Cancer-Related Fatigue: The Scale of the Problem
Tóm tắt
Fatigue is one of the most common and debilitating symptoms experienced by patients with cancer. Cancer-related fatigue (CRF) is characterized by feelings of tiredness, weakness, and lack of energy, and is distinct from the “normal” drowsiness experienced by healthy individuals in that it is not relieved by rest or sleep. It occurs both as a consequence of the cancer itself and as a side effect of cancer treatment, although the precise underlying pathophysiology is largely unknown. CRF may be an early symptom of malignant disease and is reported by as many as 40% of patients at diagnosis. Virtually all patients expect fatigue from cancer therapy. Up to 90% of patients treated with radiation and up to 80% of those treated with chemotherapy experience fatigue. CRF continues for months and even years ollowing completion of treatment in approximately one third of the patients with cancer. The impact of CRF on a patient's quality of life (QoL), particularly in relation to physical functioning and the ability to perform activities of daily living, is both profound and pervasive. In addition, CRF is associated with considerable psychological distress and can impose a significant financial burden by limiting a patient's ability to work. These effects can extend to caregivers and family members, who may also have to reduce their working capacity in order to provide additional care for a patient with CRF. This paper examines the prevalence of CRF and explores the impact of this distressing symptom on patients' functioning and QoL.
Disclosure of potential conflicts of interest is found at the end of this article.
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Tài liệu tham khảo
Cella, 2001, Cancer-related fatigue: Prevalence of proposed diagnostic criteria in a United States sample of cancer survivors, J Clin Oncol, 19, 3385, 10.1200/JCO.2001.19.14.3385
Irvine, 1994, The prevalence and correlates of fatigue in patients receiving treatment with chemotherapy and radiotherapy. A comparison with the fatigue experienced by healthy individuals, Cancer Nurs, 17, 367, 10.1097/00002820-199410000-00001
Stone, 1999, Fatigue in advanced cancer: A prospective controlled cross-sectional study, Br J Cancer, 79, 1479, 10.1038/sj.bjc.6690236
Andrykowski, 1998, Off-treatment fatigue in breast cancer survivors: A controlled comparison, J Behav Med, 21, 1, 10.1023/A:1018700303959
Broeckel, 1998, Characteristics and correlates of fatigue after adjuvant chemotherapy for breast cancer, J Clin Oncol, 16, 1689, 10.1200/JCO.1998.16.5.1689
Loge, 2000, Fatigue and psychiatric morbidity among Hodgkin's disease survivors, J Pain Symptom Manage, 19, 91, 10.1016/S0885-3924(99)00148-7
Smets, 1998, Fatigue and radiotherapy: (A) Experience in patients undergoing treatment, Br J Cancer, 78, 899, 10.1038/bjc.1998.599
Smets, 1998, Fatigue and radiotherapy: (B) Experience in patients 9 months following treatment, Br J Cancer, 78, 907, 10.1038/bjc.1998.600
World Health Organization, 2007, International Statistical Classification of Diseases and Related Health Problems
Mock, 2000, NCCN Practice Guidelines for Cancer-Related Fatigue, Oncology (Williston Park), 14, 151
National Institutes of Health Consensus Development Panel, 2006, Symptom Management in Cancer: Pain, Depression, and Fatigue
Glaus, 1996, A qualitative study to explore the concept of fatigue/tiredness in cancer patients and in healthy individuals, Support Care Cancer, 4, 82, 10.1007/BF01845757
American Cancer Society, 2006, Surveillance Research: Estimated New Cancer Cases and Deaths by Sex for All Sites, US, 2005
American Cancer Society, 2006, Surveillance Research: Estimated New Cancer Cases and Deaths by Sex for All Sites, US, 2006
Hofman, 2004, Cancer patients' expectations of experiencing treatment-related side effects: A University of Rochester Cancer Center–Community Clinical Oncology Program study of 938 patients from community practices, Cancer, 101, 851, 10.1002/cncr.20423
Lawrence, 2004, Evidence report on the occurrence, assessment, and treatment of fatigue in cancer patients, J Natl Cancer Inst Monogr, 40, 10.1093/jncimonographs/lgh027
Jacobsen, 2004, Assessment of fatigue in cancer patients, J Natl Cancer Inst Monogr, 93, 10.1093/jncimonographs/lgh010
Hurny, 1993, “Fatigue and malaise” as a quality-of-life indicator in small-cell lung cancer patients. The Swiss Group for Clinical Cancer Research (SAKK), Support Care Cancer, 1, 316, 10.1007/BF00364969
Hickok, 1996, Frequency and correlates of fatigue in lung cancer patients receiving radiation therapy: Implications for management, J Pain Symptom Manage, 11, 370, 10.1016/0885-3924(96)00008-5
Jacobsen, 1999, Fatigue in women receiving adjuvant chemotherapy for breast cancer: Characteristics, course, and correlates, J Pain Symptom Manage, 18, 233, 10.1016/S0885-3924(99)00082-2
Gaston-Johansson, 1999, Fatigue, pain, and depression in pre-autotransplant breast cancer patients, Cancer Pract, 7, 240, 10.1046/j.1523-5394.1999.75008.x
