CD8+ T cells PUF(A)ing the flames of cancer ferroptotic cell death

Dixon, 2015, Human Haploid Cell Genetics Reveals Roles for Lipid Metabolism Genes in Nonapoptotic Cell Death, ACS Chem. Biol., 10, 1604, 10.1021/acschembio.5b00245 Doll, 2017, ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition, Nat. Chem. Biol., 13, 91, 10.1038/nchembio.2239 Killion, 2018, A role for long-chain acyl-CoA synthetase-4 (ACSL4) in diet-induced phospholipid remodeling and obesity-associated adipocyte dysfunction, Mol. Metab., 9, 43, 10.1016/j.molmet.2018.01.012 Liao, 2022, CD8+ T cells and fatty acids orchestrate tumor ferroptosis and immunity via ACSL4, Cancer Cell, 40, 10.1016/j.ccell.2022.02.003 Matsushita, 2015, T cell lipid peroxidation induces ferroptosis and prevents immunity to infection, J. Exp. Med., 212, 555, 10.1084/jem.20140857 Stockwell, 2017, Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease, Cell, 171, 273, 10.1016/j.cell.2017.09.021 Wang, 2019, CD8+ T cells regulate tumour ferroptosis during cancer immunotherapy, Nature, 569, 270, 10.1038/s41586-019-1170-y Wang, 2019, Paradoxical effects of obesity on T cell function during tumor progression and PD-1 checkpoint blockade, Nat. Med., 25, 141, 10.1038/s41591-018-0221-5 Zhang, 2022, PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis, Nat. Cell Biol., 24, 88, 10.1038/s41556-021-00818-3 Zilka, 2017, On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death, ACS Cent. Sci., 3, 232, 10.1021/acscentsci.7b00028