Cadmium stress: an oxidative challenge

Al-Nasser IA (2000) Cadmium hepatotoxicity and alterations of the mitochondrial function. Clin Toxicol 38:407–413

ATSDR (2005) Agency for Toxic Substance and Disease Registry, U.S. Toxicological Profile for Cadmium. Department of Health and Humans Services, Public Health Service, Centers for Disease Control, Atlanta, GA

Babu KR, Rajmohan HRR, Rajan BKM et al (2006) Plasma lipid peroxidation and erythrocyte antioxidant enzymes status in workers exposed to cadmium. Toxicol Ind Health 22(8):329–335

Barranco-Medina S, Lázaro J-L, Dietz K-J (2009) The oligomeric conformation of peroxiredoxins links redox state to function. FEBS Lett 583:1809–1816

Belyaeva EA, Korotkov SM (2003) Mechanism of primary Cd2+-induced rat liver mitochondria dysfunction: discrete modes of Cd2+ action on calcium and thiol-dependent domains. Toxicol Appl Pharm 192:56–68

Belyaeva EA, Glazunov VV, Korotkov SM (2002) Cyclosporin A-sensitive permeability transition pore is involved in Cd2+-induced dysfunction of isolated rat liver mitochondria: doubts no more. Arch Biochem Biophys 405:252–264

Belyaeva EA, Glazunov VV, Korotkov SM (2004) Cd2+ versus Ca2+-produced mitochondrial membrane permeabilization: a proposed direct participation of respiratory complexes I and III. Chem Biol Interact 150:253–270

Belyaeva EA, Dymkowska D, Więckowski MR et al (2006) Reactive oxygen species produced by the mitochondrial respiratory chain are involved in Cd2+-induced injury of rat ascites hepatoma AS-30D cells. Biochim Biophys Acta Bioenerg 1757:1568–1574

Belyaeva EA, Dymkowska D, Więckowski MR et al (2008) Mitochondria as an important target in heavy metal toxicity in rat hepatoma AS-30D cells. Toxicol Appl Pharm 231:34–42

Bertin G, Averbeck D (2006) Cadmium: cellular effects, modifications of biomolecules, modulation of DNA repair and genotoxic consequences (a review). Biochimie 88:1549–1559

Biteau B, Labarre J, Toledano (2003) ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin. Nature 425:980–984

Bokoch GM, Knaus UG (2003) NADPH oxidases: not just for leukocytes anymore!. Trends Biochem Sci 28:502–508

Boveris A, Cadenas E, Stoppani AO (1976) Role of ubiquinone in the mitochondrial generation of hydrogen peroxide. Biochem J 156:435–444

Brandao R, Weber Santos F, Oliveira R (2009) Involvement of non-enzymatic antioxidant defenses in the protective effect of diphenyl diselenide on testicular damage induced by cadmium in mice. J Trace Elem Med Biol 23:324–333

Brigelius-Flohe R (1999) Tissue-specific functions of individual glutathione peroxidases. Free Radic Biol Med 27(9–10):951–965

Cameron I, McNamee PM, Markham A et al (1986) The effects of cadmium on succinate and NADH-linked substrate oxidations in rat hepatic mitochondria. J Appl Toxicol 6:325–330

Casalino E, Sblano C, Landriscina C (1997) Enzyme activity alteration by cadmium administration to rats: the possibility of iron involvement in lipid peroxidation. Arch Biochem Biophys 346(2):171–179

Casalino E, Calzaretti G, Sblano C et al (2002) Molecular inhibitory mechanisms of antioxidant enzymes in rat liver and kidney by cadmium. Toxicology 179(1–2):37–50

Chatterjee S, Kundu S, Sengupta S et al (2009) Divergence to apoptosis from ROS induced cell cycle arrest: effect of cadmium. Mutat Res 663:22–31

Chen L, Liu L, Huang S (2008) Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5. Free Radic Biol Med 45:1035–1044

Coonse KG, Coonts AJ, Morrison EV et al (2007) Cadmium induces apoptosis in the human osteoblast-like cell line Saos-2. J Toxicol Environ Health A 70:575–581

Coutant A, Lebeau J, Bidon-Wagner N et al (2006) Cadmium-induced apoptosis in lymphoblastoid cell line: involvement of caspase-dependent and -independent pathways. Biochimie 88:1815–1822

