Calmodulin Binding Proteins and Alzheimer’s Disease
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Brookmeyer, 2007, Forecasting the global burden of Alzheimer’s disease, Alzheimers Dement, 3, 186, 10.1016/j.jalz.2007.04.381
Hippius, 2003, The discovery of Alzheimer’s disease, Dialogues Clin Neurosci, 5, 101, 10.31887/DCNS.2003.5.1/hhippius
O’Day, 2004, Calmodulin-binding domains in Alzheimer’s disease proteins: Extending the calcium hypothesis, Biochem Biophys Res Commun, 230, 1051, 10.1016/j.bbrc.2004.06.070
Chavez, 2007, Current Research on Alzheimer’s Disease, 37
Canobbio, 2011, Calmodulin regulates the non-amyloidogenic metabolism of amyloid precursor protein in platelets, Biochem Biophys Acta, 1813, 500, 10.1016/j.bbamcr.2010.12.002
Khachaturian, 1994, Calcium hypothesis of Alzheimer’s disease and brain aging, Ann N Y Acad Sci, 747, 1, 10.1111/j.1749-6632.1994.tb44398.x
Chin, 2000, Calmodulin: A prototypical calcium sensor, Trends Cell Biol, 10, 322, 10.1016/S0962-8924(00)01800-6
Rhoads, 1997, Sequence motifs for calmodulin recognition, FASEB J, 11, 331, 10.1096/fasebj.11.5.9141499
Tidow, 2013, Structural diversity of calmodulin binding to its target sites, FEBS J, 280, 5551, 10.1111/febs.12296
Villarroel, 2014, The ever changing moods of calmodulin: How structurallasticity entails transductional adaptability, J Mol Biol, 426, 2717, 10.1016/j.jmb.2014.05.016
Hardy, 1992, Alzheimer’s disease: The amyloid cascade hypothesis, Science, 256, 184, 10.1126/science.1566067
Hardy, 2002, The amyloid hypothesis of Alzheimer’s disease: Progress and problems on the road to therapeutics, Science, 297, 353, 10.1126/science.1072994
Sunde, 1998, From the globular to the fibrous state: Protein structure and structural conversion in amyloid formation, Q Rev Biophys, 31, 1, 10.1017/S0033583598003400
Kojro, 2005, The non-amyloidogenic pathway: Structure and function of alpha-secretases, Subcell Biochem, 38, 105, 10.1007/0-387-23226-5_5
Dobson, 2004, Protein chemistry. In the footsteps of alchemists, Science, 304, 1259, 10.1126/science.1093078
Chow, 2010, An overview of APP processing enzymes and products, Neuromolecular Med, 12, 1, 10.1007/s12017-009-8104-z
McLachlan, 1987, Calmodulin and calbindin D28K in Alzheimer disease, Alzheimer Dis Assoc Discord, 1, 171, 10.1097/00002093-198701030-00009
Holsinger, 2002, Increased expression of the amyloid precursor beta-secretase in Alzheimer’s disease, Ann Neurol, 51, 783, 10.1002/ana.10208
Laird, 2005, BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cofnitive, emotional, and synaptic functions, J Neurosci, 25, 11693, 10.1523/JNEUROSCI.2766-05.2005
Saito, 2008, X11 proteins regulate the translocation of amyloid beta-protein precursor (APP) into detergent-resistent membrane and suppress the amyloidogenic cleavage of APP by beta-site-cleaving enzyme in the brain, J Biol Chem, 283, 35763, 10.1074/jbc.M801353200
Li, 2009, Toward structural elucidation of the γ-secretase complex, Structure, 17, 326, 10.1016/j.str.2009.01.007
Michno, 2009, Intracellular calcium deficits incholinergic neurons expressing wild type or FAD-mutant presenilin, PLoS One, 4, e6904, 10.1371/journal.pone.0006904
Pacheco-Quinto, 2013, Endothelin-converting enzymes degrade intracellular β-amyloid produced within endosomal/lysosomal pathway and autophagosomes, J Biol Chem, 288, 5606, 10.1074/jbc.M112.422964
