Cancer invasion and metastasis: interacting ecosystems
Archiv für pathologische Anatomie und Physiologie und für klinische Medicin - Tập 454 - Trang 599-622 - 2009
Tóm tắt
Malignant tumors invade and metastasize. They consist of cancer cells, evolving through genetic and epigenetic modulation, mixed with tumor-associated host cells, emerging from resident or bone marrow-derived precursors. These cells establish ecosystems to activate cellular programs for local invasion and distant metastasis. Characteristic of such malignancy-related activities is communication inside ecosystems between cells, ligands, receptor protein complexes, and signaling pathways as well as between ecosystems comprising the primary tumor, lymph node and distant metastasis, bone marrow and blood and lymph circulation. Complexity is another characteristic, resulting from: heterogeneity of the cell populations; the numbers of promoter and suppressor genes, their levels of regulation, and the pleiotropic activities of their products; biological redundancy of the molecular mechanisms underpinning invasion-related activities. Clinical attention is paid to putative new targets, namely host cells, individual molecules and their signaling pathways, as well as the effects of current treatment on invasion and metastasis.
Tài liệu tham khảo
Tarin D (2006–2007) New insights into the pathogenesis of breast cancer metastasis. Breast Dis 26:13–25
Stafford LJ, Vaidya KS, Welch DR (2008) Metastasis suppressors genes in cancer. Int J Biochem Cell Biol 40:874–891
Oliveira MJ (2004) The effect of bacteria on colon cancer cell invasion: molecular mechanisms associated. Faculty of Medicine and Health Sciences. Ghent University. PhD thesis
Madani I, De Neve W, Mareel M (2008) Does ionizing radiation stimulate cancer invasion and metastasis? Bull Cancer 95:292–300
De Wever O, Mareel M (2003) Role of tissue stroma in cancer cell invasion. J Pathol 200:429–447
Bracke ME, Vanhoecke BW, Derycke L et al (2008) Plant polyphenolics as anti-invasive cancer agents. Anticancer Agents Med Chem 8:171–185
Ottewell PD, Coleman RE, Holen I (2006) From genetic abnormality to metastases: murine models of breast cancer and their use in the development of anticancer therapies. Breast Cancer Res Treat 96:101–113
Langley RR, Fidler IJ (2007) Tumor cell-organ microenvironment interactions in the pathogenesis of cancer metastasis. Endocr Rev 28:297–321
Kuperwasser C, Chavarria T, Wu M et al (2004) Reconstruction of functionally normal and malignant human breast tissues in mice. Proc Natl Acad Sci U S A 101:4966–4971
Hoffman RM (2006) Real-time subcellular imaging in live animals: new visible targets for cancer drug discovery. IDrugs 9:632–635
Fomchenko EI, Holland EC (2006) Mouse models of brain tumors and their applications in preclinical trials. Clin Cancer Res 12:5288–5297
Gingrich JR, Barrios RJ, Morton RA et al (1996) Metastatic prostate cancer in a transgenic mouse. Cancer Res 56:4096–4102
Perl AK, Wilgenbus P, Dahl U et al (1998) A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 392:190–193
Ambartsumian N, Grigorian M, Lukanidin E (2005) Genetically modified mouse models to study the role of metastasis-promoting S100A4 (mts1) protein in metastatic mammary cancer. J Dairy Res 72:27–33
Scherer RL, McIntyre JO, Matrisian LM (2008) Imaging matrix metalloproteinases in cancer. Cancer Metastasis Rev 27:679–690
Espina V, Heiby M, Pierobon M et al (2007) Laser capture microdissection technology. Expert Rev Mol Diagn 7:647–657
Eccles SA, Welch DR (2007) Metastasis: recent discoveries and novel treatment strategies. Lancet 369:1742–1757
Brenton JD, Carey LA, Ahmed AA et al (2005) Molecular classification and molecular forecasting of breast cancer: ready for clinical application? J Clin Oncol 23:7350–7360
Montel V, Huang TY, Mose E et al (2005) Expression profiling of primary tumors and matched lymphatic and lung metastases in a xenogeneic breast cancer model. Am J Pathol 166:1565–1579
