Can lenticular factors improve the posttrauma fate of neurons?

Progress in Retinal and Eye Research - Tập 24 - Trang 241-257 - 2005
T. Stupp1, S. Thanos1
1Department of Experimental Ophthalmology, School of Medicine, University Eye Hospital of Münster and Interdisciplinary Clinical Research Center (IZKF), Domagkstraße 15, D-48149 Münster, Germany

Tài liệu tham khảo

Alemany, 1990, Insulin receptors and insulin-like growth factor I receptors are functional during organogenesis of the lens, Mol. Cell Endocrinol., 74, 155, 10.1016/0303-7207(90)90117-Q Andley, 1996, Cloning, expression, and chaperone-like activity of human alphaA-crystallin, J. Biol. Chem., 271, 31973, 10.1074/jbc.271.50.31973 Andley, 1998, The molecular chaperone alphaA-crystallin enhances lens epithelial cell growth and resistance to UVA stress, J. Biol. Chem., 273, 31252, 10.1074/jbc.273.47.31252 Bassnett, 1992, Mitochondrial dynamics in differentiating fiber cells of the mammalian lons, Curr. Eye Res., 11, 1227, 10.3109/02713689208999548 Bajramovic, 2000, Presentation of alpha B-crystallin to T cells in active multiple sclerosis lesions, J. Immunol., 164, 4359, 10.4049/jimmunol.164.8.4359 Bassas, 1987, Insulin and IGF receptors are developmentally regulated in the chick embryo eye lens, Exp. Cell Res., 168, 561, 10.1016/0014-4827(87)90029-2 Bassnett, 1997, Chromatin degradation in differentiating fiber cells of the eye lens, J. Cell Biol., 137, 37, 10.1083/jcb.137.1.37 Beebe, 1980, Lentropin, Proc. Natl. Acad. Sci. USA, 77, 490, 10.1073/pnas.77.1.490 Beebe, 1987, Lentropin, a protein that controls lens fiber formation, is related functionally and immunologically to the insulin-like growth factors, Proc. Natl. Acad. Sci. USA, 84, 2327, 10.1073/pnas.84.8.2327 Benowitz, 1997, GAP-43, Trends Neurosci, 20, 84, 10.1016/S0166-2236(96)10072-2 Berry, 1999, Optic nerve regeneration after intravitreal peripheral nerve implants, J. Neurocytol., 28, 721, 10.1023/A:1007086004022 Brewitt, 1988, Growth and transparency in the lens, an epithelial tissue, stimulated by pulses of PDGF, Science, 242, 777, 10.1126/science.3187521 Brewitt, 1990, A new method for study of normal lens development in vitro using pulsatile delivery of PDGF or EGF in HL-1 serum-free medium, In Vitro Cell Dev. Biol., 26, 305, 10.1007/BF02624462 Caldes, 1991, Expression of insulin-like growth factor I in developing lens is compartmentalized, J. Biol. Chem., 266, 20786, 10.1016/S0021-9258(18)54777-3 Campbell, 1986, A lens fibre differentiation factor from calf neural retina, Exp. Cell Res., 163, 453, 10.1016/0014-4827(86)90076-5 Caroni, 1988, Antibody against myelin-associated inhibitor of neurite growth neutralizes nonpermissive substrate properties of CNS white matter, Neuron, 1, 85, 10.1016/0896-6273(88)90212-7 Chamberlain, 1989, Induction of lens fibre differentiation by acidic and basic fibroblast growth factor (FGF), Growth Factors, 1, 125, 10.3109/08977198909029122 Chamberlain, 1991, The effects of insulin and basic fibroblast growth factor on fibre differentiation in rat lens epithelial explants, Growth Factors, 4, 183, 10.3109/08977199109104814 Chen, 2000, Nogo-A is a myelin-associated neurite outgrowth inhibitor and an antigen for monoclonal antibody IN-1, Nature, 403, 434, 10.1038/35000219 Chen, 2001, A role for endogenous TGFalpha and associated signaling pathways in the differentiation of lens fiber cells, J. Cell. Physiol., 186, 288, 10.1002/1097-4652(200002)186:2<288::AID-JCP1031>3.0.CO;2-H Chow, 1995, FGF suppresses apoptosis and induces differentiation of fibre cells in the mouse lens, Development, 121, 4383, 10.1242/dev.121.12.4383 