Cancer research: from folate antagonism to molecular targets

Best Practice & Research Clinical Haematology - Tập 22 Số 4 - Trang 577-582 - 2009
Joseph R. Bertino1,2,3
1Cancer Institute of New Jersey, 195 Little Albany Street, Room 3033, New Brunswick, NJ 08901, USA
2Stem Cell Institute of New Jersey, USA
3University Professor of Medicine and Pharmacology, USA

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Tài liệu tham khảo

Osborn, 1958, Inhibition of dihydrofolic reductase by aminopterin and amethopterin, Proc Soc Exp Biol Med, 97, 429, 10.3181/00379727-97-23764

O'Connor, 2009, Phase II-I-II Study of Two Different Doses and Schedules of Pralatrexate, a High-Affinity Substrate for the Reduced Folate Carrier, in Patients With Relapsed or Refractory Lymphoma Reveals Marked Activity in T-Cell Malignancies, J Clin Oncol, 10.1200/JCO.2008.20.8470

Wang, 2004, Characterization of a folate transporter in HeLa cells with a low pH optimum and high affinity for pemetrexed distinct from the reduced folate carrier, Clin Cancer Res, 10, 6256, 10.1158/1078-0432.CCR-04-0645

Mitchell, 1968, Effectiveness of high-dose infusions of methotrexate followed by leucovorin in carcinoma of the head and neck, Cancer Res, 28, 1088

Berd, 1975, Long-term remission in diffuse histiocytic lymphoma treated with combination sequential chemotherapy, Cancer, 35, 1050, 10.1002/1097-0142(197504)35:4<1050::AID-CNCR2820350406>3.0.CO;2-F

Bertino, 1979, 2,4-diamino-5-methyl-6-[(3,4,5-trimethoxyanilino)methyl]quinazoline (tmq), a potent non-classical folate antagonist inhibitor–I effect on dihydrofolate reductase and growth of rodent tumors in vitro and in vivo, Biochem Pharmacol, 28, 1983, 10.1016/0006-2952(79)90655-5

Allegra, 1987, Activity of antifolates against Pneumocystis carinii dihydrofolate reductase and identification of a potent new agent, J Exp Med, 165, 926, 10.1084/jem.165.3.926

Lacerda, 1995, Selective treatment of SCID mice bearing methotrexate-transport-resistant human acute lymphoblastic leukemia tumors with trimetrexate and leucovorin protection, Blood, 85, 2675, 10.1182/blood.V85.10.2675.bloodjournal85102675

Szelenyi, 2000, Sequential trimetrexate, 5-fluorouracil and folinic acid are effective and well tolerated in metastatic colorectal carcinoma. The phase II study group of the AIO, Oncology, 58, 273, 10.1159/000012112

Punt, 2001, Phase I and pharmacokinetic study of the orally administered farnesyl transferase inhibitor R115777 in patients with advanced solid tumors, Anticancer Drugs, 12, 193, 10.1097/00001813-200103000-00003

Bertino, 2002, Modulation of 5-fluorouracil/leucovorin by trimetrexate–did it work?, Ann Oncol, 13, 10, 10.1093/annonc/mdf086

Chabner, 1972, Enzymatic cleavage of methotrexate provides a method for prevention of drug toxicity, Nature, 239, 395, 10.1038/239395b0

DeAngelis, 1996, Carboxypeptidase G2 rescue after high-dose methotrexate, J Clin Oncol, 14, 2145, 10.1200/JCO.1996.14.7.2145

Capizzi, 1993, Asparaginase revisited, Leuk Lymphoma, 10, 147, 10.3109/10428199309149127

Alt, 1978, Selective multiplication of dihydrofolate reductase genes in methotrexate-resistant variants of cultured murine cells, J Biol Chem, 253, 1357, 10.1016/S0021-9258(17)34875-5

Gorlick, 1996, Intrinsic and acquired resistance to methotrexate in acute leukemia, N Engl J Med, 335, 1041, 10.1056/NEJM199610033351408

Budak-Alpdogan, 2009, Chemoprotection by transfer of resistance genes, Methods Mol Biol, 542, 661, 10.1007/978-1-59745-561-9_34

Budak-Alpdogan, 2004, Methotrexate and cytarabine inhibit progression of human lymphoma in NOD/SCID mice carrying a mutant dihydrofolate reductase and cytidine deaminase fusion gene, Mol Ther, 10, 574, 10.1016/j.ymthe.2004.06.115

Cavazzana-Calvo, 2000, Gene therapy of human severe combined immunodeficiency (SCID)-X1 disease, Science, 288, 669, 10.1126/science.288.5466.669

Noguchi, 2003, Risks and benefits of gene therapy, N Engl J Med, 348, 193, 10.1056/NEJMp020184

Deichmann, 2007, Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy, J Clin Invest, 117, 2225, 10.1172/JCI31659

Aiuti, 2007, Multilineage hematopoietic reconstitution without clonal selection in ADA-SCID patients treated with stem cell gene therapy, J Clin Invest, 117, 2233, 10.1172/JCI31666

Shou, 2006, Unique risk factors for insertional mutagenesis in a mouse model of XSCID gene therapy, Proc Natl Acad Sci U S A, 103, 11730, 10.1073/pnas.0603635103

Ercikan-Abali, 1997, Dihydrofolate reductase protein inhibits its own translation by binding to dihydrofolate reductase mRNA sequences within the coding region, Biochemistry, 36, 12317, 10.1021/bi971026e

Chu, 1993, Specific binding of human dihydrofolate reductase protein to dihydrofolate reductase messenger RNA in vitro, Biochemistry, 32, 4756, 10.1021/bi00069a009

Guo, 1999, Mechanisms of methotrexate resistance in osteosarcoma, Clin Cancer Res, 5, 621

Goto, 2001, A novel single-nucleotide polymorphism in the 3'-untranslated region of the human dihydrofolate reductase gene with enhanced expression, Clin Cancer Res, 7, 1952

Mishra, 2007, A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance, Proc Natl Acad Sci U S A, 104, 13513, 10.1073/pnas.0706217104

Song, 2008, miR-192 Regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit, Clin Cancer Res, 14, 8080, 10.1158/1078-0432.CCR-08-1422