Cancer cell mechanobiology: a new frontier for cancer research

Journal of the National Cancer Center - Tập 2 - Trang 10-17 - 2022
Weibo Yu1, Shivani Sharma1, Elizabeth Rao1, Amy C. Rowat2, James K. Gimzewski3, Dong Han4, Jianyu Rao1
1Department of Pathology and Laboratory Medicine, University of California at Los Angeles, California, USA
2Department of Integrative Biology and Physiology, University of California at Los Angeles, California, USA
3Department of Chemistry and Biochemistry, University of California at Los Angeles, California, USA
4National Center for Nanoscience and Technology, Beijing, China

Tài liệu tham khảo

Bhadriraju, 2002, Extracellular matrix- and cytoskeleton-dependent changes in cell shape and stiffness, Experimental cell research, 278, 92, 10.1006/excr.2002.5557 de Las Heras, 2013, Cancer biology and the nuclear envelope: a convoluted relationship, Semin Cancer Biol, 23, 125, 10.1016/j.semcancer.2012.01.008 Fedorchak, 2014, Cellular mechanosensing: getting to the nucleus of it all, Prog Biophys Mol Biol, 115, 76, 10.1016/j.pbiomolbio.2014.06.009 Cross, 2007, Nanomechanical analysis of cells from cancer patients, Nat Nanotechnol, 2, 780, 10.1038/nnano.2007.388 Nyberg, 2018, Predicting cancer cell invasion by single-cell physical phenotyping, Integr Biol (Camb), 10, 218, 10.1039/C7IB00222J Cross, 2011, Green tea extract selectively targets nanomechanics of live metastatic cancer cells, Nanotechnology, 22, 10.1088/0957-4484/22/21/215101 Cross, 2008, AFM-based analysis of human metastatic cancer cells, Nanotechnology, 19, 10.1088/0957-4484/19/38/384003 Sharma, 2012, Correlative nanomechanical profiling with super-resolution F-actin imaging reveals novel insights into mechanisms of cisplatin resistance in ovarian cancer cells, Nanomedicine, 8, 757, 10.1016/j.nano.2011.09.015 Sharma, 2014, The role of Rho GTPase in cell stiffness and cisplatin resistance in ovarian cancer cells, Integr Biol (Camb), 6, 611, 10.1039/C3IB40246K Gossett, 2012, Hydrodynamic stretching of single cells for large population mechanical phenotyping, Proc Natl Acad Sci U S A, 109, 7630, 10.1073/pnas.1200107109 Tse, 2013, Quantitative diagnosis of malignant pleural effusions by single-cell mechanophenotyping, Sci Transl Med, 5, 10.1126/scitranslmed.3006559 Dhar, 2016, Label-free enumeration, collection and downstream cytological and cytogenetic analysis of circulating tumor cells, Sci Rep, 6, 35474, 10.1038/srep35474 Edwards, 1999, Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics, Nat Cell Bio, 1, 253, 10.1038/12963 Huang, 1997, Down-regulation of the filamentous actin cross-linking activity of cortactin by Src-mediated tyrosine phosphorylation, J Bio Chem, 272, 13911, 10.1074/jbc.272.21.13911 Rao, 2002, Tissue microarray analysis of cytoskeletal actin-associated biomarkers gelsolin and E-cadherin in urothelial carcinoma, Cancer, 95, 1247, 10.1002/cncr.10823 Rao, 1990, Cellular F-Actin Levels as a Marker for Cellular Transformation: Relationship to Cell Division and Differentiation, Cancer Res, 50, 2215 Rao, 1993, Alterations in phenotypic biochemical markers in bladder epithelium during tumorigenesis, Proc Natl Acad Sci U S A, 90, 8287, 10.1073/pnas.90.17.8287 Lu, 2005, Green tea extract modulates actin remodeling via Rho activity in an in vitro multistep carcinogenic model, Clin Cancer Res, 11, 1675, 10.1158/1078-0432.CCR-04-1608 Lu, 2007, Green tea induces annexin-I expression in human lung adenocarcinoma A549 cells: involvement of annexin-I