Cardiac defects in chromosomally normal fetuses with abnormal ductus venosus blood flow at 10–14 weeks

Wiley - Tập 14 Số 5 - Trang 307-310 - 1999
Alexandra Matias1,2, I. C. Huggon1, José Carlos Areias3, Nuno Montenegro2, K. H. Nicolaides1
1Harris Birthright Research Centre for Fetal Medicine, King's College Hospital Medical School, London, UK
2Ultrasound Unit, Department of Obstetrics and Gynecology, Medicine Faculty of Porto, S. João Hospital, Porto, Portugal
3Pediatric Cardiology Unit, Medicine Faculty of Porto, S. João Hospital, Porto, Portugal

Tóm tắt

AbstractObjectiveTo assess a possible relationship between ductus venosus blood flow abnormalities and cardiac defects in chromosomally normal fetuses with increased nuchal translucency thickness at 10–14 weeks of gestation.MethodsDuctus venosus Doppler ultrasound blood flow velocity waveforms were obtained at 10–14 weeks' gestation immediately before fetal karyotyping in 200 consecutive singleton pregnancies with increased nuchal translucency. Fetal echocardiography was subsequently carried out in those with normal fetal karyotype.ResultsReverse or absent flow during atrial contraction was observed in 11 of the 142 chromosomally normal fetuses with increased nuchal translucency. Major defects of the heart and/or great arteries were present in seven of the 11 with abnormal ductal flow and increased nuchal translucency, but in none of the 131 with normal flow.ConclusionThese preliminary results suggest that abnormal ductus venosus blood flow in chromosomally normal fetuses with increased nuchal translucency identifies those with an underlying major cardiac defect. Copyright © 1999 International Society of Ultrasound in Obstetrics and Gynecology

Từ khóa


Tài liệu tham khảo

Thông tin
Thông tin xuất bản

Wiley

Tập 14 Số 5

307-310

Thông tin tác giả