Ca2+/calmodulin-dependent protein kinase kinase-β acts upstream of AMP-activated protein kinase in mammalian cells

Altarejos, 2005, Myocardial ischemia differentially regulates LKB1 and an alternate 5′-AMP-activated protein kinase kinase, J. Biol. Chem., 280, 183, 10.1074/jbc.M411810200

Anderson, 1998, Components of a calmodulin-dependent protein kinase cascade. Molecular cloning, functional characterization and cellular localization of Ca2+/calmodulin-dependent protein kinase kinase beta, J. Biol. Chem., 273, 31880, 10.1074/jbc.273.48.31880

Andersson, 2004, AMP-activated protein kinase plays a role in the control of food intake, J. Biol. Chem., 279, 12005, 10.1074/jbc.C300557200

Bardeesy, 2002, Loss of the Lkb1 tumour suppressor provokes intestinal polyposis but resistance to transformation, Nature, 419, 162, 10.1038/nature01045

Carafoli, 2004, Calcium-mediated cellular signals: a story of failures, Trends Biochem. Sci., 29, 371, 10.1016/j.tibs.2004.05.006

Carling, 2004, The AMP-activated protein kinase cascade—a unifying system for energy control, Trends Biochem. Sci., 29, 18, 10.1016/j.tibs.2003.11.005

Carling, 1989, Purification and characterisation of the AMP-activated protein kinase, Eur. J. Biochem., 186, 129, 10.1111/j.1432-1033.1989.tb15186.x

Chen, 1987, High efficiency transformation of mammalian cells by plasmid DNA, Mol. Cell. Biol., 7, 2745, 10.1128/MCB.7.8.2745

Choi, 2001, The regulation of AMP-activated protein kinase by H2O2, Biochem. Biophys. Res. Commun., 287, 92, 10.1006/bbrc.2001.5544

Davies, 1989, Tissue distribution of AMP-activated protein kinase, and lack of activation by cyclic AMP-dependent protein kinase, studied using a specific and sensitive peptide assay, Eur. J. Biochem., 186, 123, 10.1111/j.1432-1033.1989.tb15185.x

Edelman, 1996, Multiple Ca(2+)-calmodulin-dependent protein kinase kinases from rat brain. Purification, regulation by Ca(2+)-calmodulin, and partial amino acid sequence, J. Biol. Chem., 271, 10806, 10.1074/jbc.271.18.10806

Fryer, 2002, The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways, J. Biol. Chem., 277, 25226, 10.1074/jbc.M202489200

Hardie, 1998, The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?, Annu. Rev. Biochem., 67, 821, 10.1146/annurev.biochem.67.1.821

Hawley, 1995, 5′-AMP activates the AMP-activated protein kinase cascade and Ca2+/calmodulin activates the calmodulin-dependent protein kinase-I cascade, via 3 independent mechanisms, J. Biol. Chem., 270, 27186, 10.1074/jbc.270.45.27186

Hawley, 1996, Characterisation of the AMP-activated protein kinase kinase from rat liver and identification of threonine-172 as the major site at which it phosphorylates AMP-activated protein kinase, J. Biol. Chem., 271, 27879, 10.1074/jbc.271.44.27879

Hawley, 2003, Complexes between the LKB1 tumor suppressor, STRADα/β and MO25α/β are upstream kinases in the AMP-activated protein kinase cascade, J. Biol., 2, 28, 10.1186/1475-4924-2-28

Hedbacker, 2004, Pak1 protein kinase regulates activation and nuclear localization of Snf1-Gal83 protein kinase, Mol. Cell. Biol., 24, 8255, 10.1128/MCB.24.18.8255-8263.2004

Hemminki, 1998, A serine/threonine kinase gene defective in Peutz-Jeghers syndrome, Nature, 391, 184, 10.1038/34432

Hong, 2003, Activation of yeast Snf1 and mammalian AMP-activated protein kinase by upstream kinases, Proc. Natl. Acad. Sci. USA, 100, 8839, 10.1073/pnas.1533136100

Hong, 2005, Function of mammalian LKB1 and Ca2+/calmodulin-dependent protein kinase kinase alpha as Snf1-activating kinases in yeast, J. Biol. Chem., 280, 21804, 10.1074/jbc.M501887200

Hsu, 1998, Cloning, expression and chromosomal localization of human Ca2+/calmodulin-dependent protein kinase kinase, J. Biomed. Sci., 5, 141

Ishikawa, 2003, Identification and characterization of novel components of a Ca2+/calmodulin-dependent protein kinase cascade in HeLa cells, FEBS Lett., 550, 57, 10.1016/S0014-5793(03)00817-2

Jenne, 1998, Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase, Nat. Genet., 18, 38, 10.1038/ng0198-38

Kahn, 2005, AMP-activated protein kinase: ancient energy gauge provides clues to modern understanding of metabolism, Cell Metab., 1, 15, 10.1016/j.cmet.2004.12.003

Kim, 2004, C75, a fatty acid synthase inhibitor, reduces food intake via hypothalamic AMP-activated protein kinase, J. Biol. Chem., 279, 19970, 10.1074/jbc.M402165200

