Cancer of unknown primary (CUP) – lokal begrenzt, oligometastatisch und im Kopf-Hals-Bereich

Maria Pouyiourou1, Sebastian Regnery2, Tilmann Bochtler3, Klaus Herfarth2, Alwin Krämer3
1Klinische Kooperationseinheit Molekulare Hämatologie/Onkologie, Deutsches Krebsforschungszentrum (DKFZ) und Medizinische Klinik V, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 280, 69120, Heidelberg, Deutschland
2Abteilung für Radioonkologie und Strahlentherapie, Universitätsklinikum Heidelberg, Im Neuenheimer Feld 400, 69120, Heidelberg, Deutschland
3Medizinische Klinik V, Universitätsklinikum Heidelberg, Heidelberg, Deutschland

Tóm tắt

Từ khóa


Tài liệu tham khảo

Balaker AE, Abemayor E, Elashoff D et al (2012) Cancer of unknown primary: does treatment modality make a difference? Laryngoscope 122:1279–1282

Bartelt S, Lutterbach J (2003) Brain metastases in patients with cancer of unknown primary. J Neurooncol 64:249–253

Bochtler T, Reiling A, Endris V et al (2020) Integrated clinicomolecular characterization identifies RAS activation and CDKN2A deletion as independent adverse prognostic factors in cancer of unknown primary. Int J Cancer 146:3053–3064

Bochtler T, Wohlfromm T, Hielscher T et al (2022) Prognostic impact of copy number alterations and tumor mutational burden in carcinoma of unknown primary. Genes Chromosomes Cancer 61:551–560

Chalabi M, Verschoor YL, van den Berg J et al (2022) LBA7 neoadjuvant immune checkpoint inhibition in locally advanced MMR-deficient colon cancer: the NICHE-2 study. Ann Oncol 33:S1389

Cheraghlou S, Torabi SJ, Husain ZA et al (2019) HPV status in unknown primary head and neck cancer: prognosis and treatment outcomes. Laryngoscope 129:684–691

Farooq S, Khandavilli S, Dretzke J et al (2019) Transoral tongue base mucosectomy for the identification of the primary site in the work-up of cancers of unknown origin: systematic review and meta-analysis. Oral Oncol 91:97–106

Frank SJ, Rosenthal DI, Petsuksiri J et al (2010) Intensity-modulated radiotherapy for cervical node squamous cell carcinoma metastases from unknown head-and-neck primary site: M. D. Anderson Cancer Center outcomes and patterns of failure. Int J Radiat Oncol Biol Phys 78:1005–1010

Ghatasheh H, Huang SH, Su J et al (2022) Evaluation of risk-tailored individualized selection of radiation therapy target volume for head and neck carcinoma of unknown primary. Radiother Oncol 175:56–64

Guarischi A, Keane TJ, Elhakim T (1987) Metastatic inguinal nodes from an unknown primary neoplasm. A review of 56 cases. Cancer 59:572–577

Jereczek-Fossa BA, Jassem J, Orecchia R (2004) Cervical lymph node metastases of squamous cell carcinoma from an unknown primary. Cancer Treat Rev 30:153–164

Johansen J, Buus S, Loft A et al (2008) Prospective study of 18FDG-PET in the detection and management of patients with lymph node metastases to the neck from an unknown primary tumor. Results from the DAHANCA-13 study. Head Neck 30:471–478

Krämer A, Bochtler T, Pauli C et al (2023) Cancer of unknown primary: ESMO clinical practice guideline for diagnosis, treatment and follow-up. Ann Oncol 34(3):228–246. https://doi.org/10.1016/j.annonc.2022.11.013

Lacas B, Carmel A, Landais C et al (2021) meta-analysis of chemotherapy in head and neck cancer (MACH-NC): an update on 107 randomized trials and 19,805 patients, on behalf of MACH-NC group. Radiother Oncol 156:281–293

Ludford K, Ho WJ, Thomas JV et al (2023) Neoadjuvant pembrolizumab in localized microsatellite instability high/deficient mismatch repair solid tumors. J Clin Oncol. https://doi.org/10.1200/JCO.22.01351

Machiels JP, René Leemans C, Golusinski W et al (2020) Squamous cell carcinoma of the oral cavity, larynx, oropharynx and hypopharynx: EHNS-ESMO-ESTRO clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 31:1462–1475

Mackenzie K, Watson M, Jankowska P et al (2016) Investigation and management of the unknown primary with metastatic neck disease: United Kingdom national multidisciplinary guidelines. J Laryngol Otol 130:S170–s175

Maghami E, Ismaila N, Alvarez A et al (2020) Diagnosis and management of squamous cell carcinoma of unknown primary in the head and neck: ASCO guideline. J Clin Oncol 38:2570–2596

Matsuyama S, Nakafusa Y, Tanaka M et al (2006) Iliac lymph node metastasis of an unknown primary tumor: report of a case. Surg Today 36:655–658

Møller AK, Loft A, Berthelsen AK et al (2012) A prospective comparison of 18F-FDG PET/CT and CT as diagnostic tools to identify the primary tumor site in patients with extracervical carcinoma of unknown primary site. Oncologist 17:1146–1154

Motz K, Qualliotine JR, Rettig E et al (2016) Changes in unknown primary squamous cell carcinoma of the head and neck at initial presentation in the era of human papillomavirus. JAMA Otolaryngol Head Neck Surg 142:223–228

Pouyiourou M, Wohlfromm T, Kraft B et al (2021) Local ablative treatment with surgery and/or radiotherapy in single-site and oligometastatic carcinoma of unknown primary. Eur J Cancer 157:179–189

Reddy SP, Marks JE (1997) Metastatic carcinoma in the cervical lymph nodes from an unknown primary site: results of bilateral neck plus mucosal irradiation vs. ipsilateral neck irradiation. Int J Radiat Oncol Biol Phys 37:797–802

Roh JL, Kim JS, Lee JH et al (2009) Utility of combined (18)F-fluorodeoxyglucose-positron emission tomography and computed tomography in patients with cervical metastases from unknown primary tumors. Oral Oncol 45:218–224

Rudà R, Borgognone M, Benech F et al (2001) Brain metastases from unknown primary tumour: a prospective study. J Neurol 248:394–398

Tanzler ED, Amdur RJ, Morris CG et al (2016) Challenging the need for random directed biopsies of the nasopharynx, pyriform sinus, and contralateral tonsil in the workup of unknown primary squamous cell carcinoma of the head and neck. Head Neck 38:578–581

Zhu L, Wang N (2013) 18F-fluorodeoxyglucose positron emission tomography-computed tomography as a diagnostic tool in patients with cervical nodal metastases of unknown primary site: a meta-analysis. Surg Oncol 22:190–194