Karpf AR, Jones DA (2002) Reactivating the expression of methylation silenced genes in human cancer. Oncogene 21:5496–5503
Feng Y, Sun B, Li X et al (2007) Differentially expressed genes between primary cancer and paired lymph node metastases predict clinical outcome of node-positive breast cancer patients. Breast Cancer Res Treat 103:319–329
van ‘t Veer LJ, Dai H, van de Vijver MJ et al (2002) Gene expression profiling predicts clinical outcome of breast cancer. Nature 415:530–536
Wang Y, Klijn JG, Zhang Y et al (2005) Gene-expression profiles to predict distant metastasis of lymph-node-negative primary breast cancer. Lancet 365:671–679
Eckhardt BL, Parker BS, van Laar RK et al (2005) Genomic analysis of a spontaneous model of breast cancer metastasis to bone reveals a role for the extracellular matrix. Mol Cancer Res 3:1–13
Adib TR, Henderson S, Perrett C et al (2004) Predicting biomarkers for ovarian cancer using gene-expression microarrays. Br J Cancer 90:686–692
Suzuki M, Tarin D (2007) Gene expression profiling of human lymph node metastases and matched primary breast carcinomas: clinical implications. Mol Oncol 1:172–180
Chang HY, Nuyten DS, Sneddon JB et al (2005) Robustness, scalability, and integration of a wound-response gene expression signature in predicting breast cancer survival. Proc Natl Acad Sci U S A 102:3738–3743
Finak G, Bertos N, Pepin F et al (2008) Stromal gene expression predicts clinical outcome in breast cancer. Nat Med 14:518–527
Clark IM, Swingler TE, Sampieri CL et al (2008) The regulation of matrix metalloproteinases and their inhibitors. Int J Biochem Cell Biol 40:1362–1378
Li Y, Liang J, Kang S et al (2008) E-cadherin gene polymorphisms and haplotype associated with the occurrence of epithelial ovarian cancer in Chinese. Gynecol Oncol 108:409–414
Brendle A, Lei H, Brandt A et al (2008) Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic marker. Carcinogenesis 29:1394–1399
Hunter KW, Crawford NP (2006) Germ line polymorphism in metastatic progression. Cancer Res 66:1251–1254
Crawford NP, Ziogas A, Peel DJ et al (2006) Germline polymorphisms in SIPA1 are associated with metastasis and other indicators of poor prognosis in breast cancer. Breast Cancer Res 8:R16
van Roy F, Berx G (2008) The cell-cell adhesion molecule E-cadherin. Cell Mol Life Sci 65:3756–3788
Bartel DP, Chen CZ (2004) Micromanagers of gene expression: the potentially widespread influence of metazoan microRNAs. Nat Rev Genet 5:396–400
Ma L, Weinberg RA (2008) Micromanagers of malignancy: role of microRNAs in regulating metastasis. Trends Genet 24:448–456
Graff JR, Zimmer SG (2003) Translational control and metastatic progression: enhanced activity of the mRNA cap-binding protein eIF-4E selectively enhances translation of metastasis-related mRNAs. Clin Exp Metastasis 20:265–273
Hao X, Sun B, Hu L (2004) Differential gene and protein expression in primary breast malignancies and their lymph node metastases as revealed by combined cDNA microarray and tissue microarray analysis. Cancer 100(6):1110–1122
Hakomori S (1996) Tumor malignancy defined by aberrant glycosylation and sphingo(glyco) lipid metabolism. Cancer Res 56:5309–5318
Yoshimura M, Ihara Y, Matsuzawa Y et al (1996) Aberrant glycosylation of E-cadherin enhances cell–cell binding to suppress metastasis. J Biol Chem 271:13811–13815
McLachlan RW, Yap AS (2007) Not so simple: the complexity of phosphotyrosine signaling at cadherin adhesive contacts. J Mol Med 85:545–554
Wipff PJ, Hinz B (2008) Integrins and the activation of latent transforming growth factor beta1—an intimate relationship. Eur J Cell Biol 87:601–615
Paredes J, Correia AL, Ribeiro AS et al (2007) P-cadherin expression in breast cancer: a review. Breast Cancer Res 9:214
Van Marck V, Stove C, Van Den Bossche K et al (2005) P-cadherin promotes cell–cell adhesion and counteracts invasion in human melanoma. Cancer Res 65:8774–8783