in actin remodeling, Lab Invest, 87, 456, 10.1038/labinvest.3700534 Hemstreet, 2001, Biomarker risk assessment and bladder cancer detection in a cohort exposed to benzidine, J Natl Cancer Inst, 93, 427, 10.1093/jnci/93.6.427 Rao, 2004, Microfilament Actin Remodeling as a Potential Target for Cancer Drug Development, Curr Cancer Drug Targets, 4, 345, 10.2174/1568009043332998 Caille, 2002, Contribution of the nucleus to the mechanical properties of endothelial cells, J Biomech, 35, 177, 10.1016/S0021-9290(01)00201-9 Lammerding, 2011, Mechanics of the nucleus, Compr Physiol, 1, 783, 10.1002/cphy.c100038 Peter, 2012, Evolution of the lamin protein family: what introns can tell, Nucleus, 3, 44, 10.4161/nucl.18927 Rowat, 2006, Mechanical properties of the cell nucleus and the effect of emerin deficiency, Biophys J, 91, 4649, 10.1529/biophysj.106.086454 Schape, 2009, Influence of lamin A on the mechanical properties of amphibian oocyte nuclei measured by atomic force microscopy, Biophys J, 96, 4319, 10.1016/j.bpj.2009.02.048 Rowat, 2013, Nuclear envelope composition determines the ability of neutrophil-type cells to passage through micron-scale constrictions, J Biol Chem, 288, 8610, 10.1074/jbc.M112.441535 Swift, 2013, Nuclear lamin-A scales with tissue stiffness and enhances matrix-directed differentiation, Science, 341, 10.1126/science.1240104 Sullivan, 1999, Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy, J Cell Biol, 147, 913, 10.1083/jcb.147.5.913 Puckelwartz, 2011, Gene expression, chromosome position and lamin A/C mutations, Nucleus, 2, 162, 10.4161/nucl.2.3.16003 Simon, 2013, Partners and post-translational modifications of nuclear lamins, Chromosoma, 122, 13, 10.1007/s00412-013-0399-8 Mislow, 2002, Nesprin-1alpha self-associates and binds directly to emerin and lamin A in vitro, FEBS Lett, 525, 135, 10.1016/S0014-5793(02)03105-8 Provenzano, 2009, Matrix density-induced mechanoregulation of breast cell phenotype, signaling and gene expression through a FAK-ERK linkage, Oncogene, 28, 4326, 10.1038/onc.2009.299 Lo, 2000, Cell movement is guided by the rigidity of the substrate, Biophys J, 79, 144, 10.1016/S0006-3495(00)76279-5 Riching, 2014, 3D collagen alignment limits protrusions to enhance breast cancer cell persistence, Biophys J, 107, 2546, 10.1016/j.bpj.2014.10.035 Bordeleau, 2014, Physical biology in cancer. 5. The rocky road of metastasis: the role of cytoskeletal mechanics in cell migratory response to 3D matrix topography, Am J Physiol Cell Physiol, 306, C110, 10.1152/ajpcell.00283.2013 Wolf, 2009, Mapping proteolytic cancer cell-extracellular matrix interfaces, Clin Exp Metastasis, 26, 289, 10.1007/s10585-008-9190-2 Kraning-Rush, 2013, Microfabricated collagen tracks facilitate single cell metastatic invasion in 3D, Integr Biol (Camb), 5, 606, 10.1039/c3ib20196a Levental, 2009, Matrix crosslinking forces tumor progression by enhancing integrin signaling, Cell, 139, 891, 10.1016/j.cell.2009.10.027 Wolf, 2007, Multi-step pericellular proteolysis controls the transition from individual to collective cancer cell invasion, Nat Cell Biol, 9, 893, 10.1038/ncb1616 Jansen, 2015, A guide to mechanobiology: Where biology and physics meet, Biochim Biophys Acta, 1853, 3043, 10.1016/j.bbamcr.2015.05.007 Goldmann, 2013, Vinculin, cell mechanics and tumour cell invasion, Cell Biol Int, 37, 397, 10.1002/cbin.10064 Joyce, 2015, T cell exclusion, immune privilege, and the tumor microenvironment, Science, 348, 74, 10.1126/science.aaa6204 