Các kênh K+ kiểu BK được kích hoạt bởi Ca2+ trong não chuột

Springer Science and Business Media LLC - Tập 125 - Trang 725-741 - 2005
Ulrike Sausbier1, Matthias Sausbier1, Claudia A. Sailer2, Claudia Arntz1, Hans-Günther Knaus2, Winfried Neuhuber3, Peter Ruth1
1Pharmakologie und Toxikologie, Pharmazeutisches Institut der Universität Tübingen, Tübingen, Germany
2Division für Molekulare und Zelluläre Pharmakologie, Medizinische Universität Innsbruck, Innsbruck, Austria
3Institut für Anatomie der Friedrich-Alexander-Universität Erlangen-Nürnberg, Nürnberg, Germany

Tóm tắt

Kháng thể chống lại 442 axit amin đầu cuối carboxy của chuỗi α kênh BK phát hiện sự phản ứng miễn dịch cao trong telencephalon, cụ thể là trong vỏ não, củ khứu giác, hạch nền và hồi hải mã, trong khi mức độ thấp hơn được tìm thấy ở các vùng não nền và hạch hạnh nhân. Trong diencephalon, mật độ cao được tìm thấy trong các nhân của thalamus ventral và dorsal cũng như nhân habenular giữa, và mật độ thấp trong hypothalamus. Fasciculus retroflexus và điểm kết thúc của nó trong nhân liên chân não giữa được nhuộm rõ ràng. Các vị trí biểu hiện khác của não giữa bao gồm chất xám quanh ống nước và các nhân raphe. Trong rhombencephalon, các kênh BK được làm giàu trong vỏ tiểu não và trong locus coeruleus. Phản ứng miễn dịch mạnh cũng có mặt trong các nhân vestibular, nhưng không có trong các dây thần kinh sọ và đường đi nội tủy của các rễ thần kinh này. Ở cấp độ tế bào, các kênh BK thể hiện sự định vị tiền và hậu synap, tức là trong soma, nhánh, axon và các tận cùng synap.

Từ khóa

#kênh K+ kiểu BK #kích hoạt bởi Ca2+ #não chuột #phản ứng miễn dịch #telencephalon #diencephalon #rhombencephalon

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