CREB AND MEMORY

Annual Review of Neuroscience - Tập 21 Số 1 - Trang 127-148 - 1998
Alcino J. Silva1, Jeffrey H. Kogan1, Paul W. Frankland1, Satoshi Kida1
1Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724

Tóm tắt

▪ Abstract  The cAMP responsive element binding protein (CREB) is a nuclear protein that modulates the transcription of genes with cAMP responsive elements in their promoters. Increases in the concentration of either calcium or cAMP can trigger the phosphorylation and activation of CREB. This transcription factor is a component of intracellular signaling events that regulate a wide range of biological functions, from spermatogenesis to circadian rhythms and memory. Here we review the key features of CREB-dependent transcription, as well as the involvement of CREB in memory formation. Evidence from Aplysia, Drosophila, mice, and rats shows that CREB-dependent transcription is required for the cellular events underlying long-term but not short-term memory. While the work in Aplysia and Drosophila only involved CREB function in very simple forms of conditioning, genetic and pharmacological studies in mice and rats demonstrate that CREB is required for a variety of complex forms of memory, including spatial and social learning, thus indicating that CREB may be a universal modulator of processes required for memory formation.

Từ khóa


Tài liệu tham khảo

10.1016/S0092-8674(00)81904-2

10.1016/0092-8674(94)90386-7

10.1126/science.7682336

10.1006/smns.1994.1005

10.1016/0896-6273(95)90166-3

Barondes SH. 1975.Protein synthesis dependent and protein synthesis independent memory storage processes.In Short-Term Memory, ed. D Deutsch, JA Deutsch, pp. 379–90. New York: Academic

10.1016/0092-8674(95)90213-9

10.1016/S0092-8674(00)81816-4

10.1002/j.1460-2075.1996.tb00447.x

10.1038/361031a0

10.1016/0896-6273(95)90018-7

10.1016/0092-8674(94)90400-6

10.1016/S0959-437X(05)80274-6

10.1002/hipo.450050606

10.1152/physrev.1987.67.2.329

Byrne JH, Zwartjes R, Homayouni R, Critz SD, Eskin A. 1993. Roles of second messenger pathways in neuronal plasticity and in learning and memory. Insights gained fromAplysia. InAdvances in Second Messenger and Phosphoprotein Research, ed. S Shenolikar, AC Nairn, pp. 47–108. New York: Raven

10.1126/science.6681571

10.1126/science.175.4020.451

10.1523/JNEUROSCI.07-07-02232.1987

10.1038/345718a0

10.1073/pnas.88.11.5061

10.1016/S0896-6273(00)80199-3

10.1037//0033-2909.96.3.518

10.1016/S0896-6273(00)80026-4

10.1146/annurev.ps.29.020178.003103

Ebbinghaus H. 1885.Über das Gedächtnis. New York: Dover

10.1126/science.8211146

10.1037//0097-7403.14.2.187

Fantozzi DA, 1994, J. Biol. Chem., 269, 2676, 10.1016/S0021-9258(17)41997-1

10.1126/science.141.3575.57

10.1016/0092-8674(91)90503-Q

10.1126/science.8389057

10.1016/0006-8993(88)90008-X

10.1016/0006-8993(90)91578-5

10.1073/pnas.82.23.8266

10.1016/0031-9384(88)90285-5

10.1016/S0003-3472(83)80232-2

10.1126/science.7716515

10.1126/science.8097062

10.1016/0092-8674(89)90013-5

10.1038/337749a0

10.1073/pnas.94.6.2693

10.1016/0092-8674(92)90537-M

10.1128/MCB.13.8.4852

10.1101/gad.3.12b.2083

10.1038/385260a0

10.1126/science.2974179

Huang Y-Y, 1994, Learn. Mem., 1, 74, 10.1101/lm.1.1.74

10.1101/lm.3.2-3.74

10.1073/pnas.91.12.5647

10.1016/S0896-6273(00)80120-8

10.1016/0896-6273(93)90331-K

10.1016/S0092-8674(00)81118-6

10.1126/science.273.5280.1402

10.1073/pnas.89.11.4820

10.1126/science.1585183

10.1016/S0960-9822(06)00022-4

10.1002/j.1460-2075.1993.tb05759.x

10.1146/annurev.ps.46.020195.001233

10.1016/S0896-6273(00)80245-7

Madison DV, 1991, New Biol., 3, 549

10.1016/0092-8674(94)90517-7

10.1126/science.7973700

10.1016/0166-4328(89)90004-1

10.1006/nlme.1995.1001

10.1016/0301-0082(89)90024-5

10.1523/JNEUROSCI.16-22-07099.1996

10.1016/0959-4388(95)80019-0

10.1037//0033-295X.102.3.419

10.1146/annurev.ne.12.030189.001351

10.1126/science.1662413

10.1016/0092-8674(93)90532-U

10.1126/science.3775383

10.1074/jbc.271.24.14214

10.1016/0023-9690(81)90020-5

10.1038/297681a0

10.1126/science.8066450

10.1038/376348a0

10.1037//0735-7044.106.2.274

10.1146/annurev.cb.11.110195.002035

10.1126/science.2454509

10.1016/S0896-6273(00)80197-X

10.1016/S0896-6273(00)80198-1

10.1126/science.1646483

10.1016/0959-4388(94)90104-X

10.1037//0735-7036.98.3.257

10.1038/350622a0

10.1016/0304-3940(82)90032-5

Tully T. 1991. Genetic dissection of learning and memory inDrosophila melanogaster. InNeurobiology of Learning, Emotion, and Affect, ed. J Madden, pp. 30–66. New York: Raven

10.1016/0092-8674(94)90398-0

10.1128/MCB.15.1.415

Wen W, 1994, J. Biol. Chem., 269, 32214, 10.1016/S0021-9258(18)31623-5

10.1016/0166-4328(90)90012-4

10.1016/0092-8674(90)90664-Z

10.1016/0092-8674(95)90375-5

10.1016/0092-8674(94)90399-9

10.1126/science.275.5304.1318

Thông tin
Thông tin xuất bản

Annual Review of Neuroscience

Tập 21 Số 1

127-148

Thông tin tác giả