Carbon Nanotubes Elicit DNA Damage and Inflammatory Response Relative to Their Size and Shape

Inflammation - Tập 33 - Trang 276-280 - 2010
Kohei Yamashita1,2, Yasuo Yoshioka1,2,3, Kazuma Higashisaka1,2, Yuki Morishita1,2, Tokuyuki Yoshida1,2, Maho Fujimura1,2, Hiroyuki Kayamuro1,2, Hiromi Nabeshi1,2, Takuya Yamashita1,2, Kazuya Nagano2, Yasuhiro Abe2, Haruhiko Kamada2,3, Yuichi Kawai4, Tadanori Mayumi4, Tomoaki Yoshikawa1,2, Norio Itoh1, Shin-ichi Tsunoda1,2,3, Yasuo Tsutsumi1,2,3
1Department of Toxicology, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan
2Laboratory of Pharmaceutical Proteomics, National Institute of Biomedical Innovation (NiBio), Ibaraki, Japan
3The Center for Advanced Medical Engineering and Informatics, Osaka University, Suita, Japan
4Graduate School of Pharmaceutical Sciences, Kobegakuin University, Kobe, Japan

Tóm tắt

Carbon nanotubes (CNTs) have been one of the most extensively researched and developed nanomaterials. However, little concern has been placed on their safety. The biological effects of CNTs are believed to differ relative to size and shape. Thus, the relationship between the characteristics of CNTs and their safety needs to be evaluated. In this study, we examined the biological effects of different-sized multi-walled CNTs (MWCNTs) and single-walled CNTs (SWCNTs). Long and thick MWCNTs induced the strongest DNA damage while similar SWCNTs caused little effect. Comparison of inflammatory responses of various types of CNTs found that peritoneal CNT administration of long and thick MWCNTs increased the total cell number in abdominal lavage fluid in mice. These results indicate that long and thick MWCNT, but not short and thin MWCNT, cause DNA damage and severe inflammatory effects. These findings might provide useful information for constructing novel CNTs with safety.

Tài liệu tham khảo

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Thông tin xuất bản

Inflammation

Tập 33

276-280

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