Wheelock MJ, Shintani Y, Maeda M et al (2008) Cadherin switching. J Cell Sci 121:727–735
De Wever O, Westbroek W, Verloes A et al (2004) Critical role of N-cadherin in myofibroblast invasion and migration in vitro stimulated by colon-cancer-cell-derived TGF-beta or wounding. J Cell Sci 117:4691–4703
Alexander NR, Tran NL, Rekapally H et al (2006) N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1. Cancer Res 66:3365–3369
Stove C, Bracke M (2004) Roles for neuregulins in human cancer. Clin Exp Metastasis 21:665–684
Kerbel RS (2008) Tumor angiogenesis. N Engl J Med 358:2039–2049
Chabottaux V, Noel A (2007) Breast cancer progression: insights into multifaceted matrix metalloproteinases. Clin Exp Metastasis 24:647–656
Noël A, Jost M, Maquoi E (2008) Matrix metalloproteinases at cancer tumor–host interface. Semin Cell Dev Biol 19:52–60
Jones RB, Gordus A, Krall JA et al (2006) A quantitative protein interaction network for the ErbB receptors using protein microarrays. Nature 439:168–174
Pawson T, Nash P (2003) Assembly of cell regulatory systems through protein interaction domains. Science 300:445–452
Kopfstein L, Christofori G (2006) Metastasis: cell-autonomous mechanisms versus contributions by the tumor microenvironment. Cell Mol Life Sci 63:449–468
Paget S (1889) The distribution of secondary growths in cancer of the breast. Lancet 1:571–573
Mareel MM, Behrens J, Birchmeier W et al (1991) Down-regulation of E-cadherin expression in Madin Darby canine kidney (MDCK) cells inside tumors of nude mice. Int J Cancer 47:922–928
Creighton CJ, Bromberg-White JL, Misek DE et al (2005) Analysis of tumor–host interactions by gene expression profiling of lung adenocarcinoma xenografts identifies genes involved in tumor formation. Mol Cancer Res 3:119–129
Dimanche-Boitrel MT, Vakaet L Jr, Pujuguet P et al (1994) In vivo and in vitro invasiveness of a rat colon-cancer cell line maintaining E-cadherin expression: an enhancing role of tumor-associated myofibroblasts. Int J Cancer 56:512–521
Lin EY, Pollard JW (2007) Tumor-associated macrophages press the angiogenic switch in breast cancer. Cancer Res 67:5064–5066
Korc M (2007) Pancreatic cancer-associated stroma production. Am J Sur 194(4 Suppl):S84–S86
He Y, Rajantie I, Pajusola K et al (2005) Vascular endothelial cell growth factor receptor 3-mediated activation of lymphatic endothelium is crucial for tumor cell entry and spread via lymphatic vessels. Cancer Res 65:4739–4746
Mahabeleshwar GH, Byzova TV (2007) Angiogenesis in melanoma. Semin Oncol 34:555–565
Benoy IH, Salgado R, Elst H et al (2005) Relative microvessel area of the primary tumour, and not lymph node status, predicts the presence of bone marrow micrometastases detected by reverse transcriptase polymerase chain reaction in patients with clinically non-metastatic breast cancer. Breast Cancer Res 7:R210–R219
Hicklin DJ, Ellis LM (2005) Role of the vascular endothelial growth factor pathway in tumor growth and angiogenesis. J Clin Oncol 23:1011–1027
Schoppmann SF, Bayer G, Aumayr K, Austrian Breast and Colorectal Cancer Study Group et al (2004) Prognostic value of lymphangiogenesis and lymphovascular invasion in invasive breast cancer. Ann Surg 240:306–312
Tobler NE, Detmar M (2006) Tumor and lymph node lymphangiogenesis—impact on cancer metastasis. J Leukoc Biol 80:691–696
Nathanson SD (2007) Preclinical models of regional lymph node tumor metastasis. In: Leong S (ed) Cancer metastasis and the lymphvascular system: basis for rational therapy. Springer, New York, pp 129–156
Wissmann C, Detmar M (2006) Pathways targeting tumor lymphangiogenesis. Clin Cancer Res 12:6865–6868
Rafii DC, Psaila B, Butler J et al (2008) Regulation of vasculogenesis by platelet-mediated recruitment of bone marrow-derived cells. Arterioscler Thromb Vasc Biol 28:217–222
Mantovani A, Sica A et al (2004) The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol 25:677–686