Kim, 2004, Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase, Nat. Med., 10, 727, 10.1038/nm1061

Kishi, 2000, AMP-activated protein kinase is activated by the stimulations of G(q)-coupled receptors, Biochem. Biophys. Res. Commun., 276, 16, 10.1006/bbrc.2000.3417

Leclerc, 2004, AMP-activated protein kinase: a new beta-cell glucose sensor? Regulation by amino acids and calcium ions, Diabetes Suppl. 3, 53, S67

Lee, 1994, A protein activator of Ca(2+)-calmodulin-dependent protein kinase Ia, J. Biol. Chem., 269, 2158, 10.1016/S0021-9258(17)42149-1

Marley, 1996, Biochemical characterization and deletion analysis of recombinant human protein phosphatase 2C alpha, Biochem. J., 320, 801, 10.1042/bj3200801

Minokoshi, 2002, Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase, Nature, 415, 339, 10.1038/415339a

Minokoshi, 2004, AMP-kinase regulates food intake by responding to hormonal and nutrient signals inthe hypothalamus, Nature, 428, 569, 10.1038/nature02440

Neumann, 2003, Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli, Protein Expr. Purif., 30, 230, 10.1016/S1046-5928(03)00126-8

Patel, 2001, Dissociation of 5′ AMP-activated protein kinase activation and glucose uptake stimulation by mitochondrial uncoupling and hyperosmolar stress: differential sensitivities to intracellular Ca2+ and protein kinase C inhibition, Biochem. Biophys. Res. Commun., 285, 1066, 10.1006/bbrc.2001.5275

Qin, 1997, Syk-dependent and -independent signaling cascades in B cells elicited by osmotic and oxidative stress, J. Biol. Chem., 272, 2098, 10.1074/jbc.272.4.2098

Salt, 1998, AMP-activated protein kinase: greater AMP dependence, and preferential nuclear localization, of complexes containing the α2 isoform, Biochem. J., 334, 177, 10.1042/bj3340177

Selbert, 1995, Phosphorylation and activation of Ca(2+)-calmodulin-dependent protein kinase IV by Ca(2+)-calmodulin-dependent protein kinase Ia kinase. Phosphorylation of threonine 196 is essential for activation, J. Biol. Chem., 270, 17616, 10.1074/jbc.270.29.17616

Shaw, 2004, The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress, Proc. Natl. Acad. Sci. USA, 101, 3329, 10.1073/pnas.0308061100

Song, 1998, Srb/mediator proteins interact functionally and physically with transcriptional repressor Sfl1, EMBO J., 17, 5757, 10.1093/emboj/17.19.5757

Stein, 2000, The regulation of AMP-activated protein kinase by phosphorylation, Biochem. J., 345, 437, 10.1042/0264-6021:3450437

Sutherland, 2003, Elm1p is one of three upstream kinases for the Saccharomyces cerevisiae SNF1 complex, Curr. Biol., 13, 1299, 10.1016/S0960-9822(03)00459-7

Thors, 2004, Thrombin and histamine stimulate endothelial nitric-oxide synthase phosphorylation at Ser1177 via an AMPK mediated pathway independent of PI3K-Akt, FEBS Lett., 573, 175, 10.1016/j.febslet.2004.07.078

Tiainen, 1999, Growth suppression by Lkb1 is mediated by a G1 cell cycle arrest, Proc. Natl. Acad. Sci. USA, 96, 9248, 10.1073/pnas.96.16.9248

Tokumitsu, 1995, Characterization of a Ca2+/calmodulin-dependent protein kinase cascade. Molecular cloning and expression of calcium/calmodulin-dependent protein kinase kinase, J. Biol. Chem., 270, 19320, 10.1074/jbc.270.33.19320

Tokumitsu, 2000, Regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase, J. Biol. Chem., 275, 20090, 10.1074/jbc.M002193200

Tokumitsu, 2001, Differential regulatory mechanism of Ca2+/calmodulin-dependent protein kinase kinase isoforms, Biochemistry, 40, 13925, 10.1021/bi010863k

Tokumitsu, 2002, STO-609, a specific inhibitor of the Ca(2+)/calmodulin-dependent protein kinase kinase, J. Biol. Chem., 277, 15813, 10.1074/jbc.M201075200

Woods, 1996, Characterization of AMP-activated protein kinase β subunit and γ subunit—assembly of the heterotrimeric complex in vitro, J. Biol. Chem., 271, 10282, 10.1074/jbc.271.17.10282

Woods, 1996, The α1 and α2 isoforms of the AMP-activated protein kinase have similar activities in rat liver but exhibit differences in substrate specificity in vitro, FEBS Lett., 397, 347, 10.1016/S0014-5793(96)01209-4

Woods, 2003, LKB1 is the upstream kinase in the AMP-activated protein kinase cascade, Curr. Biol., 13, 2004, 10.1016/j.cub.2003.10.031

Yamauchi, 2002, Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase, Nat. Med., 8, 1288, 10.1038/nm788