Handorf, 2015, Tissue stiffness dictates development, homeostasis, and disease progression, Organogenesis, 11, 1, 10.1080/15476278.2015.1019687 Paszek, 2004, The tension mounts: mechanics meets morphogenesis and malignancy, J Mammary Gland Biol Neoplasia, 9, 325, 10.1007/s10911-004-1404-x Paszek, 2005, Tensional homeostasis and the malignant phenotype, Cancer Cell, 8, 241, 10.1016/j.ccr.2005.08.010 Griffith, 2006, Capturing complex 3D tissue physiology in vitro, Nat Rev Mol Cell Biol, 7, 211, 10.1038/nrm1858 Fraley, 2010, A distinctive role for focal adhesion proteins in three-dimensional cell motility, Nat Cell Biol, 12, 598, 10.1038/ncb2062 Karreman, 2016, Intravital Correlative Microscopy: Imaging Life at the Nanoscale, Trends Cell Biol, 26, 848, 10.1016/j.tcb.2016.07.003 Yang, 2011, The Emergence of AFM Applications to Cell Biology: How new technologies are facilitating investigation of human cells in health and disease at the nanoscale, J Nanosci Lett, 1, 87 Yallapu, 2015, The roles of cellular nanomechanics in cancer, Med Res Rev, 35, 198, 10.1002/med.21329 Binnig, 1986, Atomic force microscope, Physical review letters, 56, 930, 10.1103/PhysRevLett.56.930 Nyberg, 2016, The physical origins of transit time measurements for rapid, single cell mechanotyping, Lab Chip, 16, 3330, 10.1039/C6LC00169F Nyberg, 2017, Quantitative Deformability Cytometry: Rapid, Calibrated Measurements of Cell Mechanical Properties, Biophys J, 113, 1574, 10.1016/j.bpj.2017.06.073 Li, 2008, AFM indentation study of breast cancer cells, Biochem Biophys Res Commun, 374, 609, 10.1016/j.bbrc.2008.07.078 Corbin, 2015, Biophysical properties of human breast cancer cells measured using silicon MEMS resonators and atomic force microscopy, Lab Chip, 15, 839, 10.1039/C4LC01179A Hou, 2009, Deformability study of breast cancer cells using microfluidics, Biomed Microdevices, 11, 557, 10.1007/s10544-008-9262-8 Guck, 2005, Optical deformability as an inherent cell marker for testing malignant transformation and metastatic competence, Biophys J, 88, 3689, 10.1529/biophysj.104.045476 Plodinec, 2012, The nanomechanical signature of breast cancer, Nat Nanotechnol, 7, 757, 10.1038/nnano.2012.167 Lekka, 2012, Cancer cell detection in tissue sections using AFM, Arch Biochem Biophys, 518, 151, 10.1016/j.abb.2011.12.013 Lekka, 2012, Atomic force microscopy: A tip for diagnosing cancer, Nat Nanotechnol, 7, 691, 10.1038/nnano.2012.196 Samani, 2004, A method to measure the hyperelastic parameters of ex vivo breast tissue samples, Phys Med Biol, 49, 4395, 10.1088/0031-9155/49/18/014 Lekka, 1999, Elasticity of normal and cancerous human bladder cells studied by scanning force microscopy, Eur Biophys J, 28, 312, 10.1007/s002490050213 Canetta, 2014, Discrimination of bladder cancer cells from normal urothelial cells with high specificity and sensitivity: combined application of atomic force microscopy and modulated Raman spectroscopy, Acta Biomater, 10, 2043, 10.1016/j.actbio.2013.12.057 Lekka, 2012, Cancer cell recognition-mechanical phenotype, Micron, 43, 1259, 10.1016/j.micron.2012.01.019 Xu, 2012, Cell stiffness is a biomarker of the metastatic potential of ovarian cancer cells, PLoS One, 7, e46609, 10.1371/journal.pone.0046609 Babahosseini, 2014, Biomechanical profile of cancer stem-like/tumor-initiating cells derived from a progressive ovarian cancer model, Nanomedicine, 10, 1013, 10.1016/j.nano.2013.12.009 Swaminathan, 2011, Mechanical stiffness grades metastatic potential in patient tumor