O’Day, 2007, Alzheimer’s Disease Research Trends, 1
Berrocal, 2012, Calmodulin antagonizes amyloid-β peptides-mediated inhibition of brain plasma membrane Ca(2+)-ATPase, Biochim Biophys Acta, 1822, 961, 10.1016/j.bbadis.2012.02.013
Nagano, 2004, Cell-matrix interaction via CD44 is independently regulated by different metalloproteinases activated in response to extraceullular Ca(2+) influx and PKC activation, J Cell Biol, 165, 893, 10.1083/jcb.200310024
Kuhn, 2010, ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons, EMBO J, 29, 3020, 10.1038/emboj.2010.167
Horiuchi, 2007, Substrate selectivity of epidermal growth factor-receptor ligand sheddases and their regulation by phorbol esters and calcium influx, Mol Biol Cell, 18, 176, 10.1091/mbc.e06-01-0014
Díaz-Rodríguez, 2000, Stimulation of cleavage of membrane proteins by calmodulin inhibitors, Biochem J, 346, 359, 10.1042/bj3460359
Lee, 2005, Tau phosphorylation in Alzheimer’s disease: Pathogen or protector?, Trends Mol Med, 11, 164, 10.1016/j.molmed.2005.02.008
Martin, 2013, Tau protein kinases; Involvement in Alzheimer’s disease, Ageing Res Rev, 12, 289, 10.1016/j.arr.2012.06.003
Padilla, 1990, Calmodulin binds to a tubulin binding site of the microtubule-associated protein tau, Mol Cell Biochem, 97, 35, 10.1007/BF00231699
Baudier, 1987, Comparison of S100b protein with calmodulin: Interactions with melittin and microtubule-associated tau roteins and inhibition ofhosphorylation of tau poteins by protein kinase C, Biochemistry, 26, 2886, 10.1021/bi00384a033
Lee, 1984, Calmodulin binds to both microtubule-associated protein 2 and tau proteins, J Biol Chem, 259, 1226, 10.1016/S0021-9258(17)43592-7
Mietelska-Porowska, 2014, Tau protein modifications and interactions: Their role in function and dysfunction, Int J Mol Sci, 15, 46741, 10.3390/ijms15034671
Yu, 2008, Tau binds both subunits of calcineurin, and binding is impaired by calmodulin, Biochem Biophys Acta, 1783, 2255, 10.1016/j.bbamcr.2008.06.015
Steiner, 1990, Phosphorylation of microtubule-associaed protein tau: Identification of the site for Ca2(+)-calmodulin dependent kinase and relationship with tau phosphorylation in Alzheimer tangles, EMBO J, 9, 3539, 10.1002/j.1460-2075.1990.tb07563.x
Singh, 1996, Calcium/calmodulin-dependent protein kinase II phosphorylates au at Ser-262 but only partially inhibits its binding to microtubules, FEBS Lett, 387, 145, 10.1016/0014-5793(96)00485-1
Yamamoto, 2002, Phosphorylation of microtubule-associaed protein tau by Ca2+/calmodulin-dependent protein kinase II in its tubulin binding sites, Arch Biochem Biophys, 408, 255, 10.1016/S0003-9861(02)00556-8
Yoshimura, 2003, Phosphorylation of tau protein to sites found in Alzheimer’s disease brain is catalyzed by Ca2+/calmodulin-dependent protein kinase II as demonstrated tandem mass spectrometry, Neurosci Lett, 353, 185, 10.1016/j.neulet.2003.09.037
Yamamoto, 2005, Phosphorylation of tau at serine 416 by Ca2+/calmodulin-dependent protein kinase II in neuronal soma in brain, J Neurochem, 94, 1438, 10.1111/j.1471-4159.2005.03307.x
Straton, 2013, Structural studies on the regulation of Ca2+/calmodulin dependent protein kinase II, Curr Opin Sruct Biol, 23, 292, 10.1016/j.sbi.2013.04.002