Cuypers A, Smeets K, vangronsveld J (2009) Heavy metal stress in plants. In: Hirt H (ed) Plant stress biology. WILEY-VCH Verlag GmbH & Co., KGaA, Weinheim, pp 161–178

de Haan JB, Bladier C, Griffiths P et al (1998) Mice with a homozygous null mutation for the most abundant glutathione peroxidase, Gpx1, show increased susceptibility to the oxidative stress-inducing agents paraquat and hydrogen peroxide. J Biol Chem 273(35):22528–22536

Dickinson DA, Forman HJ (2002) Cellular glutathione and thiols metabolism. Biochem Pharmacol 64:1019–1026

Dorta DJ, Leite S, DeMarco KC et al (2003) A proposed sequence of events for cadmium-induced mitochondrial impairment. J Inorg Biochem 97:251–257

Dudley RE, Klaassen CD (1984) Changes in hepatic glutathione concentration modify cadmium-induced hepatotoxicity. Toxicol Appl Pharm 72(3):530–538

Early JL, Nonavinakere VK, Weaver A (1992) Effect of cadmium and/or selenium on liver mitochondria and rough endoplasmic reticulum in the rat. Toxicol Lett 62:73–83

El-Demerdash FM, Yousef MI, Kedwany FS et al (2004) Cadmium-induced changes in lipid peroxidation, blood hematology, biochemical parameters and semen quality of male rats: protective role of vitamin E and b-carotene. Food Chem Toxicol 42:1563–1571

Ercal N, Gurer-Orhan H, Aykin-Burns N (2001) Toxic metals and oxidative stress part 1: mechanisms involved in metal induced oxidative damage. Curr Top Med Chem 1:529–539

Erdogan Z, Erdogan S, Celik S et al (2005) Effects of ascorbic acid on cadmium-induced oxidative stress and performance of broilers. Biol Trace Elem Res 104(1):19–32

Fleury C, Mignotte B, Vayssière J-L (2002) Mitochondrial reactive oxygen species in cell death signalling. Biochimie 84:131–141

Fotakis G, Cemeli E, Anderson D et al (2005) Cadmium-chloride induced DNA and lysosomal damage in a hepatoma cell line. Toxicol In Vitro 19:481–489

Fowler BA (2009) Monitoring human populations for early markers of cadmium toxicity: a review. Toxicol Appl Pharm 238:294–300

Galán A, García-Bermejo L, Troyano A et al (2001) The role of intracellular oxidation in death induction (apoptosis and necrosis) in human promonocytic cells treated with stress inducers (cadmium, heat, X-rays). Eur J Cell Biol 80:312–320

Gao L, Laude K, Cai H (2008) Mitochondrial pathophysiology, reactive oxygen species, and cardiovascular diseases. Vet Clin North Am Small Anim Pract 38:137–155

Gong P, Chen FX, Ma GF et al (2008) Endomorphin 1 effectively protects cadmium chloride-induced hepatic damage in mice. Toxicology 251(1–3):35–44

Grosicki A (2004) Influence of vitamin C on cadmium absorption and distribution in rats. J Trace Elem Med Biol 18:183–187

Haberstroh KMW, Kapron CM (2006) Activation of c-Jun N-terminal kinase by cadmium in mouse embryo neural cells in vitro. Environ Toxicol Pharm 22(1):1–7

Halliwell B (2006) Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life. Plant Physiol 141(2):312–322

Hamada T, Tanimoto A, Sasaguri Y (1997) Apoptosis induced by cadmium. Apoptosis 2:359–367

Hansen JM, Zhang H, Jones DP (2006) Differential oxidation of thioredoxin 1, thioredoxin 2 and glutathione by metal ions. Free Radic Biol Med 40:138–145

Hart BA, Lee CH, Shukla A et al (1999) Characterization of cadmium-induced apoptosis in rat lung epithelial cells: evidence for the participation of oxidant stress. Toxicology 133:43–58

Hassoun EA, Stohs SJ (1996) Cadmium-induced production of superoxide anion and nitric oxide, DNA single strand breaks and lactate dehydrogenase leakage in J774A.1 cell cultures. Toxicology 112:219–226

Hispard F, de Vaufleury A, Martin H et al (2008) Effects of subchronic digestive exposure to organic or inorganic cadmium on biomarkers in rat tissues. Ecotoxicol Environ Saf 70(3):490–498

