Carboxymethylcellulose/MOF-5/Graphene oxide bio-nanocomposite as antibacterial drug nanocarrier agent

BioImpacts - Tập 9 Số 1 - Trang 5-13
Zahra Karimzadeh1, Siamak Javanbakht1, Hassan Namazi2,1
1Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran
2Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran

Tóm tắt

Introduction: In recent years, more attention was dedicated to developing new methods for designing of drug delivery systems. The aim of present work is to improve the efficiency of the antibacterial drug delivery process, and to realize and to control accurately the release. Methods: First, graphene oxide (GO) was prepared according to the modified Hummers method then the GO was modified with carboxymethylcellulose (CMC) and Zn-based metal-organic framework (MOF-5) through the solvothermal technique. Results: Performing the various analysis methods including scanning electron microscope (SEM), X-ray diffraction (XRD), EDX, Fourier transform infrared (FTIR) spectroscopy and Zeta potentials on the obtained bio-nanocomposite showed that the new modified GO has been prepared. With using common analysis methods the structure of synthesized materials was determined and confirmed and finally, their antibacterial behavior was examined based on the broth microdilution methods. Conclusion: Carboxymethylcellulose/MOF-5/GO bio-nanocomposite (CMC/MOF-5/GO) was successfully synthesized through the solvothermal technique. Tetracycline (TC) was encapsulated in the GO and CMC/MOF-5/GO. The drug release tests showed that the TC-loaded CMC/MOF5/GO has an effective protection against stomach pH. With controlling the TC release in the gastrointestinal tract conditions, the long-time stability of drug dosing was enhanced. Furthermore, antibacterial activity tests showed that the TC-loaded CMC/MOF-5/GO has an antibacterial activity to negatively charge E. coli bacteria in contrast to TC-loaded GO.

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Tài liệu tham khảo

10.1016/j.carbpol.2016.06.024

10.1016/S0169-409X(02)00228-4

Langer R, 1998, Drug delivery and targeting, Nature, 392, 5

10.1080/00914037.2010.531824

Namazi H, 2001, Synthesis and hydrolysis of acrylic type polymers containing nonsteroidal antiinflammatory drugs, Journal of Polymer Materials, 18, 301

10.1016/j.ijbiomac.2015.12.076

10.1007/s13346-013-0155-x

10.15171/bi.2017.09

10.1016/j.jconrel.2011.03.010

10.1016/j.biomaterials.2004.04.014

10.1016/S0076-6879(05)91004-5

10.1016/j.jcis.2017.04.036

10.1038/nrd2614

10.1021/am3013104

10.1039/B200393G

10.1002/pi.4769

10.1126/science.1230444

10.1021/cr200256v

Geim AK, 2007, The rise of graphene, Nat Mater, 6, 183, 10.1038/nmat1849

10.1021/acsbiomaterials.7b00342

10.1007/s13762-014-0595-y

10.1002/adma.200901581

10.2166/wst.2016.009

10.1021/ja105089w

10.1016/j.micromeso.2011.09.012

10.1016/j.apsusc.2017.05.158

10.1016/j.addr.2003.10.038

10.1016/j.clay.2015.12.026

10.1007/s10965-014-0454-z

10.1016/j.ijbiomac.2015.05.002

10.1016/j.ijbiomac.2015.04.032

10.1016/j.ijbiomac.2014.10.063

10.1007/s11051-013-1563-z

10.1016/j.ijbiomac.2014.11.032

10.1016/j.ijbiomac.2014.11.032

10.1002/cplu.201402017

10.1128/MMBR.65.2.232-260.2001

10.1016/j.msec.2018.02.010

10.1016/j.carbpol.2018.04.103

10.1007/s13762-014-0595-y

10.1007/s10570-014-0366-4

10.1002/ange.201000270

10.1021/ja0675447

10.2147/IJN.S51880

Barzegar-Jalali M, 2008, Kinetic analysis of drug release from nanoparticles, J Pharm Pharm Sci, 11, 167, 10.18433/J3D59T

Waitz JA. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. National Committee for Clinical Laboratory Standards; 1990.

10.1093/jac/48.suppl_1.5

10.1155/2015/168125

10.1002/1439-2054(20010501)286:5<267::AID-MAME267>3.0.CO;2-3

10.1039/B908862H

10.1016/j.carbpol.2006.06.030

10.1016/j.nano.2017.05.007

10.1016/j.nano.2017.09.010

10.1002/smll.201100191

10.1080/1061186X.2016.1238475

10.1021/acsbiomaterials.5b00234

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BioImpacts

Tập 9 Số 1

5-13

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