Canine degenerative myelopathy: a model of human amyotrophic lateral sclerosis

Acevedo-Arozena, 2011, A comprehensive assessment of the SOD1G93A low-copy transgenic mouse, which models human amyotrophic lateral sclerosis, Dis. Models Mech., 4, 686, 10.1242/dmm.007237 Al-Chalabi, 1998, Recessive amyotrophic lateral sclerosis families with the D90A SOD1 mutation share a common founder: evidence for a linked protective factor, Hum. Mol. Genet., 7, 2045, 10.1093/hmg/7.13.2045 Al-Chalabi, 2012, The genetics and neuropathology of amyotrophic lateral sclerosis, Acta Neuropathol., 124, 339, 10.1007/s00401-012-1022-4 Allen, 2014, Superoxide dismutase 1 mutation in a cellular model of amyotrophic lateral sclerosis shifts energy generation from oxidative phosphorylation to glycolysis, Neurobiol. Aging, 35, 499, 10.1016/j.neurobiolaging.2013.11.025 Andersen, 1995, Amyotrophic lateral sclerosis associated with homozygosity for an Asp90Ala mutation in Cu/Zn-superoxide dismutase, Nat. Genet., 10, 61, 10.1038/ng0595-61 Andersen, 1996, Autosomal recessive adult-onset amyotrophic lateral sclerosis associated with homozygosity for Asp90Ala Cu/Zn-superoxide dismutase mutation. A clinical and genealogical study of 36 patients, Brain, 119, 1153, 10.1093/brain/119.4.1153 Armstrong, 1982, Distribution of fiber types in locomotory muscles of dogs, Am. J. Anat., 163, 87, 10.1002/aja.1001630107 Ausborn, 2009, The interaction of positive and negative sensory feedback loops in dynamic regulation of a motor pattern, J. Comput. Neurosci., 27, 245, 10.1007/s10827-009-0140-z Averill, 1973, Degenerative myelopathy in the aging German Shepherd dog: clinical and pathologic findings, J. Am. Vet. Med. Assoc., 162, 1045 Awano, 2009, Genome-wide association analysis reveals a SOD1 mutation in canine degenerative myelopathy that resembles amyotrophic lateral sclerosis, Proc. Natl. Acad. Sci. U. S. A., 106, 2794, 10.1073/pnas.0812297106 Baloh, 2007, Frequent atrophic groups with mixed-type myofibers is distinctive to motor neuron syndromes, Muscle Nerve, 36, 107, 10.1002/mus.20755 Barbeito, 2004, A role for astrocytosis in motor neuron loss in amyotrophic lateral sclerosis, Brain Res. Brain Res. Rev., 47, 263, 10.1016/j.brainresrev.2004.05.003 Bassel-Duby, 2006, Signaling pathways in skeletal muscle remodeling, Annu. Rev. Biochem., 75, 19, 10.1146/annurev.biochem.75.103004.142622 Bichsel, 1983, Degenerative myelopathy in a family of Siberian husky dogs, J. Am. Vet. Med. Assoc., 183, 998 Bradley, 1983, Morphometric and biochemical studies on peripheral nerves in amyotrophic lateral sclerosis, Ann. Neurol., 14, 267, 10.1002/ana.410140304 Braund, 1978, German Shepherd dog myelopathy—a morphologic and morphometric study, Am. J. Vet. Res., 39, 1309 Braund, 1982, Observations on normal skeletal muscle of mature dogs: a cytochemical, histochemical, and morphometric study, Vet. Pathol., 19, 577, 10.1177/030098588201900601 Brooke, 1970, Muscle fiber types: how many and what kind?, Arch. Neurol., 23, 369, 10.1001/archneur.1970.00480280083010 Brooks, 2000, El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis, Amyotroph. Lateral Scler. Other Motor Neuron Disord., 1, 293, 10.1080/146608200300079536 Bruijn, 1998, Aggregation and motor neuron toxicity of an ALS-linked SOD1 mutant independent from wild-type SOD1, Science, 281, 1851, 10.1126/science.281.5384.1851 Bruijn, 2004, Unraveling the mechanisms involved in motor neuron degeneration in ALS, Annu. Rev. Neurosci., 27, 723, 10.1146/annurev.neuro.27.070203.144244 Chang, 2013, Genotyping assays for the canine degenerative myelopathy-associated c.118G>A (p.E40K) mutation of the SOD1 gene using conventional and real-time PCR methods: a high prevalence in the Pembroke Welsh Corgi breed in Japan, J. Vet. Med. Sci., 75, 795, 10.1292/jvms.12-0451 Charcot, 1869, Deuxcas