CTLA-4 gene expression is influenced by promoter and exon 1 polymorphisms

Martino G, Hartung HP Immunopathogenesis of multiple sclerosis: the role of T cells Curr Opin Neurol 1999 12 309–321

Karandikar NJ, Vanderlugt CL, Walunas TL, Miller SD, Bluestone JA CTLA-4: a negative regulator of autoimmune disease J Exp Med 1996 184 783–788

Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone AJ, Sharpe AH Los of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4 Immunity 1995 3 541–547

Carreno BM, Bennett F, Chau TA et al CTLA-4 (CD152) can inhibit T cell activation by two different mechanisms depending on its level of cell surface expression J Immunol 2000 165 1352–1356

Brunet JF, Denizot F, Luciani MF, Roux-Dosseto M, Suzan M, Mattei MG A new member of the immunoglobulin superfamily – CTLA-4 Nature 1987 328 267–270

Harper K, Balzano C, Rouvier E, Mattei MG, Luciani MF, Golstein P CTLA-4 and CD28 activated lymphocyte molecules are closely related in both mouse and human as to sequence, message expression, gene structure, and chromosomal location J Immunol 1991 147 1037–1044

Linsley PS, Greene JL, Tan P et al Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes J Exp Med 1992 176 1595–1604

Kuiper HM, Brouwer M, Linsley PS, van Lier RA Activated T cells can induce high levels of CTLA-4 expression on B cells J Immunol 1995 155 1776–1783

Donner H, Rau H, Walfish PG et al CTLA-4 alanine-17 confers genetic susceptibility to Graves’ disease and to type 1 diabetes mellitus J Clin Endocrinol Metab 1997 82 143–146

Marron MP, Raffel LJ, Garchon HJ et al Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups Hum Mol Genet 1997 6 1275–1282

Yanagawa T, Hidaka Y, Guimaraes V, Soliman M, DeGroot LJ CTLA-4 gene polymorphism associated with Graves’ disease in a Caucasian population J Clin Endocrinol Metab 1995 80 41–45

Ligers A, Xu C, Saarinen S, Hillert J, Olerup O The CTLA-4 gene is associated with multiple sclerosis J Neuroimmunol 1999 97 182–190

Harbo HF, Celius EG, Vartdal F, Spurkland A CTLA-4 promoter and exon 1 dimorphisms in multiple sclerosis Tissue Antigens 1999 53 106–110

Heward JM, Allahabadia A, Carr-Smith J et al No evidence for allelic association of a human CTLA-4 promoter polymorphism with autoimmune thyroid disease in either population-based case-control or family-based studies Clin Endocrinol 1998 49 331–334

Seidl C, Donner H, Fischer B et al CTLA4 codon 17 dimorphism in patients with rheumatoid arthritis Tissue Antigens 1998 51 62–66

Vandenborre K, Delabie J, Boogaerts MA et al Human CTLA-4 is expressed in situ on T lymhocytes in germinal centres, in cutaneous graft-versus host disease, and in Hodgkins disease Am J Pathol 1998 152 963–973

Liu MF, Liu HS, Wang CR, Lei HY Expression of CTLA-4 molecule in peripheral blood T lymphocytes from patients with systemic lupus erythematosus J Clin Immunol 1998 18 392–398

Liu MF, Yang CY, Li JS, Lai KA, Chao SC, Lei HY Increased expression of down-regulatory CTLA-4 molecule on T lymphocytes from rheumatoid synovial compartment Scand J Immunol 1999 50 68–72

Mena E, Rohowsky-Kochan C Expression of costimulatory molecules on peripheral blood mononuclear cells in multiple sclerosis Acta Neurol Scand 1999 100 92–96

Magistrelli G, Jeannin P, Herbault N et al A soluble form of CTLA-4 generated by alternative splicing is expressed by non stimulated human T cells Eur J Immunol 1999 29 3596–3602

Oaks MK, Hallett KM, Penwell RT, Stauber EC, Warren SJ, Tector AJ A native soluble form of CTLA-4 Cell Immunol 2000 201 144–153

