Calcium Channels

Abe, 1987, Identification of the receptor for ω-conotoxin in brain, J. Biol. Chem., 262, 9877, 10.1016/S0021-9258(18)48015-5 Abe, 1986, Binding of ω-conotoxin to receptor sites associated with the voltage-sensitive calcium channel, Neurosci. Lett., 71, 203, 10.1016/0304-3940(86)90559-8 Affolter, 1985, Agonists Bay-K 8644 and GCP-28392 open calcium channels reconstituted from skeletal muscle transverse tubules, Biophys. J., 48, 341, 10.1016/S0006-3495(85)83789-9 Affolter, 1986, Sidedness of reconstituted calcium channels from muscle transverse tubules as determined by D600 and D890 blockade, Biophys. J., 49, 767, 10.1016/S0006-3495(86)83703-1 Almers, 1978, Gating currents and charge movements in excitable membranes, Rev. Physiol. Biochem. Pharmacol., 82, 97 Almers, 1984, Non-selective conductance in calcium channels of frog muscle: Calcium selectivity in a single-file pore, J. Physiol. (London), 353, 585, 10.1113/jphysiol.1984.sp015352 Almers, 1985, Calcium channels in vertebrate skeletal muscle, 321 Almers, 1986, The mechanism of ion selectivity in calcium channels of skeletal muscle membranes, Prog. Zool., 33, 61 Alsobrook, 1987, Cloning the calcium channel, Trends Neurosci., 11, 1, 10.1016/0166-2236(88)90037-9 Armstrong, 1987, Voltage-activated calcium channels that must be phosphorylated to respond to membrane depolarization, Proc. Natl. Acad. Sci. U.S.A., 84, 2518, 10.1073/pnas.84.8.2518 Armstrong, 1985, Two distinct populations of calcium channels in a clonal line of pituitary cells, Science, 277, 65, 10.1126/science.2578071 Ashcroft, 1982, Calcium and potassium currents in muscle fibres of an insect (Carausius morosus), J. Physiol. (London), 323, 93, 10.1113/jphysiol.1982.sp014063 Balwierczak, 1987, Specific binding of [3H]d-cis-diltiazem to cardiac sarcolemma and its inhibition by calcium, Eur. J. Pharmacol., 116, 193, 10.1016/0014-2999(85)90205-5 Balwierczak, 1987, The relationship between the binding site of [3H]d-cis-diltiazem and that of other non-dihydropyridine calcium entry blockers in cardiac sarcolemma, Mol. Pharmacol., 31, 175 Bayley, 1983 Beam, 1986, A lethal mutation in mice eliminates the slow calcium current in skeletal muscle cells, Nature (London), 320, 168, 10.1038/320168a0 Bean, 1984, Nitrendipine block of cardiac calcium channels: High-affinity binding to the inactivated state, Proc. Natl. Acad. Sci. U.S.A., 81, 6388, 10.1073/pnas.81.20.6388 Bean, 1985, Two kinds of calcium channels in canine atrial cells, J. Gen. Physiol., 86, 1, 10.1085/jgp.86.1.1 Bean, 1983, Lidocaine block of cardiac sodium channels, J. Gen. Physiol., 81, 613, 10.1085/jgp.81.5.613 Bean, 1986, Calcium channel in muscle cells isolated from rat mesenteric arteries: Modulation by dihydropyridine drugs, Circ. Res., 59, 229, 10.1161/01.RES.59.2.229 Bellemann, 1981, [3H]Nitrendipine, a potent calcium antagonist, binds with high affinity to cardiac membranes, Arzneim. Forsch., 31, 2064 Belluzzi, 1985, Identification of delayed potassium and calcium currents in the rat sympathetic neurone under voltage clamp, J. Physiol. (London), 358, 109, 10.1113/jphysiol.1985.sp015543 Benson, 1986, Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules, Biochemistry, 25, 3077, 10.1021/bi00359a002 Berwe, 1987, The effects of the Ca-antagonist gallopamil (D600) upon excitation—contraction coupling in toe muscle fibres of the frog, J. Physiol. (London), 385, 693, 10.1113/jphysiol.1987.sp016515 Blume, 1979, Coupling of opiate receptors to adenylate cyclase: Requirement for Na+ and GTP, Proc. Natl. Acad. Sci. U.S.A., 76, 5626, 10.1073/pnas.76.11.5626 Bolger, 1984, Characterization of binding of the calcium channel antagonist, [3H]nitrendipine, to guinea pig ileal smooth muscle, J. Pharmacol. Exp. Ther., 225, 291 Borsotto, 1984, Purification of the dihydropyridine receptor of the voltage-dependent Ca2+ channel from skeletal muscle transverse tubules using (+)-[3H]PN 200–110, Biochem. Biophys. Res. Commun., 122, 1357, 10.1016/0006-291X(84)91241-5 Borsotto, 1984, Solubilization of the nitrendipine receptor from skeletal muscle transverse tubule membranes, Eur. J. Biochem., 142, 449, 10.1111/j.1432-1033.1984.tb08307.x Borsotto, 1985, The 1,4-dihydropyridine receptor associated with the skeletal muscle voltage-dependent Ca2+ channel, J. Biol. Chem., 260, 14255, 10.1016/S0021-9258(17)38711-2 Bossert, 1971, Dihydropyridine, eine neue Gruppe stark wirksamer Coronartherapeutika, Naturwissenschaften, 58, 578, 10.1007/BF00598745 Bourne, 1986, One molecular machine can transduce diverse signals, Nature (London), 321, 814, 10.1038/321814a0 Brandt, 1980, ATP-energized Ca2+ pump in isolated transverse tubes of skeletal muscle, J. Biol. Chem., 255, 6290, 10.1016/S0021-9258(18)43736-2 Breitwieser, 1985, Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channel by a guanine nucleotide analogue, Nature (London), 317, 538, 10.1038/317538a0 Brown, 1988, Direct G-protein gating of ion channels, Am. J. Physiol., 254, H401 Brown, 1986, Dual effects of dihydropyridines on whole cell and unitary calcium currents in single ventricular cells of guinea pig, J. Physiol. (London), 379, 495, 10.1113/jphysiol.1986.sp016266 Brum, 1983, Injection of catalytic subunit of cAMP-dependent protein kinase into islated cardic myocytes, Pflügers Arch., 398, 147, 10.1007/BF00581064 Brum, 1984, β-Adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp, Pflügers Arch., 401, 111, 10.1007/BF00583870 Byerly, 1985, Permeation and interaction of divalent cations in calcium channels of snail neurons, J. Gen. Physiol., 85, 491, 10.1085/jgp.85.4.491 Cachelin, 1983, Ca2+ channel modulation by 8-bromocyclic AMP in cultured heart cells, Nature (London), 304, 462, 10.1038/304462a0 Campbell, 1984, Direct photoaffinity labeling of the high affinity nitrendipine-binding site in subcellular membrane fractions isolated from canine myocardium, J. Biol. Chem., 259, 5384, 10.1016/S0021-9258(18)91018-5 Canfield, 1984, Pharmacological characterization of amine receptors on embryonic chick sensory neurones, Br. J. Pharmacol., 82, 557, 10.1111/j.1476-5381.1984.tb10794.x Cantor, 1984, Interaction of calcium channel blockers with non-neuronal benzodiazepine binding sites, Proc. Natl. Acad. Sci. U.S.A., 81, 1549, 10.1073/pnas.81.5.1549 Carbone, 1984, A low voltage-activated, fully inactivating Ca++ channel in vertebrate sensory neurones, Nature (London), 310, 501, 10.1038/310501a0 Carbone, 1984, A low voltage-activated calcium conductance in embryonic chick sensory neurons, Biophys. J., 46, 413, 10.1016/S0006-3495(84)84037-0 Casadei, 1986, Immunoaffinity isolation of Na+ channels from rat skeletal muscle, J. Biol. Chem., 261, 4318, 10.1016/S0021-9258(17)35663-6 Caswell, 1978, β-Adrenergic receptor and adenylate cyclase in transverse tubules of skeletal muscle, J. Biol. Chem., 253, 3049, 10.1016/S0021-9258(17)40801-5 Cavalié, 1986, Fast and slow gating behaviour of single calcium channels in cardiac cells, Pflügers Arch., 406, 241, 10.1007/BF00640910 Chad, 1985, Calcineurin, a calcium-dependent phosphatase, enhances Ca-mediated inactivation of Ca current in perfused snail neurons, Biophys. J., 47, 266 Chandler, 1976, Effects of glycerol treatment and maintained depolarization on charge movement in skeletal muscle, J. Physiol. (London), 254, 285, 10.1113/jphysiol.1976.sp011233 Chandler, 1976, A non-linear voltage dependent charge movement in frog skeletal muscle, J. Physiol. (London), 254, 