Mantovani A, Romero P, Palucka AK et al (2008) Tumour immunity: effector response to tumour and role of the microenvironment. Lancet 371:771–783
Talmadge JE, Donkor M, Scholar E (2007) Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Rev 26:373–400
Lewis CE, Pollard JW (2006) Distinct role of macrophages in different tumor microenvironments. Cancer Res 66:605–612
Condeelis J, Pollard JW (2006) Macrophages: obligate partners for tumor cell migration, invasion, and metastasis. Cell 124:263–266
Wyckoff JB, Wang Y, Lin EY et al (2007) Direct visualization of macrophage-assisted tumor cell intravasation in mammary tumors. Cancer Res 67:2649–2656
Mahadevan D, Von Hoff DD (2007) Tumor–stroma interactions in pancreatic ductal adenocarcinoma. Mol Cancer Ther 6:1186–1197
De Wever O, Demetter P, Mareel M et al (2008) Stromal myofibroblasts are drivers of invasive cancer growth. Int J Cancer 123:2229–2238
Massaguè J (2008) TGFbeta in cancer. Cell 134:215–230
Hu M, Yao J, Carroll DK et al (2008) Regulation of in situ to invasive breast carcinoma transition. Cancer Cell 13:394–406
Lerwill MF (2004) Current practical applications of diagnostic immunohistochemistry in breast pathology. Am J Surg Pathol 28:1076–1091
Allinen M, Beroukhim R, Cai L et al (2004) Molecular characterization of the tumor microenvironment in breast cancer. Cancer Cell 6:17–32
Hu M, Yao J, Cai L et al (2005) Distinct epigenetic changes in the stromal cells of breast cancers. Nat Genet 37:899–905
Barsky SH, Karlin NJ (2005) Myoepithelial cells: autocrine and paracrine suppressors of breast cancer progression. J Mammary Gland Biol Neoplasia 10:249–260
Polyak K, Hu M (2005) Do myoepithelial cells hold the key for breast tumor progression? J Mammary Gland Biol Neoplasia 10:231–247
Mantyh PW, Clohisy DR, Koltzenburg M et al (2002) Molecular mechanisms of cancer pain. Nat Rev Cancer 2:201–209
Ayala GE, Dai H, Powell M et al (2008) Cancer-related axonogenesis and neurogenesis in prostate cancer. Clin Cancer Res 14:7593–7603
Wang W, Zhao H, Zhang S, et al (2008) Patterns of expression and function of the p75(NGFR) protein in pancreatic cancer cells and tumours. Eur J Surg Oncol Nov 26 (in press)
Marchesi F, Piemonti L, Fedele G et al (2008) The chemokine receptor CX3CR1 is involved in the neural tropism and malignant behavior of pancreatic ductal adenocarcinoma. Cancer Res 68:9060–9069
Zhang S, Qi L, Li M et al (2008) Chemokine CXCL12 and its receptor CXCR4 expression are associated with perineural invasion of prostate cancer. J Exp Clin Cancer Res 27:62
Andarawewa KL, Motrescu ER, Chenard MP et al (2005) Stromelysin-3 is a potent negative regulator of adipogenesis participating to cancer cell-adipocyte interaction/crosstalk at the tumor invasive front. Cancer Res 65:10862–10871
Caers J, Van Valckenborgh E, Menu E et al (2008) Unraveling the biology of multiple myeloma disease: cancer stem cells, acquired intracellular changes and interactions with the surrounding micro-environment. Bull Cancer 95:301–313
Vona-Davis L, Rose DP (2007) Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer 14:189–206
Kunduzova O, Alet N, Delesque-Touchard N et al (2008) Apelin/APJ signaling system: a potential link between adipose tissue and endothelial angiogenic processes. FASEB J 22:4146–4153
Cirillo D, Rachiglio AM, la Montagna R et al (2008) Leptin signaling in breast cancer: an overview. J Cell Biochem 105:956–964
Jaffe T, Schwartz B (2008) Leptin promotes motility and invasiveness in human colon cancer cells by activating multiple signal-transduction pathways. Int J Cancer 123:2543–2556
Horiguchi A, Sumitomo M, Asakuma J et al (2006) Leptin promotes invasiveness of murine renal cancer cells via extracellular signal-regulated kinases and rho dependent pathway. J Urol 176:1636–1641
Bussard KM, Gay CV, Mastro AM (2008) The bone microenvironment in metastasis; what is special about bone? Cancer Metastasis Rev 27:41–55
