Carcinogenicity of a Nephrotoxic Metabolite of the “Nongenotoxic” Carcinogen Hydroquinone

Proteus J. W., 1949, Biochem., 44, 61

Parke D. V., 1953, Biochem. J., 55, 10.1042/bj0550337

Ishiguro S., 1976, Glass capillary column gas chromatographic analysis of tobacco and cellulose cigarette smoke. I. Acidic fractions. Kenkyu HokokuNippon Senbai Kosha Chuo Kenkyusho 118, 207−211

Kari F. W., 1992, Toxicity and carcinogenicity of hydroquinone in F344/N rats and B6C3F1 mice. Food Chem. Toxicol. 30, 737−747

Muscat J. E., 1995, The epidemiology of renal cell carcinoma. A second look. Cancer 75, 2552−2557

Tavani A., 1997, J. Nephrol., 10, 106

Randerath E., 1993, Monitoring tobacco smoke-induced DNA damage by 32P-postlabelling. IARC Sci. Publ. 124, 305−314

Church D. F., 1985, Free-radical chemistry of cigarette smoke and its toxicological implications. Environ. Health Perspect. 64, 111−126

Florin I., 1980, Screening of tobacco smoke constituents for mutagenicity using the Ames test. Toxicology 15, 219−232

Sakai M., 1985, Mutat. Res., 156, 67, 10.1016/0165-1218(85)90007-2

Gocke E., 1983, Mutagenicity studies with the mouse spot test. Mutat. Res. 117, 201−212

Gocke E., 1981, Mutat. Res., 90, 109, 10.1016/0165-1218(81)90072-0

Hakura A., 1996, Mutagenicity of dihydroxybenzenes and dihydroxynaphthalenes for Ames Salmonella tester strains. Mutat. Res. 371, 293−299

Hakura A., 1995, Mutat. Res., 347, 43

Tsutsui, T., Hayashi, N., Maizumi, H., Huff, J., and Barrett, J. C. (1997) Benzene- catechol- hydroquinone- and phenol-induced cell transformation, gene mutations, chromosome aberrations, aneuploidy, sister chromatid exchanges and unscheduled DNA synthesis in Syrian hamster embryo cells.Mutat. Res.373, 113−123.

Leanderson P., 1990, Chem.-Biol. Interact., 75, 81, 10.1016/0009-2797(90)90023-G

Lau S. S., 1996, Linking the metabolism of hydroquinone to its nephrotoxicity and nephrocarcinogenicity. Adv. Exp. Med. Biol. 387, 267−273

Walles S. A., 1992, Cancer Lett., 63, 52

Shibata M. A., 1991, Jpn. J. Cancer Res., 82

Yamaguchi S., 1989, Modification by catechol and resorcinol of upper digestive tract carcinogenesis in rats treated with methyl-N-amylnitrosamine. Cancer Res. 49, 6015−6018

Peters M. M., 1997, Cytotoxicity and cell-proliferation induced by the nephrocarcinogen hydroquinone and its nephrotoxic metabolite 2,3,5-tris(glutathion-S-yl)hydroquinone. Carcinogenesis 18, 2393−2401

Lau S. S., 1988, Sequential oxidation and glutathione addition to 1,4-benzoquinone:  correlation of toxicity with increased glutathione substitution. Mol. Pharmacol. 34, 829−836

Hill B. A., 1993, Identification of multi-S-substituted conjugates of hydroquinone by HPLC-coulometric electrode array analysis and mass spectroscopy. Chem. Res. Toxicol. 6, 459−469

Yeung R. S., 1995, Mol. Carcinog., 14, 36, 10.1002/mc.2940140107

Eker R., 1961, A dominant gene for renal adenomas in the rat. Nature 189, 858−859

Yeung R. S., 1994, Proc. Natl. Acad. Sci. U.S.A. 91

Hino O., 1995, Mol. Carcinog., 14, 27, 10.1002/mc.2940140106

Walker C., 1998, Molecular genetics of renal carcinogenesis. Toxicol. Pathol. 26, 113−120

Satake N., 1998, Int. J. Cancer, 77, 10.1002/(SICI)1097-0215(19980911)77:6<895::AID-IJC16>3.0.CO;2-0

Toyokuni S., 1998, Jpn. J. Cancer Res., 89, 10.1111/j.1349-7006.1998.tb00633.x

Green A. J., 1994, Loss of heterozygosity on chromosome 16p13.3 in hamartomas from tuberous sclerosis patients. Nat. Genet. 6, 193−196

