of acute graft attrition after myoblast transplantation to the heart, FASEB J, 18, 1153, 10.1096/fj.03-1308fje

Swedberg, 2005, Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology, Eur Heart J, 26, 1115, 10.1093/eurheartj/ehi204

Swynghedauw, 1999, Molecular mechanisms of myocardial remodeling, Physiol Rev, 79, 215, 10.1152/physrev.1999.79.1.215

Takahashi, 1994, Hypertrophic stimuli induce transforming growth factor-β1 expression in rat ventricular myocytes, J Clin Invest, 94, 1470, 10.1172/JCI117485

Tamamori, 1997, Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides, Cell Biol Int, 21, 175, 10.1006/cbir.1997.0130

Tao, 2004, Temporal changes in matrix metalloproteinase expression and inflammatory response associated with cardiac rupture after myocardial infarction in mice, Life Sci, 74, 1561, 10.1016/j.lfs.2003.09.042

Teunissen, 2007, Activation of PPARδ inhibits cardiac fibroblast proliferation and the transdifferentiation into myofibroblasts, Cardiovasc Res, 75, 519, 10.1016/j.cardiores.2007.04.026

1998, Prevention of cardiovascular events and death with pravastatin in patients with coronary heart disease and a broad range of initial cholesterol levels, N Engl J Med, 339, 1349, 10.1056/NEJM199811053391902

Thibault, 2001, Upregulation of α8β1-integrin in cardiac fibroblast by angiotensin II and transforming growth factor-β1, Am J Physiol Cell Physiol, 281, C1457, 10.1152/ajpcell.2001.281.5.C1457

Thomas, 1998, Increased matrix metalloproteinase activity and selective upregulation in LV myocardium from patients with end-stage dilated cardiomyopathy, Circulation, 97, 1708, 10.1161/01.CIR.97.17.1708

Thum, 2008, MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts, Nature, 456, 980, 10.1038/nature07511

Tian, 2003, Effects of atorvastatin on the proliferation and collagen synthesis of rat cardiac fibroblasts, Zhonghua Yi Xue Za Zhi, 83, 118

Tomasek, 2002, Myofibroblasts and mechano-regulation of connective tissue remodelling, Nat Rev Mol Cell Biol, 3, 349, 10.1038/nrm809

Tomita, 1998, Early induction of transforming growth factor-beta via angiotensin II type 1 receptors contributes to cardiac fibrosis induced by long-term blockade of nitric oxide synthesis in rats, Hypertension, 32, 273, 10.1161/01.HYP.32.2.273

Tousoulis, 2005, Effects of combined administration of low dose atorvastatin and vitamin E on inflammatory markers and endothelial function in patients with heart failure, Eur J Heart Fail, 7, 1126, 10.1016/j.ejheart.2005.03.007

Touyz, 2006, Peroxisome proliferator-activated receptors in vascular biology-molecular mechanisms and clinical implications, Vasc Pharmacol, 45, 19, 10.1016/j.vph.2005.11.014

Tsai, 2008, Angiotensin II activates signal transducer and activators of transcription 3 via Rac1 in atrial myocytes and fibroblasts: implication for the therapeutic effect of statin in atrial structural remodeling, Circulation, 117, 344, 10.1161/CIRCULATIONAHA.107.695346

Tsouli, 2008, Should a statin be prescribed to every patient with heart failure?, Heart Fail Rev, 13, 211, 10.1007/s10741-007-9041-2

Tsuruda, 2002, Brain natriuretic peptide is produced in cardiac fibroblasts and induces matrix metalloproteinases, Circ Res, 91, 1127, 10.1161/01.RES.0000046234.73401.70

Tsuruda, 2004, Matrix metalloproteinases: pathways of induction by bioactive molecules, Heart Fail Rev, 9, 53, 10.1023/B:HREV.0000011394.34355.bb

Tsuruda, 2002, Cardiotrophin-1 stimulation of cardiac fibroblast growth: roles for glycoprotein 130/leukemia inhibitory factor receptor and the endothelin type A receptor, Circ Res, 90, 128, 10.1161/hh0202.103613