Hodkova A, Kotyzova R, Brtko J et al (2008) Influence of curcumin, resveratrol and sodium selenite on thioredoxin reductase, glutathione peroxidase and iodothyronine-5-deiodinase activity in rats—interaction with cadmium. Toxicol Lett 180S:S32–S246

Hossain S, Liu H-N, Nguyen M et al (2009) Cadmium exposure induces mitochondria-dependent apoptosis in oligodendrocytes. Neurotoxicology 30:544–554

Huang T-T, Carlson EJ, Raineri I et al (1999) The use of transgenic and mutant mice to study oxygen free radical metabolism. Ann N Y Acad Sci 893:95–112

Hussain T, Shukla GS, Chandra GS (1987) Effects of cadmium on superoxide-dismutase and lipid-peroxidation in liver and kidney of growing rats—in vivo and in vitro studies. Pharmacol Toxicol 60(5):355–358

Ishido M, Ohtsubo R, Adachi T et al (2002) Attenuation of both apoptotic and necrotic actions of cadmium by Bcl-2. Environ Health Perspect 110:37–42

Jarup L, Åkesson A (2009) Current status of cadmium as an environmental health problem. Toxicol Appl Pharm 238(3):201–208

Jarup L, Berglund M, Elinder CG et al (1998) Health effects of cadmium exposure—a review on the literature and a risk estimate. Scand J Work Environ Health 24(S1):1–51

Ježek P, Hlavatá L (2005) Mitochondria in homeostasis of reactive oxygen species in cell, tissues, and organism. Cell Physiol Biochem 37:2478–2503

Jihen EH, Imed M, Fatima H et al (2009) Protective effects of selenium (Se) and zinc (Zn) on cadmium (Cd) toxicity in the liver of the rat: effects on the oxidative stress. Ecotoxicol Environ Saf 72(5):1559–1564

Jiménez I, Gotteland M, Zarzuelo A et al (1997) Loss of metal binding properties of metallothionein induced by hydrogen peroxide and free radicals. Toxicology 120(1):37–46

Jones DP, Go YM, Anderson CL et al (2004) Cysteine/cystine couple as a newly recognized node in the circuitry for biologic redox signaling and control. FASEB J 18:1246–1248

Joseph P (2009) Mechanisms of cadmium carcinogenesis. Toxicol Appl Pharm 238(3):272–279

Jurczuk M, Brzoska MM, Moniuszko-Jakoniuk J et al (2004) Antioxidant enzymes activity and lipid peroxidation in liver and kidney of rats exposed to cadmium and ethanol. Food Chem Toxicol 42(3):429–438

Kamiyama T, Miyakawa H, Li JP et al (1995) Effects of one-year cadmium exposure on livers and kidneys and their relation to glutathione levels. Res Commun Pathol Pharmacol 88(2):177–186

Kara H, Cevik A, Konar V et al (2008) Effects of selenium with vitamin E and melatonin on cadmium-induced oxidative damage in rat liver and kidneys. Biol Trace Elem Res 125(3):236–244

Karabulut-Bulan O, Bolkent S, Yanardag R et al (2008) The role of vitamin C, vitamin E, and selenium on cadmium-induced renal toxicity of rats. Drug Chem Toxicol 31(4):413–426

Kawata K, Shimazaki R, Okabe S (2009) Comparison of gene expression profiles in HepG2 cells exposed to arsenic, cadmium, nickel, and three model carcinogens for investigating the mechanisms of metal carcinogenesis. Environ Mol Mutagen 50:46–59

Kefaloyianni E, Gourgou E, Ferle V et al (2005) Acute thermal stress and various heavy metals induce tissue-specific pro- or anti-apoptotic events via the p38-MAPK signal transduction pathway in Mytilus galloprovincialis (Lam.). J Exp Biol 208(23):4427–4436

Kehrer JP (2000) The Haber–Weiss reaction and mechanisms of toxicity. Toxicology 149:43–50

Kidd P (1997) Glutathione: systemic protectant against oxidative and free radical damage. Altern Med Rev 2:155–176

Kim JH, Dahms HU, Rhee JS et al (2010) Expression profiles of seven glutathione S-transferase (GST) genes in cadmium-exposed river pufferfish (Takifugu obscurus). Comp Biochem Physiol C Toxicol Pharm 151(1):99–106

