CRISPR/Cas9-Mediated Adenine Base Editing in Rice Genome

Che, 2015, Control of grain size and rice yield by GL2-mediated brassinosteroid responses, Nat Plants, 2, 15195, 10.1038/nplants.2015.195 Dang, 2015, Optimizing sgRNA structure to improve CRISPR- Cas9 knockout efficiency, Genome Biol, 16, 280, 10.1186/s13059-015-0846-3 Gaudelli, 2017, Programmable base editing of A·T to G·C in genomic DNA without DNA cleavage, Nature, 551, 464, 10.1038/nature24644 Hu, 2018, Increasing the efficiency of CRISPR-Cas9-VQR precise genome editing in rice, Plant Biotechnol J, 16, 292, 10.1111/pbi.12771 Hua, 2018, Precise A·T to G·C base editing in the rice genome, Mol Plant, 11, 627, 10.1016/j.molp.2018.02.007 Koblan, 2018, Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction, Nat Biotechnol, 10.1038/nbt.4172 Komor, 2016, Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage, Nature, 533, 420, 10.1038/nature17946 Li, 2018, Expanded base editing in rice and wheat using a Cas9-adenosine deaminase fusion, Genome Biol, 19, 59, 10.1186/s13059-018-1443-z Liu, 2014, OsmiR396d-regulated OsGRFs function in floral organogenesis in rice through binding to their targets OsJMJ706 and OsCR4, Plant Physiol, 165, 160, 10.1104/pp.114.235564 Lu, 2017, Precise editing of a target base in the rice genome using a modified CRISPR/Cas9 system, Mol Plant, 10, 523, 10.1016/j.molp.2016.11.013 Miki, 2018, CRISPR/Cas9-mediated gene targeting in Arabidopsis using sequential transformation, Nat Commun, 9, 1967, 10.1038/s41467-018-04416-0 Sato, 2002, Molecular characterization of Wx-mq, a novel mutant gene for low-amylose content in endosperm of rice (Oryza sativa L.), Jpn J Breeding, 52, 131 Xing, 2014, A CRISPR/Cas9 toolkit for multiplex genome editing in plants, BMC Plant Biol, 14, 327, 10.1186/s12870-014-0327-y Xu, 2016, Rapid improvement of grain weight via highly efficient CRISPR/Cas9-mediated multiplex genome editing in rice, J Genet Genom, 43, 529, 10.1016/j.jgg.2016.07.003 Yan, 2018, Highly efficient A·T to G·C base editing by Cas9n-guided tRNA adenosine deaminase in rice, Mol Plant, 11, 631, 10.1016/j.molp.2018.02.008 Zong, 2017, Precise base editing in rice, wheat and maize with a Cas9-cytidine deaminase fusion, Nat Biotechnol, 35, 438, 10.1038/nbt.3811