245, 10.1113/jphysiol.1976.sp011232 Cherubini, 1984, Inhibition of calcium spikes and transmitter release by γ-aminobutyric acid in the guinea pig myenteric plexus, Br. J. Pharmacol., 82, 101, 10.1111/j.1476-5381.1984.tb16446.x Cherubini, 1985, k-opioids inhibit transmitter release by different mechanisms, Proc. Natl. Acad. Sci. U.S.A., 82, 1860, 10.1073/pnas.82.6.1860 Cognard, 1986, Different types of Ca2+ channels in mammalian skeletal muscle cells in culture, Proc. Natl. Acad. Sci. U.S.A., 83, 517, 10.1073/pnas.83.2.517 Cognard, 1986, Dihydropyridine-sensitive Ca2+ channels in mammalian skeletal muscle cell in culture: Electrophysiological properties and interaction with Ca2+ channel activator (Bay K 8644) and inhibitor (PN 200–110), Proc. Natl. Acad. Sci. U.S.A., 83, 1518, 10.1073/pnas.83.5.1518 Cooper, 1987, Purification and characterization of the dihydropyridine-sensitive voltage-dependent calcium channel from cardiac tissue, J. Biol. Chem., 262, 509, 10.1016/S0021-9258(19)75807-4 Cooper, 1985, Differential effect of phorbol ester on phenylephrine and vasopressin-induced calcium mobilization in isolated hepatocytes, J. Biol. Chem., 260, 3281, 10.1016/S0021-9258(19)83618-9 Coronado, 1986, Insulation of the conduction pathway of muscle transverse tubule calcium channels from the surface charge of bilayer phospholipid, J. Gen. Physiol., 87, 933, 10.1085/jgp.87.6.933 Cota, 1986, A fast-activated inward calcium current in twitch muscle fibers of the frog (Rana montezume), J. Physiol. (London), 370, 151, 10.1113/jphysiol.1986.sp015927 Covarrubias, 1986, Equilibrium binding of cholinergic ligands to the membrane-bound acetylcholine receptor, J. Biol. Chem., 261, 14955, 10.1016/S0021-9258(18)66811-5 Crowder, 1986, Morphine inhibition of calcium fluxes, neurotransmitter release and protein and lipid phosphorylation in brain slices and synaptosomes, Biochem. Pharmacol., 35, 2501, 10.1016/0006-2952(86)90046-8 Cruz, 1986, Calcium channel antagonists, J. Biol. Chem., 261, 6230, 10.1016/S0021-9258(19)84552-0 Cruz, 1987, Characterization of the ω-conotoxin target: Evidence for tissue-specific heterogeneity in calcium channel types, Biochemistry, 26, 820, 10.1021/bi00377a024 Curtis, 1984, Purification of the calcium antagonist receptor of the voltage-sensitive calcium channel from skeletal muscle transverse tubules, Biochemistry, 23, 2113, 10.1021/bi00305a001 Curtis, 1985, Phosphorylation of the calcium antagonist receptor of the voltage-sensitive calcium channel by cAMP-dependent protein kinase, Proc. Natl. Acad. Sci. U.S.A., 82, 2528, 10.1073/pnas.82.8.2528 Curtis, 1986, Reconstitution of the voltage-sensitive calcium channel purified from skeletal muscle transverse tubules, Biochemistry, 25, 3077, 10.1021/bi00359a002 Dascal, 1986, Expression and modulation of voltage-gated calcium channels after RNA injection in Xenopus oocytes, Science, 231, 1147, 10.1126/science.2418503 Deisz, 1985, γ-Aminobutyric acid induced depression of calcium currents of chick sensory neuron, Neurosci. Lett., 56, 205, 10.1016/0304-3940(85)90130-2 De Pover, 1983, Diltiazem potentiates the negative inotropic action of nimodipine in heart, Biochem. Biophys. Res. Commun., 114, 922, 10.1016/0006-291X(83)90648-4 DeRiemer, 1985, Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C, Nature (London), 313, 313, 10.1038/313313a0 Di Virgilio, 1986, Tumor promoter phorbol myristate acetate inhibits Ca2+ influx through voltagegated Ca2+ channels in two secretory cell lines, PC 12 and RINm5F, J. Biol. Chem., 261, 32, 10.1016/S0021-9258(17)42424-0 Doble, 1985, Dihydropyridine and peripheral type benzodiazepine binding sites, subcellular distribution and molecular size determination, Eur. J. Pharmacol., 119, 153, 10.1016/0014-2999(85)90291-2 Dolphin, 1986, Calcium-dependent currents in cultured rat dorsal root ganglion neurones are inhibited by an adenosine analogue, J. Physiol. (London), 373, 47, 10.1113/jphysiol.1986.sp016034 Dörrscheidt-Käfer, 1977, The action of D600 on frog skeletal muscle: Facilitation of excitation-contraction coupling, Pflügers. Arch., 369, 259, 10.1007/BF00582193 Drummond, 1985, Bidirectional control of cytosolic free calcium by thyrotropin-releasing hormone in pituitary cells, Nature (London), 315, 752, 10.1038/315752a0 Dudel, 1983, Graded or all-or-nothing release of transmitter quanta by local depolarizations of nerve terminals on crayfish muscle, Pflügers Arch., 398, 155, 10.1007/BF00581065 Dunlap, 1981, Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones, J. Physiol. (London), 317, 519, 10.1113/jphysiol.1981.sp013841 Ehara, 1978, The voltage- and time-dependent effects of (-)-verapamil on the slow inward current in isolated cat ventricular myocardium, J. Pharmacol. Exp. Ther., 207, 49 Ehrlich, 1984, Voltage-dependent calcium channels from paramecium cilia incorporated into planar lipid bilayers, Science, 225, 427, 10.1126/science.6330895 Ehrlich, 1986, Incorporation of calcium channels from cardiac sarcolemmal membrane vesicles into planar lipid bilayers, Proc. Natl. Acad. Sci. U.S.A., 83, 193, 10.1073/pnas.83.1.193 Eisenberg, 1983, Quantitative infrastructure of mammalian skeletal muscle, Handb. Physiol., 10, 73 Eisenberg, 1983, Paralysis of frog skeletal muscle fibres by the calcium antagonist D-600, J. Physiol. (London), 341, 495, 10.1113/jphysiol.1983.sp014819 Fabiato, 1985, Calcium-induced release of calcium from the sarcoplasmic reticulum of skinned fibers from the frog semitendinosus, Biophys. J., 47, 195 Fatt, 1958, The ionic requirements for the production of action potentials in crustacean muscle fibers, J. Physiol. (London), 142, 516, 10.1113/jphysiol.1958.sp006034 Fatt, 1953, The electrical properties of crustacean muscle fibers, J. Physiol. (London), 129, 171, 10.1113/jphysiol.1953.sp004884 Fedulova, 1985, Two types of calcium channels in the somatic membrane of new-born rat dorsal root ganglion neurons, J. Physiol. (London), 359, 431, 10.1113/jphysiol.1985.sp015594 Ferguson, 1984, Subunit structure of junctional feet in triads of skeletal muscle: A freeze-drying, rotary-shadowing study, J. Cell. Biol., 99, 1735, 10.1083/jcb.99.5.1735 Ferry, 1982, Evidence for multiple receptor sites within the putative calcium channel, Naunyn—Schmiedeberg's Arch. Pharmacol., 321, 80, 10.1007/BF00586355 Ferry, 1982, Identification of putative calcium channels in skeletal muscle microsomes, FEBS Lett., 148, 331, 10.1016/0014-5793(82)80835-1 Ferry, 1983, Tissue-specific regulation of [3H]nimodipine binding by the active isomer of diltiazem, Br. J. Pharmacol., 78, 81 Ferry, 1984, 125I-Iodipine, a new high affinity ligand for the putative calcium channel, Naunyn—Schmiedeberg's Arch. Pharmacol., 325, 186, 10.1007/BF00506200 Ferry, 1983, Differential labeling of putative skeletal muscle calcium channels by [3H]nifedipine, [3H]nitrendipine, [3H]nimodipine and [3H]PN 200–110, Naunyn-Schmiedeberg's Arch. Pharmacol., 323, 276, 10.1007/BF00497674 Ferry, 1983, Calcium channels: Evidence for oligomeric nature by target size analysis, EMBO J., 2, 1729, 10.1002/j.1460-2075.1983.tb01649.x Ferry, 1983, Putative calcium channel molecular weight determination by target size analysis, Naunyn—Schmiedeberg's Arch. Pharmacol., 323, 292, 10.1007/BF00512466 Ferry, 1984, (—)-[3H]Desmethoxyverapamil labelling of putative calcium channels in brain: Autoradiographic distribution and allosteric coupling to 1,4-dihydropyridine and diltiazem binding