d’atrophie musculaire progressive avec lesions del substance grise et de faisceaux anterolateraux de moelle epiniere, Arch. Physiol. Norm. Pathol., 2, 354 Coates, 2010, Canine degenerative myelopathy, Vet. Clin. N. Am. Small Anim. Pract., 40, 929, 10.1016/j.cvsm.2010.05.001 Coates, 2007, Clinical characterization of a familial degenerative myelopathy in Pembroke Welsh Corgi dogs, J. Vet. Intern. Med., 21, 1323, 10.1111/j.1939-1676.2007.tb01955.x Coren, 2004 Corrado, 2010, Mutations of FUS gene in sporadic amyotrophic lateral sclerosis, J. Med. Genet., 47, 90, 10.1136/jmg.2009.071027 Corti, 2009, Amyotrophic lateral sclerosis linked to a novel SOD1 mutation with muscle mitochondrial dysfunction, J. Neurol. Sci., 276, 170, 10.1016/j.jns.2008.09.030 Crisp, 2013, Canine degenerative myelopathy: biochemical characterization of superoxide dismutase 1 in the first naturally occurring non-human amyotrophic lateral sclerosis model, Exp. Neurol., 248, 1, 10.1016/j.expneurol.2013.05.009 Dadon-Nachum, 2011, The dying-back phenomenon of motor neurons in ALS, J. Mol. Neurosci., 43, 470, 10.1007/s12031-010-9467-1 de Carvalho, 2010, Association of paraspinal and diaphragm denervation in ALS, Amyotroph. Lateral Scler., 11, 63, 10.3109/17482960902730080 Dion, 2009, Genetics of motor neuron disorders: new insights into pathogenic mechanisms, Nat. Rev. Genet., 10, 769, 10.1038/nrg2680 di Trapani, 1986, Morphological studies of sural nerve biopsies in the pseudopolyneuropathic form of amyotrophic lateral sclerosis, Clin. Neuropathol., 5, 134 Dobrowolny, 2008, Local expression of mIgf-1 modulates ubiquitin, caspace and CDK5 expression in skeletal muscle of an ALS mouse model, Neurol. Res., 30, 131, 10.1179/174313208X281235 Dyck, 1975, Frequency of nerve fiber degeneration of peripheral motor and sensory neurons in amyotrophic lateral sclerosis. Morphometry of deep and superficial peroneal nerves, Neurology, 25, 781, 10.1212/WNL.25.8.781 Engel, 1965, An inherited disease similar to amyotrophic lateral sclerosis with a pattern of posterior column involvement. An intermediate form?, Brain, 82, 203, 10.1093/brain/82.2.203 Fischer, 2004, Amyotrophic lateral sclerosis is a distal axonopathy: evidence in mice and man, Exp. Neurol., 185, 232, 10.1016/j.expneurol.2003.10.004 Fischer, 2013, Axonal degeneration in the peripheral nervous system: implications for the pathogenesis of amyotrophic lateral sclerosis, Exp. Neurol., 246, 6, 10.1016/j.expneurol.2013.05.001 Frey, 2000, Early and selective loss of neuromuscular synapse subtypes with low sprouting competence in motoneuron diseases, J. Neurosci., 20, 2534, 10.1523/JNEUROSCI.20-07-02534.2000 Giannini, 2010, D90A-SOD1 mutation in ALS: the first report of heterozygous Italian patients and unusual findings, Amyotroph. Lateral Scler., 11, 216, 10.3109/17482960902721642 Gitcho, 2008, TDP-43 A315T mutation in familial motor neuron disease, Ann. Neurol., 63, 535, 10.1002/ana.21344 Griffiths, 1975, Chronic degenerative radiculomyelopathy in the dog, J. Small Anim. Pract., 16, 461, 10.1111/j.1748-5827.1975.tb05773.x Guo, 2009, Sensory involvement in the SOD1-G93A mouse model of amyotrophic lateral sclerosis, Exp. Mol. Med., 41, 140, 10.3858/emm.2009.41.3.017 Gurney, 1994, Motor neuron degeneration in mice that express a human Cu, Zn superoxide dismutase mutation, Science, 264, 1772, 10.1126/science.8209258 Heads, 1991, Sensory nerve pathology in amyotrophic lateral sclerosis, Acta Neuropathol., 82, 316, 10.1007/BF00308818 Hegedus, 2007, Time course of preferential motor unit loss in the SOD1 G93A mouse model of amyotrophic lateral sclerosis, Neurobiol. Dis., 28, 154, 10.1016/j.nbd.2007.07.003 Hirano, 1967, Familial amyotrophic lateral sclerosis: a subgroup characterized by posterior and spinocerebellar tract involvement and hyaline inclusions in the