Cancer Chemopreventive Effect of Bergenin from Peltophorum pterocarpum Wood

Wiley - Tập 10 Số 10 - Trang 1866-1875 - 2013
Jie Zhang1, Yoshihiro Nishimoto1, Harukuni Tokuda2, Nobutaka Suzuki2, Ken Yasukawa3, Worapong Kitdamrongtham4,5, Hiroyuki Akazawa4,5, Aranya Manosroi4,5, Jiradej Manosroi4,5, Toshihiro Akihisa1
1College of Science and Technology, Nihon University, 1-8-14 Kanda Surugadai, Chiyoda-ku, Tokyo 101-8308, Japan
2Graduate School of Medical Science, Kanazawa University, 13-1 Takara-machi, Kanazawa 920-8640, Japan
3School of Pharmacy, Nihon University, 7-7-1 Narashinodai, Funabashi-shi, Chiba 274-8555, Japan
4Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand, (phone: +66-53-944338
5fax: +66-53-894169)

Tóm tắt

AbstractThe aqueous extract of Peltophorum pterocarpum (Fabaceae) wood exhibited potent inhibitory effects against EpsteinBarr virus early antigen (EBV‐EA) activation induced with 12‐O‐tetradecanoylphorbol‐13‐acetate (TPA) in Raji cells and against melanogenesis in α‐melanocyte‐stimulating hormone (α‐MSH)‐stimulated B16 melanoma cells, as well as potent 1,1‐diphenyl‐2‐picrylhydrazyl (DPPH) free radical‐scavenging activity. Two phenolic acid derivatives, bergenin (1) and gallic acid (2), were isolated from the ethyl acetate (AcOEt)‐soluble fraction obtained from the extract. Compound 1 exhibited potent inhibitory effect against EBV‐EA activation and against skin tumor promotion in an in vivo two‐stage mouse skin carcinogenesis test based on 7,12‐dimethylbenz[a]anthracene (DMBA) as initiator, and with TPA as promoter. Both compounds 1 and 2 exhibited melanogenesis‐inhibitory activities in α‐MSH‐stimulated B16 melanoma cells, and, in addition, compound 2 showed strong DPPH radical‐scavenging activity.

Từ khóa


Tài liệu tham khảo

Jain S. C., 2011, Int. J. Phytomed. Rel. Ind., 3, 265

10.1016/j.jep.2004.03.036

10.1248/jhs.54.81

10.1016/j.foodchem.2011.05.041

Sethuraman M. G., 1984, Fitoterapia, 55, 177

10.1186/1472-6882-6-35

10.3923/rjmp.2011.274.280

Raju B., 2011, Int. J. Phytopharmacol., 2, 1

Islam M. S., 2011, Int. J. Pharm. Sci. Res., 2, 2309

Satish S., 2007, J. Agric. Technol., 3, 109

Islam M. S., 2011, J. Med. Plants Res., 5, 3745

Menon P. S., 1982, Indian Drugs, 19, 345

Swarnalakshmi T., 1984, Curr. Sci., 53, 917

10.1016/S2221-1691(12)60333-5

10.1590/S0103-50532009000600009

10.1021/np200232s

Chauhan R., 2012, Int. J. Pharm. Sci. Rev. Res., 14, 139

X.Piegen in ‘Natural Products as Medicinal Agents’ Ed. J. L. Beal E. Reinhard Hippokrates Verlag Stuttgart 1980 p. 100.

10.1002/ptr.2650060403

10.1016/j.fitote.2011.12.008

10.1021/np960074h

10.1055/s-2002-26758

10.1016/S0378-8741(99)00137-3

10.1016/S0378-8741(00)00260-9

10.1159/000056115

10.1016/j.bmcl.2005.06.013

10.1016/S0968-0896(02)00666-1

Goel R. K., 1997, Indian J. Exp. Biol., 35, 1080

10.1016/0306-3623(80)90100-7

10.1016/S1537-1891(03)00042-9

10.1016/j.bmc.2005.09.047

10.1016/j.jep.2007.06.006

10.1039/b804385j

10.1046/j.1365-3059.1997.d01-220.x

10.1016/j.bmcl.2011.04.131

10.1021/np980107o

10.1016/j.jep.2012.05.012

10.1016/0031-9422(91)83676-C

10.1111/j.1745-7254.2007.00685.x

10.1016/0304-3835(92)90208-D

10.1007/s12272-009-1309-8

10.1080/14786419.2010.488631

10.1016/j.tips.2005.04.004

10.1038/nrc969

10.5650/jos.59.49

10.1248/bpb.28.1404

10.1021/np100402b

10.1021/jf040199p

10.5650/jos.59.273

10.1021/np058080d

10.1248/bpb.29.1970

10.1002/cbdv.200790027

10.1248/cpb.54.735

Thông tin
Thông tin xuất bản

Wiley

Tập 10 Số 10

1866-1875

Thông tin tác giả