Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes

Aitken, 1984, The structure of the B subunit of calcineurin, Eur. J. Biochem., 139, 663, 10.1111/j.1432-1033.1984.tb08055.x

Bierer, 1990, Two distinct signal transmission pathways in T lymphocytes are inhibited by complexes formed between an immunophilin and either FK506 or rapamycin, 87, 9231

Bierer, 1990, Probing immunosuppressant action with a nonnatural immunophilin ligand, Science, 250, 556, 10.1126/science.1700475

Blumenthal, 1986, Dephosphorylation of cAMP-dependent protein kinase regulatory subunit (type II) by calmodulin-dependent protein phosphatase, J. Biol. Chem., 261, 8140, 10.1016/S0021-9258(19)83888-7

Burnette, 1981, “Western blotting”: electrophoretic transfer of proteins from sodium dodecyl sulfate-polyacrylamide gels to unmodified nitrocellulose and radiographic detection with antibody and radioiodinated protein A, Anal. Biochem., 112, 195, 10.1016/0003-2697(81)90281-5

Dumont, 1990, The immunosuppressive macrolides FK506 and rapamycin act as reciprocal antagonists in murine T cells, J. Immunol., 144, 1418

Dumont, 1990, Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK506 and rapamycin, J. Immunol., 144, 251

Emmel, 1989, Cyclosporin A specifically inhibits function of nuclear proteins involved in T cell activation, Science, 246, 1617, 10.1126/science.2595372

Fischer, 1989, Cyclophilin and peptidyl-prolyl cis-trans isomerase are probably identical proteins, Nature, 337, 476, 10.1038/337476a0

Fretz, 1991, Rapamycin and FK506 binding proteins (immunophilins), J. Am. Chem. Soc., 113, 1409, 10.1021/ja00004a051

Friedman, 1991, Two cytoplasmic candidates for immunophilin action are revealed by affinity for a new cyclophilin: one in the presence and one in the absence of CsA, Cell, 66, 10.1016/0092-8674(91)90123-G

Handschumacher, 1984, Cyclophilin: a specific cytosolic binding protein for cyclosporin A, Science, 226, 544, 10.1126/science.6238408

Harding, 1989, A receptor for the immunosuppressant FK506 is a cis-trans peptidylprolyl isomerase, Nature, 341, 758, 10.1038/341758a0

Heitman, 1991, FK506-binding protein proline rotamase is a target for the immunosuppressive agent FK506 in Saccharomyces cerevisiae, 88, 1948

Heitman, 1991, Targets for cell cycle arrest by the immunosuppressive agent rapamycin, Science, 10.1126/science.1715094

Hubbard, 1989, Functional domain structure of calcineurin A: mapping by limited proteolysis, Biochemistry, 28, 1868, 10.1021/bi00430a066

Hultsch, 1991, Immunophilin ligands demonstrate common features of signal transduction leading to exocytosis or transcription, 88, 6229

Jin, 1991, Molecular cloning of a membrane-associated human FK506 and rapamycin binding protein, FKBP-13, 88, 6677

Johansson, 1990, Evidence that the immunosuppressive effects of FK506 and cyclosporine are identical, Transplantation, 50, 1001, 10.1097/00007890-199012000-00021

Kincaid, 1987, Differential expression of calmodulin-binding proteins in B, T lymphocytes and thymocytes, Nature, 330, 176, 10.1038/330176a0

Klee, 1978, Purification of cyclic 3′,5′-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to Sepharose, Biochemistry, 17, 120, 10.1021/bi00594a017

Klee, 1982, Calmodulin. Adv. Protein Chem., 35, 213, 10.1016/S0065-3233(08)60470-2

Klee, 1979, Calcineurin: a calcium and calmodulin-binding protein of the nervous system, 76, 6270

Klee, 1988, Calcineurin, Vol. 61, 149

Koltin, 1991, Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein, Mol. Cell. Biol., 11, 1718, 10.1128/MCB.11.3.1718

Lin, 1991, FK506 and cyclosporin A inhibit highly similar signal transduction pathways in human T lymphocytes, Cell. Immunol., 133, 269, 10.1016/0008-8749(91)90103-I

Manalan, 1983, Activation of calcineurin by limited proteolysis, 80, 4291

Maruyama, 1984, Detection of calcium binding proteins by 45Ca autoradiography on nitrocellulose membrane after sodium dodecyl sulfate gel electrophoresis, J. Biochem., 95, 511, 10.1093/oxfordjournals.jbchem.a134633

Mattila, 1990, The actions of cyclosporin-A and FK506 suggest a novel step in the activation of T lymphocytes, EMBO J., 9, 4425, 10.1002/j.1460-2075.1990.tb07893.x

Michnick, 1991, Solution structure of a rotamase enzyme and receptor for FK506 and rapamycin, human FKBP, Science, 251, 836, 10.1126/science.1709301

Moore, 1991, Solution structure of the major binding protein for the immunosuppressant FK506, Nature, 351, 248, 10.1038/351248a0

Price, 1991, Human cyclophilin B: a second cyclophilin gene encodes a peptidyl-prolyl isomerase with a signal sequence, 88, 1903

Schreiber, 1991, Chemistry and biology of the immunophilins and their immunosuppressive ligands, Science, 251, 283, 10.1126/science.1702904

Siekierka, 1989, A cytosolic binding protein for the immunosuppressant FK506 has peptidyl-prolyl isomerase activity but is distinct from cyclophilin, Nature, 341, 755, 10.1038/341755a0

Sigal, 1991, Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A?, J. Exp. Med., 173, 619, 10.1084/jem.173.3.619

Smith, 1988, Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase, Gene, 67, 31, 10.1016/0378-1119(88)90005-4

Stamnes, 1991, The cyclophilin homolog ninaA is a tissue-specific integral membrane protein required for the proper synthesis of a subset of Drosophila rhodopsins, Cell, 65, 219, 10.1016/0092-8674(91)90156-S

Standaert, 1990, Molecular cloning and overexpression of the human FK506-binding Protein, FKBP, Nature, 346, 671, 10.1038/346671a0

Stewart, 1982, Discovery of a Ca2+- and calmodulin-dependent protein phosphatase, FEBS Lett., 137, 80, 10.1016/0014-5793(82)80319-0

Takahashi, 1989, Peptidyl-prolyl cis-trans isomerase is the cyclosporin A-binding protein cyclophilin, Nature, 337, 473, 10.1038/337473a0

Tocci, 1989, The immunosuppressant FK506 selectively inhibits expression of early T cell activation genes, J. Immunol., 143, 718

Tropschug, 1989, Sensitivity to cyclosporin A is mediated by cyclophilin in Neurospora crassa and Saccharomyces cerevisiae, Nature, 342, 953, 10.1038/342953a0

Van Duyne, 1991, Atomic structure of FKBP-FK506, an immunophilin-immunosuppressant complex, Science, 251, 839, 10.1126/science.1709302