Calcium Channel α2δ1 Subunit Mediates Secondary Orofacial Hyperalgesia Through PKC-TRPA1/Gap Junction Signaling

The Journal of Pain - Tập 21 - Trang 238-257 - 2020
Wen-Qiang Cui1,2,3, Yu-Xia Chu1,2,3, Fei Xu3,4, Teng Chen1,2,3, Lu Gao5, Yi Feng1,2,3, Xue-Ming Hu1,2,3, Wei Yang1,2,3, Li-Xia Du1,2,3, Wen-Wen Zhang1,2,3, Qi-Liang Mao-Ying1,2,3, Wen-Li Mi1,2,3, Yan-Qing Wang1,2,3
1Department of Integrative Medicine and Neurobiology, School of Basic Medical Sciences, Fudan University, Shanghai, P.R. China
2Institutes of Brain Science, Brain Science Collaborative Innovation Center, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, P.R. China
3Institutes of Integrative Medicine, Fudan University, Shanghai, P.R. China
4Department of Integrative Medicine, Huashan Hospital, Fudan University, Shanghai, P. R. China
5Department of Anatomy, School of Basic Medical Sciences, Fudan University, Shanghai, P.R. China

Tài liệu tham khảo

Abe, 2002, Changes in expression of voltage-dependent ion channel subunits in dorsal root ganglia of rats with radicular injury and pain, Spine (Phila Pa 1976), 27, 1517, 10.1097/00007632-200207150-00007 Aita, 2010, Trigeminal injury causes kappa opioid-dependent allodynic, glial and immune cell responses in mice, Mol Pain, 6, 8, 10.1186/1744-8069-6-8 Andrade, 2012, TRPA1 antagonists as potential analgesic drugs, Pharmacol Ther, 133, 189, 10.1016/j.pharmthera.2011.10.008 Cassidy, 2014, Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary alpha2delta-1 subunits, Proc Natl Acad Sci USA, 111, 8979, 10.1073/pnas.1403731111 Chen, 2018, The alpha2delta-1-NMDA receptor complex is critically involved in neuropathic pain development and gabapentin therapeutic actions, Cell Rep, 22, 2307, 10.1016/j.celrep.2018.02.021 Clark, 2006, Persistent orodental pain, atypical odontalgia, and phantom tooth pain: When are they neuropathic disorders?, J Calif Dent Assoc, 34, 599, 10.1080/19424396.2006.12222229 Corey, 2004, TRPA1 is a candidate for the mechanosensitive transduction channel of vertebrate hair cells, Nature, 432, 723, 10.1038/nature03066 Devor, 1990, Cross-excitation in dorsal root ganglia of nerve-injured and intact rats, J Neurophysiol, 64, 1733, 10.1152/jn.1990.64.6.1733 Dworkin, 2010, Recommendations for the pharmacological management of neuropathic pain: An overview and literature update, Mayo Clin Proc, 85, S3, 10.4065/mcp.2009.0649 Garrett, 2008, Differential expression of connexins in trigeminal ganglion neurons and satellite glial cells in response to chronic or acute joint inflammation, Neuron Glia Biol, 4, 295, 10.1017/S1740925X09990093 Goldberg, 2002, Gap junctions between cells expressing connexin 43 or 32 show inverse permselectivity to adenosine and ATP, J Biol Chem, 277, 36725, 10.1074/jbc.M109797200 Guo, 2017, Increased thrombospondin-4 after nerve injury mediates disruption of intracellular calcium signaling in primary sensory neurons, Neuropharmacology, 117, 292, 10.1016/j.neuropharm.2017.02.019 Gurnett, 1996, Dual function of the voltage-dependent Ca2+ channel alpha 2 delta subunit in current stimulation and subunit interaction, Neuron, 16, 431, 10.1016/S0896-6273(00)80061-6 Hendrich, 2008, Pharmacological disruption of calcium channel trafficking by the alpha2delta ligand gabapentin, Proc Natl Acad Sci USA, 105, 3628, 