sites, Naunyn—Schmiedeberg's Arch. Pharmacol., 327, 183, 10.1007/BF00500915 Ferry, 1984, Photoaffinity labeling of Ca2+ channels with [3H]azidopine, FEBS Lett., 169, 112, 10.1016/0014-5793(84)80299-9 Ferry, 1985, Relationship between the stereoselective negative inotropic effects of verapamil enantiomers and their binding to putative calcium channels in human heart, Br. J. Pharmacol., 84, 811, 10.1111/j.1476-5381.1985.tb17375.x Ferry, 1985, Subunit composition of skeletal muscle transverse tubule calcium channel evaluated with the 1,4-dihydropyridine photoaffinity probe, [3H]azidopine, EMBO J., 4, 1933, 10.1002/j.1460-2075.1985.tb03873.x Ferry, 1987, Photoaffinity labeling of the cardiac calcium channel, Biochem. J., 243, 127, 10.1042/bj2430127 Fill, 1986, Contracture of skinned skeletal muscle fibers induced by ionic substitution: Comparison of block by D-600 and nitrendipine, Biophys. J., 49, 13 Fischmeister, 1986, Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle, J. Physiol. (London), 376, 183, 10.1113/jphysiol.1986.sp016148 Fleckenstein, 1983 Flockerzi, 1983, Phosphorylation of purified bovine cardiac sarcolemma and potassium-stimulated calcium uptake, Eur. J. Biochem., 135, 131, 10.1111/j.1432-1033.1983.tb07628.x Flockerzi, 1986, The purified dihydropyridine-binding site from skeletal muscle T-tubules is a functional calcium channel, Nature (London), 323, 66, 10.1038/323066a0 Forscher, 1985, Modulation of calcium channels by norepinephrine in internally dialyzed avian sensory neurons, J. Gen. Physiol., 85, 743, 10.1085/jgp.85.5.743 Forscher, 1986, Noradrenaline modulates calcium channels in avian dorsal root ganglion cells through tight receptor-channel coupling, J. Physiol. (London), 379, 131, 10.1113/jphysiol.1986.sp016244 Fosset, 1983, [3H]Nitrendipine receptors in skeletal muscle, J. Biol. Chem., 258, 6086, 10.1016/S0021-9258(18)32376-7 Franckowiak, 1985, The optical isomers of the 1,4-dihydropyridine Bay K 8644 show opposite effects on the Ca-channel, Eur. J. Pharmacol., 114, 223, 10.1016/0014-2999(85)90631-4 Frank, 1980, Commentary. The current view of the source of trigger calcium in excitation—contraction coupling in vertebrate skeletal muscle, Biochem. Pharmacol., 29, 2399, 10.1016/0006-2952(80)90341-X Frank, 1984, Blockade of Ca2+ channels inhibits K+ contractures but not twitches in skeletal muscle, Can. J. Physiol. Pharmacol., 62, 374, 10.1139/y84-059 Franzini-Armstrong, 1970, Studies of the triad: Structure of the junction in frog twitch fibers, J. Cell Biol., 47, 488, 10.1083/jcb.47.2.488 Franzini-Armstrong, 1983, Junctional feet and particles in the triads of fast-twitch muscle fiber, J. Muscle Res. Cell Motil., 4, 233, 10.1007/BF00712033 Freedman, 1984, Interactions of maitotoxin with voltage-sensitive calcium channels in cultured neuronal cells, Proc. Natl. Acad. Sci. U.S.A., 81, 4582, 10.1073/pnas.81.14.4582 Fukushima, 1985, Current carried by monovalent cations through calcium channels in mouse neoplastic B lymphocytes, J. Physiol. (London), 358, 255, 10.1113/jphysiol.1985.sp015550 Galizzi, 1984, Properties of receptors for Ca2+-channel blocker verapamil in transverse-tubule membranes of skeletal muscle, Eur. J. Biochem., 144, 211, 10.1111/j.1432-1033.1984.tb08451.x Galizzi, 1984, [3H]Verpamil binding sites in skeletal muscle transverse tubule membranes, Biochem. Biophys. Res. Commun., 118, 239, 10.1016/0006-291X(84)91092-1 Galizzi, 1985, Characterization of the Ca2+ coordination site regulating binding of Ca2+ channel inhibitors d-cis-diltiazem, (±)bepridil and (−)desmethoxyverapamil to their receptor site in skeletal muscle transverse tubule membranes, Biochem. Biophys. Res. Commun., 132, 49, 10.1016/0006-291X(85)90986-6 Galizzi, 1986, Neuroleptics of the diphenylbutylpiperidine series are potent calcium channel inhibitors, Proc. Natl. Acad. Sci. U.S.A., 83, 7513, 10.1073/pnas.83.19.7513 Galizzi, 1986, Characterization and photoaffinity labeling of receptor sites for the Ca2+ channel inhibitors d-cis-diltiazem, (±)-bepridil, desmethoxyverapamil, and (+)-PN 200–110 in skeletal muscle tranverse tubule membranes, J. Biol. Chem., 261, 1393, 10.1016/S0021-9258(17)36105-7 Galizzi, 1987, Activation of calcium channels in smooth muscle cells by protein kinase C activators (diacylglycerol and phorbol esters) and by peptides (vasopressin and bombesin) that stimulate phosphoinositide breakdown, J. Biol. Chem., 262, 6947, 10.1016/S0021-9258(18)48182-3 Galvan, 1982, Control of calcium current in rat sympathetic neurons by norepinephrine, Brain Res., 244, 135, 10.1016/0006-8993(82)90911-8 Garcia, 1986, Binding of Ca2+ entry blockers to cardiac sarcolemmal membrane vesicles, J. Biol. Chem., 261, 8146, 10.1016/S0021-9258(19)83889-9 Gilly, 1984, Contractile activation in scorpion striated muscle fibers, J. Gen. Physiol., 84, 321, 10.1085/jgp.84.3.321 Gjörstrup, 1986, The enantiomers of the dihydropyridine derivative H 160/51 show opposite effects of stimulation and inhibition, Eur. J. Pharmacol., 122, 357, 10.1016/0014-2999(86)90417-6 Glossmann, 1982, FEBS Lett., 148, 331, 10.1016/0014-5793(82)80835-1 Glossmann, 1983, Molecular approach to the calcium channel, Drug. Dev., 9, 63 Glossmann, 1983, Solubilization and partial purification of putative calcium channels labelled with [3H]nimodipine, Naunyn—Schmiedeberg's Arch. Pharmacol., 323, 279, 10.1007/BF00512465 Glossmann, 1985, Assay for calcium channels, 109, 513 Glossmann, 1982, Calcium channels: Direct identification with radioligand binding studies, Trends Pharmacol. Sci., 3, 431, 10.1016/0165-6147(82)91221-4 Glossmann, 1983, Temperature-dependent regulation of [3H]d-cis-diltiazem binding to Ca2+ channels by 1,4-dihydropyridine channel agonists and antagonists, FEBS Lett., 160, 226, 10.1016/0014-5793(83)80972-7 Glossmann, 1983, Purification of the putative calcium channel from skeletal muscle with the aid of [3H]nimodipine binding, Naunyn—Schmiedeberg's Arch. Pharmacol., 323, 1, 10.1007/BF00498821 H. Glossmann D.R. Ferry A. Goll (1984a). Molecular pharmacology of the calcium channel. Proc. IUPHAR Int. Congr. Pharmacol. 9th, pp. 329–336 Glossmann, 1984, Molecular pharmacology of the calcium channel: Evidence for subtypes, multiple drug-receptor sites, channel sub-units, and the development of a radioiodinated 1,4-dihydropyridine calcium channel label, [125I]iodipine, J. Cardiovasc. Pharmacol., 6, 608, 10.1097/00005344-198406004-00007 Glossmann, 1985, Calcium channels and calcium channel drugs: Recent biochemical and biophysical findings, Arzneim. Forsch., 35, 1917 Glossmann, 1985, Calcium channels: Basic properties as revealed by radioligand binding studies, J. Cardiovasc. Pharmacol., 7, S20, 10.1097/00005344-198500076-00005 Glossmann, 1985, Calcium channels: Introduction to their molecular pharmacology, 113 Glossmann, 1987, Purification and reconstitution of calcium channel drug receptor sites, Ann. N.Y. Acad. Sci. Glossmann, 1987, Resolving the structure of the Ca2+ channel by photoaffinity labeling, Trends Pharmacol. Sci., 8, 95, 10.1016/0165-6147(87)90082-4 Glossmann, 1987, Interaction between calcium channel ligands and calcium channels, Circ. Res., 61, 130 Godfraind, 1986, Calcium antagonism and calcium entry blockade, Pharmacol. Rev., 38, 321 Goldin, 1985, Molecular characterization, reconstitution, and “transport-specific fractionation” of the saxitoxin binding protein/Na+ gate of mammalian brain, Proc. Natl. Acad. Sci. U.S.A., 77, 6884, 