Cohen, 1997, Caspases, Biochem. J., 326, 1, 10.1042/bj3260001 Collison, 2001, Regional differences in functional receptor distribution and calcium mobilization in the intact human lens, Invest. Ophthalmol. Vis. Sci., 42, 2355 Connor, 1989, Correlation of fibrosis and transforming growth factor-beta type 2 levels in the eye, J. Clin. Invest., 83, 1661, 10.1172/JCI114065 Coop, 1998, Translocation of beta crystallin in neural cells in response to stress, FEBS Lett., 431, 319, 10.1016/S0014-5793(98)00783-2 Cousins, 1991, Identification of transforming growth factor-beta as an immunosuppressive factor in aqueous humor, Invest. Ophthalmol. Vis. Sci., 32, 2201 Dahm, 1998, Susceptibility of lens epithelial and fibre cells at different stages of differentiation to apoptosis, Biochem. Soc. Trans., 26, S349, 10.1042/bst026s349 de Iongh, 1992, Distribution of acidic and basic fibroblast growth factors (FGF) in the foetal rat eye, Growth Factors, 6, 159, 10.3109/08977199209011018 de Iongh, 1997, Differential expression of fibroblast growth factor receptors during rat lens morphogenesis and growth, Invest. Ophthalmol. Vis. Sci., 38, 1688 de Iongh, 2001, Requirement for TGFbeta receptor signaling during terminal lens fiber differentiation, Development, 128, 3995, 10.1242/dev.128.20.3995 de Jong, 1993, Evolution of the alpha-crystallin/small heat-shock protein family, Mol. Biol. Evol., 10, 103 Decsi, 1994, Lens expression of TGF alpha in transgenic mice produces two distinct eye pathologies in the absence of tumors, Oncogene, 9, 1965 Delaye, 1983, Short-range order of crystallin proteins accounts for eye lens transparency, Nature, 302, 415, 10.1038/302415a0 Doster, 1991, Expression of the growth-associated protein GAP-43 in adult rat retinal ganglion cells following axon injury, Neuron, 6, 635, 10.1016/0896-6273(91)90066-9 Eaton, 1994, UV-mediated cataractogenesis, Doc. Ophthalmol., 88, 233, 10.1007/BF01203677 Fatma, 2001, Transcriptional regulation of the antioxidant protein 2 gene, a thiol-specific antioxidant, by lens epithelium-derived growth factor to protect cells from oxidative stress, J. Biol. Chem., 276, 48899, 10.1074/jbc.M100733200 Ferreira-Cornwell, 2000, N-cadherin function is required for differentiation-dependent cytoskeletal reorganization in lens cells in vitro, Exp. Cell Res., 256, 237, 10.1006/excr.2000.4819 Filiz, 2002, Localization of neural cell adhesion molecule (N-CAM) immunoreactivity in adult rat tissues, Biotech. Histochem., 77, 127, 10.1080/bih.77.3.127.135 Fischer, D. 2000. Protektiver Einfluss von beta- und gamma-Kristallinen auf das neuronale Ueberleben und die axonale Regeneration im adulten zentralen Nervensystem. PhD Thesis, Westfäolische Wilhelms-Universitäot, Münster. Fischer, 2000, Cataractogenic lens injury prevents traumatic ganglion cell death and promotes axonal regeneration both in vivo and in culture, Invest. Ophthalmol. Vis. Sci., 41, 3943 Fischer, 2004, Counteracting the Nogo receptor enhances optic nerve regeneration if retinal ganglion cells are in an active growth state, J. Neurosci., 24, 1646, 10.1523/JNEUROSCI.5119-03.2004 Fischer, 2001, Lens-injury-stimulated axonal regeneration throughout the optic pathway of adult rats, Exp. Neurol., 172, 257, 10.1006/exnr.2001.7822 Fishman, 1996, GAP-43, Perspect. Dev. Neurobiol., 4, 193 Frenzel, 1996, Gap junction formation between cultured embryonic lens cells is inhibited by antibody to N-cadherin, Dev. Biol., 179, 1, 10.1006/dbio.1996.0237 Fromm, 1997, Inhibition of cell death by lens-specific overexpression of bcl-2 in transgenic mice, Dev. Genet., 20, 276, 10.1002/(SICI)1520-6408(1997)20:3<276::AID-DVG10>3.0.CO;2-6 