Tsutsumi, 1998, Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expression, Circ Res, 83, 1035, 10.1161/01.RES.83.10.1035

Turner, 2003, Chronic β2-adrenergic receptor stimulation increases proliferation of human cardiac fibroblasts via an autocrine mechanism, Cardiovasc Res, 57, 784, 10.1016/S0008-6363(02)00729-0

Turner, 2004, Endothelin-1 is an essential co-factor for β2-adrenergic receptor-induced proliferation of human cardiac fibroblasts, FEBS Lett, 576, 156, 10.1016/j.febslet.2004.08.080

Turner, 2007, Simvastatin inhibits TNFα-induced invasion of human cardiac myofibroblasts via both MMP-9-dependent and -independent mechanisms, J Mol Cell Cardiol, 43, 168, 10.1016/j.yjmcc.2007.05.006

Turner, 2007, Mechanism of TNFα-induced IL-1α, IL-1β and IL-6 expression in human cardiac fibroblasts: Effects of statins and thiazolidinediones, Cardiovasc Res, 76, 81, 10.1016/j.cardiores.2007.06.003

Tyagi, 1996, Matrix metalloproteinase activity expression in infarcted, noninfarcted and dilated cardiomyopathic human hearts, Mol Cell Biochem, 155, 13, 10.1007/BF00714328

Tyagi, 1995, Co-expression of tissue inhibitor and matrix metalloproteinase in myocardium, J Mol Cell Cardiol, 27, 2177, 10.1016/S0022-2828(95)91443-9

Tyagi, 1995, Induction of tissue inhibitor and matrix metalloproteinase by serum in human heart-derived fibroblast and endomyocardial endothelial cells, J Cell Biochem, 58, 360, 10.1002/jcb.240580309

Tyagi, 1998, Stretch-induced membrane type matrix metalloproteinase and tissue plasminogen activator in cardiac fibroblast cells, J Cell Physiol, 176, 374, 10.1002/(SICI)1097-4652(199808)176:2<374::AID-JCP16>3.0.CO;2-3

Van Aelst, 1997, Rho GTPases and signaling networks, Genes Dev, 11, 2295, 10.1101/gad.11.18.2295

van Amerongen, 2008, Bone marrow-derived myofibroblasts contribute functionally to scar formation after myocardial infarction, J Pathol, 214, 377, 10.1002/path.2281

van Kesteren, 1997, Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblasts, J Mol Cell Cardiol, 29, 2147, 10.1006/jmcc.1997.0448

van Wamel, 2001, The role of angiotensin II, endothelin-1 and transforming growth factor-β as autocrine/paracrine mediators of stretch-induced cardiomyocyte hypertrophy, Mol Cell Biochem, 218, 113, 10.1023/A:1007279700705

Vanden Berghe, 2000, Signal transduction by tumor necrosis factor and gene regulation of the inflammatory cytokine interleukin-6, Biochem Pharmacol, 60, 1185, 10.1016/S0006-2952(00)00412-3

Villarreal, 1996, Adenovirus-mediated overexpression of human transforming growth factor-beta 1 in rat cardiac fibroblasts, myocytes and smooth muscle cells, J Mol Cell Cardiol, 28, 735, 10.1006/jmcc.1996.0068

Villarreal, 2003, Modulation of cardiac remodeling by adenosine: in vitro and in vivo effects, Mol Cell Biochem, 251, 17, 10.1023/A:1025401026441

Visconti, 2006, Recruitment of new cells into the postnatal heart: potential modification of phenotype by periostin, Ann N Y Acad Sci, 1080, 19, 10.1196/annals.1380.003

Visse, 2003, Matrix metalloproteinases and tissue inhibitors of metalloproteinases: structure, function, and biochemistry, Circ Res, 92, 827, 10.1161/01.RES.0000070112.80711.3D