10.1073/pnas.0708930105 Hoppa, 2012, alpha2delta expression sets presynaptic calcium channel abundance and release probability, Nature, 486, 122, 10.1038/nature11033 Kim, 2016, Coupled activation of primary sensory neurons contributes to chronic pain, Neuron, 91, 1085, 10.1016/j.neuron.2016.07.044 Kim, 2014, Central terminal sensitization of TRPV1 by descending serotonergic facilitation modulates chronic pain, Neuron, 81, 873, 10.1016/j.neuron.2013.12.011 Kwan, 2006, TRPA1 contributes to cold, mechanical, and chemical nociception but is not essential for hair-cell transduction, Neuron, 50, 277, 10.1016/j.neuron.2006.03.042 Lemos, 2010, Effectiveness of the association between carbamazepine and peripheral analgesic block with ropivacaine for the treatment of trigeminal neuralgia, J Pain Res, 3, 201 Li, 2014, Calcium channel alpha2delta1 proteins mediate trigeminal neuropathic pain states associated with aberrant excitatory synaptogenesis, J Biol Chem, 289, 7025, 10.1074/jbc.M114.548990 Lim, 2007, Intracisternal administration of mitogen-activated protein kinase inhibitors reduced mechanical allodynia following chronic constriction injury of infraorbital nerve in rats, Prog Neuropsychopharmacol Biol Psychiatry, 31, 1322, 10.1016/j.pnpbp.2007.05.016 Luccarini, 2006, The orofacial formalin test in the mouse: A behavioral model for studying physiology and modulation of trigeminal nociception, J Pain, 7, 908, 10.1016/j.jpain.2006.04.010 Luo, 2002, Injury type-specific calcium channel alpha 2 delta-1 subunit up-regulation in rat neuropathic pain models correlates with antiallodynic effects of gabapentin, J Pharmacol Exp Ther, 303, 1199, 10.1124/jpet.102.041574 Mandadi, 2011, Protein kinase C modulation of thermo-sensitive transient receptor potential channels: Implications for pain signaling, J Nat Sci Biol Med, 2, 13, 10.4103/0976-9668.82311 Marais, 2001, Calcium channel alpha (2)delta subunits-structure and Gabapentin binding, Mol Pharmacol, 59, 1243, 10.1124/mol.59.5.1243 Marone, 2018, TRPA1/NOX in the soma of trigeminal ganglion neurons mediates migraine-related pain of glyceryl trinitrate in mice, Brain, 141, 2312, 10.1093/brain/awy177 Muller, 2010, Quantitative proteomics of the Cav2 channel nano-environments in the mammalian brain, Proc Natl Acad Sci U S A, 107, 14950, 10.1073/pnas.1005940107 Munro, 1994, Evidence for a role of protein kinase C in the sustained activation of rat dorsal horn neurons evoked by cutaneous mustard oil application, Neurosci Lett, 170, 199, 10.1016/0304-3940(94)90318-2 Nassini, 2014, The TRPA1 channel in inflammatory and neuropathic pain and migraine, Rev Physiol Biochem Pharmacol, 167, 1, 10.1007/112_2014_18 Newton, 2001, Dorsal root ganglion neurons show increased expression of the calcium channel alpha2delta-1 subunit following partial sciatic nerve injury, Brain Res Mol Brain Res, 95, 1, 10.1016/S0169-328X(01)00188-7 Nilius, 2007, Transient receptor potential cation channels in disease, Physiol Rev, 87, 165, 10.1152/physrev.00021.2006 Obata, 2005, TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury, J Clin Invest, 115, 2393, 10.1172/JCI25437 Okubo, 2013, Transition to persistent orofacial pain after nerve injury involves supraspinal serotonin mechanisms, J Neurosci, 33, 5152, 10.1523/JNEUROSCI.3390-12.2013 Pahujaa, 2007, Phosphorylation