Gao, 1999, Changes in cyclin dependent kinase expression and activity accompanying lens fiber cell differentiation, Exp. Eye Res., 69, 695, 10.1006/exer.1999.0749 Goldschmidt, 1982, The immune response to homologous lens crystallin, II. A model of ocular inflammation involving eye injuries at separate times. J. Immunol., 129, 1658 Gordon-Thomson, 1998, Differential cataractogenic potency of TGF-beta1, -beta2, and -beta3 and their expression in the postnatal rat eye, Invest. Ophthalmol. Vis. Sci., 39, 1399 Grainger, 1992, Embryonic lens induction, Trends Genet., 8, 349, 10.1016/0168-9525(92)90280-H Granstein, 1990, Aqueous humor contains transforming growth factor-beta and a small (less than 3500 daltons) inhibitor of thymocyte proliferation, J. Immunol., 144, 3021, 10.4049/jimmunol.144.8.3021 Graw, 1997, The crystallins, Biol. Chem., 378, 1331 Hales, 1994, TGF-beta 1 induces lens cells to accumulate alpha-smooth muscle actin, a marker for subcapsular cataracts, Curr. Eye Res., 13, 885, 10.3109/02713689409015091 He, 1998, Transient activation of cyclin B/Cdc2 during terminal differentiation of lens fiber cells, Dev. Dyn., 211, 26, 10.1002/(SICI)1097-0177(199801)211:1<26::AID-AJA3>3.0.CO;2-9 Head, 1995, Beta B2-crystallin in the mammalian retina, Exp. Eye. Res., 61, 423, 10.1016/S0014-4835(05)80137-X Heumann, 1987, Differential regulation of mRNA encoding nerve growth factor and its receptor in rat sciatic nerve during development, degeneration, and regeneration, Proc. Natl. Acad. Sci. USA, 84, 8735, 10.1073/pnas.84.23.8735 Hightower, 1995, The role of the lens epithelium in development of UV cataract, Curr. Eye Res., 14, 71, 10.3109/02713689508999916 Hommel, 1992, Human epidermal growth factor, High resolution solution structure and comparison with human transforming growth factor alpha. J. Mol. Biol., 227, 271 Hongo, 1993, Distribution of epidermal growth factor receptors in rabbit lens epithelial cells, Invest. Ophthalmol. Vis. Sci., 34, 401 Horwitz, 1992, Alpha-crystallin can function as a molecular chaperone, Proc. Natl. Acad. Sci. USA, 89, 10449, 10.1073/pnas.89.21.10449 Ibaraki, 1995, Effects of growth factors on proliferation and differentiation in human lens epithelial cells in early subculture, Invest. Ophthalmol. Vis. Sci., 36, 2304 Inomata, 2003, Lens epithelium-derived growth factor, Brain Res., 991, 163, 10.1016/j.brainres.2003.08.011 Isenmann, 2003, Molecular determinants of retinal ganglion cell development, survival, and regeneration, Prog. Retin. Eye Res., 22, 483, 10.1016/S1350-9462(03)00027-2 Ishizaki, 1993, Control of lens epithelial cell survival, J. Cell. Biol., 121, 899, 10.1083/jcb.121.4.899 Ishizaki, 1998, A role for caspases in lens fiber differentiation, J. Cell. Biol., 140, 153, 10.1083/jcb.140.1.153 Izumoto, 1997, Hepatoma-derived growth factor belongs to a gene family in mice showing significant homology in the amino terminus, Biochem. Biophys. Res. Commun., 238, 26, 10.1006/bbrc.1997.7233 Jampel, 1990, Transforming growth factor-beta in human aqueous humor, Curr. Eye Res., 9, 963, 10.3109/02713689009069932 Jones, 1998, Expression of alphaB-crystallin in a mouse model of inherited retinal degeneration, Neuroreport, 9, 4161, 10.1097/00001756-199812210-00030 Jones, 1999, Retinal expression of gamma-crystallins in the mouse, Invest. Ophthalmol. Vis. Sci., 40, 3017 Katar, 1993, NCAM of the mammalian lens, Curr. Eye Res., 12, 191, 10.3109/02713689308999486 Kidd, 1998, Proteolytic activities that mediate apoptosis, Annu. Rev. phycioal., 60, 533, 10.1146/annurev.physiol.60.1.533 Klemenz, 1991, Alpha B-crystallin is a small