Esteras, 2013, Downregulation of extracellular signal-regulated kinase 1/2 activity by calmodulin KII modulates p21Cip1 levels and survival of immortalized lymphocytes from Alzheimer’s disease patients, Neurobiol Aging, 34, 1090, 10.1016/j.neurobiolaging.2012.10.014
Berchtold, 2014, The many faces of calmodulin in cell proliferation, programmed cell death, autophagy and cancer, Biochim Biopys Acta, 1843, 398, 10.1016/j.bbamcr.2013.10.021
Lund, 2001, Characterization of the in vitro phosphorylation of human tau by tau protein kinase II (cdk5/p20) using mass spectrometry, J Neurochem, 76, 1221, 10.1046/j.1471-4159.2001.00130.x
Hashiguchi, 2002, Truncation of CDK5 activator p35 induces intensive phosphorylation of Ser202/Thr205 of human tau, J Biol Chem, 277, 44525, 10.1074/jbc.M207426200
Noble, 2003, Cdk5 is a key factor in tau aggregation and tangle formation in vivo, Neuron, 38, 555, 10.1016/S0896-6273(03)00259-9
Götz, 2001, Compartmentalized tau hyperphosphorylation and increased levels of kinases in transgenic mice, Neuroreport, 12, 2007, 10.1097/00001756-200107030-00045
Patrick, 1999, Conversion of p35 to p25 deregulates Cdk5 activity and promotes neurodegeneration, Nature, 402, 615, 10.1038/45159
Piedrahita, 2010, Silencing of CDK5 reduces neurofibrillary tangles in transgenic Alzheimer’s mice, J Neurosci, 30, 13966, 10.1523/JNEUROSCI.3637-10.2010
He, 2008, Calmodulin binding and Cdk5 phosphorylation of p35 regulate its effect on microtubules, J Biol Chem, 283, 13252, 10.1074/jbc.M706937200
Hou, 2007, Microtubule association of the neuronal p35 activator of Cdk5, J Biol Chem, 282, 18666, 10.1074/jbc.C700052200
Huber, 2013, Cyclin-dependent kinase 5 is a calmodulin-binding protein that associates with puromycin-sensitive aminopeptidase in the nucleus of Dictyostelium, Biochem Biophys Acta, 1833, 11, 10.1016/j.bbamcr.2012.10.005
Hoekman, 2006, Molecular modeling of the calmodulin binding region of calcineurin, Protein J, 25, 175, 10.1007/s10930-006-9000-0
Klee, 1998, Regulation of the calmodulin-stimulated protein phosphatase, calcineurin, J Biol Chem, 273, 13367, 10.1074/jbc.273.22.13367
Drewes, 1993, Dephosphorylation of tau protein and Alzheimer paired helical filaments by calcineurin and phosphatase-2A, FEBS Lett, 336, 425, 10.1016/0014-5793(93)80850-T
Gong, 1994, Alzheimer’s disease abnormally phosphorylated tau is dephosphorylated by protein phosphatase-2B (calcineurin), J Neurochem, 62, 803, 10.1046/j.1471-4159.1994.62020803.x
Rahman, 2006, PP2B isolated from human brain preferentially dephosphorylates Ser-262 and Ser-396 of the Alzheimer disease abnormally hyperphosphorylated tau, J Neural Transm, 113, 219, 10.1007/s00702-005-0313-5
Liu, 2005, Contributions of protein phosphatases PP1, PP2A, PP2B and PP5 to the regulation of tau phosphorylation, Eur J Neurosci, 22, 1942, 10.1111/j.1460-9568.2005.04391.x
Liu, 2005, Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain, J Biol Chem, 280, 37755, 10.1074/jbc.M507475200
Garver, 1999, Reduction of calcineurin activity in brain by antisense oligonucleotides leads to persistent phosphorylation of tau protein at Thr181 and Thr231, Mol Pharmacol, 55, 632
Yu, 2006, Inhibition of calcineurin by infusion of CsA causes hyperphosphorylation of tau and is accompanied by abnormal behavior in mice, Biol Chem, 387, 977, 10.1515/BC.2006.121
Luo, 2008, Infusion of FK506, a specific inhibitor of calcineurin, induces potent tau hyperphosphorylation in mouse brain, Brain Res Bull, 76, 464, 10.1016/j.brainresbull.2007.12.005