10.1073/pnas.77.11.6884 Goll, 1983, Target size analysis of skeletal muscle Ca2+-channels. Positive allosteric heterotropic regulation by d-cis-diltiazem is associated with apparent channel oligomer dissociation, FEBS Lett., 157, 63, 10.1016/0014-5793(83)81117-X Goll, 1983, Target size analysis reveals subunit composition of calcium channels in brain and skeletal muscle, Naunyn—Schmiedeberg's Arch. Pharmacol., 324, 178 Goll, 1984, (-)-[3H]Desmethoxyverapamil, a novel Ca2+ channel probe. Binding characteristics and target size analysis of its receptor in skeletal muscle, FEBS Lett., 176, 371, 10.1016/0014-5793(84)81199-0 Goll, 1984, Target size analysis and molecular properties of Ca2+-channels labelled with [3H]verapamil, Eur. J. Biochem., 141, 177, 10.1111/j.1432-1033.1984.tb08172.x Goll, 1986, Correlation between the negative inotropic potency and binding parameters of 1,4-dihydropyridine and phenylalkylamine calcium channel blockers in cat heart, Naunyn—Schmiedeberg's Arch. Pharmacol., 334, 303, 10.1007/BF00508786 Gonzales-Serratos, 1982, Slow inward-calcium currents have no obvious role in muscle excitation—contraction coupling, Nature (London), 298, 292, 10.1038/298292a0 Gould, 1982, [3H]Nitrendipine-labelled calcium channels discriminate inorganic calcium agonists and antagonist, Proc. Natl. Acad. Sci. U.S.A., 79, 3656, 10.1073/pnas.79.11.3656 Gould, 1983, Antischizophrenic drugs of the diphenylbutylpiperidine type act as calcium channel antagonists, Proc. Natl. Acad. Sci. U.S.A., 80, 5122, 10.1073/pnas.80.16.5122 Gould, 1983, Tissue heterogeneity of calcium channel antagonist binding sites labeled by [3H]nitrendipine, Mol. Pharmacol., 25, 235 Gray, 1987, Noradrenaline and β-adrenoceptor agonists increase activity of voltage-dependent calcium channels in hippocampal neurons, Nature (London), 327, 620, 10.1038/327620a0 Greenberg, 1985, Reversible dihydropyridine isothiocyanate binding to brain calcium channels, J. Neurochem., 44, 319, 10.1111/j.1471-4159.1985.tb07148.x Gross, 1987, Dynorphin A selectively reduces a large transient (N-type) calcium current of mouse dorsal root ganglion neurons in cell culture, Proc. Natl. Acad. Sci. U.S.A., 84, 5469, 10.1073/pnas.84.15.5469 Hagiwara, 1981, Calcium channel, Annu. Rev. Neurosci., 4, 69, 10.1146/annurev.ne.04.030181.000441 Hamilton, 1985, Atrotoxin: A specific agonist for calcium currents in heart, Science, 229, 182, 10.1126/science.3160111 Harris, 1986, Protein kinase C mediated regulation of calcium channels in PC-12 pheochromocytoma cells, Biochem. Biophys. Res. Commun., 134, 1298, 10.1016/0006-291X(86)90391-8 Hartzell, 1986, Opposite effects of cyclic GMP and cyclic AMP on Ca2+ current in single heart cells, Nature (London), 323, 273, 10.1038/323273a0 Heizmann, 1987, Expression of parvalbumin and other Ca2+-binding proteins in normal and tumor cells: A topical review, Cell Calcium, 8, 1, 10.1016/0143-4160(87)90034-0 Hescheler, 1986, On the mechanism of muscarinic inhibition of the cardiac Ca current, Pflügers Arch., 407, 182, 10.1007/BF00580674 Hescheler, 1987, The GTP-binding protein, Go, regulates neuronal calcium channels, Nature (London), 325, 445, 10.1038/325445a0 Hess, 1984, Mechanism of ion permeation through calcium channels, Nature (London), 309, 453, 10.1038/309453a0 Hess, 1986, Calcium channel selectivity for divalent and monovalent cations, J. Gen. Physiol., 88, 293, 10.1085/jgp.88.3.293 Hidalgo, 1986, Phosphorylation of phosphatidylinositol by transverse tubule vesicles and its possible role in excitation—contraction coupling, FEBS Lett., 202, 69, 10.1016/0014-5793(86)80651-2 Hille, 1984 Hille, 1978, Potassium channels as multi-ion single-file pores, J. Gen. Physiol., 72, 409, 10.1085/jgp.72.4.409 Hirashawa, 1985, Phosphatidylinositol turnover in receptor mechanism and signal transduction, Annu. Rev. Pharmacol. Toxicol., 25, 147, 10.1146/annurev.pa.25.040185.001051 Hof, 1985, A stereoselectivity at the calcium channel: opposite action of the enantiomers of a 1,4-dihydropyridine, J. Cardiovasc. Pharmacol., 7, 687, 10.1097/00005344-198507000-00012 Hofmann, 1987, Regulation of the L-type calcium channel, Trends Pharmacol. Sci., 8, 393, 10.1016/0165-6147(87)90103-9 Höltje, 1987, A molecular graphics study on structure—action relationship of calcium antagonistic and agonistic 1,4-dihydropyridines, J. Comput. Aid. Mol. Des., 1, 23, 10.1007/BF01680555 Holz, 1986, Serotonin decreases the duration of action potentials recorded from tetraethylammonium-treated bullfrog dorsal root ganglion cells, J. Neurosci., 6, 620, 10.1523/JNEUROSCI.06-03-00620.1986 Holz, 1986, GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels, Nature (London), 319, 670, 10.1038/319670a0 Hondeghem, 1977, Time and voltage dependent interactions of antiarrhythmic drugs with cardiac sodium channels, Biochim. Biophys. Acta, 472, 373, 10.1016/0304-4157(77)90003-X Horn, 1980, α-Adrenergic inhibition of calcium dependent potentials in rat sympathetic neurons, J. Physiol. (London), 301, 191, 10.1113/jphysiol.1980.sp013198 Horne, 1984, Nitrendipine and isoproterenol induce phosphorylation of A 42,000 dalton protein that co-migrates with the affinity labeled calcium channel regulatory subunit, Biochem. Biophys. Res. Commun., 121, 890, 10.1016/0006-291X(84)90761-7 Horne, 1986, Solubilization and hydro-dynamic characterization of the dihydropyridine receptor from rat ventricular muscle, J. Biol. Chem., 261, 3588, 10.1016/S0021-9258(17)35687-9 Horwitz, 1986, Pharmacology of calcium channels and smooth muscle, Annu. Rev. Pharmacol. Toxicol., 26, 225, 10.1146/annurev.pa.26.040186.001301 Hosey, 1986, Phosphorylation and dephosphorylation of dihydropyridine-sensitive voltage-dependent Ca2+ channel in skeletal muscle membranes by cAMP- and Ca2+ -dependent processes, Proc. Natl. Acad. Sci. U.S.A., 83, 3733, 10.1073/pnas.83.11.3733 Hui, 1983, Charge movement in skeletal muscle fibers paralyzed by the calcium entry blocker D600, Proc. Natl. Acad. Sci. U.S.A., 81, 2582, 10.1073/pnas.81.8.2582 Huxley, 1971, The Croonian Lecture 1967. The activation of striated muscle and its mechanical response, Proc. R. Soc. London Ser. B, 178, 1, 10.1098/rspb.1971.0049 Hymel, 1988, Purified ryanodine receptor of skeletal muscle sarcoplasmic reticulum forms calcium activated oligomeric calcium channels in planar bilayers, Proc. Natl. Acad. Sci. U.S.A., 85, 441, 10.1073/pnas.85.2.441 Hymel, 1988, Purified skeletal muscle 1,4-dihydropyridine receptor forms phosphorylation-dependent oligomeric calcium channels in planar bilayers, Proc. Natl. Acad. Sci. U.S.A., 10.1073/pnas.85.12.4290 Hymel, 1988, Ann. N.Y. Acad. Sci. Ildefonse, 1985, Excitation-contraction coupling in skeletal muscle: Evidence for a role of slow Ca2+ channels using Ca2+ channel activators and inhibitors in the dihydropyridine series, Biochem. Biophys. Res. Commun., 129, 904, 10.1016/0006-291X(85)91977-1 Imagawa, 1987, Phosphorylation of the 1,4-dihydropyridine receptor of the voltage-dependent Ca2+ channel by an intrinsic protein kinase in isolated triads from rabbit skeletal muscle, J. Biol. Chem., 262, 8333, 10.1016/S0021-9258(18)47568-0 Imagawa, 1987, Purified ryanodine receptor from skeletal muscle sarcoplasmic reticulum is the Ca2+ -permeable pore of the calcium release channel, J. Biol. Chem., 262, 16636, 10.1016/S0021-9258(18)49303-9 Inui, 1987, Purification of the ryanodine receptor and identity with feet structures of junctional terminal