Klaassen Cd, Liu J, Choudhuri S (1999) Metallothionein: an intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 39:267–294

Klaassen CD, Liu J, Diwan BA (2009) Metallothionein protection of cadmium toxicity. Toxicol Appl Pharm 238(3):215–220

Koizumi T, Yokota T, Shirakura H (1994) Potential mechanism of cadmium-induced cytotoxicity in rat hepatocytes: inhibitory action of cadmium on mitochondrial respiratory activity. Toxicology 92:115–125

Koizumi S, Gong PF, Suzuki K (2007) Cadmium-responsive element of the human heme oxygenase-1 gene mediates heat shock factor 1-dependent transcriptional activation. J Biol Chem 282(12):8715–8723

Kondoh M, Araragi S, Sato K et al (2002) Cadmium induces apoptosis partly via caspase-9 activation in HL-60 cells. Toxicology 170:111–117

Kotelnikova SV, Sokolova NG, Kotelnikov AV (2008) Lipid peroxidation in various organs and tissues of albino rats with cadmium intoxication in winter and summer. Bull Exp Biol Med 146(3):291–292

Krause KH (2004) Tissue distribution and putative physiological function of NOX family NADPH oxidases. Jpn J Infect Dis 57:S28–S29

Lasfer M, Vadrot N, Aoudjehane L et al (2008) Cadmium induces mitochondria-dependent apoptosis of normal human hepatocytes. Cell Biol Toxicol 24:55–62

Lee W-K, Bork U, Thévenod F (2004) Mitochondria as a target of cadmium nephrotoxicity: induction of swelling and cytochrome c release. Toxicol Mech Methods 14:67–71

Lee W-K, Abouhamed M, Thévenod F (2006) Caspase-dependent and -independent pathways for cadmium-induced apoptosis in cultured kidney proximal tubule cells. Am J Physiol Renal Physiol 291:F823–F832

Lemarié A, Lagadic-Gossmann D, Morzadec C et al (2004) Cadmium induces caspase-independent apoptosis in liver Hep3B cells: role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor. Free Radic Biol Med 36:1517–1531

Li JM, Shah AM (2003) ROS generation by nonphagocytic NADPH oxidase: potential relevance in diabetic nephropathy. J Am Soc Nephrol 14:S221–S226

Li M, Kondo T, Zhao Q-L et al (2000) Apoptosis induced by cadmium in human lymphoma U937 cells through Ca2+-calpain and caspase-mitochondria-dependent pathways. J Biol Chem 275:39702–39709

Li GY, Kim M, Kim JH et al (2008) Gene expression profiling in human lung fibroblast following cadmium exposure. Food Chem Toxicol 46:1131–1137

Linster CL, Van Schaftingen E (2007) Vitamin C. Biosynthesis, recycling, degradation in mammals. FEBS J 274(1):1–22

Liu J, Corton C, Dix DJ et al (2001) Genetic background, but not metallothionein phenotype dictates sensitivity to cadmium–induced testicular injury in mice. Toxicol Appl Pharm 176(1):1–9

Liu J, Kadiiska MB, Corton JC et al (2002) Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II null mice. Free Radic Biol Med 32:525–535

Liu J, Qu W, Kadiiska MB (2009) Role of oxidative stress in cadmium toxicity and carcinogenesis. Toxicol Appl Pharm 238(3):209–214

Lopez E, Arce C, Oset-Gasque MJ et al (2006) Cadmium induces reactive oxygen species generation and lipid peroxidation in cortical neurons in culture. Free Radic Biol Med 40:940–951

Maret W, Vallee BL (1998) Thiolate ligands in metallothionein confer redox activity on zinc clusters. Proc Natl Acad Sci USA 95:3478–3482

Mates JM (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Biog Amines 16(1):53–62

Matsuoka M, Igisu H (1998) Activation of c-Jun NH2-terminal kinase (JNK/SAPK) in LLC-PK1 cells by cadmium. Biochem Biophys Res Commun 251(2):527–532

Meyer Y, Siala W, Bashandy T et al (2008) Glutaredoxins and thioredoxins in plants. Biochim Biophys Acta 1783:589–600