Koffie, 2011, Alzheimer’s disease: Synapses gone cold, Mol Neurodegener, 6, 63, 10.1186/1750-1326-6-63
Reese, 2011, A role for calcineurin in Alzheimer’s disease, Curr Neuropharmacol, 9, 685, 10.2174/157015911798376316
Wu, 2010, Amyloid beta induces the morphological neurodegenerative triad of spine loss, dendritic simplification, and neuritic dystrophies through calcineurin activation, J Neurosci, 30, 2636, 10.1523/JNEUROSCI.4456-09.2010
Rozkalne, 2011, Calcineurin inhibition with FK506 ameliorates dendritic spine density deficits in plaque-bearing Alzheimer model mice, Neurobiol Dis, 41, 650, 10.1016/j.nbd.2010.11.014
Sun, 2014, Reduced synaptic STIM2 expression and impaired store-operated calcium entry cause destabilization of mature spines in mutant presenilin mice, Neuron, 82, 79, 10.1016/j.neuron.2014.02.019
Berridge, 2014, Calcium regulation of neural rhythms, memory and Alzheimer’s disease, J Physiol, 592, 281, 10.1113/jphysiol.2013.257527
Richter, 1980, Acetylcholine and choline levels in post-mortem human brain tissue: Preliminary observations in Alzheimer’s disease, Life Sci, 26, 1683, 10.1016/0024-3205(80)90176-9
Francis, 1999, The cholinergic hypothesis of Alzheimer’s disease: A review of progress, J Neurol Neurosurg Psychol, 66, 137, 10.1136/jnnp.66.2.137
Jiang, 2014, M1 muscarinic acetycholine receptor in Alzheimer’s disease, Neurosci Bull, 30, 295, 10.1007/s12264-013-1406-z
Anand, 2013, A review on cholinesterase inhibitors for Alzheimer’s disease, Arch Pharm Res, 36, 375, 10.1007/s12272-013-0036-3
Lucas, 2006, Calmodulin binding to peptides derived from the i3 loop of muscarinic receptors, Pharmaceutical Res, 23, 647, 10.1007/s11095-006-9784-9
Kim, 2005, Activation of M1 muscarinic acetylcholine receptors stimulates the formation of a multiprotein complex centered on TRPC6 channels, J Biol Chem, 2080, 32035, 10.1074/jbc.M500429200
Ehlers, 1996, Inactivation of NMDA receptors by direct interaction of calmodulin with the NR1 subunit, Cell, 84, 745, 10.1016/S0092-8674(00)81052-1
Danysz, 2012, Alzheimer’s disease, β-amyloid, glutamate, NMDA receptors and memantine— searching for the connections, Brit J Pharmacol, 167, 324, 10.1111/j.1476-5381.2012.02057.x
Alberdi, 2010, Amyloid beta oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors, Cell Calcium, 47, 264, 10.1016/j.ceca.2009.12.010
Papadia, 2008, Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses, Nat Neurosci, 11, 476, 10.1038/nn2071
Gonzalez, 2014, NMDARs in neurological diseases: A potential therapeutic target, Int J Neurosci, 124, 717
Hisatsune, 1997, Phosphorylation-dependent regulation of N-methyl-D-aspartate receptors by calmodulin, J Biol Chem, 272, 20805, 10.1074/jbc.272.33.20805
Rycroft, 2002, Direct effects of calmodulin on NMDA receptor single-channel gating in rat hippocampal granule cells, J Neurosci, 22, 8860, 10.1523/JNEUROSCI.22-20-08860.2002
Zhang, 1999, Calmodulin modification of NMDA receptors, Methods Mol Biol, 128, 103
Akyol, 2004, Apo-calmodulin binds with its C-terminal domain to the N-methyl-D-aspartate receptor NR1 C0 region, J Biol Chem, 279, 2166, 10.1074/jbc.M302542200
Ataman, 2007, The NMDA receptor NR1 C1 region bound to calmodulin: Structural insights into functional differences between homologous domains, Structure, 15, 1603, 10.1016/j.str.2007.10.012