cisternae of sarcoplasmatic reticulum from fast skeletal muscle, J. Biol. Chem., 262, 1740, 10.1016/S0021-9258(19)75701-9 Inui, 1987, Isolation of the ryanodine receptor from cardiac sarcoplasmatic reticulum and identity with the feet structures, J. Biol. Chem., 262 Judd, 1986, Protein kinase C activators and calcium-mobilizing agents synergistically increase GH, LH, and TSH secretion from anterior pituitary cells, Neuroendocrinology, 42, 197, 10.1159/000124440 Kameyama, 1986, Modulation of Ca current during the phosphorylation cycle in guinea pig heart, Pflügers Arch., 407, 123, 10.1007/BF00580662 Kaumann, 1976, Reversible inhibition of potassium contractures by optical isomers of verapamil and D 600 on slow muscle fibres of the frog, Naunyn-Schmiedeberg's Arch. Pharmacol., 292, 21, 10.1007/BF00506485 Kerr, 1982, Effects of the calcium antagonists bepridil (CERM-1978) and verapamil on Ca++-dependent slow action potentials in frog skeletal muscle, J. Pharmacol. Exp. Ther., 222, 80 King, 1988, Interaction of tetrandrine with slowly inactivating calcium channels: Characterization of calcium channel modulation by an alkaloid of Chinese medicinal herb origin, J. Biol. Chem., 263, 2238, 10.1016/S0021-9258(18)69196-3 King, 1988, Interaction of fluspirilene with cardiac L-type calcium channels, Biophys. J., 53, 557 Kirley, 1984, Solubilization and affinity labeling of a dihydropyridine binding site from skeletal muscle: Effects of temperature and diltiazem on [3H]dihydropyridine binding to transverse tubules, Biochem. Biophys. Res. Commun., 123, 41, 10.1016/0006-291X(84)90377-2 Knaus, 1987, Neurotoxic aminoglycoside antibiotics are potent inhibitors of [125I]-ω-conotoxin GVIA binding to guinea pig cerebral cortex membranes, Naunyn-Schmiedeberg's Arch. Pharmacol., 336, 583, 10.1007/BF00169318 Knudson, 1986, Developmental increase in skeletal muscle slow calcium current, Biophys. J., 49, 13 Koketsu, 1982, Modulation of slow inward Ca current by adrenaline in bullfrog sympathetic ganglia, Jpn. J. Physiol., 32, 137, 10.2170/jjphysiol.32.137 Kokubun, 1986, Studies on Ca channels in intact cardiac cells: Voltage dependent effects and cooperative interactions of dihydropyridine enantiomers, Mol. Pharmacol., 30, 571 Kostyuk, 1981, Ionic current in the somatic membrane of rat dorsal root ganglion neurons—II. Calcium current, Neuroscience, 6, 2431, 10.1016/0306-4522(81)90089-0 Kostyuk, 1983, Two ion-selecting filters in the calcium channel of the somatic membrane of mollusc neurons, J. Membr. Biol., 76, 83, 10.1007/BF01871455 Kozlowski, 1986, o-Isothiocyanato-dihydropyridine (oNCS-DHP), a long-acting reversible inhibitor of the Ca++ channel, J. Pharmacol. Exp. Ther., 238, 1084 Lai, 1988, Purification and reconstitution of the calcium release channel from skeletal muscle, Nature (London), 331, 315, 10.1038/331315a0 Lamb, 1986, Components of asymmetric charge movement in contracting skeletal muscle fibers of the rabbit, Biophys. J., 49, 12 Lamb, 1986, Asymmetric charge movement in contracting muscle fibers in the rabbit, J. Physiol. (London), 376, 63, 10.1113/jphysiol.1986.sp016142 Lamb, 1986, Components of asymmetric charge movement in rabbit skeletal muscle: Effects of tetracaine and nifedipine, J. Physiol. (London), 376, 85, 10.1113/jphysiol.1986.sp016143 Langs, 1984, Chemical structure and pharmacological activities of Ca2+ channel antagonists, Proc. IUPHAR Int. Congr. Pharmacol., 9th, 2, 323, 10.1007/978-1-349-86029-6_42 Langs, 1985, Conformational features of calcium channel agonist and antagonist analogs of nifedipine, Mol. Pharmacol., 27, 544 Lansman, 1986, Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+, J. Gen. Physiol., 88, 321, 10.1085/jgp.88.3.321 Lea, 1986, An examination of the ability of inositol 1, 4, 5-trisphosphate to induce calcium release and tension development in skinned skeletal muscle fibres of frog and Crustacea, FEBS Lett., 207, 153, 10.1016/0014-5793(86)80031-X Lee, 1985, Potent enhancement of [3H]nitrendipine binding in rat cerebral cortical and cardiac homogenates: A putative mechanism for the action of MDL 12,330A, J. Pharmacol. Exp. Therp., 233, 611 Lee, 1983, Mechanisms of calcium channel blockade by verapamil, D600, diltiazem and nitrendipine in single dialysed heart cells, Nature (London), 302, 790, 10.1038/302790a0 Leonard, 1987, Ca channels induced in Xenopus oocytes by rat brain mRNA, J. Neurosci., 7, 875, 10.1523/JNEUROSCI.07-03-00875.1987 Leung, 1987, Structural characterization of the 1,4-dihydropyridine receptor of the voltage-dependent calcium channel from rabbit skeletal muscle. Evidence for two distinct high molecular weight subunits, J. Biol. Chem., 262, 7943, 10.1016/S0021-9258(18)47507-2 Levi, 1986, Sodium-conducting channels in cardiac membranes in low calcium, Biophys. J., 50, 5, 10.1016/S0006-3495(86)83433-6 Lewis, 1986, A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line, Proc. Natl. Acad. Sci. U.S.A., 83, 9035, 10.1073/pnas.83.23.9035 Linn, 1983, A novel phosphonate slow channel blocker is an allosteric regulator of 1,4-dihydropyridine binding, Naunyn-Schmiedeberg's Arch. Pharmacol., 324, R45 Lopez, 1983, Determination of ionic calcium in frog skeletal muscle fibers, Biophys. J., 43, 1, 10.1016/S0006-3495(83)84316-1 Luchowski, 1984, Effects of metal cations and calmodulin antagonists on [3H]nitrendipine binding in smooth and cardiac muscle, J. Pharmacol. Exp. Ther., 230, 607 Lüttgau, 1986, The role of Ca2+ in inactivation and paralysis of excitation-contraction coupling in skeletal muscle, Prog. Zool., 33, 195 McAfee, 1981, Calcium currents modulated by adrenergic receptors in sympathetic neurons, Fed. Proc, Fed. Am. Soc. Exp. Biol., 40, 2246 McCleskey, 1985, Calcium channels and intracellular calcium release are pharmacologically different in frog skeletal muscle, J. Physiol. (London), 361, 231, 10.1113/jphysiol.1985.sp015643 McCleskey, 1985, The Ca channel in skeletal muscle is a large pore, Proc. Natl. Acad. Sci. U.S.A., 82, 7149, 10.1073/pnas.82.20.7149 McCleskey, 1986, Different types of calcium channels, J. Exp. Biol., 124, 177, 10.1242/jeb.124.1.177 McCleskey, 1987, ω-Conotoxin: Direct and persistent blockade of specific types of calcium channels in neurons but not muscle, Proc. Natl. Acad. Sci. U.S.A., 84, 4327, 10.1073/pnas.84.12.4327 MacDonald, 1986, Dynorphin decreases voltage-dependent calcium conductance of mouse dorsal root ganglion neurones, J. Physiol. (London), 377, 237, 10.1113/jphysiol.1986.sp016184 MacDonald, 1986, Adenosine agonists reduce voltage-dependent calcium conductance of mouse sensory neurones in cell culture, J. Physiol. (London), 370, 75, 10.1113/jphysiol.1986.sp015923 McDonald, 1984, Cat ventricular muscle treated with D600: Characteristics of calcium block and unblock, J. Physiol. (London), 354, 217, 10.1113/jphysiol.1984.sp015288 MacVicar, 1984, Voltage-dependent calcium channel in glial cells, Science, 226, 1345, 10.1126/science.6095454 Mannhold, 1986, Importance of nitrile substitution for the Ca antagonistic action of verapamil, Arch. Pharmacol., 319, 990, 10.1002/ardp.19863191107 Mannhold, 1987, Comparative QSAR studies on vasodilatory and negative inotropic properties of ring-varied verapamil congeners, Arzneim. Forsch., 37, 419 Marchetti, 1986, Effects of dopamine and noradrenaline on Ca channels of cultured sensory and sympathetic neurons of chick, Pflügers Arch., 406, 104, 10.1007/BF00586670 Mathias, 1980, Electrical