cells and in cancer cell lines, Cancer Res, 71, 5075, 10.1158/0008-5472.CAN-11-0247 Ding, 2015, Mechanical characterization of cervical squamous carcinoma cells by atomic force microscopy at nanoscale, Med Oncol, 32, 71, 10.1007/s12032-015-0507-0 Palmieri, 2014, Biomechanical investigation of colorectal cancer cells, Appl Phys Lett, 105, 10.1063/1.4896161 Tang, 2014, A mechanically-induced colon cancer cell population shows increased metastatic potential, Mol Cancer, 13, 131, 10.1186/1476-4598-13-131 Rebelo, 2013, Comparison of the viscoelastic properties of cells from different kidney cancer phenotypes measured with atomic force microscopy, Nanotechnology, 24, 10.1088/0957-4484/24/5/055102 Suganuma, 2013, Abstract 2640A: Cell stiffness as a new indicator of diagnosis for human lung cancer cells and their metastasis, Cancer Res, 73, 2640A, 10.1158/1538-7445.AM2013-2640A Watanabe, 2012, Higher cell stiffness indicating lower metastatic potential in B16 melanoma cell variants and in (-)-epigallocatechin gallate-treated cells, J Cancer Res Clin Oncol, 138, 859, 10.1007/s00432-012-1159-5 Faria, 2008, Measurement of elastic properties of prostate cancer cells using AFM, Analyst, 133, 1498, 10.1039/b803355b Chen, 2013, Single-cell analysis of circulating tumor cells identifies cumulative expression patterns of EMT-related genes in metastatic prostate cancer, Prostate, 73, 813, 10.1002/pros.22625 Ahn, 2010, Mechanical property characterization of prostate cancer using a minimally motorized indenter in an ex vivo indentation experiment, Urology, 76, 1007, 10.1016/j.urology.2010.02.025 Shin, 2013, Robotic mechanical localization of prostate cancer correlates with magnetic resonance imaging scans, Yonsei Med J, 54, 907, 10.3349/ymj.2013.54.4.907 Fuhrmann, 2011, AFM stiffness nanotomography of normal, metaplastic and dysplastic human esophageal cells, Phys Biol, 8, 10.1088/1478-3975/8/1/015007 Prabhune, 2012, Comparison of mechanical properties of normal and malignant thyroid cells, Micron, 43, 1267, 10.1016/j.micron.2012.03.023 Tan, 2010, Mechanical characterization of human red blood cells under different osmotic conditions by robotic manipulation with optical tweezers, IEEE Trans Biomed Eng, 57, 1816, 10.1109/TBME.2010.2042448 Tan, 2013 Rosenbluth, 2006, Force microscopy of nonadherent cells: a comparison of leukemia cell deformability, Biophys J, 90, 2994, 10.1529/biophysj.105.067496 Tan, 2011, Biophysical characterization of hematopoietic cells from normal and leukemic sources with distinct primitiveness, Appl Phys Lett, 99, 083702, 10.1063/1.3610938 Zheng, 2015, Decreased deformability of lymphocytes in chronic lymphocytic leukemia, Sci Rep, 5, 7613, 10.1038/srep07613 Shojaei-Baghini, 2013, Automated micropipette aspiration of single cells, Ann Biomed Eng, 41, 1208, 10.1007/s10439-013-0791-9 Luo, 2016, Cell stiffness determined by atomic force microscopy and its correlation with cell motility, Biochim Biophys Acta, 1860, 1953, 10.1016/j.bbagen.2016.06.010 Omidvar, 2014, Atomic force microscope-based single cell force spectroscopy of breast cancer cell lines: an approach for evaluating cellular invasion, J Biomech, 47, 3373, 10.1016/j.jbiomech.2014.08.002 Hayashi, 2015, Stiffness of cancer cells measured with an AFM indentation method, J Mech Behav Biomed Mater, 49, 105, 10.1016/j.jmbbm.2015.04.030 Alibert, 2017, Are cancer cells really softer than normal cells?, Biol Cell, 109, 167, 10.1111/boc.201600078 Liu, 2015, Vimentin contributes to