CMLS forum reviews: mitochondrial damage control
Tóm tắt
Mitochondria supply cellular energy through oxidative phosphorylation and fulfill numerous additional functions that are fundamental to cellular homeostasis and stress responses. Mitochondrial malfunction, arising from inherent defects of the organelle itself, aging, or acute or chronic stress, can cause substantial damage to organismal health. For instance, mitochondrial malfunction contributes to inflammation, neurodegeneration, tumorigenesis and cardiovascular diseases. Therefore, various quality control mechanisms exist that support a functional mitochondrial organelle compartment. The CMLS Forum Reviews introduced here present a collection of articles covering select topics on basic mechanisms and pathophysiological contexts of mitochondrial damage control.
Tài liệu tham khảo
Quiros PM, Langer T, Lopez-Otin C (2015) New roles for mitochondrial proteases in health, ageing and disease. Nat Rev Mol Cell Biol 16:345–359. https://doi.org/10.1038/nrm3984
Soubannier V et al (2012) A vesicular transport pathway shuttles cargo from mitochondria to lysosomes. Curr Biol 22:135–141. https://doi.org/10.1016/j.cub.2011.11.057
Sugiura A, McLelland GL, Fon EA, McBride HM (2014) A new pathway for mitochondrial quality control: mitochondrial-derived vesicles. EMBO J 33:2142–2156. https://doi.org/10.15252/embj.201488104
Hamacher-Brady A, Brady NR (2016) Mitophagy programs: mechanisms and physiological implications of mitochondrial targeting by autophagy. Cell Mol Life Sci 73:775–795. https://doi.org/10.1007/s00018-015-2087-8
Pickles S, Vigie P, Youle RJ (2018) Mitophagy and quality control mechanisms in mitochondrial maintenance. Curr Biol 28:R170–R185. https://doi.org/10.1016/j.cub.2018.01.004
Jornayvaz FR, Shulman GI (2010) Regulation of mitochondrial biogenesis. Essays Biochem 47:69–84. https://doi.org/10.1042/bse0470069
Jazwinski SM (1833) The retrograde response: when mitochondrial quality control is not enough. Biochim Biophys Acta 400–409:2013. https://doi.org/10.1016/j.bbamcr.2012.02.010
Bock FJ, Tait SWG (2019) Mitochondria as multifaceted regulators of cell death. Nat Rev Mol Cell Biol. https://doi.org/10.1038/s41580-019-0173-8
Fuchs Y, Steller H (2015) Live to die another way: modes of programmed cell death and the signals emanating from dying cells. Nat Rev Mol Cell Biol 16:329–344. https://doi.org/10.1038/nrm3999
Strasser A, Cory S, Adams JM (2011) Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases. EMBO J 30:3667–3683. https://doi.org/10.1038/emboj.2011.307
Galluzzi L et al (2018) Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ 25:486–541. https://doi.org/10.1038/s41418-017-0012-4
Tait SW, Green DR (2010) Mitochondria and cell death: outer membrane permeabilization and beyond. Nat Rev Mol Cell Biol 11:621–632. https://doi.org/10.1038/nrm2952
Valm AM et al (2017) Applying systems-level spectral imaging and analysis to reveal the organelle interactome. Nature 546:162–167. https://doi.org/10.1038/nature22369
Murley A, Nunnari J (2016) The emerging network of mitochondria-organelle contacts. Mol Cell 61:648–653. https://doi.org/10.1016/j.molcel.2016.01.031
de Brito OM, Scorrano L (2010) An intimate liaison: spatial organization of the endoplasmic reticulum-mitochondria relationship. EMBO J 29:2715–2723. https://doi.org/10.1038/emboj.2010.177
Rowland AA, Voeltz GK (2012) Endoplasmic reticulum-mitochondria contacts: function of the junction. Nat Rev Mol Cell Biol 13:607–625. https://doi.org/10.1038/nrm3440
Prudent J, McBride HM (2017) The mitochondria-endoplasmic reticulum contact sites: a signalling platform for cell death. Curr Opin Cell Biol 47:52–63. https://doi.org/10.1016/j.ceb.2017.03.007
Wong YC, Kim S, Peng W, Krainc D (2019) Regulation and function of mitochondria-lysosome membrane contact sites in cellular homeostasis. Trends Cell Biol 29:500–513. https://doi.org/10.1016/j.tcb.2019.02.004
Desai R et al (2020) Mitochondria form contact sites with the nucleus to couple prosurvival retrograde response. Sci Adv. https://doi.org/10.1126/sciadv.abc9955
Giacomello M, Pyakurel A, Glytsou C, Scorrano L (2020) The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol 21:204–224. https://doi.org/10.1038/s41580-020-0210-7
Wai T, Langer T (2016) Mitochondrial Dynamics and Metabolic Regulation. Trends Endocrinol Metab 27:105–117. https://doi.org/10.1016/j.tem.2015.12.001
Mishra P, Chan DC (2016) Metabolic regulation of mitochondrial dynamics. J Cell Biol 212:379–387. https://doi.org/10.1083/jcb.201511036
Melkov A, Abdu U (2018) Regulation of long-distance transport of mitochondria along microtubules. Cell Mol Life Sci 75:163–176. https://doi.org/10.1007/s00018-017-2590-1
Chan DC (2020) Mitochondrial dynamics and its involvement in disease. Annu Rev Pathol 15:235–259. https://doi.org/10.1146/annurev-pathmechdis-012419-032711
Dorn GW 2nd, Vega RB, Kelly DP (2015) Mitochondrial biogenesis and dynamics in the developing and diseased heart. Genes Dev 29:1981–1991. https://doi.org/10.1101/gad.269894.115
Hom J, Sheu SS (2009) Morphological dynamics of mitochondria–a special emphasis on cardiac muscle cells. J Mol Cell Cardiol 46:811–820. https://doi.org/10.1016/j.yjmcc.2009.02.023
Glancy B et al (2017) Power grid protection of the muscle mitochondrial reticulum. Cell Rep 19:487–496. https://doi.org/10.1016/j.celrep.2017.03.063
Ballinger SW (2005) Mitochondrial dysfunction in cardiovascular disease. Free Radic Biol Med 38:1278–1295. https://doi.org/10.1016/j.freeradbiomed.2005.02.014
Bonora M et al (2019) Targeting mitochondria for cardiovascular disorders: therapeutic potential and obstacles. Nat Rev Cardiol 16:33–55. https://doi.org/10.1038/s41569-018-0074-0