CLINICAL EFFICACY OF PROBIOTICS AS AN ADJUNCTIVE THERAPY TO SCALING AND ROOT PLANNING IN THE MANAGEMENT OF PERIODONTITIS: A SYSTEMATIC REVIEW AND META-ANALYSIS OF RANDOMIZED CONTROLLED TRAILS

Baelum, 2013, Periodontal disease epidemiology - learned and unlearned?, Periodontol 2000, 62, 37, 10.1111/j.1600-0757.2012.00449.x Aljateeli, 2014, Surgical periodontal therapy with and without initial scaling and root planing in the management of chronic periodontitis: a randomized clinical trial, J Clin Periodontol, 41, 693, 10.1111/jcpe.12259 Mombelli, 2018, Microbial colonization of the periodontal pocket and its significance for periodontal therapy, Periodontol 2000, 76, 85, 10.1111/prd.12147 Bonito, 2005, Impact of local adjuncts to scaling and root planing in periodontal disease therapy: a systematic review, J Periodontol, 76, 1227, 10.1902/jop.2005.76.8.1227 Gandhi, 2019, Effectiveness of adjunctive use of low-level laser therapy and photodynamic therapy after scaling and root planing in patients with chronic periodontitis, Int J Periodontics Restorative Dent, 39, 837, 10.11607/prd.4252 Gruner, 2016, Probiotics for managing caries and periodontitis: systematic review and meta-analysis, J Dent, 48, 16, 10.1016/j.jdent.2016.03.002 Saxelin, 2005, Probiotic and other functional microbes: from markets to mechanisms, Curr Opin Biotechnol, 16, 204, 10.1016/j.copbio.2005.02.003 Matsubara, 2016, The role of probiotic bacteria in managing periodontal disease: a systematic review, Expert Rev Anti Infect Ther, 14, 643, 10.1080/14787210.2016.1194198 Ince, 2015, Clinical and biochemical evaluation of lozenges containing lactobacillus reuteri as an adjunct to non-surgical periodontal therapy in chronic periodontitis, J Periodontol, 86, 746, 10.1902/jop.2015.140612 Invernici, 2018, Effects of Bifidobacterium probiotic on the treatment of chronic periodontitis: a randomized clinical trial, J Clin Periodontol, 45, 1198, 10.1111/jcpe.12995 Tekce, 2015, Clinical and microbiological effects of probiotic lozenges in the treatment of chronic periodontitis: a 1-year follow-up study, J Clin Periodontol, 42, 363, 10.1111/jcpe.12387 Teughels, 2013, Clinical and microbiological effects of Lactobacillus reuteri probiotics in the treatment of chronic periodontitis: a randomized placebo-controlled study, J Clin Periodontol, 40, 1025, 10.1111/jcpe.12155 Martin-Cabezas, 2016, Clinical efficacy of probiotics as an adjunctive therapy to non-surgical periodontal treatment of chronic periodontitis: a systematic review and meta-analysis, J Clin Periodontol, 43, 520, 10.1111/jcpe.12545 Liberati, 2009, The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration, BMJ, 339, b2700, 10.1136/bmj.b2700 Song, 2020, Role of probiotics containing Lactobacillus reuteri in adjunct to scaling and root planing for management of patients with chronic periodontitis: a meta-analysis, Eur Rev Med Pharmacol Sci, 24, 4495 Alshareef, 2020, Effectiveness of Probiotic Lozenges in Periodontal Management of Chronic Periodontitis Patients: clinical and Immunological Study, Eur J Dent, 14, 281, 10.1055/s-0040-1709924 Chandra, 2016, Effect of a locally delivered probiotic-prebiotic mixture as an adjunct to scaling and root planing in the management of chronic periodontitis, J Int Acad Periodontol, 18, 67 Costacurta, 2018, Clinical effects of lactobacillus reuteri probiotic in treatment of chronic periodontitis. A randomized, controlled trial, Oral Implantol, 11, 191 Dhaliwal, 2017, Clinical and microbiological investigation of the effects of probiotics combined with scaling and root planing in the management of chronic periodontitis: a randomized, controlled study, J Int Acad Periodontol, 19, 101 Ikram, 2019, Clinical effcacy of probiotics as an adjunct to scaling and root planing in the treatment of chronic periodontitis, Annals ASH KMDC, 24, 31 Invernici, 2020, Bifidobacterium animalis subsp lactis HN019 presents antimicrobial potential against periodontopathogens and modulates the immunological response of oral mucosa in periodontitis patients, PLoS ONE, 15, 10.1371/journal.pone.0238425 Laleman, 2020, A dual-strain Lactobacilli reuteri probiotic improves the treatment of residual pockets: a randomized controlled clinical trial, J Clin Periodontol, 47, 43, 10.1111/jcpe.13198 Laleman, 2015, The effect of a streptococci containing probiotic in periodontal therapy: a randomized controlled trial, J