epithelial-mesenchymal transition cancer cell mechanics by mediating cytoskeletal organization and focal adhesion maturation, Oncotarget, 6, 15966, 10.18632/oncotarget.3862 Kim, 2016, Cancer cells become less deformable and more invasive with activation of beta-adrenergic signaling, J Cell Sci, 129, 4563 Yu, 2020, Single Cell Mechanotype and Associated Molecular Changes in Urothelial Cell Transformation and Progression, Front Cell Dev Biol, 8, 10.3389/fcell.2020.601376 Sokolov, 2018, Non-invasive diagnostic imaging using machine-learning analysis of nanoresolution images of cell surfaces: Detection of bladder cancer, Proc Natl Acad Sci U S A, 115, 12920, 10.1073/pnas.1816459115 Dasgupta, 2017, Circulating and disseminated tumor cells: harbingers or initiators of metastasis?, Mol Oncol, 11, 40, 10.1002/1878-0261.12022 Karabacak, 2014, Microfluidic, marker-free isolation of circulating tumor cells from blood samples, Nat Protoc, 9, 694, 10.1038/nprot.2014.044 Sullivan, 2010, Urine cytology and adjunct markers for detection and surveillance of bladder cancer, Am J Transl Res, 2, 412 Wickramaratne, 2015, Fine Needle Elastography (FNE) device for biomechanically determining local variations of tissue mechanical properties, J Biomech, 48, 81, 10.1016/j.jbiomech.2014.10.038 Sharma, 2019, Piezoelectric needle sensor reveals mechanical heterogeneity in human thyroid tissue lesions, Sci Rep, 9, 9282, 10.1038/s41598-019-45730-x Schillers, 2017, Standardized Nanomechanical Atomic Force Microscopy Procedure (SNAP) for Measuring Soft and Biological Samples, Sci Rep, 7, 5117, 10.1038/s41598-017-05383-0 Stylianou, 2018, AFM assessing of nanomechanical fingerprints for cancer early diagnosis and classification: from single cell to tissue level, Nanoscale, 10, 20930, 10.1039/C8NR06146G Lekka, 2016, Discrimination Between Normal and Cancerous Cells Using AFM, Bionanoscience, 6, 65, 10.1007/s12668-016-0191-3 Tian, 2015, The nanomechanical signature of liver cancer tissues and its molecular origin, Nanoscale, 7, 12998, 10.1039/C5NR02192H Radhakrishnan, 2017, Machine Learning for Nuclear Mechano-Morphometric Biomarkers in Cancer Diagnosis, Sci Rep, 7, 17946, 10.1038/s41598-017-17858-1 Jain, 2007, Effect of vascular normalization by antiangiogenic therapy on interstitial hypertension, peritumor edema, and lymphatic metastasis: insights from a mathematical model, Cancer Res, 67, 2729, 10.1158/0008-5472.CAN-06-4102 Stylianopoulos, 2017, The Solid Mechanics of Cancer and Strategies for Improved Therapy, J Biomech Eng, 139, 10.1115/1.4034991 Jain, 2014, Antiangiogenesis strategies revisited: from starving tumors to alleviating hypoxia, Cancer Cell, 26, 605, 10.1016/j.ccell.2014.10.006 Barsoum, 2014, Mechanisms of hypoxia-mediated immune escape in cancer, Cancer Res, 74, 7185, 10.1158/0008-5472.CAN-14-2598 Stylianopoulos, 2012, Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors, Proc Natl Acad Sci U S A, 109, 15101, 10.1073/pnas.1213353109 Diop-Frimpong, 2011, Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors, Proc Natl Acad Sci U S A, 108, 2909, 10.1073/pnas.1018892108 Olive, 2009, Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer, Science, 324, 1457, 10.1126/science.1171362 Zhang, 2018, Targeting Biophysical Cues: a Niche Approach to Study, Diagnose, and Treat Cancer, Trends Cancer, 4, 268, 10.1016/j.trecan.2018.02.006 Liu, 2017, Mechanoresponsive stem cells to target cancer metastases through biophysical cues, Sci Transl Med, 9, 10.1126/scitranslmed.aan2966