Mittler R, Vanderauwera S, Gollery M et al (2004) Reactive oxygen gene network of plants. Trends Plant Sci 9(10):490–498

Müller L (1986) Consequences of cadmium toxicity in rat hepatocytes: mitochondrial dysfunction and lipid peroxidation. Toxicology 40:285–295

Mustafa MG, Cross CE (1971) Pulmonary alveolar macrophage. Oxidative metabolism of isolated cells and mitochondria and effect of cadmium ion on electron- and energy-transfer reactions. Biochemistry 10:4176–4185

Nawrot TS, Van Hecke E, Thijs L et al (2008) Cadmium-related mortality and long-term secular trends in the cadmium body burden of an environmentally exposed population. Environ Health Perspect 116(12):1620–1628

Neumann C, Krause D, Carman C et al (2003) Essential role for the peroxiredoxin Prdx1 in erythrocyte antioxidant defence and tumour suppression. Nature 424(6948):561–565

Newairy AA, Ei-Sharaky AS, Badreldeen MM et al (2007) The hepatoprotective effects of selenium against cadmium toxicity in rats. Toxicology 242(1–3):23–30

Nishitai G, Matsuoka M (2008) Differential regulation of HSP70 expression by the JNK kinases SEK1 and MKK7 in mouse embryonic stem cells treated with cadmium. J Cell Biochem 104(5):1771–1780

Noctor G, Foyer CH (1998) Ascorbate and glutathione: keeping active oxygen under control. Annu Rev Plant Physiol Plant Mol Biol 49:249–279

Nriagu J (1988) A silent killer of environmental metal poisoning. Environ Pollut 50(1–2):139–161

Ognjanovic BI, Pavlovic SZ, Maletic SD (2003) Protective influence of vitamin E on antioxidant defense system in the blood of rats treated with cadmium. Physiol Res 52(5):563–570

Ognjanovic BI, Markovic SD, Pavlovic SZ et al (2008) Effect of chronic cadmium exposure on antioxidant defense system in some tissues of rats: protective effect of selenium. Physiol Res 57(3):403–411

Oh SH, Lim S-C (2006) A rapid and transient ROS generation by cadmium triggers apoptosis via caspase-dependent pathway in HepG2 cells and this is inhibited through N-acetylcysteine-mediated catalase upregulation. Toxicol Appl Pharm 212:212–223

Oh MJ, Chae GY, Ahn KH (2009) Involvement of oxidised Peroxiredoxin-3 in cadmium- and ceramide-induced apoptosis of human neuroblastoma cells. J Health Sci 55(5):739–749

Packer L, Weber SU, Rimbach G (2001) Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. J Nutr 131(2):369S–373S

Papadakis ES, Finegan KG, Wang X et al (2006) The regulation of Bax by c-Jun N-terminal protein kinase (JNK) is a prerequisite to the mitochondrial-induced apoptotic pathway. FEBS Lett 580(5):1320–1326

Pathak N, Khandelwal S (2006) Oxidative stress and apoptotic changes in murine splenocytes exposed to cadmium. Toxicology 220(1):26–36

Picaud T, Desbois A (2006) Interaction of glutathione reductase with heavy metal: the binding of Hg(II) or Cd(II) to the reduced enzyme affects both the redox dithiol pair and the flavin. Biochemistry 45:15829–15837

Poliandri AHB, Machiavelli LI, Quinteros AF et al (2006) Nitric oxide protects the mitochondria of anterior pituitary cells and prevents cadmium-induced cell death by reducing oxidative stress. Free Radic Biol Med 40:679–688

Qu W, Diwan BA, Reece JM et al (2005) Cadmium-induced malignant transformation in rat liver cells: role of aberrant oncogene expression and minimal role of oxidative stress. Int J Cancer 114(3):346–355

Qu W, Fuquay R, Sakurai T et al (2006) Acquisition of apoptotic resistance in cadmium-induced malignant transformation: specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression. Mol Carcinog 45:561–571

Quinn MT, Ammons MCB, DeLeo FR (2006) The expanding role of NADPH oxidases in health and disease: no longer just agents of death and destruction. Clin Sci 111:1–20

Rana SV, Verma S (1996) Protective effects of GSH, vitamin E, and selenium on lipid peroxidation in cadmium fed rats. Biol Trace Elem Res 51(2):161–168