models of excitation-contraction coupling and charge movement in skeletal muscle, J. Gen. Physiol., 76, 1, 10.1085/jgp.76.1.1 Meissner, 1984, Adenine nucleotide stimulation of Ca-induced Ca release in sarcoplasmic reticulum, J. Biol. Chem., 259, 2365, 10.1016/S0021-9258(17)43361-8 Melzer, 1986, Intramembrane charge movement and calcium release in frog skeletal muscle, J. Physiol. (London), 373, 481, 10.1113/jphysiol.1986.sp016059 Messing, 1986, Inhibition of calcium flux and calcium channel agonist binding in the PC12 neural cell line by phorbol esters and protein kinase C, Biochem. Biophys. Res. Commun., 136, 1049, 10.1016/0006-291X(86)90439-0 Meyer, 1985, Chemistry of 1,4-dihydropyridines, 90 Miller, 1986 Miller, 1985, How many types of calcium channels exist in neurones, Trends Neurosci., 8, 45, 10.1016/0166-2236(85)90023-2 Miller, 1987, Multiple calcium channels and neuronal function, Science, 235, 46, 10.1126/science.2432656 Mir, 1987, Calcium-antagonist properties of diclofurime isomers. II. Molecular aspects: Allosteric interactions with dihydropyridine recognition sites, J. Cardiovasc. Pharmacol., 9, 469, 10.1097/00005344-198704000-00012 Mitchell, 1983, Morphology of isolated triads, J. Cell Biol., 96, 1017, 10.1083/jcb.96.4.1017 Mo, 1985, Prostaglandin E1 inhibits calcium-dependent potentials in mammalian sympathetic neurons, Brain Res., 334, 325, 10.1016/0006-8993(85)90225-2 Mobley, 1975, Sizes of components in frog skeletal muscle measured by methods of stereology, J. Gen. Physiol., 66, 31, 10.1085/jgp.66.1.31 Moorman, 1987, Expression of single calcium channels in Xenopus oocytes after injection of mRNA from rat heart, Am. J. Physiol., 253, H985 Morton, 1987, Monoclonal antibody identifies a 200-kDa subunit of the dihydropyridine-sensitive calcium channel, J. Biol. Chem., 262, 11904, 10.1016/S0021-9258(18)45292-1 Murphy, 1983, A unitary mechanism of calcium antagonist drug action, Proc. Natl. Acad. Sci. U.S.A., 80, 860, 10.1073/pnas.80.3.860 Nagao, 1972, Studies on a new 1,5-benzothiazepine derivative (CRD-401). III. Effects of optical isomers of CRD-401 on smooth muscle and other pharmacological properties, Jpn. J. Pharmacol., 22, 467, 10.1254/jjp.22.467 Nakayama, 1987, Purification of a putative calcium channel protein from rabbit skeletal muscle, J. Biol. Chem., 262, 6572, 10.1016/S0021-9258(18)48279-8 Nelson, 1986, Interactions of divalent cations with single calcium channels from rat brain synaptosomes, J. Gen. Physiol., 87, 201, 10.1085/jgp.87.2.201 Nelson, 1984, Voltage-dependent calcium channels from brain incorporated into planar lipid bilayers, Nature (London), 308, 77, 10.1038/308077a0 Neuhaus, 1986, The effect of nifedipine on slow Ca2+ inward current and force development in skeletal muscle fibers of the frog, J. Physiol. (London), 378, 128P Nilius, 1985, A novel type of cardiac calcium channel in ventricular cells, Nature (London), 316, 443, 10.1038/316443a0 Nilius, 1986, Two kinds of calcium channels in isolated ventricular cells from guinea pig heart, Prog. Zool., 33, 75 Noda, 1986, Expression of functional sodium channels from cloned cDNA, Nature (London), 322, 826, 10.1038/322826a0 Norman, 1983, Determination of the molecular size of the nitrendipine-sensitive Ca2+ -channel by radiation inactivation, Biochem. Biophys. Res. Commun., 111, 878, 10.1016/0006-291X(83)91381-5 Norman, 1987, Monoclonal antibodies against the 1,4-dihydropyridine receptor associated with voltage-sensitive Ca2+ channels detect similar polypeptides from a variety of tissues and species, FEBS Lett., 212, 127, 10.1016/0014-5793(87)81570-3 North, 1983, Opiate activation of potassium conductance inhibits calcium action potential in rat locus coeruleus neurones, Br. J. Pharmacol., 80, 225, 10.1111/j.1476-5381.1983.tb10023.x Nowycky, 1985, Three types of neuronal calcium channel with different calcium agonist sensitivity, Nature (London), 316, 440, 10.1038/316440a0 Nowycky, 1985, Long-opening mode of gating of neuronal calcium channels and its promotion by the dihydropyridine calcium agonist Bay K 8644, Proc. Natl. Acad. Sci. U.S.A., 82, 2178, 10.1073/pnas.82.7.2178 Oeken, 1987, Purification of the dihydropyridine receptor from bovine cardiac muscle, Naunyn—Schmiedeberg's Arch. Pharmacol., 335, R193 Ogura, 1984, Differential effect of a dihydropyridine to Ca2+ entry pathways in neuronal preparations, Brain Res., 301, 323, 10.1016/0006-8993(84)91101-6 Olivera, 1985, Peptide neurotoxins from fish-hunting cone snails, Science, 230, 1338, 10.1126/science.4071055 Osterrieder, 1982, Injection of subunits of cyclic AMP-dependent protein kinase into cardiac myocytes modulates Ca2+ current, Nature (London), 298, 576, 10.1038/298576a0 Osugi, 1986, 1-Oleoyl-2-acetyl-glycerol and phorbol diester stimulate Ca2+ influx through Ca2+ channels in neuroblastoma × glioma hybrid NG108–15 cells, Eur. J. Pharmacol., 126, 47, 10.1016/0014-2999(86)90736-3 Paupardin-Tritsch, 1986, cGMP-dependent protein kinase enhances Ca2+ current and potentiates the serotonin-induced Ca2+ current increase in snail neurones, Nature (London), 323, 812, 10.1038/323812a0 Pauron, 1987, Identification and affinity labeling of very high affinity binding sites for the phenylalkylamine series of calcium channel blockers in the Drosophila nervous system, Biochemistry, 26, 6311, 10.1021/bi00394a003 Pauwels, 1987, Depolarization of chick myotubes triggers the appearance of (+)-[3H]PN200–110-binding sites, Mol. Pharmacol., 32, 785 Peachey, 1965, The sarcoplasmic reticulum and transverse tubules of the frog's sartorius, J. Cell Biol., 25, 209, 10.1083/jcb.25.3.209 Franzini-Armstrong Peachey, 1983, Structure and function of membrane systems of skeletal muscle cells, Handb. Physiol., 10, 23 Pelzer, 1982, Calcium channel block and recovery from block in mammalian ventricular muscle treated with organic channel inhibitors, Pflügers Arch., 394, 97, 10.1007/BF00582909 Pelzer, 1986, Macroscopic and elementary currents through cardiac calcium channels, Prog. Zool., 33, 83 Pelzer, 1987, Two types of calcium channels from skeletal muscle transverse tubule in lipid bilayers: Differences in conductance properties, gating kinetics, and chemical modulation, Pflügers Arch., 410, R35 Pincon-Raymond, 1985, Abnormal transverse tubule system and abnormal amount of receptors for Ca2+ channel inhibitors of the dihydropyridine family in skeletal muscle from mice with embryonic muscular dysgenesis, Dev. Biol., 112, 458, 10.1016/0012-1606(85)90418-X Ptasienski, 1985, High and low affinity states of the dihydropyridine and phenylalkylamine receptors on the cardiac calcium channel and their interconversion by divalent cations, Biochem. Biophys. Res. Commun., 129, 910, 10.1016/0006-291X(85)91978-3 Qar, 1986, A polypeptide toxin from the cora, Goniopora. FEBS Lett., 202, 331, 10.1016/0014-5793(86)80712-8 Qar, 1987, Receptors for diphenylbutyl-piperidine neuroleptics in brain, cardiac and smooth muscle membranes. Relationship with receptors for 1,4-dihydropyridines and phenylalkylamines and with calcium channel blockade, Eur. J. Pharmacol., 141, 261, 10.1016/0014-2999(87)90271-8 Racker, 1985 Rane, 1986, Kinase C activator 1,2-oleoylacetylglycerol attenuates voltage-dependent calcium current in sensory neurons, Proc. Natl. Acad. Sci. U.S.A., 83, 184, 10.1073/pnas.83.1.184 Rengasamy, 1985, Purification of the cardiac 1,4-dihydropyridine receptor/calcium channel complex, Biochem. Biophys. Res. Commun., 