CRISPR-PIN: Modifying gene position in the nucleus via dCas9-mediated tethering

Misteli, 2007, Beyond the sequence: cellular organization of genome function, Cell, 128, 787, 10.1016/j.cell.2007.01.028 Baudat, 2013, Meiotic recombination in mammals: localization and regulation, Nat Rev Genet, 14, 794, 10.1038/nrg3573 de Juan, 2013, Emerging methods in protein co-evolution, Nat Rev Genet, 14, 249, 10.1038/nrg3414 Lee, 2008, Surface sites for engineering allosteric control in proteins, Science, 322, 438, 10.1126/science.1159052 Marsh, 2015, Structure, dynamics, assembly, and evolution of protein complexes, Annu Rev Biochem, 84, 551, 10.1146/annurev-biochem-060614-034142 Laskowski, 2009, The structural basis of allosteric regulation in proteins, FEBS Lett, 583, 1692, 10.1016/j.febslet.2009.03.019 Teixeira, 2018, YEASTRACT: an upgraded database for the analysis of transcription regulatory networks in Saccharomyces cerevisiae, Nucleic Acids Res, 46, 348, 10.1093/nar/gkx842 Morse, 2017, Yeast terminator function can be modulated and designed on the basis of predictions of nucleosome occupancy, ACS Synth Biol, 6, 2086, 10.1021/acssynbio.7b00138 Curran, 2014, Design of synthetic yeast promoters via tuning of nucleosome architecture, Nat Commun, 5, 4002, 10.1038/ncomms5002 Keung, 2015, Chromatin regulation at the frontier of synthetic biology, Nat Rev Genet, 16, 159, 10.1038/nrg3900 Lanctot, 2007, Dynamic genome architecture in the nuclear space: regulation of gene expression in three dimensions, Nat Rev Genet, 8, 104, 10.1038/nrg2041 Nguyen, 2015, Gene positioning effects on expression in eukaryotes, Annu Rev Genet, 49, 627, 10.1146/annurev-genet-112414-055008 Green, 2012, A negative feedback loop at the nuclear periphery regulates GAL gene expression, Mol Biol Cell, 23, 1367, 10.1091/mbc.e11-06-0547 Tokuda, 2017, Heterogeneous spatial distribution of transcriptional activity in budding yeast nuclei, Biophys J, 112, 491, 10.1016/j.bpj.2016.11.3201 Andrulis, 1998, Perinuclear localization of chromatin facilitates transcriptional silencing, Nature, 394, 592, 10.1038/29100 Reddy, 2008, Transcriptional repression mediated by repositioning of genes to the nuclear lamina, Nature, 452, 243, 10.1038/nature06727 Kumaran, 2008, A genetic locus targeted to the nuclear periphery in living cells maintains its transcriptional competence, J Cell Biol, 180, 51, 10.1083/jcb.200706060 Taddei, 2006, Nuclear pore association confers optimal expression levels for an inducible yeast gene, Nature, 441, 774, 10.1038/nature04845 Finlan, 2008, Recruitment to the nuclear periphery can alter expression of genes in human cells, PLoS Genet, 4, 10.1371/journal.pgen.1000039 Kiermaier, 2009, A Dam1-based artificial kinetochore is sufficient to promote chromosome segregation in budding yeast, Nat Cell Biol, 11, 1109, 10.1038/ncb1924 Lacefield, 2009, Recruiting a microtubule-binding complex to DNA directs chromosome segregation in budding yeast, Nat Cell Biol, 11, 1116, 10.1038/ncb1925 Wang, 2018, CRISPR-mediated programmable 3D genome positioning and nuclear organization, Cell, 175, 10.1016/j.cell.2018.09.013 Chavez, 2015, Highly efficient Cas9-mediated transcriptional programming, Nat Methods, 12, 326, 10.1038/nmeth.3312 Lin, 2017, Synthetic protein scaffolds for biosynthetic pathway colocalization on lipid droplet membranes, ACS Synth Biol, 6, 1534, 10.1021/acssynbio.7b00041 Gehlen, 2011, Nuclear geometry and rapid mitosis ensure asymmetric episome segregation in yeast, Curr Biol, 21, 25, 10.1016/j.cub.2010.12.016 Ahmed, 2010, DNA zip codes control an ancient mechanism for gene targeting to the nuclear periphery, Nat Cell Biol, 12, 111, 10.1038/ncb2011