Wakeno, 2006, Long-term stimulation of adenosine A2b receptors begun after myocardial infarction prevents cardiac remodeling in rats, Circulation, 114, 1923, 10.1161/CIRCULATIONAHA.106.630087

Wallace, 2005, Simvastatin decreases myocardial tumor necrosis factor α content in heart transplant recipients, J Heart Lung Transplant, 24, 46, 10.1016/j.healun.2003.09.037

Wang, 2003, Mechanical force regulation of myofibroblast differentiation in cardiac fibroblasts, Am J Physiol Heart Circ Physiol, 285, H1871, 10.1152/ajpheart.00387.2003

Wang, 2001, Use of conditionally immortalized mouse cardiac fibroblasts to examine the effect of mechanical stretch on α-smooth muscle actin, Tissue Cell, 33, 86, 10.1054/tice.2000.0160

Wang, 2000, Force regulates smooth muscle actin in cardiac fibroblasts, Am J Physiol Heart Circ Physiol, 279, H2776, 10.1152/ajpheart.2000.279.6.H2776

Wang, 2007, Resveratrol inhibits proliferation of cultured rat cardiac fibroblasts: correlated with NO-cGMP signaling pathway, Eur J Pharmacol, 567, 26, 10.1016/j.ejphar.2007.04.023

Wayman, 2002, Ligands of the peroxisome proliferator-activated receptors (PPAR-γ and PPAR-α) reduce myocardial infarct size, FASEB J, 16, 1027, 10.1096/fj.01-0793com

Weber, 1989, Cardiac interstitium in health and disease: the fibrillar collagen network, J Am Coll Cardiol, 13, 1637, 10.1016/0735-1097(89)90360-4

Weber, 1997, Extracellular matrix remodeling in heart failure: a role for de novo angiotensin II generation, Circulation, 96, 4065, 10.1161/01.CIR.96.11.4065

Weber, 2004, Fibrosis in hypertensive heart disease: focus on cardiac fibroblasts, J Hypertens, 22, 47, 10.1097/00004872-200401000-00011

Weber, 1994, Collagen network of the myocardium: function, structural remodeling and regulatory mechanisms, J Mol Cell Cardiol, 26, 279, 10.1006/jmcc.1994.1036

Weiss, 2004, Prostaglandin E1 induces vascular endothelial growth factor-1 in human adult cardiac myocytes but not in human adult cardiac fibroblasts via a cAMP-dependent mechanism, J Mol Cell Cardiol, 36, 539, 10.1016/j.yjmcc.2004.02.001

Wessels, 2004, The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells, Anat Rec A Discov Mol Cell Evol Biol, 276, 43, 10.1002/ar.a.10129

1998, Influence of pravastatin and plasma lipids on clinical events in the West of Scotland Coronary Prevention Study (WOSCOPS), Circulation, 97, 1440, 10.1161/01.CIR.97.15.1440

Willems, 1994, The alpha-smooth muscle actin-positive cells in healing human myocardial scars, Am J Pathol, 145, 868

Xiao, 2008, Interleukin-1β inhibits collagen synthesis and promotes its decomposition in cultured cardiac fibroblasts, Sheng Li Xue Bao, 60, 355

Xie, 2004, Differential regulation of matrix metalloproteinase-2 and -9 expression and activity in adult rat cardiac fibroblasts in response to interleukin-1β, J Biol Chem, 279, 39513, 10.1074/jbc.M405844200

Xie, 2003, Osteopontin inhibits interleukin-1beta-stimulated increases in matrix metalloproteinase activity in adult rat cardiac fibroblasts: role of protein kinase C-zeta, J Biol Chem, 278, 48546, 10.1074/jbc.M302727200

Xu, 2006, Effects of simvastatin on DNA synthesis in rat cardiac fibroblasts, Nan Fang Yi Ke Da Xue Xue Bao, 26, 205

Yang, 2006, Role of AcSDKP on collagen synthesis and degradation in cultured rat cardiac fibroblast, Zhonghua Xin Xue Guan Bing Za Zhi, 34, 843