anterior horn cells, Arch. Neurol., 16, 232, 10.1001/archneur.1967.00470210008002 Isaacs, 2007, Amyotrophic lateral sclerosis with sensory neuropathy: part of a multisystem disorder?, J. Neurol. Neurosurg. Psychiatry, 78, 750, 10.1136/jnnp.2006.098798 Kato, 2008, Amyotrophic lateral sclerosis models and human neuropathology: similarities and differences, Acta Neuropathol., 115, 97, 10.1007/s00401-007-0308-4 Katsuno, 2012, Pathogenesis and therapy of spinal and bulbar muscular atrophy (SBMA), Prog. Neurobiol., 99, 246, 10.1016/j.pneurobio.2012.05.007 Kawamura, 1981, Morphometric comparison of the vulnerability of peripheral motor and sensory neurons in amyotrophic lateral sclerosis, J. Neuropathol. Exp. Neurol., 40, 667, 10.1097/00005072-198111000-00008 Khoris, 2000, Coexistence of dominant and recessive familial amyotrophic lateral sclerosis with the D90A Cu,Zn superoxide dismutase mutation within the same country, Eur. J. Neurol., 7, 207, 10.1046/j.1468-1331.2000.00028.x King, 2011, Neuron–glia interactions underlie ALS-like axonal cytoskeletal pathology, Neurobiol. Aging, 32, 459, 10.1016/j.neurobiolaging.2009.04.004 Kwiatkowski, 2009, Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis, Science, 323, 1205, 10.1126/science.1166066 Johnston, 2000, Central nervous system pathology in 25 dogs with chronic degenerative radiculomyelopathy, Vet. Rec., 146, 629, 10.1136/vr.146.22.629 Lobsiger, 2005, Altered axonal architecture by removal of the heavily phosphorylated neurofilament tail domains strongly slows superoxide dismutase 1 mutant-mediated ALS, Proc. Natl. Acad. Sci. U. S. A., 102, 10351, 10.1073/pnas.0503862102 Lovett, 2014, Quantitative assessment of hsp70, IL-1β and TNF-α in the spinal cord of dogs with E40K-SOD1-associated degenerative myelopathy, Vet. J., 200, 312, 10.1016/j.tvjl.2014.03.003 March, 2009, Degenerative myelopathy in 18 Pembroke Welsh Corgi dogs, Vet. Pathol., 46, 241, 10.1354/vp.46-2-241 Matthews, 1985, Degenerative myelopathy in an adult miniature poodle, J. Am. Vet. Med. Assoc., 186, 1213 Mentis, 2011, Early functional impairment of sensory-motor connectivity in a mouse model of spinal muscular atrophy, Neuron, 69, 453, 10.1016/j.neuron.2010.12.032 Miller, 2009, Degenerative myelopathy in two Boxer dogs, Vet. Pathol., 46, 684, 10.1354/vp.08-VP-0270-M-BC Morgan, 2013, Characterization of intercostal muscle pathology in canine degenerative myelopathy: a disease model for amyotrophic lateral sclerosis, J. Neurosci. Res., 91, 1639, 10.1002/jnr.23287 Morgan, 2014, Characterization of thoracic motor and sensory neurons and spinal nerve roots in canine degenerative myelopathy, a potential disease model of amyotrophic lateral sclerosis, J. Neurosci. Res., 92, 531, 10.1002/jnr.23332 Mulder, 1983, Motor neuron disease (ALS): evaluation of detection thresholds of cutaneous sensation, Neurology, 33, 1625, 10.1212/WNL.33.12.1625 Ogawa, 2014, A seeded propagation of Cu, Zn-superoxide dismutase aggregates in amyotrophic lateral sclerosis, Front. Cell. Neurosci., 8 Ogawa, 2011, Immunohistochemical observation of canine degenerative myelopathy in two Pembroke Welsh Corgi dogs, J. Vet. Med. Sci., 73, 1275, 10.1292/jvms.11-0097 Ogawa, 2014, Neuronal loss and decreased GLT-1 expression observed in the spinal cord of Pembroke Welsh Corgi dogs with canine degenerative myelopathy, Vet. Pathol., 51, 591, 10.1177/0300985813495899 Ogawa, 2015, Expression of autophagy-related proteins in the spinal cord of Pembroke Welsh Corgi dogs with canine degenerative myelopathy, Vet. Pathol., 10.1177/0300985815570070 Pugdahl, 2007, Generalised sensory system abnormalities in amyotrophic lateral sclerosis: a European multicentre study, J. Neurol. Neurosurg. Psychiatry, 78, 746, 10.1136/jnnp.2006.098533 Rahn, 2012, Glutamate in CNS neurodegeneration and cognition and its regulation