126, 1, 10.1016/0006-291X(85)90563-7 Reuter, 1983, Calcium channel modulation by neurotransmitters, enzymes and drugs, Nature (London), 301, 569, 10.1038/301569a0 Reuter, 1977, The regulation of the calcium conductance of cardiac muscle by adrenaline, J. Physiol. (London), 264, 49, 10.1113/jphysiol.1977.sp011657 Reuter, 1986, Properties and modulation of cardiac calcium channels, J. Exp. Biol., 124, 191, 10.1242/jeb.124.1.191 Reynolds, 1986, Brain voltage-sensitive calcium channel subtypes differentiated by ω-conotoxin fraction GVIA, Proc. Natl. Acad. Sci. U.S.A., 83, 8804, 10.1073/pnas.83.22.8804 Reynolds, 1986, (-)-[3H]Desmethoxyverapamil labels multiple calcium channel modulator receptors in brain and skeletal muscle membranes: Differentiation by temperature and dihydropyridines, J. Pharmacol. Exp. Ther., 237, 731 Rinaldi, 1981, The epinephrine-induced activation of the cardiac slow Ca2+ channel is mediated by the cAMP-dependent phosphorylation of calciductin, a 23,000 Mr sarcolemmal protein, FEBS Lett., 129, 277, 10.1016/0014-5793(81)80183-4 Rios, 1987, Involvement of dihydropyridine receptors in excitation-contraction coupling in skeletal muscle, Nature (London), 325, 717, 10.1038/325717a0 Rios, 1986, E-C coupling effects of interventions that reduce slow Ca2+ current suggest a role of T-tubule Ca channels in skeletal muscle function, Biophys. J., 49, 13 Rivier, 1987, Neuronal calcium channel inhibitors: Synthesis of ω-conotoxin GVIA and effects on 45Ca uptake by synaptosomes, J. Biol. Chem., 262, 1194, 10.1016/S0021-9258(19)75770-6 Romey, 1986, The electrophysiological expression of Ca2+ channels and of apamin sensitive Ca2+ activated K+ channels is abolished in skeletal muscle cells from mice with muscular dysgenesis, Biochem. Biophys. Res. Commun., 136, 935, 10.1016/0006-291X(86)90422-5 Rosenberg, 1986, Calcium channels in planar lipid bilayers: Insights into mechanisms of ion permeation and gating, Science, 231, 1564, 10.1126/science.2420007 Ruoho, 1981, Approaches to the identification of receptors utilizing photoaffinity labelling, 119 Ruth, 1985, Characterization of the binding site for nimodipine and (-)-desmethoxyverapamil in bovine cardiac sarcolemma, Eur. J. Biochem., 150, 313, 10.1111/j.1432-1033.1985.tb09023.x Ruth, 1986, Solubilization of the bovine cardiac sarcolemmal binding sites for calcium channel blockers, Eur. J. Biochem., 155, 613, 10.1111/j.1432-1033.1986.tb09532.x Sagi-Eisenberg, 1985, Protein kinase C regulation of the receptor-coupled calcium signal in histamine-secreting rat basophilic leukaemia cells, Nature (London), 313, 59, 10.1038/313059a0 Sakman, 1983 Salkoff, 1983, Ion currents in Drosophila flight muscles, J. Physiol., 337, 687, 10.1113/jphysiol.1983.sp014649 Sandow, 1952, Excitation-contraction coupling in muscular response, Yale J. Biol. Med., 25, 176 Sandow, 1965, Excitation-contraction coupling in skeletal muscle, Pharmacol. Rev., 17, 265 Sanguinetti, 1984, Voltage-dependent block of calcium channel current in the calf cardiac purkinje fiber by dihydropyridine calcium channel antagonists, Circ. Res., 55, 336, 10.1161/01.RES.55.3.336 Sanguinetti, 1986, Voltage-dependent modulation of Ca channel current in heart cells by Bay K 8644, J. Gen. Physiol., 88, 369, 10.1085/jgp.88.3.369 Sarmiento, 1986, Photoaffinity labelling of a 33–35,000 dalton protein in cardiac, skeletal and smooth muscle membranes using a new 125I-labelled 1,4-di-hydropyridine calcium channel antagonist, Life Sci., 39, 2401, 10.1016/0024-3205(86)90481-9 Scherer, 1985, Inositol 1,4,5-trisphosphate is not effective in releasing calcium from skeletal sarcoplasmic reticulum microsomes, Biochem. Biophys. Res. Commun., 128, 1064, 10.1016/0006-291X(85)91048-4 Scheuer, 1986, Charge movement and depolarization-contraction coupling in arthropod vs. vertebrate skeletal muscle, Proc. Natl. Acad. Sci. U.S.A., 83, 8799, 10.1073/pnas.83.22.8799 Schindler, 1980, Formation of planar bilayers from artificial or native membrane vesicles, FEBS Lett., 122, 77, 10.1016/0014-5793(80)80405-4 Schindler, 1988, Planar lipid-protein membranes: Strategies of formation and of detecting dependencies of ion transport functions on membrane conditions Schindler, 1984, Differential channel properties of torpedo acetylcholine receptor monomers and dimers reconstituted in planar membranes, Proc. Natl. Acad. Sci. U.S.A., 81, 6222, 10.1073/pnas.81.19.6222 Schmid, 1984, The nitrendipine-selective Ca2+ channel in chick muscle cells and its appearance during myogenesis in vitro an, in vivo. J. Biol. Chem., 259, 11366, 10.1016/S0021-9258(18)90870-7 Schmid, 1985, Short-term and long-term effects of β-adrenergic effectors and cyclic AMP on nitrendipine-sensitive voltage-dependent Ca2+ channels of skeletal muscle, J. Biol. Chem., 260, 13041, 10.1016/S0021-9258(17)38835-X Schmid, 1986, Immunochemical analysis of subunit structures of 1,4-dihydropyridine receptors associated with voltage-dependent Ca2+ channels in skeletal, cardiac and smooth muscles, Biochemistry, 25, 3492, 10.1021/bi00360a002 Schmid, 1986, Antibodies reveal the cytolocalization and subunit structure of the 1,4-dihydropyridine component of the neuronal calcium channel, Biochem. Biophys. Res. Commun., 139, 996, 10.1016/S0006-291X(86)80276-5 Schneider, 1981, Membrane charge movement and depolarization-contraction coupling, Annu. Rev. Physiol., 43, 507, 10.1146/annurev.ph.43.030181.002451 Schneider, 1973, Voltage dependent charge movement in skeletal muscle: A possible step in excitation-contraction coupling, Nature (London), 242, 244, 10.1038/242244a0 Schoemaker, 1985, [3H]Diltiazem binding to calcium channel antagonists recognition sites in rat cerebral cortex, Eur. J. Pharmacol., 111, 273, 10.1016/0014-2999(85)90768-X Schramm, 1983, Novel dihydropyridines with positive inotropic action through activation of Ca2 + channels, Nature (London), 303, 535, 10.1038/303535a0 Schramm, 1986, Calcium antagonist and calcium agonist drugs, Neurol. Neurobiol., 20, 213 Schwartz, 1985, Dihydropyridine receptors in muscle are voltage-dependent but most are not functional calcium channels, Nature (London), 314, 747, 10.1038/314747a0 Scott, 1986, Regulation of calcium currents by a GTP analogue: Potentiation of (-)-baclofen-mediated inhibition, Neurosci. Lett., 69, 59, 10.1016/0304-3940(86)90414-3 Scott, 1987, Activation of a G protein promotes agonist responses to calcium channel ligands, Nature (London), 330, 760, 10.1038/330760a0 Scott, 1987, Calcium channel currents and their inhibition by (-)-baclofen in rat sensory neurons: Modulation by guanine nucleotides, J. Physiol., 386, 1, 10.1113/jphysiol.1987.sp016518 Sharp, 1987, Identification and characterization of the dihydropyridine-binding subunit of the skeletal muscle dihydropyridine receptor, J. Biol. Chem., 262, 12309, 10.1016/S0021-9258(18)45353-7 Sieber, 1987, The 165 kDa peptide of the purified skeletal muscle dihydropyridine receptor contains the known regulatory sites of the calcium channel, Eur. J. Biochem., 167, 117, 10.1111/j.1432-1033.1987.tb13311.x Smith, 1987, Calcium channel activity in a purified dihydropyridine-receptor preparation of skeletal muscle, Biochemistry, 26, 7182, 10.1021/bi00396a046 Spedding, 1985, Activators and inactivators of Ca+ + channels: New perspectives, J. Pharmacol. (Paris), 4, 319 Spedding, 1987, Calcium antagonist properties of diclofurime isomers. I. Functional aspects, J. Cardiovasc. Pharmacol., 