RC IA (1993) Cadmium and cadmium compounds. IARC Monographs. International Agency for research on Cancer, Lyon, France

Renugadevi J, Prabu SM (2009) Naringenin protects against cadmium-induced oxidative renal dysfunction in rats. Toxicology 256(1–2):128–134

Rhee S, Chae H, Kim K (2005) Peroxiredoxins: a historical overview and speculative preview of novel mechanisms and emerging concepts in cell signalling. Free Radic Biol Med 38(12):1543–1552

Rockwell P, Martinez J, Papa L et al (2004) Redox regulates COX-2 upregulation and cell death in the neuronal response to cadmium. Cell Signal 16:343–353

Salmeen A, Andersen JN, Myers MP et al (2003) Redox regulation of protein tyrosine phosphatase 1B involves a sulphenyl-amide intermediate. Nature 423:769–773

Sancho P, Fernández C, Yuste VJ et al (2006) Regulation of apoptosis/necrosis execution in cadmium-treated human promonocytic cells under different forms of oxidative stress. Apoptosis 11:673–686

Schrader M, Fahimi HD (2004) Mammalian peroxisomes and reactive oxygen species. Histochem Cell Biol 122(4):383–393

Seifried HE, Anderson DE, Fisher EI et al (2007) A review of the interaction among dietary antioxidants and reactive oxygen species. Nutr Biochem 18:567–579

Sen Gupta R, Kim J, Gomes C et al (2004) Effect of ascorbic acid supplementation on testicular steroidogenesis and germ cell death in cadmium-treated male rats. Mol Cell Endocrinol 221(1–2):57–66

Sheader DL, Williams TD, Lyons BP et al (2006) Oxidative stress response of European flounder (Platichthys flesus) to cadmium determined by a custom cDNA microarray. Mar Environ Res 62:33–44

Shih C-M, Ko W-C, Wu J-S et al (2004) Mediating of caspase-independent apoptosis by cadmium through the mitochondria-ROS pathway in MRC-5 fibroblasts. J Cell Biochem 91:384–397

Sies H (1997) Impaired endothelial and smooth muscle cell function in oxidative stress. Exp Physiol 82:291–295

Slyuzova OV, Stepanova EV, Temraleeva AD et al (2008) Effects of prenatal and neonatal cadmium intoxication on the intensity of lipid peroxidation and activity of glutathione system in progeny of albino rats. Bull Exp Biol Med 146(1):41–44

Souza V, Escobar MD, Gomez-Quiroz L et al (2004) Acute cadmium exposure enhances AP-1 DNA binding and induces cytokines expression and heat shock protein 70 in HepG2 cells. Toxicology 197(3):213–228

Souza V, Escobar M, Bucio L et al (2009) NADPH oxidase and ERK1/2 are involved in cadmium induced STAT3 activation in HepG2 cells. Toxicol Lett 187:180–186

Stohs SJ, Bagchi D (1995) Oxidative mechanisms in the toxicity of metal ions. Free Radic Biol Med 18:321–336

Suzuki JS, Kodama N, Molotkov A et al (1998) Isolation and identification of metallothionein isoforms (MT-1 and MT-2) in the rat testis. Biochem J 334:695–701

Szuster-Ciesielska A, Stachura A, Slotwinska M et al (2000) The inhibitory effect of zinc on cadmium-induced cell apoptosis and reactive oxygen species (ROS) production in cell cultures. Toxicology 145:159–171

Takahashi A, Masuda A, Sun M et al (2004) Oxidative stress-induced apoptosis is associated with alterations in mitochondrial caspase activity and Bcl-2-dependent alterations in mitochondrial pH (pHm). Brain Res Bull 62:497–504

Takeshige K, Minakami S (1979) NADH- and NADPH-dependent formation of superoxide anions by bovine heart submitochondrial particles and NADH-ubiquinone reductase preparation. Biochem J 180:129–135

Tandon SK, Singh S, Prasad S (2003) Reversal of cadmium induced oxidative stress by chelating agent, antioxidant or their combination in rat. Toxicol Lett 145(3):211–217

Tang W, Shaikh ZA (2001) Renal cortical mitochondrial dysfunction upon cadmium metallothionein administration to Sprague-Dawley rats. J Toxicol Environ Health A 63:221–235

