CD4+T Cells and Toll-Like Receptors RecognizeSalmonellaAntigens Expressed in Bacterial Surface Organelles

Infection and Immunity - Tập 73 Số 3 - Trang 1350-1356 - 2005
Molly A. Bergman1,2, Lisa A. Cummings3,4,1, Sara L. Rassoulian Barrett3,4,1, Kelly D. Smith5,6, J C Lara1,2, Alan Aderem5, Brad T. Cookson1,2
1Departments of Microbiology
2Laboratory Medicine 2 , and Pathology 3 , University of Washington, and Institute for Systems Biology,
3Department of Molecular Biology and Microbi-ology, Tufts University School of Medicine, Boston, MA 021112.
4Departments of Labo-ratory Medicine and Microbiology, University of Washington Med-ical Center, Mailstop 357110, 1959 NE Pacific Ave., Seattle, WA 98195.
5Institute for Systems Biology, Seattle, Washington
6Pathology, University of Washington

Tóm tắt

ABSTRACTA better understanding of immunity to infection is revealed from the characteristics of microbial ligands recognized by host immune responses. Murine infection with the intracellular bacteriumSalmonellagenerates CD4+T cells that specifically recognizeSalmonellaproteins expressed in bacterial surface organelles such as flagella and membrane vesicles. These naturalSalmonellaantigens are also ligands for Toll-like receptors (TLRs) or avidly associated with TLR ligands such as lipopolysaccharide (LPS). PhoP/PhoQ, a regulon controllingSalmonellavirulence and remodeling of LPS to resist innate immunity, coordinately represses production of surface-exposed antigens recognized by CD4+T cells and TLRs. These data suggest that genetically coordinated surface modifications may provide a growth advantage forSalmonellain host tissues by limiting both innate and adaptive immune recognition.

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Infection and Immunity

Tập 73 Số 3

1350-1356

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