Vakaet LA, Boterberg T (2004) Pain control by ionizing radiation of bone metastasis. Int J Dev Biol 48:599–606
Oliveira MJ, Van Damme J, Lauwaet T et al (2003) Beta-casein-derived peptides, produced by bacteria, stimulate cancer cell invasion and motility. EMBO J 22:6161–6173
Oliveira MJ, Costa AC, Costa AM et al (2006) Helicobacter pylori induces gastric epithelial cell invasion in a c-Met and type IV secretion system-dependent manner. J Biol Chem 281:34888–34896
Oliveira MJ, Costa AM, Costa AC, et al (2009) CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell invasive phenotype. J Infect Dis (in press)
Miller MJ, Wei SH, Parker I et al (2002) Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science 296:1869–1873
Mullen JT, Wang H, Yao JC et al (2005) Carcinoid tumors of the duodenum. Surgery 138:971–977
Hoon DS, Kitago M, Kim J et al (2006) Molecular mechanisms of metastasis. Cancer Metastasis Rev 25:203–220
Müller A, Homey B, Soto H et al (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50–56
Hirakawa S, Brown LF, Kodama S et al (2007) VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 109:1010–1017
Van den Eynden GG, Vandenberghe MK, van Dam PJ et al (2007) Increased sentinel lymph node lymphangiogenesis is associated with nonsentinel axillary lymph node involvement in breast cancer patients with a positive sentinel node. Clin Cancer Res 13:5391–5397
DiMeo TA, Kuperwasser C (2006) The evolving paradigm of tissue-specific metastasis. Breast Cancer Res 8:301
Andre F, Cabioglu N, Assi H et al (2006) Expression of chemokine receptors predicts the site of metastatic relapse in patients with axillary node positive primary breast cancer. Ann Oncol 17:945–951
Stessels F, Van den Eynden G, Van der Auwera I et al (2004) Breast adenocarcinoma liver metastases, in contrast to colorectal cancer liver metastases, display a non-angiogenic growth pattern that preserves the stroma and lacks hypoxia. Br J Cancer 90:1429–1436
Mendes O, Kim HT, Lungu G et al (2007) MMP2 role in breast cancer brain metastasis development and its regulation by TIMP2 and ERK1/2. Clin Exp Metastasis 24:341–351
Kaplan RN, Psaila B, Lyden D (2006) Bone marrow cells in the 'pre-metastatic niche': within bone and beyond. Cancer Metastasis Rev 25:521–529
Hiratsuka S, Watanabe A, Aburatani H et al (2006) Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nat Cell Biol 8:1369–1375
Kaplan RN, Psaila B, Lyden D (2007) Niche-to-niche migration of bone-marrow-derived cells. Trends Mol Med 13:72–81
Pantel K, Brakenhoff RH (2004) Dissecting the metastatic cascade. Nat Rev Cancer 4:448–456
Vincent-Salomon A, Bidard FC, Pierga JY (2008) Bone marrow micrometastasis in breast cancer: review of detection methods, prognostic impact and biological issues. J Clin Pathol 61:570–576
Bidard FC, Vincent-Salomon A, Gomme S, Institut Curie Breast Cancer Study Group et al (2008) Disseminated tumor cells of breast cancer patients: a strong prognostic factor for distant and local relapse. Clin Cancer Res 14:3306–3311
Ceelen WP, Bracke ME (2009) Peritoneal minimal residual disease in colorectal cancer: mechanisms, prevention, and treatment. Lancet Oncol 10:72–79
Bidard FC, Pierga JY, Vincent-Salomon A et al (2008) A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Cancer Metastasis Rev 27:5–10
Bertolini F, Mancuso P, Shaked Y et al (2007) Molecular and cellular biomarkers for angiogenesis in clinical oncology. Drug Discov Today 12:806–812
Shields JD, Fleury ME, Yong C et al (2007) Autologous chemotaxis as a mechanism of tumor cell homing to lymphatics via interstitial flow and autocrine CCR7 signaling. Cancer Cell 11:526–538
Nierodzik ML, Karpatkin S (2006) Thrombin induces tumor growth, metastasis, and angiogenesis: evidence for a thrombin-regulated dormant tumor phenotype. Cancer Cell 10:355–362
Podsypanina K, Du YC, Jechlinger M et al (2008) Seeding and propagation of untransformed mouse mammary cells in the lung. Science 321:1841–1844