heat shock protein, Proc. Natl. Acad. Sci. USA, 88, 3652, 10.1073/pnas.88.9.3652 Klok, 1998, Induction and maintenance of differentiation of rat lens epithelium by FGF-2, insulin and IGF-1, Exp. Eye Res., 67, 425, 10.1006/exer.1998.0534 Knorr, 1993, [Expression of platelet derived growth factor receptors in cultivated lens epithelial cells], Ophthalmologe, 90, 750 Knorr, 1993, Lens epithelial cell response to isoforms of platelet-derived growth factor, Graefes Arch. Clin. Exp. Ophthalmol., 231, 424, 10.1007/BF00919653 Kok, 2002, Influence of platelet-derived growth factor on lens epithelial cell proliferation and differentiation, Growth Factors, 20, 27, 10.1080/08977190290022202 Kroemer, 1997, The proto-oncogene Bcl-2 and its role in regulating apoptosis, Nat. Med., 3, 614, 10.1038/nm0697-614 Kurosaka, 1994, Inhibitory effect of TGF-beta 2 in human aqueous humor on bovine lens epithelial cell proliferation, Invest. Ophthalmol. Vis. Sci., 35, 3408 Kuwabara, 1975, The maturation of the lens cell, Exp. Eye Res., 20, 427, 10.1016/0014-4835(75)90085-8 Kuwabara, 1974, Denucleation process of the lens, Invest. Ophthalmol., 13, 973 Le, 2001, A novel role for FGF and extracellular signal-regulated kinase in gap junction-mediated intercellular communication in the lens, J. Cell Biol., 154, 197, 10.1083/jcb.200101057 Lee, 2002, TGF-beta-induced apoptosis and reduction of Bcl-2 in human lens epithelial cells in vitro, Curr. Eye Res., 25, 147, 10.1076/ceyr.25.3.147.13475 Leenders, 1997, Synergism between temporally distinct growth factors, Mech. Dev., 67, 193, 10.1016/S0925-4773(97)00121-4 Leon, 2000, Lens injury stimulates axon regeneration in the mature rat optic nerve, J. Neurosci., 20, 4615, 10.1523/JNEUROSCI.20-12-04615.2000 Liang, 1997, Molecular chaperones and the cytoskeleton, J. Cell Sci., 110, 1431, 10.1242/jcs.110.13.1431 Liu, 1994, Induction of cataract-like changes in rat lens epithelial explants by transforming growth factor beta, Invest. Ophthalmol. Vis. Sci., 35, 388 Liu, 1996, IGF enhancement of FGF-induced fibre differentiation and DNA synthesis in lens explants, Exp. Eye Res., 63, 621, 10.1006/exer.1996.0156 Liu, 1996, Phase separation in aqueous solutions of lens gamma-crystallins, Proc. Natl. Acad. Sci. USA, 93, 377, 10.1073/pnas.93.1.377 Lorber, 2002, Effect of lens lesion on neurite outgrowth of retinal ganglion cells in vitro, Mol. Cell Neurosci., 21, 301, 10.1006/mcne.2002.1175 Lovicu, 1989, Structural analysis of lens epithelial explants induced to differentiate into fibres by fibroblast growth factor (FGF), Exp. Eye Res., 49, 479, 10.1016/0014-4835(89)90056-0 Lovicu, 1992, The age of rats affects the response of lens epithelial explants to fibroblast growth factor, An ultrastructural analysis. Invest. Ophthalmol. Vis. Sci., 33, 2269 Lovicu, 1993, Localization of acidic fibroblast growth factor, basic fibroblast growth factor, and heparan sulphate proteoglycan in rat lens, Invest. Ophthalmol. Vis. Sci., 34, 3355 Lovicu, 2001, FGF-induced lens cell proliferation and differentiation is dependent on MAPK (ERK1/2) signalling, Development, 128, 5075, 10.1242/dev.128.24.5075 Lovicu, 1995, Differential effects of aqueous and vitreous on fiber differentiation and extracellular matrix accumulation in lens epithelial explants, Invest. Ophthalmol. Vis. Sci., 36, 1459 Machida, 2001, Lens epithelium-derived growth factor promotes photoreceptor survival in light-damaged and RCS rats, Invest. Ophthalmol. Vis. Sci., 42, 1087 Mailhos, 1993, Heat shock protects neuronal cells from programmed cell death by apoptosis, Neuroscience, 55, 621, 10.1016/0306-4522(93)90428-I Majima, 