9, 464, 10.1097/00005344-198704000-00011 Stefani, 1982, Ionic channels in skeletal muscle, Annu. Rev. Physiol., 44, 357, 10.1146/annurev.ph.44.030182.002041 Striessnig, 1985, Human red blood cell Ca2+ antagonist binding sites: Evidence for an unusual receptor coupled to the nucleoside transporter, Eur. J. Biochem., 150, 67, 10.1111/j.1432-1033.1985.tb08989.x Striessnig, 1986, Stereoselective photoaffinity labelling of the purified 1,4-dihydropyridine receptor of the voltage-dependent calcium channel, Eur. J. Biochem., 161, 603, 10.1111/j.1432-1033.1986.tb10484.x Striessnig, 1986, Purified calcium channels have three allosterically coupled drug receptors, FEBS Lett., 197, 204, 10.1016/0014-5793(86)80327-1 Striessnig, 1987, Photoaffinity labelling of the phenylalkylamine receptor of the skeletal muscle transverse-tubule calcium channel, FEBS Lett., 212, 247, 10.1016/0014-5793(87)81354-6 Striessnig, 1988, Evidence for a distinct calcium antagonist receptor for the novel benzothiazinone compound HOE 166, Naunyn-Schmiedeberg's Arch. Pharmacol., 337, 331, 10.1007/BF00168847 Striessnig, 1988, Photoaffinity labelling of the calcium channel associated 1,4-dihydropyridine and phenylalkylamine receptor in guinea pig hippocampus, Biochem. J., 10.1042/bj2530039 Strong, 1986, Phorbol ester promotes a large conductance Ca channel in Aplysia bag cell neurons, Biophys. J., 49, 430 Strong, 1987, Stimulation of protein kinase C recruits covert calcium channels in Aplysia bag cell neurons, Nature (London), 325, 714, 10.1038/325714a0 Takahashi, 1987, Dihydropyridine-sensitive calcium channels in cardiac and skeletal muscle membranes: Studies with antibodies against the α subunits, Biochemistry, 26, 5518, 10.1021/bi00391a046 Takahashi, 1987, Identification of an α subunit of the dihydropyridine-sensitive calcium channels, Science, 236, 88, 10.1126/science.2436296 Takahashi, 1987, Subunit structure of dihydropyridine-sensitive calcium channels from skeletal muscle, Proc. Natl. Acad. Sci. U.S.A., 84, 5478, 10.1073/pnas.84.15.5478 Tanabe, 1987, Primary structure of the receptor for calcium channel blockers from skeletal muscle, Nature (London), 328, 313, 10.1038/328313a0 Talvenheimo, 1987, Heterogeneity of calcium channels from a purified dihydropyridine receptor preparation, Biophys. J., 52, 891, 10.1016/S0006-3495(87)83283-6 Theodore, 1986, Studies on Ca2+ channel agonists. 5-[(3,4-Dimethoxyphenethyl)methyl-amino]-2-(3,4-dimethoxyphenyl)-2-isopropylpentyl isothiocyanate, a chemoaffinity ligand derived from verapamil, J. Med. Chem., 29, 1789, 10.1021/jm00159a040 Thieleczek, 1986, Inositol 1,4,5-trisphosphate enhances Ca2 +-sensitivity of the contractile mechanism of chemically skinned rabbit skeletal muscle fibres, Biochem. Biophys. Res. Commun., 135, 662, 10.1016/0006-291X(86)90044-6 Trautwein, 1985, Cardiac calcium channels and their control by neurotransmitters and drugs, J. Am. Coll. Cardiol., 6, 1409, 10.1016/S0735-1097(85)80233-3 Triggle, 1983, Calcium antagonists, Circ. Res., 52, 17 Uematsu, 1986, Effects of the enantiomers of the dihydropyridine derivative 202–791 on contractility, coronary flow and ischemia-related arrhythmias in rat heart, Eur. J. Pharmacol., 123, 455, 10.1016/0014-2999(86)90723-5 Umbach, 1987, Expression of an ω-conotoxin-sensitive calcium channel in Xenopus oocytes injected with mRNA from Torpedo electric lobe, Proc. Natl. Acad. Sci. U.S.A., 84, 5464, 10.1073/pnas.84.15.5464 Vaghy, 1985, A proposed pharmacological role for dihydropyridine binding sites in heart and coronary smooth muscle, 156 Vaghy, 1987, Receptor pharmacology of calcium entry blocking agents, Am. J. Cardiol., 59, 9, 10.1016/0002-9149(87)90170-6 Vaghy, 1987, Identification of a novel 1,4-dihydropyridine-and phenylalkylamine-binding polypeptide in a calcium channel preparation, J. Biol. Chem., 262, 14337, 10.1016/S0021-9258(18)47943-4 Vandaele, 1987, Monoclonal antibodies that coimmunoprecipitate the 1,4-dihydropyridine and phenylalkylamine receptors and reveal the Ca2+ channel structure, Biochemistry, 26, 5, 10.1021/bi00375a002 Varsányi, 1986, Phosphatidylinositol 4,5-disphosphate formation in rabbit skeletal and heart muscle membranes, Biochem. Biophys. Res. Commun., 138, 1395, 10.1016/S0006-291X(86)80438-7 Venter, 1983, Molecular properties of the slow inward calcium channel, J. Biol. Chem., 258, 9344, 10.1016/S0021-9258(17)44673-4 Vergara, 1985, Inositol 1,4,5-trisphosphate: A possible chemical link in excitation-contraction coupling in muscle, Proc. Natl. Acad. Sci. U.S.A., 82, 6352, 10.1073/pnas.82.18.6352 Vincentini, 1985, Tumor promotor phorbol 12-myristate-13-acetate inhibits phosphoinositide hydrolysis and cytosolic Ca2 + rise induced by the activation of muscarinic receptors in PC12 cells, Biochem. Biophys. Res. Commun., 127, 310, 10.1016/S0006-291X(85)80160-1 Volpe, 1986, Ca2+ Dependence of transverse tubule-mediated calcium release in skinned skeletal muscle fibers, J. Gen. Physiol., 87, 271, 10.1085/jgp.87.2.271 Volpe, 1985, Inositol 1,4,5-trisphosphate induces calcium release from sarcoplasmic reticulum of skeletal muscle, Nature (London), 316, 347, 10.1038/316347a0 Volpe, 1986, Role of inositol 1,4,5-trisphosphate in excitation-contraction coupling in skeletal muscle, FEBS Lett., 197, 1, 10.1016/0014-5793(86)80285-X Volpe, 1986, Calcium-gated calcium channels in sarcoplasmic reticulum of rabbit skinned skeletal muscle fibers, J. Gen. Physiol., 87, 289, 10.1085/jgp.87.2.289 Wagner, 1987, Aminoglycoside effects on voltage-sensitive calcium channels and neurotoxicity, N. Engl. J. Med., 317, 1669, 10.1056/NEJM198712243172617 Walsh, 1984, Diltiazem potentiates mechanical activity in mammalian skeletal muscle, Biochem. Biophys. Res. Commun., 122, 1091, 10.1016/0006-291X(84)91203-8 Walsh, 1985, Effect of calcium antagonist drugs on calcium current in mammalian skeletal muscle fibers, J. Pharmacol. Exp. Ther., 236, 403 Walsh, 1987, Suppression of charge movement by calcium antagonists is not related to calcium channel block, Pflüger's Arch., 409, 217, 10.1007/BF00584775 Watson, 1985, 12-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: Possible implications for negative feedback regulation of inositol phospholipid hydrolysis, Proc. Natl. Acad. Sci. U.S.A., 82, 2623, 10.1073/pnas.82.9.2623 Williams, 1985, Catecholamine inhibition of calcium action potentials in rat locus coeruleus neurones, Neuroscience, 14, 103, 10.1016/0306-4522(85)90167-8 Williams, 1985, Characterization of α2-adrenoceptors which increase potassium conductance in rat locus coeruleus neurones, Neuroscience, 14, 95, 10.1016/0306-4522(85)90166-6 Worley, 1986, Single nislodipine-sensitive calcium channels in smooth muscle cells isolated from rabbit mesenteric artery, Proc. Natl. Acad. Sci. U.S.A., 83, 5746, 10.1073/pnas.83.15.5746 Yatani, 1987, A G protein directly regulates mammalian cardiac calcium channels, Science, 238, 1288, 10.1126/science.2446390 Yeager, 1987, Transmitter release from presynaptic terminals of electric organ: Inhibition by the calcium channel antagonist ω-conotoxin, J. Neurosci., 7, 2390 Zernig, 1988, A novel 1,4-dihydropyridine-binding site on mitochondrial membranes from guinea-pig heart, liver and kidney, Biochem J., 10.1042/bj2530049 Zernig, 1986, Stereospecific regulation of [3H]inositol monophosphate accumulation by calcium channel drugs from all three main chemical classes, Eur. J. Pharmacol., 128, 221, 10.1016/0014-2999(86)90769-7