Aguirre-Ghiso JA (2007) Models, mechanisms and clinical evidence for cancer dormancy. Nat Rev Cancer 7:834–846
Brackstone M, Townson JL, Chambers AF (2007) Tumour dormancy in breast cancer: an update. Breast Cancer Res 9:208
O'Reilly MS, Holmgren L, Shing Y et al (1994) Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. Cell 79:315–328
Norton L, Massagué J (2006) Is cancer a disease of self-seeding? Nat Med 12:875–878
Bidard FC (2008) Interactions en coopérations cellulaires dans le processus métastatique. MSc thesis. L’Université Paris XI
Benvenuti S, Comoglio PM (2007) The MET receptor tyrosine kinase in invasion and metastasis. J Cell Physiol 213:316–325
Mareel M, Leroy A (2003) Clinical, cellular, and molecular aspects of cancer invasion. Physiol Rev 83:337–376
Christofori G (2006) New signals from the invasive front. Nature 441:444–450
Sabbah M, Emami S, Redeuilh G et al (2008) Molecular signature and therapeutic perspective of the epithelial-to-mesenchymal transitions in epithelial cancers. Drug Resist Updat 11:123–151
Thiery JP, Sleeman JP (2006) Complex networks orchestrate epithelial-mesenchymal transitions. Nat Rev Mol Cell Biol 7:131–142
Yang J, Weinberg RA (2008) Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev Cell 14:818–829
Christiansen JJ, Rajasekaran AK (2006) Reassessing epithelial to mesenchymal transition as a prerequisite for carcinoma invasion and metastasis. Cancer Res 66:8319–8326
Brabletz T, Jung A, Spaderna S et al (2005) Opinion: migrating cancer stem cells—an integrated concept of malignant tumour progression. Nat Rev Cancer 5:744–749
Tarin D, Thompson EW, Newgreen DF (2005) The fallacy of epithelial mesenchymal transition in neoplasia. Cancer Res 65:5996–6000
Garber K (2008) Epithelial-to-mesenchymal transition is important to metastasis, but questions remain. J Natl Cancer Inst 100:232–239
De Wever O, Derycke L, Hendrix A et al (2007) Soluble cadherins as cancer biomarkers. Clin Exp Metastasis 24:685–697
Bellahcène A, Castronovo V, Ogbureke KU et al (2008) Small integrin-binding ligand N-linked glycoproteins (SIBLINGs): multifunctional proteins in cancer. Nat Rev Cancer 8:212–226
Gimona M, Buccione R (2006) Adhesions that mediate invasion. Int J Biochem Cell Biol 38:1875–1892
Gimona M, Buccione R, Courtneidge SA et al (2008) Assembly and biological role of podosomes and invadopodia. Curr Opin Cell Biol 20:235–241
López-Otín C, Matrisian LM (2007) Emerging roles of proteases in tumour suppression. Nat Rev Cancer 7:800–808
Martin MD, Matrisian LM (2007) The other side of MMPs: protective roles in tumor progression. Cancer Metastasis Rev 26:717–724
Sahai E (2005) Mechanisms of cancer cell invasion. Curr Opin Genet Dev 15:87–96
Wolf K, Mazo I, Leung H et al (2003) Compensation mechanism in tumor cell migration: mesenchymal-amoeboid transition after blocking of pericellular proteolysis. J Cell Biol 160:267–277
Wolf K, Friedl P (2006) Molecular mechanisms of cancer cell invasion and plasticity. Br J Dermatol 154(Suppl 1):11–15
Yilmaz M, Christofori G, Lehembre F (2007) Distinct mechanisms of tumor invasion and metastasis. Trends Mol Med 13:535–541
Wicki A, Christofori G (2007) The potential role of podoplanin in tumour invasion. Br J Cancer 96:1–5
Yamaguchi H, Condeelis J (2007) Regulation of the actin cytoskeleton in cancer cell migration and invasion. Biochim Biophys Acta 1773:642–652
Sahai E, Garcia-Medina R, Pouysségur J et al (2007) Smurf1 regulates tumor cell plasticity and motility through degradation of RhoA leading to localized inhibition of contractility. J Cell Biol 176:35–42
Gentile A, Trusolino L, Comoglio PM (2008) The Met tyrosine kinase receptor in development and cancer. Cancer Metastasis Rev 27:85–94
Lengyel E, Sawada K, Salgia R (2007) Tyrosine kinase mutations in human cancer. Curr Mol Med 7:77–84
Funasaka T, Raz A (2007) The role of autocrine motility factor in tumor and tumor microenvironment. Cancer Metastasis Rev 26:725–735