Harold, 2009, Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease, Nat Genet, 41, 1088, 10.1038/ng.440
Naj, 2011, Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease, Nat Genet, 43, 436, 10.1038/ng.801
Hollingworth, 2011, Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease, Nat Genet, 43, 429, 10.1038/ng.803
Lambert, 2013, Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease, Nat Genet, 45, 1452, 10.1038/ng.2802
Karch, 2015, Alzheimer’s disease risk genes and mechanisms of disease pathogenesis, Biol Psychiatry, 77, 43, 10.1016/j.biopsych.2014.05.006
Kang, 2012, Lipid metabolism and neuroinflammation in Alzheimer’s disease: A role for liver X receptors, Endocr Rev, 33, 715, 10.1210/er.2011-1049
Fassbender, 2001, Simvastatin strongly reduces levels of Alzheimer’s disease beta-amyloid peptides Abeta 42 and Abeta 40 in vitro and in vivo, Proc Nat Acad Sci U S A, 98, 5856, 10.1073/pnas.081620098
Schönknecht, 2002, Cerebrospinal fluid 24S-hydroxycholesterol is increased in patients with Alzheimer’s disease compared to healthy controls, Neurosci Lett, 324, 83, 10.1016/S0304-3940(02)00164-7
Jurevics, 1995, Cholesterol for synthesis of myelin is made locally, not imported into brain, J Neurochem, 64, 895, 10.1046/j.1471-4159.1995.64020895.x
Nuutinen, 2009, Clusterin: A forgotten player in Alzheimer’s disease, Brain Res Rev, 61, 89, 10.1016/j.brainresrev.2009.05.007
Kim, 2008, Role of ATP-binding cassette transporters in brain lipid transport and neurological disease, J Neurochem, 104, 1145, 10.1111/j.1471-4159.2007.05099.x
Iwamoto, 2010, Calmodulin interacts with ATP binding cassette transporter A1 to protect from calpain-mediated degradation and upregulates high-density lipoprotein generation, Arterioscler Thromb Vasc Biol, 30, 1446, 10.1161/ATVBAHA.110.203927
Akiyama, 2000, Inflammation and Alzheimer’s disease, Neurobiol Aging, 21, 383, 10.1016/S0197-4580(00)00124-X
Crehan, 2012, Complement receptor 1 (CR1) and Alzheimer’s disease, Immunobiology, 217, 244, 10.1016/j.imbio.2011.07.017
Choy, 2012, Amyloid precursor protein (APP) traffics from the cell surface via endosomes for amyloid β (Aβ) production in the trans-Golgi network, Proc Natl Acad Sci U S A, 109, E2077, 10.1073/pnas.1208635109
Carey, 2005, Inhibition of dynamin-dependent endocytosis increases shedding of the amyloid precursor protein ectodomain and reduces generation of amyloid beta protein, BMC Cell Biol, 6, 30, 10.1186/1471-2121-6-30
Berggård, 2006, 140 mouse brain proteins identified by Ca2+-calmodulin affinity chromatography and tandem mass spectrometry, J Proteome Res, 5, 669, 10.1021/pr050421l
Arendt, 2005, Alzheimer’s disease as a disorder of dynamic brain self-organization, Prog Brain Res, 147, 355, 10.1016/S0079-6123(04)47025-3
Nagy, 2000, Cell cycle regulatory failure in neurones: Causes and consequences, Neurobiol Aging, 21, 761, 10.1016/S0197-4580(00)00223-2
Zhu, 2004, Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer’s disease, J Neurosci Res, 75, 698, 10.1002/jnr.20028
Yang, 2001, DNA replication precedes neuronal cell death in Alzheimer’s disease, J Neurosci, 21, 2661, 10.1523/JNEUROSCI.21-08-02661.2001
Nagy, 1997, Apoptosis-related protein expression in the hippocampus in Alzheimer’s disease, Neurobiol Aging, 18, 565, 10.1016/S0197-4580(97)00157-7
