Calcium phosphate coating formed in infusion fluid mixture to enhance fixation strength of titanium screws

Springer Science and Business Media LLC - Tập 18 - Trang 1799-1808 - 2007
Hirotaka Mutsuzaki1,2, Atsuo Ito2, Masataka Sakane1, Yu Sogo2, Ayako Oyane3, Yuko Ebihara4, Noboru Ichinose4, Naoyuki Ochiai1
1Department of Orthopaedic Surgery, Institute of Clinical Medicine, Graduate School of Comprehensive Human Sciences, University of Tsukuba, Tsukuba, Japan
2Institute for Human Science and Biomedical Engineering, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
3Nanotechnology Research Institute, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan
4Department of Materials Science and Engineering, School of Science and Engineering, Waseda University, Shinjuku-ku, Japan

Tóm tắt

A novel technique was developed to coat a calcium phosphate (CaP) layer on titanium screws with a titanium oxide surface layer, using infusion fluids officially approved for clinical use. A calcium-containing solution, a phosphate-containing solution, and a sodium bicarbonate solution prepared from the infusion fluids were mixed at a Ca/P molar ratio of 2.0. Each screw was immersed in 10 mL of the resulting mixture at 37 °C for 2 days. A low-crystalline apatite layer (Ca/P molar ratio = 1.681 ± 0.038) was formed on the screws. The layer consisted of a few 100 nm diameter particles fixed on the screw surface. In animal experiments, the screws were percutaneously implanted in both proximal tibial metaphyses of rabbits. The insertion torque was not significantly different between the CaP-coated screws (0.132 ± 0.002 Nm, n = 10) and uncoated screws (0.140 ± 0.002 Nm, n = 10) (p = 0.5785). After the insertion torque test, the apatite layer remained on the surface of the screws, which means that the apatite layer survived the friction of screw insertion. The extraction torque of the screws in the CaP-coated group (0.239 ± 0.066 Nm, n = 19) was significantly higher (by 29.9%) than that in the uncoated group (0.184 ± 0.062 Nm, n = 18) 4 weeks after the operations (p = 0.0132). Histologically, a larger amount of new bone formation was observed around the CaP-coated screws than that around the uncoated screws. Even after the removal of the screw, the CaP layer remained on the screw at the site where soft tissues were attached. The coating technique with the use of the infusion fluids is an effective method of improving bone-screw interface strength.

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Springer Science and Business Media LLC

Tập 18

1799-1808

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