Hehlgans S, Haase M, Cordes N (2007) Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 1775:163–180
Douma S, Van Laar T, Zevenhoven J et al (2004) Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB. Nature 430:1034–1039
Geiger TR, Peeper DS (2005) The neurotrophic receptor TrkB in anoikis resistance and metastasis: a perspective. Cancer Res 65:7033–7036
Sandri MT (2007) Circulating tumor cells. IEO—Scientific Report 2007—Ongoing research 2008; pp 192–194
Gnerlich J, Jeffe DB, Deshpande AD et al (2007) Surgical removal of the primary tumor increases overall survival in patients with metastatic breast cancer: analysis of the 1988–2003 SEER data. Ann Surg Oncol 14:2187–2194
Salama JK, Chmura SJ, Mehta N et al (2008) An initial report of a radiation dose-escalation trial in patients with one to five sites of metastatic disease. Clin Cancer Res 14:5255–5259
Dollé L, Depypere HT, Bracke ME (2006) Anti-invasive/anti-metastasis strategies: new roads, new tools and new hopes. Curr Cancer Drug Targets 6:729–751
Fox SB, Generali DG, Harris AL (2007) Breast tumour angiogenesis. Breast Cancer Res 9:216
Shaked Y, Kerbel RS (2007) Antiangiogenic strategies on defense: on the possibility of blocking rebounds by the tumor vasculature after chemotherapy. Cancer Res 67:7055–7058
Formenti SC, Demaria S (2008) Local control by radiotherapy: is that all there is? Breast Cancer Res 10:215
Hüsemann Y, Geigl JB, Schubert F et al (2008) Systemic spread is an early step in breast cancer. Cancer Cell 13:58–68
Denys H, Derycke L, Hendrix A et al (2008) Differential impact of TGF-beta and EGF on fibroblast differentiation and invasion reciprocally promotes colon cancer cell invasion. Cancer Lett 266:263–274
Milas L, Mason K, Liao Z et al (2003) Role of cyclooxygenase-2 (COX-2) and its inhibition in tumor biology and radiotherapy. In: Nieder C, Milas L, Ang KK (eds) Modification of radiation response. Springer, Berlin, pp 241–258
Opdenakker G, Van Damme J (2004) The countercurrent principle in invasion and metastasis of cancer cells. Recent insights on the roles of chemokines. Int J Dev Biol 48:519–527
Nugent JL, Bunn PA Jr, Matthews MJ et al (1979) CNS metastases in small cell bronchogenic carcinoma: increasing frequency and changing pattern with lengthening survival. Cancer 44:1885–1893
Camphausen K, Moses MA, Beecken WD et al (2001) Radiation therapy to a primary tumor accelerates metastatic growth in mice. Cancer Res 61:2207–2211
Ramaswamy S, Ross KN, Lander ES et al (2003) A molecular signature of metastasis in primary solid tumors. Nat Genet 33:49–54
Chen YJ, Lin SC, Kao T et al (2004) Genome-wide profiling of oral squamous cell carcinoma. J Pathol 204:326–332
Perou CM, Sørlie T, Eisen MB et al (2000) Molecular portraits of human breast tumours. Nature 406:747–752
LaTulippe E, Satagopan J, Smith A et al (2002) Comprehensive gene expression analysis of prostate cancer reveals distinct transcriptional programs associated with metastatic disease. Cancer Res 62:4499–4506
Lapointe J, Li C, Giacomini CP et al (2007) Genomic profiling reveals alternative genetic pathways of prostate tumorigenesis. Cancer Res 67:8504–8510
Lips EH, van Eijk R, de Graaf EJ et al (2008) Integrating chromosomal aberrations and gene expression profiles to dissect rectal tumorigenesis. BMC Cancer 8:314
Cromer A, Carles A, Millon R et al (2004) Identification of genes associated with tumorigenesis and metastatic potential of hypopharyngeal cancer by microarray analysis. Oncogene 23:2484–2498
Couvelard A, Hu J, Steers G et al (2006) Identification of potential therapeutic targets by gene-expression profiling in pancreatic endocrine tumors. Gastroenterology 131:1597–1610
Bertucci F, Finetti P, Rougemont J et al (2004) Gene expression profiling for molecular characterization of inflammatory breast cancer and prediction of response to chemotherapy. Cancer Res 64:8558–8565