Clin Periodontol, 42, 1032, 10.1111/jcpe.12464 Mani, 2017, Efficacy of oral probiotics as an adjunct to scaling and root planing in nonsurgical treatment outcome of generalized chronic periodontitis patients: a clinico-microbiological study, Int J Exp Dent Sci, 6, 6, 10.5005/jp-journals-10029-1145 Meenakshi, 2018, Adjunctive effect of probiotic (Lactobacillus casei Shirota) to scaling and root planing in the management of chronic periodontitis, Drug Invention Today, 10, 1381 Morales, 2016, clinical effects of lactobacillus rhamnosus in non-surgical treatment of chronic periodontitis: a randomized placebo-controlled trial with 1-year follow-up, J Periodontol, 87, 944, 10.1902/jop.2016.150665 Morales, 2018, Microbiological and clinical effects of probiotics and antibiotics on nonsurgical treatment of chronic periodontitis: a randomized placebo- controlled trial with 9-month follow-up, J Appl Oral Sci, 26, 10.1590/1678-7757-2017-0075 Pelekos, 2019, A double-blind, paralleled-arm, placebo-controlled and randomized clinical trial of the effectiveness of probiotics as an adjunct in periodontal care, J Clin Periodontol, 46, 1217, 10.1111/jcpe.13191 Penala, 2016, Efficacy of local use of probiotics as an adjunct to scaling and root planing in chronic periodontitis and halitosis: a randomized controlled trial, J Res Pharm Pract, 5, 86, 10.4103/2279-042X.179568 Pudgar, 2020, Probiotic strains of Lactobacillus brevis and Lactobacillus plantarum as adjunct to non-surgical periodontal therapy: 3-month results of a randomized controlled clinical trial, Clin Oral Investig Sajedinejad, 2018, Lactobacillus salivarius NK02: a potent probiotic for clinical application in mouthwash, Probiotics Antimicrob Proteins, 10, 485, 10.1007/s12602-017-9296-4 Soares, 2019, Clinical effect of Lactobacillus on the treatment of severe periodontitis and halitosis: a double-blinded, placebo-controlled, randomized clinical trial, Am J Dent, 32, 9 Theodoro, 2019, Effects of Lactobacillus reuteri as an adjunct to the treatment of periodontitis in smokers: randomised clinical trial, Benef Microbes, 10, 375, 10.3920/BM2018.0150 Vicario, 2013, Clinical changes in periodontal subjects with the probiotic Lactobacillus reuteri Prodentis: a preliminary randomized clinical trial, Acta Odontol Scand, 71, 813, 10.3109/00016357.2012.734404 Vivekananda, 2010, Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial, J Oral Microbiol, 2, 10.3402/jom.v2i0.5344 Vohra, 2020, Effectiveness of scaling and root planing with and without adjunct probiotic therapy in the treatment of chronic periodontitis among shamma users and non-users: a randomized controlled trial, J Periodontol, 10.1002/JPER.19-0464 Murakami, 2018, Dental plaque-induced gingival conditions, J Clin Periodontol, 45, S17 Meurman, 2005, Probiotics: do they have a role in oral medicine and dentistry?, Eur J Oral Sci, 113, 188, 10.1111/j.1600-0722.2005.00191.x Albuquerque-Souza, 2019, Probiotics alter the immune response of gingival epithelial cells challenged by Porphyromonas gingivalis, J Periodontal Res, 54, 115, 10.1111/jre.12608 Szkaradkiewicz, 2014, Effect of oral administration involving a probiotic strain of Lactobacillus reuteri on pro-inflammatory cytokine response in patients with chronic periodontitis, Arch Immunol Ther Exp (Warsz), 62, 495, 10.1007/s00005-014-0277-y Cosme-Silva, 2019, Systemic administration of probiotics reduces the severity of apical periodontitis, Int Endod J, 52, 1738, 10.1111/iej.13192 Baca-Castanon, 2015, Antimicrobial Effect of Lactobacillus reuteri on Cariogenic Bacteria Streptococcus gordonii, Streptococcus mutans, and Periodontal Diseases Actinomyces naeslundii and Tannerella forsythia, Probiotics Antimicrob Proteins, 7, 1, 10.1007/s12602-014-9178-y Haukioja, 2006, Oral adhesion and survival of probiotic and other lactobacilli and bifidobacteria in vitro, Oral Microbiol Immunol, 21, 326, 10.1111/j.1399-302X.2006.00299.x Iniesta, 2012, Probiotic effects of orally administered Lactobacillus reuteri-containing tablets on the subgingival and salivary microbiota in patients with gingivitis. A randomized clinical trial, J Clin Periodontol, 39, 736, 10.1111/j.1600-051X.2012.01914.x Shimauchi, 2008, Improvement of periodontal condition by probiotics with Lactobacillus salivarius WB21: a randomized, double-blind, placebo-controlled study, J Clin Periodontol, 35, 897, 10.1111/j.1600-051X.2008.01306.x