Thévenod F (2003) Nephrotoxicity and the proximal tubule: insights from cadmium. Nephron Physiol 93:87–93

Thévenod F (2009) Cadmium and cellular signaling cascades: to be or not to be? Toxicol Appl Pharm 238(3):221–239

Thévenod F, Friedmann JM, Katsen AD et al (2000) Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappa B activation protects kidney proximal tubule cells from cadmium- and reactive oxygen species-induced apoptosis. J Appl Biol Chem 275:1887–1896

Thijssen S, Cuypers A, Maringwa J et al (2007) Low cadmium exposure triggers a biphasic oxidative stress response in mice kidneys. Toxicology 236(1–2):29–41

Turrens JF, Alexandre A, Lehninger AL (1985) Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch Biochem Biophys 237:408–414

Vairavamurthy MA, Goldenber WS, Ouyang S et al (2000) The interaction of hydrophilic thiols with cadmium: investigation with a simple model, 3-mercaptopropionic acid. Mar Chem 70:181–189

Valbonesi P, Ricci L, Franzellitti S et al (2008) Effects of cadmium on MAPK signalling pathways and HSP70 expression in a human trophoblast cell line. Placenta 29(8):725–733

Valko M, Morris H, Cronin MTD (2005) Metals, toxicity and oxidative stress. Curr Med Chem 12:1161–1208

van Montfort RLM, Congreve M, Tisi D et al (2003) Oxidation state of the active-site cyteine in protein tyrosine phosphatase 1B. Nature 423:773–777

Vangronsveld J, Van Assche F, Clijsters H (1995) Reclamation of a bare industrial area contaminated by non-ferrous metals: in situ metal immobilization and revegetation. Environ Pollut 87:51–59

Waisberg M, Joseph P, Hale B et al (2003) Molecular and cellular mechanisms of cadmium carcinogenesis. Toxicology 192(2–3):95–117

Wang YD, Fang J, Leonard SS et al (2004) Cadmium inhibits the electron transfer chain and induces reactive oxygen species. Free Radic Biol Med 36(11):1434–1443

Wang L, Cao J, Chen D et al (2009) Role of oxidative stress, apoptosis and intracellular homeostasis in primary cultures of rat proximal tubular cells exposed to cadmium. Biol Trace Elem Res 127:53–68

Winterbourn CC (1979) Comparison of superoxide with other reducing agents in the biological production of hydroxyl radicals. Biochem J 182:625–628

Wronska-Nofer T, Wisniewska-Knypl J, Dziubaltowska E et al (1999) Prooxidative and genotoxic effect of transition metals (cadmium, nickel, chromium, and vanadium) in mice. Trace Elem Electrol 16(2):87–92

Yalin S, Comelekoglu U, Bagis S et al (2006) Acute effect of single-dose cadmium treatment on lipid peroxidation and antioxidant enzymes in ovariectomized rats. Ecotoxicol Environ Saf 65(1):140–144

Yamada H, Uenishi R, Suzuki K et al (2009) Cadmium-induced alterations of gene expression in human cells. Environ Toxicol Pharm 28(1):61–69

Yang PM, Chen HC, Tsai JS et al (2007) Cadmium induces Ca2+-dependent necrotic cell death through calpain-triggered mitochondrial depolarization and reactive oxygen species-mediated inhibition of nuclear factor-kappa B activity. Chem Res Toxicol 20:406–415

Yeh J-H, Huang C-C, Yeh M-Y et al (2009) Cadmium-induced cytosolic Ca2+ elevation and subsequent apoptosis in renal tubular cells. Basic Clin Pharmacol Toxicol 104:345–351

Yiin SJ, Sheu JY, Lin TH (2000) Lipid peroxidation in rat adrenal glands after administration cadmium and role of essential metals. J Toxicol Environ Health A 62(1):47–56

Yokouchi M, Hiramatsu N, Hayakawa H et al (2008) Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response. J Biol Chem 283:4252–4260

Zalups RK, Ahmad S (2003) Molecular handling of cadmium in transporting epithelia. Toxicol Appl Pharm 186:163–188

Zhou YJ, Zhang SP, Liu CW et al (2009) The protection of selenium on ROS-mediated apoptosis by mitochondria dysfunction in cadmium-induced LLC-PK1 cells. Toxicol In Vitro 23(2):288–294