Everitt J. I., 1992, J. Urol., 148, 10.1016/S0022-5347(17)37087-8

Walker C., 1992, Predisposition to renal cell carcinoma due to alteration of a cancer susceptibility gene. Science 255, 1693−1695

Hino O., 1993, Genetic predisposition to transplacentally induced renal cell carcinomas in the Eker rat. Cancer Res. 53, 5856−5858

Rennebeck G., 1998, Proc. Natl. Acad. Sci. U.S.A. 95

Dietrich D. R., 1991, Preneoplastic lesions in rodent kidney induced spontaneously or by non-genotoxic agents:  predictive nature and comparison to lesions induced by genotoxic carcinogens. Mutat. Res. 248, 239−260

Bannasch P., 1998, ILSI Monographs on Laboratory Animal Pathology, Urinary System, 139

Berton T. R., 1997, J. Invest. Dermatol., 109, 10.1111/1523-1747.ep12335984

Kleymenova E., 2000, Application of high-pressure liquid chromatography-based analysis of DNA fragments to molecular carcinogenesis. Mol. Carcinog. (in press)

Zar, J. H. (1999) inBiostatistical Analysis, 4th ed., pp 210−214, Prentice-Hall, Upper Saddle River, NJ.

Wolf D. C., 1995, Preneoplastic and neoplastic lesions of rat hereditary renal cell tumors express markers of proximal and distal nephron. Vet. Pathol. 32, 379−386

Jeong J. K., 1999, Quinol-glutathione conjugate-induced mutation spectra in the supF gene replicated in human AD293 cells and bacterial MBL50 cells. Cancer Res. 59, 3641−3645

Eastmond D. A., 1994, Mutat. Res., 322, 20, 10.1016/0165-1218(94)90028-0

Stillman W. S., 1997, The benzene metabolite, hydroquinone, induces dose-dependent hypoploidy in a human cell line. Leukemia 11, 1540−1545

Rupa D. S., 1997, Detection of hyperdiploidy and breakage affecting the 1cen-1q12 region of cultured interphase human lymphocytes treated with various genotoxic agents. Environ. Mol. Mutagen. 29, 161−167

Monks T. J., 1994, Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity

Kleiner H. E., 1998, Immunochemical analysis of quinol-thioether-derived covalent protein adducts in rodent species sensitive and resistant to quinol-thioether-mediated nephrotoxicity. Chem. Res. Toxicol. 11, 1291−1300

Hughey R. P., 1978, Specificity of a particulate rat renal peptidase and its localization along with other enzymes of mercapturic acid synthesis. Arch. Biochem. Biophys. 186, 211−217

Tennant R. W., 1998, Evaluation and validation issues in the development of transgenic mouse carcinogenicity bioassays. Environ. Health Perspect. 106 (Suppl. 2), 473−476

Tennant R. W., 1998, Toxicol. Lett. 102−, 103

Lau, S. S., Kleiner, H. E., and Monks, T. J. (1995) Metabolism as a determinant of species susceptibility to 2,3,5-(triglutathion-S-yl)hydroquinone-mediated nephrotoxicity. The role of N-acetylation and N-deacetylation.Drug Metab. Dispos.23, 1136−1142.

Wolf D. C., 1998, Carcinogenesis 19

Wolf D. C., 2000, Promotion by sodium barbital induces early development but does not increase the multiplicity of hereditary renal tumors in Eker rats. Carcinogenesis 21, 1553−1558

Wienecke R., 1997, Am. J. Pathol., 150, 50

Wienecke R., 1995, J. Biol. Chem., 270, 10.1074/jbc.270.27.16409

Xiao G. H., 1997, J. Biol. Chem., 272

Wienecke R., 1996, Co-localization of the TSC2 product tuberin with its target Rap1 in the Golgi apparatus. Oncogene 13, 913−923

Field H., 1998, J. Biol. Chem., 273, 10.1074/jbc.273.48.32102

Barbieri M. A., 1998, J. Biol. Chem., 273

Gournier H., 1998, EMBO J., 17, 10.1093/emboj/17.7.1930

Simonsen A., 1998, EEA1 links PI(3)K function to Rab5 regulation of endosome fusion. Nature 394, 494−498

Christoforidis S., 1999, The Rab5 effector EEA1 is a core component of endosome docking. Nature 397, 621−625