1998, Effect of epidermal growth factor upon morphological changes of human lens epithelial cells, Ophthalmologica, 212, 250, 10.1159/000027302 Mansour-Robaey, 1994, Effects of ocular injury and administration of brain-derived neurotrophic factor on survival and regrowth of axotomized retinal ganglion cells, Proc. Natl. Acad. Sci. USA, 91, 1632, 10.1073/pnas.91.5.1632 Marak, 1992, Phacoanaphylactic endophthalmitis, Surv. Ophthalmol., 36, 325, 10.1016/0039-6257(92)90109-7 Maruno, 2002, Apoptosis is a feature of TGF beta-induced cataract, Clin. Exp. Optom., 85, 76, 10.1111/j.1444-0938.2002.tb03012.x Matsui, 2001, Lens epithelium-derived growth factor, Invest. Ophthalmol. Vis. Sci., 42, 2935 McAvoy, 1978, Cell division, cell elongation and distribution of alpha-, beta- and gamma-crystallins in the rat lens, J. Embryol. Exp. Morphol., 44, 149 McAvoy, 1989, Fibroblast growth factor (FGF) induces different responses in lens epithelial cells depending on its concentration, Development, 107, 221, 10.1242/dev.107.2.221 McAvoy, 1986, Nuclear pyknosis during lens fibre differentiation in epithelial explants, Curr. Eye Res., 5, 711, 10.3109/02713688609015139 McAvoy, 1991, The role of fibroblast growth factor in eye lens development, Ann. N.Y. Acad. Sci., 638, 256, 10.1111/j.1749-6632.1991.tb49036.x McAvoy, 1999, Lens development, Eye, 13, 425, 10.1038/eye.1999.117 Mehlen, 1996, Small stress proteins as novel regulators of apoptosis. Heat shock protein 27 blocks Fas/APO-1- and staurosporine-induced cell death, J. Biol. Chem., 271, 16510, 10.1074/jbc.271.28.16510 Misra, 1977, Immunopathology of the lens, II Humoral and cellular immune responses to homologous lens antigens and their roles in ocular inflammation, Br. J. Ophthalmol., 61, 285, 10.1136/bjo.61.4.285 Morrison-Graham, 1992, A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells, Development, 115, 133, 10.1242/dev.115.1.133 Nakamura, 2000, LEDGF, Invest. Ophthalmol. Vis. Sci., 41, 1168 Ng, 1995, Influence of peripheral nerve grafts on the expression of GAP-43 in regenerating retinal ganglion cells in adult hamsters, J. Neurocytol., 24, 487, 10.1007/BF01179974 Orr-Urtreger, 1992, Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation, Development, 115, 289, 10.1242/dev.115.1.289 Palmade, 1994, Insulin-like growth factor-1 (IGF-1) specifically binds to bovine lens epithelial cells and increases the number of fibronectin receptor sites, Curr. Eye Res., 13, 531, 10.3109/02713689408999885 Pelton, 1991, Immunohistochemical localization of TGF beta 1, TGF beta 2, and TGF beta 3 in the mouse embryo, J. Cell Biol., 115, 1091, 10.1083/jcb.115.4.1091 Piatigorsky, 1981, Lens differentiation in vertebrates, A review of cellular and molecular features. Differentiation, 19, 134 Polla, 1996, Mitochondria are selective targets for the protective effects of heat shock against oxidative injury, Proc. Natl. Acad. Sci. USA, 93, 6458, 10.1073/pnas.93.13.6458 Potts, 1995, Expression of transforming growth factor beta in the embryonic avian lens coincides with the presence of mitochondria, Dev Dyn, 203, 317, 10.1002/aja.1002030304 Rampalli, 1995, Insulin regulates expression of c-fos and c-jun and suppresses apoptosis of lens epithelial cells, Cell Growth Differ., 6, 945 Rapalino, 1998, Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats, Nat. Med., 4, 814, 10.1038/nm0798-814 Rappolee, 1992, Macrophage-derived growth factors, Curr. Top. Microbiol. Immunol., 181, 87 Reddan, 1983, Insulin growth factor and epidermal growth factor trigger mitosis in lenses cultured in a serum-free medium, Invest. Ophthalmol. Vis. Sci., 24, 409 Reddan, 