COVID-19 và thuốc chống động kinh: một phương pháp hướng dẫn thực hành khi nirmatrelvir/ritonavir được đồng kê đơn

European Journal of Clinical Pharmacology - Tập 78 - Trang 1697-1701 - 2022
Nadir Yalcin1,2, Karel Allegaert2,3,4
1Department of Clinical Pharmacy, Faculty of Pharmacy, Hacettepe University, Ankara, Turkey
2Department of Clinical Pharmacy, Erasmus MC, Rotterdam, The Netherlands
3Department of Pharmaceutical and Pharmacological Sciences, KU Leuven, Leuven, Belgium
4Department of Development and Regeneration, KU Leuven, Leuven, Belgium

Tóm tắt

Quản lý và điều chỉnh liều là mối quan tâm lớn đối với các bác sĩ lâm sàng trong việc thiếu dữ liệu kết quả lâm sàng cụ thể cho bệnh nhân đang sử dụng thuốc chống động kinh (AEDs), trong trường hợp đồng thời tiếp xúc ngắn hạn (5 ngày) với nirmatrelvir/ritonavir. Do đó, trong báo cáo này, chúng tôi đã xác định các loại thuốc yêu cầu điều chỉnh liều do tương tác thuốc (DDIs) giữa nirmatrelvir/ritonavir và các thuốc chống động kinh. Chúng tôi đã sử dụng bốn cơ sở dữ liệu (Micromedex Drug Interaction, Liverpool Drug Interaction Group for COVID-19 Therapies, Medscape Drug Interaction Checker và Lexicomp Drug Interactions) cùng với DDI-Predictor. Khi áp dụng DDI-Predictor, đối với carbamazepine, clobazam, oxcarbazepine, eslicarbazepine, phenytoin, phenobarbital, pentobarbital, rufinamide và valproate như là các chất cảm ứng CYP3A4, chúng tôi khuyến nghị điều chỉnh liều của nirmatrelvir/ritonavir trong thời gian ngắn như một loại thuốc nền (nạn nhân) sẽ phù hợp hơn thay vì những thuốc chống động kinh này nhằm tránh những mối đe dọa liên quan đến DDI trong bệnh nhân động kinh.

Từ khóa


Tài liệu tham khảo

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