by GCPII inhibition, Curr. Med. Chem., 19, 1335, 10.2174/092986712799462649 Redler, 2012, The complex molecular biology of amyotrophic lateral sclerosis (ALS), Prog. Mol. Biol. Transl. Sci., 107, 215, 10.1016/B978-0-12-385883-2.00002-3 Robberecht, 2013, The changing scene of amyotrophic lateral sclerosis, Nat. Rev. Neurosci., 14, 248, 10.1038/nrn3430 Rothstein, 2009, Current hypothesis for the underlying biology of amyotrophic lateral sclerosis, Ann. Neurol., 65, S3, 10.1002/ana.21543 Rosen, 1993, Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis, Nature, 362, 59, 10.1038/362059a0 Sasaki, 2000, iNOS and nitrotyrosine immunoreactivity in amyotrophic lateral sclerosis, Neurosci. Lett., 291, 44, 10.1016/S0304-3940(00)01370-7 Schaefer, 2005, A compensatory subpopulation of motor neurons in a mouse model of amyotrophic lateral sclerosis, J. Comp. Neurol., 490, 209, 10.1002/cne.20620 Shaw, 1997, Glutamate, excitotoxicity and amyotrophic lateral sclerosis, J. Neurol., 244, S3, 10.1007/BF03160574 Shelton, 2012, Degenerative myelopathy associated with a missense mutation in the superoxide dismutase 1 (SOD1) gene progresses to peripheral neuropathy in Pembroke Welsh Corgis and Boxers, J. Neurol. Sci., 318, 55, 10.1016/j.jns.2012.04.003 Shen, 2011, Muscle pathology without severe nerve pathology in a new mouse model of Charcot–Marie–Tooth disease type 2E, Hum. Mol. Genet., 20, 2535, 10.1093/hmg/ddr152 Shi, 2010, Effects of ALS-related SOD1 mutants on dynein- and KIF5-mediated retrograde and anterograde axonal transport, Biochim. Biophys. Acta, 1802, 707, 10.1016/j.bbadis.2010.05.008 Sreedharan, 2008, TDP-43 mutations in familial and sporadic amyotrophic lateral sclerosis, Science, 319, 1668, 10.1126/science.1154584 Simmons, 2011, HDACs in skeletal muscle remodeling and neuromuscular disease, Handb. Exp. Pharmacol., 206, 79, 10.1007/978-3-642-21631-2_5 Soraru, 2008, Muscle histopathology in upper motor neuron-dominant amyotrophic lateral sclerosis, Amyotroph. Lateral Scler., 9, 287, 10.1080/17482960802206801 Sunico, 2011, Reduction in the motoneuron inhibitory/excitatory synaptic ratio in an early-symptomatic mouse model of amyotrophic lateral sclerosis, Brain Pathol., 21, 1, 10.1111/j.1750-3639.2010.00417.x Tan, 2014, Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis, Biochim. Biophys. Acta, 1842, 1295, 10.1016/j.bbadis.2014.02.009 Tanaka, 2012, Neuropathology and omics in motor neuron diseases, Neuropathology, 32, 458, 10.1111/j.1440-1789.2011.01281.x Turner, 2008, Transgenics, toxicity and therapeutics in rodent models of mutant SOD1-mediated familial ALS, Prog. Neurobiol., 85, 94, 10.1016/j.pneurobio.2008.01.001 Vehviläinen, 2014, Mechanisms of mutant SOD1 induced mitochondrial toxicity in amyotrophic lateral sclerosis, Front. Cell. Neurosci., 8, 126, 10.3389/fncel.2014.00126 Vucic, 2012, FOSMN syndrome: novel insight into disease pathophysiology, Neurology, 79, 73, 10.1212/WNL.0b013e31825dce13 Weis, 2011, Small-fiber neuropathy in patients with ALS, Neurology, 76, 2024, 10.1212/WNL.0b013e31821e553a Williamson, 1999, Slowing of axonal transport is a very early event in the toxicity of ALS-linked SOD1 mutants to motor neurons, Nat. Neurosci., 2, 50, 10.1038/4553 Wong, 1995, An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria, Neuron, 14, 1105, 10.1016/0896-6273(95)90259-7 Wong, 2015, Autophagosome dynamics in neurodegeneration at a glance, J. Cell Sci., 128, 1259, 10.1242/jcs.161216 Zeng, 2014, Breed distribution of SOD1 alleles previously associated with canine degenerative myelopathy, J. Vet. Intern. Med., 28, 515, 10.1111/jvim.12317 Zhou, 2010, Hyperactive intracellular calcium signaling associated with localized mitochondrial defects in skeletal muscle of an animal model of amyotrophic lateral sclerosis, J. Biol. Chem., 285, 705, 10.1074/jbc.M109.041319