Monga, 1999, Prospective study of fatigue in localized prostate cancer patients undergoing radiotherapy, Radiat Oncol Investig, 7, 178, 10.1002/(SICI)1520-6823(1999)7:3<178::AID-ROI7>3.0.CO;2-0
Stone, 2000, Fatigue in patients with prostate cancer receiving hormone therapy, Eur J Cancer, 36, 1134, 10.1016/S0959-8049(00)00084-8
Forlenza, 2005, Epidemiology of cancer-related fatigue in the Swedish Twin Registry, Cancer, 104, 2022, 10.1002/cncr.21373
Hickok, 2005, Occurrence, severity, and longitudinal course of twelve common symptoms in 1129 consecutive patients during radiotherapy for cancer, J Pain Symptom Manage, 30, 433, 10.1016/j.jpainsymman.2005.04.012
Hofman, 2005, Cancer treatment side effects in breast cancer patients receiving radiation therapy, J Clin Oncol, 23, 705, 10.1200/jco.2005.23.16_suppl.705
Nail, 2004, My get up and go got up and went: Fatigue in people with cancer, J Natl Cancer Inst Monogr, 72, 10.1093/jncimonographs/lgh021
Curran, 2004, Ecological momentary assessment of fatigue following breast cancer treatment, J Behav Med, 27, 425, 10.1023/B:JOBM.0000047608.03692.0c
Schwartz, 2000, Fatigue patterns observed in patients receiving chemotherapy and radiotherapy, Cancer Invest, 18, 11, 10.3109/07357900009023057
Curt, 2000, Impact of cancer-related fatigue on the lives of patients: New findings from the Fatigue Coalition, The Oncologist, 5, 353, 10.1634/theoncologist.5-5-353
Bower, 2000, Fatigue in breast cancer survivors: Occurrence, correlates, and impact on quality of life, J Clin Oncol, 18, 743, 10.1200/JCO.2000.18.4.743
Bower, 2006, Fatigue in long-term breast carcinoma survivors: A longitudinal investigation, Cancer, 106, 751, 10.1002/cncr.21671
Bower, 2003, T-cell homeostastis in breast cancer survivors with persistent fatigue, J Natl Cancer Inst, 95, 1165, 10.1093/jnci/djg0019
Payne, 2002, The trajectory of fatigue in adult patients with breast and ovarian cancer receiving chemotherapy, Oncol Nurs Forum, 29, 1334, 10.1188/02.ONF.1334-1340
Ahlberg, 2005, Fatigue, psychological distress, coping resources, and functional status during radiotherapy for uterine cancer, Oncol Nurs Forum, 32, 633, 10.1188/05.ONF.633-640
Maher, 2000, Cancer Nursing: Principles and Practice, 323
Marty, 2001, Factors related to fatigue in cancer patients: The key to specific therapeutic approaches, Eur School Oncol Sci Update, 5, 33
Curt, 2001, Fatigue and Cancer, 3
Stone, 2000, Cancer-related fatigue: Inevitable, unimportant and untreatable? Results of a multi-centre patient survey. Cancer Fatigue Forum, Ann Oncol, 11, 971, 10.1023/A:1008318932641
Vogelzang, 1997, Patient, caregiver, and oncologist perceptions of cancer-related fatigue: Results of a tripart assessment survey. The Fatigue Coalition., Semin Hematol, 34, 4
Crawford, 2000, Therapeutic Options for Anemia and Fatigue, Medscape Oncology
Brown, 2005, The correlation between fatigue, physical function, the systemic inflammatory response, and psychological distress in patients with advanced lung cancer, Cancer, 103, 377, 10.1002/cncr.20777
Mallinson, 2006, Giving meaning to measure: Linking self-reported fatigue and function to performance of everyday activities, J Pain Symptom Manage, 31, 229, 10.1016/j.jpainsymman.2005.07.012
Ahlberg, 2004, Fatigue, psychological distress, coping and quality of life in patients with uterine cancer, J Adv Nurs, 45, 205, 10.1046/j.1365-2648.2003.02882.x
Flechtner, 1998, Quality of life assessment in Hodgkin's disease: A new comprehensive approach. First experience from the EORTC/GELA and GHSG trials, Ann Oncol, 9, 147, 10.1093/annonc/9.suppl_5.S147
Holzner, 2003, Fatigue in ovarian carcinoma patients: A neglected issue?, Cancer, 97, 1564, 10.1002/cncr.11253
Monga, 2005, Longitudinal study of quality of life in patients with localized prostate cancer undergoing radiotherapy, J Rehabil Res Dev, 42, 391, 10.1682/JRRD.2004.06.0071
Dimeo, 1999, Effects of physical activity on the fatigue and psychologic status of cancer patients during chemo-therapy, Cancer, 85, 2273, 10.1002/(SICI)1097-0142(19990515)85:10<2273::AID-CNCR24>3.0.CO;2-B
Stone, 2000, A study to investigate the prevalence, severity and correlates of fatigue among patients with cancer in comparison with a control group of volunteers without cancer, Ann Oncol, 11, 561, 10.1023/A:1008331230608
McDaniel, 1995, Depression in patients with cancer: Diagnosis, biology, and treatment, Arch Gen Psychiatry, 52, 89, 10.1001/archpsyc.1995.03950140007002
Irvine, 1998, Fatigue in women with breast cancer receiving radiation therapy, Cancer Nurs, 21, 127, 10.1097/00002820-199804000-00006
Tchekmedyian, 2003, The relationship between psychologic distress and cancer-related fatigue, Cancer, 98, 198, 10.1002/cncr.11463
Berndt, 2005, Reductions in anaemia and fatigue are associated with improvements in productivity in cancer patients receiving chemotherapy, Pharmacoeconomics, 23, 505, 10.2165/00019053-200523050-00009
Mormont, 2000, Marked 24-h rest/activity rhythms are associated with better quality of life, better response, and longer survival in patients with metastatic colorectal cancer and good performance status, Clin Cancer Res, 6, 3038