Cardiac and proinflammatory markers predict prognosis in cirrhosis
Tóm tắt
Inflammation and cardiac dysfunction plays an important role in the development of complications leading to increased mortality in patients with cirrhosis. Novel cardiac markers such as prohormone of ANP (proANP), copeptin and high‐sensitivity troponin T (hs‐TnT) and proinflammatory markers including soluble urokinase‐type plasminogen activator receptor (suPAR) and high‐sensitive C‐reactive protein (hs‐CRP) are related to these complications. We aimed to investigate if cardiac and proinflammatory markers are related to severity of liver disease, cardiac and haemodynamic changes, and long‐term survival.
One hundred and ninety‐three stable cirrhotic patients (Child class: A = 46; B
Soluble urokinase‐type plasminogen activator receptor soluble urokinase‐type plasminogen activator receptor, hs‐CRP, and hs‐TnT were significantly different throughout the Child classes (
Markers of cardiac dysfunction and inflammation are significantly associated with disease severity, degree of portal hypertension and survival in cirrhosis. In particular, hs‐TnT and suPAR seem to contain prognostic information.