Calcifediol supplementation in adults on hemodialysis: a randomized controlled trial

Springer Science and Business Media LLC - Tập 35 - Trang 517-525 - 2021
Luigi Morrone1, Suetonia C. Palmer2, Valeria M. Saglimbene3, Annalisa Perna4, Giuseppe Cianciolo5, Domenico Russo6, Loreto Gesualdo7, Patrizia Natale3,7, Antonio Santoro8, Sandro Mazzaferro9, Mario Cozzolino10, Adamasco Cupisti11, Marina Di Luca12, Biagio Di Iorio13, Giovanni F. M. Strippoli3,7
1Struttura complessa di nefrologia e dialisi ASL Taranto, Taranto, Italy
2Department of Medicine, University of Otago, Christchurch, New Zealand
3Faculty of Medicine and Health, Sydney School of Public Health, University of Sydney, Sydney, Australia
4Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Bergamo, Italy
5Nephrology, Dialysis and Kidney Transplantation Unit, IRCCS, Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy
6Unit of Nephrology and Hypertension, Department of Public Health, University of Naples Federico II, Naples, Italy
7Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy
8Scuola di Specializzazione in Nefrologia, Policlinico S. Orsola-Malpighi, Università degli Studi di Bologna, Bologna, Italy
9Dipartimento di Nefrologia, Policlinico Umberto I, Università La Sapienza di Roma, Roma, Italy
10Struttura Complessa di Nefrologia e Dialisi ASST Santi Paolo e Carlo, Dipartimento di Scienze della Salute, Università di Milano, Milano, Italy
11Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
12Struttura Complessa di Nefrologia e Dialisi, A.O. Ospedali Riuniti Marche Nord, Pesaro, Italy
13Struttura Complessa di Nefrologia e Dialisi, A.O. “San Giuseppe Moscati”, Avellino, Italy

Tóm tắt

Vitamin D deficiency is associated with increased risks of mortality in people with chronic kidney disease. The benefits and harm of vitamin D supplementation on cardiovascular outcomes and mortality are unknown. We aimed to assess the effectiveness of calcifediol in reducing mortality in patients with vitamin D insufficiency on hemodialysis compared to no additional therapy. A phase III, multicenter, randomized, open-label trial was conducted including 284 adults with vitamin D insufficiency undergoing hemodialysis who were randomly assigned to receive oral calcifediol or standard care for 24 months. Two hundred eighty-four participants were enrolled (143 assigned to the calcifediol group and 141 to the no additional therapy group). The primary outcome (mortality) occurred in 34 and 31 participants in the calcifediol and control group, respectively [hazard ratio (HR) 1.03; 95% confidence interval (CI) 0.63–1.67]. Calcifediol had no detectable effects on cardiovascular death (HR 1.06; 95% CI 0.41–2.74), non-cardiovascular death (HR 1.13; 95% CI 0.62–2.04), nonfatal myocardial infarction (HR 0.20; 95% CI 0.02–1.67) or nonfatal stroke (HR could not be estimated). The incidence of hypercalcemia and hyperphosphatemia was similar between groups. None of the participants underwent parathyroidectomy. In adults treated with hemodialysis and who had vitamin D insufficiency, calcifediol supplementation for 24 months had inconclusive effects on mortality and cardiovascular outcomes. NCT01457001

Tài liệu tham khảo

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