CT-Based Intratumoral and Peritumoral Radiomics Nomograms for the Preoperative Prediction of Spread Through Air Spaces in Clinical Stage IA Non-small Cell Lung Cancer

Journal of Imaging Informatics in Medicine
Yun Wang1, Deng Lyu1, Linda Hu2, Junhong Wu3, Shaofeng Duan4, Taohu Zhou1, Wenting Tu1, Yi Xiao1, Li Fan1, Shi-yuan Liu1
1Department of Radiology, Second Affiliated Hospital of Navy Medical University, Shanghai, 200003, China
2Department of Radiology Medicine, The People’s Hospital of Chizhou, Chizhou, Anhui, 247100, China
3Department of Radiology Medicine, The People’s Hospital of Guigang, Guigang, Guangxi Zhuang Autonomous Region, 537100, China
4GE Healthcare, Precision Health Institution, Shanghai, China

Tóm tắt

AbstractThe study aims to investigate the value of intratumoral and peritumoral radiomics and clinical-radiological features for predicting spread through air spaces (STAS) in patients with clinical stage IA non-small cell lung cancer (NSCLC). A total of 336 NSCLC patients from our hospital were randomly divided into the training cohort (n = 236) and the internal validation cohort (n = 100) at a ratio of 7:3, and 69 patients from the other two external hospitals were collected as the external validation cohort. Univariate and multivariate analyses were used to select clinical-radiological features and construct a clinical model. The GTV, PTV5, PTV10, PTV15, PTV20, GPTV5, GPTV10, GPTV15, and GPTV20 models were constructed based on intratumoral and peritumoral (5 mm, 10 mm, 15 mm, 20 mm) radiomics features. Additionally, the radscore of the optimal radiomics model and clinical-radiological predictors were used to construct a combined model and plot a nomogram. Lastly, the ROC curve and AUC value were used to evaluate the diagnostic performance of the model. Tumor density type (OR = 6.738) and distal ribbon sign (OR = 5.141) were independent risk factors for the occurrence of STAS. The GPTV10 model outperformed the other radiomics models, and its AUC values were 0.887, 0.876, and 0.868 in the three cohorts. The AUC values of the combined model constructed based on GPTV10 radscore and clinical-radiological predictors were 0.901, 0.875, and 0.878. DeLong test results revealed that the combined model was superior to the clinical model in the three cohorts. The nomogram based on GPTV10 radscore and clinical-radiological features exhibited high predictive efficiency for STAS status in NSCLC.

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Journal of Imaging Informatics in Medicine

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