Raina, 2001, Abortive apoptosis in Alzheimer’s disease, Acta Neuropathol, 101, 305, 10.1007/s004010100378
Herrup, 2004, Divide and die: Cell cycle events as triggers of nerve cell death, J Neurosci, 24, 9232, 10.1523/JNEUROSCI.3347-04.2004
Busser, 1998, Ectopic cell cycle proteins predict the sites of neuronal cell death in Alzheimer’s disease brain, J Neurosci, 18, 2801, 10.1523/JNEUROSCI.18-08-02801.1998
Khurana, 2006, TOR-mediated cell-cycle activation causes neurodegeneration in atauopathy model, Curr Biol, 16, 230, 10.1016/j.cub.2005.12.042
Arendt, 2010, Selective cell death of hyperploid neurons in Alzheimer’s disease, Am J Pathol, 177, 15, 10.2353/ajpath.2010.090955
Walsh, 2004, Deciphering the molecular basis of memory failure in Alzheimer’s disease, Neuron, 44, 181, 10.1016/j.neuron.2004.09.010
Zhu, 2000, Activation of p38 kinase links tau phosphorylation, oxidative stress, and cell cycle-related events in Alzheimer disease, J Neuropathol Exp Neurol, 59, 880, 10.1093/jnen/59.10.880
Mattson, 2003, Neuronal and glial calcium signaling in Alzheimer’s disease, Cell Calcium, 34, 385, 10.1016/S0143-4160(03)00128-3
Seward, 2013, Amyloid-β signals through tau to drive ectopic neuronal cell cycle re-entry in Alzheimer’s disease, J Cell Sci, 126, 1278, 10.1242/jcs.1125880
Yang, 2006, Ectopic cell cycle events link human Alzheimer’s disease and amyloid precursor protein transgenic mouse models, J Neurosci, 26, 775, 10.1523/JNEUROSCI.3707-05.2006
Lee, 2009, Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer’s disease, Neurochem Int 54, 84, 10.1016/j.neuint.2008.10.013
Kahl, 2003, Regulation of cell cycle progression by calcium/calmodulin-dependent pathways, Endocr Rev, 24, 719, 10.1210/er.2003-0008
Skelding, 2011, Controlling the cell cycle: The role of calcium/calmodulin-stimulated protein kinases I and II, Cell Cycle, 4, 631, 10.4161/cc.10.4.14798
Choi, 2006, Calmodulin-mediated cell cycle regulation: New mechanisms for old observations, Cell Cycle, 5, 2183, 10.4161/cc.5.19.3265
Gnegy, 1993, Calmodulin in neurotransmitter and hormone action, Annu Rev Pharmacol Toxicol, 33, 45, 10.1146/annurev.pa.33.040193.000401
Min, 2013, The alterations of Ca2+/calmodulin/CaMKII/CaV1.2 signaling in experimental models of Alzheimer’s disease and vascular dementia, Neurosci Lett, 538, 60, 10.1016/j.neulet.2013.02.001
Young, 2014, A data-driven model of biomarker changes in sporadic Alzheimer’s disease, Brain, 137, 2564, 10.1093/brain/awu176
Esteras, 2012, Altered calmodulin degradation and signaling in non-neuronal cells from Alzheimer’s disease patients, Curr Alzheimer Res, 9, 267, 10.2174/156720512800107564
Esteras, 2013, Calmodulin levels in blood cells as a potential marker of Alzheimer’s disease, Alzheimers Res Ther, 5, 55, 10.1186/alzrt219
Audran, 2013, A general framework to characterize inhibitors of calmodulin: Use of calmodulin inhibitors to study the interaction between calmodulin and its calmodulin binding domains, Biochim Biophys Acta, 1833, 1720, 10.1016/j.bbamcr.2013.01.008
Walling, 1998, Molecular aspects of Huntington’s disease, J Neurosci Res, 50, 301, 10.1002/(SICI)1097-4547(19981101)54:3<301::AID-JNR1>3.0.CO;2-W
Dudek, 2008, Protective effects of interrupting the binding of calmodulin to mutant huntingtin, J Neuropathol Exp Neurol, 67, 355, 10.1097/NEN.0b013e31816a9e60