Perkins D, Wang Z, Donovan C et al Regulation of CTLA-4 expression during T cell activation J Immunol 1996 156 4154–4159

Kouki T, Sawai Y, Gardine CA, Fisfalen ME, Alegre ML, DeGroot LJ CTLA-4 gene polymorphism at position 49 in exon 1 reduces the inhibitory function of CTLA-4 and contributes to the pathogenesis of Graves’ disease J Immunol 2000 165 6606–6611

Takahashi T, Tagami T, Yamazaki S et al Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4 J Exp Med 2000 192 303–310

Read S, Malmstrom V, Powrie F Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation J Exp Med 2000 192 295–302

Leung HT, Bradshaw J, Cleaveland JS, Linsley PS Cytotoxic T lymphocyte-associated molecule-4, a high avidity receptor for CD80 and CD86, contains an intracellular localization motif in its cytoplasmic tail J Biol Chem 1995 270 25107–25114

Schneider H, Martin M, Agarraberes FA et al Cytolytic T lymphocyte-associated antigen-4 and the TCRζ/CD3 complex, but not CD28, interact with clathrin adaptor complexes AP-1 and AP-2 J Immunol 1999 163 1868–1879

Alegre ML, Shiels H, Thompson CB, Gajeuski TF Expression and function of CTLA-4 in Th1 and Th2 cells J Immunol 1998 161 3347–3356

Chambers CA, Kuhns MS, Allison JP Cytotoxic T lymphocyte antigen-4 (CTLA-4) regulates primary and secondary peptide-specific CD4+ T cell responses Proc Natl Acad Sci USA 1999 96 8603–8608

Sun D, Ben-Nun A, Wekerle H Regulatory circuits in autoimmunity: recruitment of counter-regulatory CD8+ T cells by encephalitogenic CD4+ T line cells Eur J Immunol 1988 18 1993–1999

Braun J, Donner H, Siegmund T, Walfish PG, Usadel KH, Badenhoop K CTLA-4 promoter variants in patients with Graves’ disease and Hashimoto’s thyroiditis Tissue Antigens 1998 51 563–566

Park YJ, Chung HK, Park DJ et al Polymorphism in the promoter and exon 1 of the cytotoxic T lymphocyte antigen-4 gene associated with autoimmune thyroid disease in Koreans Thyroid 2000 10 453–459

Krummel MF, Allison PJ CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells J Exp Med 1996 183 2533–2540

Chen W, Jin W, Wahl SM Engagement of cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) induces transforming growth factor-β (TGF-β) production by murine CD4(+) T cells J Exp Med 1998 188 1849–1857

Bachmann MF, Köhler G, Ecabert B, Mak TW, Kopf M Cutting edge: lymphoproliferative disease in the absence of CTLA-4 is not T cell autonomous J Immunol 1999 163 1128–1131

Gribben JG, Freeman GJ, Boussiotis VA et al CTLA4 mediates antigen-specific apoptosis of human T cells Proc Natl Acad Sci USA 1995 92 811–815

Poser CM, Paty DW, Scheinberg L et al New diagnostic criteria for multiple sclerosis: guidelines for research protocols Ann of Neurol 1983 13 227–231

Huang W-X, Huang P, Link H, Hillert J Cytokine analysis in multiple clerosis by competitive RT-PCR: A decreased expression of IL-10 and an increased expression of TNF-α in chronic progression Mult Scler 1999 5 342–348

Huang W-X, Huang P, Fredrikson S, Pirskanen R, Hillert J Decreased mRNA expression of TNF-α and IL-10 in non-stimulated peripheral blood mononuclear cells in myasthenia gravis Eur J Neurol 2000 7 195–202

Olerup O, Aldener A, Fogdell A HLA-DQB1 and -DQA1 typing by PCR amplification with sequence-specific primers (PCR-SSP) in 2 hours Tissue Antigens 1993 41 119–134

Reed PW, Davies JL, Copeman JB et al Chromosome-specific microsatellite sets for fluorescence-based, semi-automatic genome mapping Nat Genet 1994 7 390–395