Camptothecin targets WRN protein: mechanism and relevance in clinical breast cancer
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Bohr, 2008, Rising from the RecQ-age: the role of human RecQ helicases in genome maintenance, Trends in biochemical sciences, 33, 609, 10.1016/j.tibs.2008.09.003
Bohr, 2014, Human RecQ helicases in DNA repair, recombination, and replication, Annual review of biochemistry, 83, 519, 10.1146/annurev-biochem-060713-035428
Monnat, 2013, Spectrum and risk of neoplasia in Werner syndrome: a systematic review, PloS one, 8, e59709, 10.1371/journal.pone.0059709
Goto, 2011, Involvement of WRN helicase in immortalization and tumorigenesis by the telomeric crisis pathway (Review), Oncology letters, 2, 609, 10.3892/ol.2011.298
von Kobbe, 2007, Role for the Werner syndrome protein in the promotion of tumor cell growth, Mechanisms of ageing and development, 128, 423, 10.1016/j.mad.2007.05.009
Esteller, 2006, Epigenetic inactivation of the premature aging Werner syndrome gene in human cancer, Proceedings of the National Academy of Sciences of the United States of America, 103, 8822, 10.1073/pnas.0600645103
Liu, 1985, Camptothecin induces protein-linked DNA breaksmammalian DNA topoisomerase I, The Journal of biological chemistry, 260, 14873, 10.1016/S0021-9258(17)38654-4
Kaina, 2013, Topoisomerase degradation, DSB repair, p53 and IAPs in cancer cell resistance to camptothecin-like topoisomerase I inhibitors, Biochimica et biophysica acta, 1835, 11
Brosh, 2007, Human RECQ1 is a DNA damage responsive protein required for genotoxic stress resistance and suppression of sister chromatid exchanges, PloS one, 2, e1297, 10.1371/journal.pone.0001297
Monnat, 2010, The human WRN and BLM RecQ helicases differentially regulate cell proliferation and survival after chemotherapeutic DNA damage, Cancer research, 70, 6548, 10.1158/0008-5472.CAN-10-0475
Matsumoto, 2002, Werner and Bloom helicases are involved in DNA repair in a complementary fashion, Oncogene, 21, 954, 10.1038/sj.onc.1205143
Wang, 2008, Sensitivity of RECQL4-deficient fibroblasts from Rothmund-Thomson syndrome patients to genotoxic agents, Human genetics, 123, 643, 10.1007/s00439-008-0518-4
Luo, 2009, Recql5 plays an important role in DNA replication and cell survival after camptothecin treatment, Molecular biology of the cell, 20, 114, 10.1091/mbc.e08-06-0565
Bohr, 2014, RECQ helicase RECQL4 participates in non-homologous end joining and interacts with the Ku complex, Carcinogenesis, 35, 2415, 10.1093/carcin/bgu137
Luo, 2010, Acetylation of WRN protein regulates its stability by inhibiting ubiquitination, PloS one, 5, e10341, 10.1371/journal.pone.0010341
Guarente, 1998, Nucleolar localization of the Werner syndrome protein in human cells, Proceedings of the National Academy of Sciences of the United States of America, 95, 6887, 10.1073/pnas.95.12.6887
Bohr, 2003, Werner protein stimulates topoisomerase I DNA relaxation activity, Cancer research, 63, 7136
D'Arpa, 1997, Ubiquitin-dependent destruction of topoisomerase I is stimulated by the antitumor drug camptothecin, The Journal of biological chemistry, 272, 24159, 10.1074/jbc.272.39.24159
Liu, 2008, A ubiquitin-proteasome pathway for the repair of topoisomerase I-DNA covalent complexes, The Journal of biological chemistry, 283, 21074, 10.1074/jbc.M803493200
Ozanne, 2007, DNA damage, cellular senescence and organismal ageing: causal or correlative?, Nucleic acids research, 35, 7417, 10.1093/nar/gkm681
Bohr, 2014, Senescence induced by RECQL4 dysfunction contributes to Rothmund-Thomson syndrome features in mice, Cell death & disease, 5, e1226, 10.1038/cddis.2014.168