1975, Induction of mitosis in the cultured rabbit lens initiated by the addition of insulin to medium KEI-4, Exp. Eye Res., 20, 45, 10.1016/0014-4835(75)90107-4 Renaud, 1994, Up-regulation of aFGF expression in quiescent cells is related to cell survival, J. Cell Physiol., 158, 435, 10.1002/jcp.1041580307 Reneker, 1995, TGF alpha can act as a chemoattractant to perioptic mesenchymal cells in developing mouse eyes, Development, 121, 1669, 10.1242/dev.121.6.1669 Richardson, 1992, Age of rats affects response of lens epithelial explants to fibroblast growth factor, Exp. Eye Res., 55, 649, 10.1016/0014-4835(92)90169-S Richardson, 1993, IGF-1 enhancement of FGF-induced lens fiber differentiation in rats of different ages, Invest. Ophthalmol. Vis. Sci., 34, 3303 Richiert, 1999, TGF-beta elicits fibronectin secretion and proliferation in cultured chick lens epithelial cells, Curr. Eye Res., 18, 62, 10.1076/ceyr.18.1.62.5393 Robinson, 1995, Expression of a truncated FGF receptor results in defective lens development in transgenic mice, Development, 121, 3959, 10.1242/dev.121.12.3959 Roovers, 1999, Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells, Mol. Biol. Cell., 10, 3197, 10.1091/mbc.10.10.3197 Sax, 1994, Expression of the alpha-crystallin/small heat-shock protein/molecular chaperone genes in the lens and other tissues, Adv. Enzymol. Relat. Areas Mol. Biol., 69, 155 Schatteman, 1992, Regulation and role of PDGF receptor alpha-subunit expression during embryogenesis, Development, 115, 123, 10.1242/dev.115.1.123 Schulz, 1993, Acidic and basic FGF in ocular media and lens, Development, 118, 117, 10.1242/dev.118.1.117 Schweigerer, 1988, Basic fibroblast growth factor, Exp. Eye Res., 46, 71, 10.1016/S0014-4835(88)80094-0 Shirke, 2001, Misexpression of IGF-I in the mouse lens expands the transitional zone and perturbs lens polarization, Mech. Dev., 101, 167, 10.1016/S0925-4773(00)00584-0 Singh, 2000, Lens epithelium-derived growth factor, Biochem. Biophys. Res. Commun., 267, 373, 10.1006/bbrc.1999.1979 Skene, 1981, Axonally transported proteins associated with axon growth in rabbit central and peripheral nervous systems, J. Cell Biol., 89, 96, 10.1083/jcb.89.1.96 Singh, 2001, LEDGF binds to heat shock and stress-related element to activate the expression of stress-related genes, Biochem. Biophys. Res. Commun., 283, 943, 10.1006/bbrc.2001.4887 Skene, 1986, A protein induced during nerve growth (GAP-43) is a major component of growth-cone membranes, Science, 233, 783, 10.1126/science.3738509 Stadelmann, 1998, Alzheimer disease, J. Neuropathol. Exp. Neurol., 57, 456, 10.1097/00005072-199805000-00009 Strittmatter, 1995, Neuronal pathfinding is abnormal in mice lacking the neuronal growth cone protein GAP-43, Cell, 80, 445, 10.1016/0092-8674(95)90495-6 Stupp, T., Pavlidis, M., Naskar, R., Thanos, S., 2004. Mol. Vis., submitted. Sue Menko, 2002, Lens epithelial cell differentiation, Exp. Eye Res., 75, 485, 10.1006/exer.2002.2057 Thanos, 1993, Treatment of the adult retina with microglia-suppressing factors retards axotomy-induced neuronal degradation and enhances axonal regeneration in vivo and in vitro, J. Neurosci., 13, 455, 10.1523/JNEUROSCI.13-02-00455.1993 Ueda, 2000, Inhibition of FGF-induced alphaA-crystallin promoter activity in lens epithelial explants by TGFbeta, Invest. Ophthalmol. Vis. Sci., 41, 1833 van Noort, 2000, Mistaken self, a novel model that links microbial infections with myelin-directed autoimmunity in multiple sclerosis, J. Neuroimmunol., 105, 46, 10.1016/S0165-5728(00)00181-8 van Sechel, 1999, EBV-induced expression and HLA-DR-restricted presentation by human