Caffeine and Pharmaceuticals as Indicators of Waste Water Contamination in Wells
Tóm tắt
The presence of caffeine or human Pharmaceuticals in ground water with elevated nitrate concentrations can provide a clear, unambiguous indication that domestic waste water is a source of some of the nitrate. Water from domestic, public supply, and monitoring wells in three communities near Reno, Nevada, was sampled to test if caffeine or Pharmaceuticals are common, persistent, and mobile enough in the environment that they can be detected in nitrate‐contaminated ground water and, thus, can be useful indicators of recharge from domestic waste water. Results of this study indicate that these compounds can be used as indicators of recharge from domestic waste water, although their usefulness is limited because caffeine is apparently nonconservative and the presence of prescription Pharmaceuticals is unpredictable. The absence of caffeine or Pharmaceuticals in ground water with elevated nitrate concentrations does not demonstrate that the aquifer is free of waste water contamination. Caffeine was detected in ground water samples at concentrations up to 0.23 μg/L. The human Pharmaceuticals chlorpropamide, phensuximide, and carbamazepine also were detected in some samples.
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Tài liệu tham khảo
Barber L.B., 1995, Organic compounds and sewage‐derived contaminants, Contaminants in the Mississippi River, 1987–1992, 115
Barber, 1997, Conjunctive Use of Water Resources‐Aquifer Storage and Recovery, 261
Buszka P.B., 1994, Organic compounds downstream from a treated‐waste water discharge near Dallas, Texas, March, USGS Water Resources InvestigationsReport, 93
Dudley K.H., 1972, Metabolic fates of N‐methyl‐α‐phenyl‐succinimide (Phensuximide, Milontin) and of a‐phenylsuccinimide in the dog, Journal of Pharmacology and Experimental Therapeutics, 180, 167
Gilbert R.M., 1976, Caffeine content of beverages as consumed, Journal of the Canadian Medical Association, 114, 205
Goodman L.S., 1975, The Pharmacological Basis of Therapeutics
Harrill J.R., 1973, Nevada Division of Water Resources Bulletin42
Katzung B.G. ed.1992.Basic and Clinical Pharmacology 5th ed. Norwalk Conneticut: Appleton and Lange.
Maggs J.L., 1997, Characterization of the metabolites of carbamazepine in patient urine by liquid chromatography/mass spectrometry, Drug Metabolism and Disposition, 25, 275
Maurer D.K.1986.Geohydrology and simulated response to ground‐water pumpage in Carson Valley a river‐dominated basin in Douglas County Nevada and Alpine county California. USGS Water‐Resources Investigations Report86–4328.
Maurer D.K., 1997, Subsurface flow and water yield from watersheds tributary to Eagle Valley hydrographic area, West Central Nevada, USGS Water-Resources Investigations Report, 97
Pintar S.1997.Interview by author April 16 Carson City Nevada.
Rogers I.H., 1986, Organic extracta‐bles in municipal waste water, Vancouver, British Columbia, Canadian Journal of Water Pollution Research, 21, 187
Tang‐Liu D.D., 1983, Disposition of caffeine and its metabolites in man, Journal of Pharmacology and Experimental Therapeutics, 24, 180
Umari A.M.J., 1995, Potential for ground‐water contamination from movement of waste water through the unsaturated zone, Upper Mojave River Basin, California, USGS Water-Resources Investigations Report, 93
U.S. Environmental Protection Agency.1980.Design manual‐On‐site waste water treatment and disposal systems. USEPA Report EPA‐6625/1‐77‐008.
Widmer M.C. andW.A.McKay.1994.Ground‐water contamination from septic tank effluent in a closed basin Washoe County Nevada. Washoe County Department of Public Works Utility Division.