of connexin43 induced by Src: Regulation of gap junctional communication between transformed cells, Exp Cell Res, 313, 4083, 10.1016/j.yexcr.2007.09.010 Reeve, 1994, Calcium channel currents in undifferentiated human neuroblastoma (SH-SY5Y) cells: Actions and possible interactions of dihydropyridines and omega-conotoxin, Eur J Neurosci, 6, 943, 10.1111/j.1460-9568.1994.tb00588.x Ringkamp, 2005, Injured versus uninjured afferents: Who is to blame for neuropathic pain?, Anesthesiology, 103, 221, 10.1097/00000542-200508000-00002 Rong, 2016, Nitric oxide, PKC-epsilon, and connexin43 are crucial for ischemic preconditioning-induced chemical gap junction uncoupling, Oncotarget, 7, 69243, 10.18632/oncotarget.12087 Rouach, 2002, Gap junctions and connexin expression in the normal and pathological central nervous system, Biol Cell, 94, 457, 10.1016/S0248-4900(02)00016-3 Scrivani, 2010, A fMRI evaluation of lamotrigine for the treatment of trigeminal neuropathic pain: Pilot study, Pain Med, 11, 920, 10.1111/j.1526-4637.2010.00859.x Shibuta, 2012, Organization of hyperactive microglial cells in trigeminal spinal subnucleus caudalis and upper cervical spinal cord associated with orofacial neuropathic pain, Brain Res, 1451, 74, 10.1016/j.brainres.2012.02.023 Smith, 2013, The psychosocial and affective burden of posttraumatic neuropathy following injuries to the trigeminal nerve, J Orofac Pain, 27, 293, 10.11607/jop.1056 Spataro, 2004, Spinal gap junctions: Potential involvement in pain facilitation, J Pain, 5, 392, 10.1016/j.jpain.2004.06.006 Tanaka, 2001, Inducible expression of mutant alpha-synuclein decreases proteasome activity and increases sensitivity to mitochondria-dependent apoptosis, Hum Mol Genet, 10, 919, 10.1093/hmg/10.9.919 Towne, 2009, Recombinant adeno-associated virus serotype 6 (rAAV2/6)-mediated gene transfer to nociceptive neurons through different routes of delivery, Mol Pain, 5, 52, 10.1186/1744-8069-5-52 Towne, 2008, Systemic AAV6 delivery mediating RNA interference against SOD1: neuromuscular transduction does not alter disease progression in fALS mice, Mol Ther, 16, 1018, 10.1038/mt.2008.73 Trevisan, 2016, TRPA1 mediates trigeminal neuropathic pain in mice downstream of monocytes/macrophages and oxidative stress, Brain, 139, 1361, 10.1093/brain/aww038 Tsuboi, 2004, Alteration of the second branch of the trigeminal nerve activity following inferior alveolar nerve transection in rats, Pain, 111, 323, 10.1016/j.pain.2004.07.014 Vickers, 2000, Neuropathic orofacial pain. Part 2-Diagnostic procedures, treatment guidelines and case reports, Aust Endod J, 26, 53, 10.1111/j.1747-4477.2000.tb00270.x Yeh, 2011, Biphasic effects of chronic intrathecal gabapentin administration on the expression of protein kinase C gamma in the spinal cord of neuropathic pain rats, Acta Anaesthesiol Taiwan, 49, 144, 10.1016/j.aat.2011.11.006 Zakrzewska, 2017, Evaluating the impact of trigeminal neuralgia, Pain, 158, 1166, 10.1097/j.pain.0000000000000853 Zhang, 2018, Inhibition of A-Type K+ channels by urotensin-II induces sensory neuronal hyperexcitability through the PKCalpha-ERK pathway, Endocrinology, 159, 2253, 10.1210/en.2018-00108 Zhang, 2015, Gabapentin effects on PKC-ERK1/2 signaling in the spinal cord of rats with formalin-induced visceral inflammatory pain, Plos One, 10