B cells of alpha B-crystallin, a candidate autoantigen in multiple sclerosis, J. Immunol., 162, 129, 10.4049/jimmunol.162.1.129 van Stipdonk, 1998, T cells discriminate between differentially phosphorylated forms of alphaB-crystallin, a major central nervous system myelin antigen, Int. Immunol., 10, 943, 10.1093/intimm/10.7.943 van Stipdonk, 2000, T- and B-cell nonresponsiveness to self-alphaB-crystallin in SJL mice prevents the induction of experimental allergic encephalomyelitis, Cell. Immunol., 204, 128, 10.1006/cimm.2000.1698 Verhaagen, 1994, Expression of the growth-associated protein B-50/GAP43 via a defective herpes-simplex virus vector results in profound morphological changes in non-neuronal cells, Brain. Res. Mol. Brain. Res., 26, 26, 10.1016/0169-328X(94)90070-1 Vidal-Sanz, 1987, Axonal regeneration and synapse formation in the superior colliculus by retinal ganglion cells in the adult rat, J. Neurosci., 7, 2894, 10.1523/JNEUROSCI.07-09-02894.1987 von Bartheld, 1998, Neurotrophins in the developing and regenerating visual system, Histol. Histopathol., 13, 437 Walker, 2002, Role for alpha 6 integrin during lens development, Dev. Dyn., 223, 273, 10.1002/dvdy.10050 Wang-Su, 2003, Proteome analysis of lens epithelia, fibers, and the HLE B-3 cell line, Invest. Ophthalmol. Vis. Sci., 44, 4829, 10.1167/iovs.03-0556 Watanabe, 1989, NCAM in the differentiation of embryonic lens tissue, Dev. Biol., 135, 414, 10.1016/0012-1606(89)90190-5 Wen, 1996, Lens epithelial cell mRNA, III. Elevated expression of macrophage migration inhibitory factor mRNA in galactose cataracts. Curr. Eye Res., 15, 125 Wickstrom, 1993, The effect of transforming growth factor-alpha (TGF alpha) on rabbit and primate lens epithelial cells in vitro, Curr. Eye Res., 12, 1123, 10.3109/02713689309033510 Widmer, 1993, Phosphorylation-site mutagenesis of the growth-associated protein GAP-43 modulates its effects on cell spreading and morphology, J. Cell Biol., 120, 503, 10.1083/jcb.120.2.503 Wistow, 1993, Lens crystallins, Trends Biochem. Sci., 18, 301, 10.1016/0968-0004(93)90041-K Wormstone, 2002, TGF-beta2-induced matrix modification and cell transdifferentiation in the human lens capsular bag, Invest. Ophthalmol. Vis. Sci., 43, 2301 Wride, 1993, Expression of tumor necrosis factor-alpha (TNF alpha)-cross-reactive proteins during early chick embryo development, Dev. Dyn., 198, 225, 10.1002/aja.1001980308 Wride, 1996, Cellular and molecular features of lens differentiation, Differentiation, 61, 77, 10.1046/j.1432-0436.1996.6120077.x Wride, 1995, Potential roles for tumour necrosis factor alpha during embryonic development, Anat. Embryol. (Berl), 191, 1, 10.1007/BF00215292 Wride, 1994, Distribution of TNF alpha-like proteins correlates with some regions of programmed cell death in the chick embryo, Int. J. Dev. Biol., 38, 673 Wride, 1999, Members of the bcl-2 and caspase families regulate nuclear degeneration during chick lens fibre differentiation, Dev. Biol., 213, 142, 10.1006/dbio.1999.9375 Xi, 2003, A comprehensive analysis of the expression of crystallins in mouse retina, Mol. Vis., 9, 410 Xu, 2002, Systematic analysis of E-, N- and P-cadherin expression in mouse eye development, Exp. Eye Res., 74, 753, 10.1006/exer.2002.1175 Yin, 2003, Macrophage-derived factors stimulate optic nerve regeneration, J. Neurosci., 23, 2284, 10.1523/JNEUROSCI.23-06-02284.2003 Zhu, 1995, Integrin-dependent activation of MAP kinase, Mol. Biol. Cell, 6, 273, 10.1091/mbc.6.3.273 Zuber, 1989, The neuronal growth-associated protein GAP-43 induces filopodia in non-neuronal cells, Science, 244, 1193, 10.1126/science.2658062