Monnat, 2003, Werner syndrome protein limits MYC-induced cellular senescence, Genes & development, 17, 1569, 10.1101/gad.1100303
Shen, 2007, Genetic variation in the premature aging gene WRN: a case-control study on breast cancer susceptibility, Cancer epidemiology, biomarkers & prevention, 16, 263, 10.1158/1055-9965.EPI-06-0678
Shen, 2009, A polymorphism in Werner syndrome gene is associated with breast cancer susceptibility in Chinese women, Breast cancer research and treatment, 118, 169, 10.1007/s10549-009-0327-z
Hoch, 2013, Two schedules of etirinotecan pegol (NKTR-102) in patients with previously treated metastatic breast cancer: a randomised phase 2 study, Lancet Oncol, 14, 1216, 10.1016/S1470-2045(13)70429-7
Nielsen, 2013, A systematic review on topoisomerase 1 inhibition in the treatment of metastatic breast cancer, Breast cancer research and treatment, 138, 347, 10.1007/s10549-013-2476-3
Pommier, 2009, Topoisomerase I levels in the NCI-60 cancer cell line panel determined by validated ELISA and microarray analysis and correlation with indenoisoquinoline sensitivity, Molecular cancer therapeutics, 8, 1878, 10.1158/1535-7163.MCT-09-0016
Liu, 2001, Ubiquitin/26S proteasome-mediated degradation of topoisomerase I as a resistance mechanism to camptothecin in tumor cells, Cancer research, 61, 5926
McKinney, 2012, The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups, Nature, 486, 346, 10.1038/nature10983
Yee, 2010, Werner syndrome as a hereditary risk factor for exocrine pancreatic cancer: potential role of WRN in pancreatic tumorigenesis and patient-tailored therapy, Cancer biology & therapy, 10, 430, 10.4161/cbt.10.5.12763
Bryant-Greenwood, 2011, The Werner's Syndrome RecQ helicase/exonuclease at the nexus of cancer and aging, Hawaii medical journal, 70, 52
Brosh, 2011, Inhibition of helicase activity by a small molecule impairs Werner syndrome helicase (WRN) function in the cellular response to DNA damage or replication stress, Proceedings of the National Academy of Sciences of the United States of America, 108, 1525, 10.1073/pnas.1006423108
Sparreboom, 2001, Modulation of camptothecin analogs in the treatment of cancer: a review, Anticancer Drugs, 12, 89, 10.1097/00001813-200102000-00002
Liu, 1988, Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes, Proceedings of the National Academy of Sciences of the United States of America, 85, 1060, 10.1073/pnas.85.4.1060
Liu, 2000, SUMO-1 conjugation to topoisomerase I: A possible repair response to topoisomerase-mediated DNA damage, Proceedings of the National Academy of Sciences of the United States of America, 97, 4046, 10.1073/pnas.080536597
Cheng, 1995, Camptothecin induction of a time- and concentration-dependent decrease of topoisomerase I and its implication in camptothecin activity, Molecular pharmacology, 47, 907
Gong, 2013, TopBP1 controls BLM protein level to maintain genome stability, Molecular cell, 52, 667, 10.1016/j.molcel.2013.10.012
Campisi, 2009, Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion, Nature cell biology, 11, 973, 10.1038/ncb1909
Wyche, 2002, Role of p21 in apoptosis and senescence of human colon cancer cells treated with camptothecin, The Journal of biological chemistry, 277, 17154, 10.1074/jbc.M112401200
Stenvang, 2015, Topoisomerase-1 gene copy aberrations are frequent in patients with breast cancer, Int J Cancer
Gibson, 2015, A review of the evolution of systemic chemotherapy in the management of colorectal cancer, Clin Colorectal Cancer, 14, 1, 10.1016/j.clcc.2014.11.002
Clark, 2005, Reporting recommendations for tumor marker prognostic studies (REMARK), J Natl Cancer Inst, 97, 1180, 10.1093/jnci/dji237