Yano, 2005, Intracardiac fibroblasts, but not bone marrow derived cells, are the origin of myofibroblasts in myocardial infarct repair, Cardiovasc Pathol, 14, 241, 10.1016/j.carpath.2005.05.004

Yin, 2003, Interleukin-6 family of cytokines mediates isoproterenol-induced delayed STAT3 activation in mouse heart, J Biol Chem, 278, 21070, 10.1074/jbc.M211028200

Yin, 2003, Expression of β2-adrenergic receptor and its effect on the proliferation of neonatal rat cardiac fibroblasts, Sheng Li Xue Bao, 55, 251

Yin, 2006, Noncanonical cAMP pathway and p38 MAPK mediate β2-adrenergic receptor-induced IL-6 production in neonatal mouse cardiac fibroblasts, J Mol Cell Cardiol, 40, 384, 10.1016/j.yjmcc.2005.12.005

Yokoyama, 1999, Angiotensin II and mechanical stretch induce production of tumor necrosis factor in cardiac fibroblasts, Am J Physiol, 276, H1968

Yoon, 2004, Therapeutic myocardial angiogenesis with vascular endothelial growth factors, Mol Cell Biochem, 264, 63, 10.1023/B:MCBI.0000044375.33928.62

Yu, 2001, Effects of combination of angiotensin-converting enzyme inhibitor and angiotensin receptor antagonist on inflammatory cellular infiltration and myocardial interstitial fibrosis after acute myocardial infarction, J Am Coll Cardiol, 38, 1207, 10.1016/S0735-1097(01)01518-2

Yue, 1998, Cytokine expression increases in nonmyocytes from rats with postinfarction heart failure, Am J Physiol, 275, H250

Zandbergen, 2007, PPARalpha in atherosclerosis and inflammation, Biochim Biophys Acta, 1771, 972, 10.1016/j.bbalip.2007.04.021

Zeisberg, 2007, Endothelial-to-mesenchymal transition contributes to cardiac fibrosis, Nat Med, 13, 952, 10.1038/nm1613

Zhang, 2005, Simvastatin regulates myocardial cytokine expression and improves ventricular remodeling in rats after acute myocardial infarction, Cardiovasc Drugs Ther, 19, 13, 10.1007/s10557-005-6893-3

Zhang, 2008, Connexin43 expression levels influence intercellular coupling and cell proliferation of native murine cardiac fibroblasts, Cell Commun Adhes, 15, 289, 10.1080/15419060802198736

Zhang, 2001, Cardiomyocyte grafting for cardiac repair: graft cell death and anti-death strategies, J Mol Cell Cardiol, 33, 907, 10.1006/jmcc.2001.1367

Zhang, 2008, Embryonic stem cell transplantation: promise and progress in the treatment of heart disease, BioDrugs, 22, 361, 10.2165/0063030-200822060-00003

Zhang, 2007, PPARβ/δ activation inhibits angiotensin II-induced collagen type I expression in rat cardiac fibroblasts, Arch Biochem Biophys, 460, 25, 10.1016/j.abb.2007.01.028

Zhao, 2001, Release of pro- and anti-angiogenic factors by human cardiac fibroblasts: effects on DNA synthesis and protection under hypoxia in human endothelial cells, Biochim Biophys Acta, 1538, 273, 10.1016/S0167-4889(01)00078-7

Zhao, 2002, Gender-related differences in basal and hypoxia-induced activation of signal transduction pathways controlling cell cycle progression and apoptosis, in cardiac fibroblasts, Endocrine, 18, 137, 10.1385/ENDO:18:2:137

Zheng, 1998, Stimulation of P2Y receptors activates c-fos gene expression and inhibits DNA synthesis in cultured cardiac fibroblasts, Cardiovasc Res, 37, 718, 10.1016/S0008-6363(97)00245-9

Zhou, 1996, Effects of angiotensin II and aldosterone on collagen gene expression and protein turnover in cardiac fibroblasts, Mol Cell Biochem, 154, 171, 10.1007/BF00226785